GIANT consortium data files

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= [[Main Page|GIANT consortium]] GWAS metadata is available here for download. =
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We are releasing the summary data from our meta-analyses of Genome-Wide Association Studies (GWAS) in order to enable other researchers to examine particular variants or loci for their evidence of association with anthropometric traits. The files include p-values and direction of effect at over 2 million directly genotyped or imputed single nucleotide polymorphisms (SNPs). To prevent the possibility of identification of individuals from these summary results, we are not releasing allele frequency data from our samples.  
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We are releasing the summary data from our 2010 meta-analyses of Genome-wide Association (GWA) data, in order to enable other researchers to examine particular variants or loci for their evidence of association with anthropometric traits. The files include p-values and direction of effect at over 2 million directly genotyped or imputed single nucleotide polymorphisms (SNPs). To prevent the possibility of identification of individuals from these summary results, we are not releasing allele frequency data from our samples. A manuscript describing the rationale for releasing association data but not frequency data is in preparation.
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='''2018 Exome Array Summary Statistics'''=
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==WHR Exome Array Summary Statistics==
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[[Media:Data_File_Description_2018_Exome_Array_Summary_Statistics_WHR_Exome_Array_Summary_Statistics.docx | Download WHR Exome Array Data File Description ]]
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'''Data file description:'''
 
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Each file consists of the following information for each SNP and its association to the specified trait based on meta-analysis in the respective publication. SNPs where N < 50% of the maximum have been excluded.
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'''WHR Data Files:'''
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*[[Media:PublicRelease.WHRadjBMI.C.All.Add.txt.gz | Download WHRadjBMI.C.All.Add GZIP ]]
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*[[Media:PublicRelease.WHRadjBMI.C.All.Rec.txt.gz | WHRadjBMI.C.All.Rec]]
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*[[Media:PublicRelease.WHRadjBMI.C.Eur.Add.txt.gz | WHRadjBMI.C.Eur.Add]]
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*[[Media:PublicRelease.WHRadjBMI.C.Eur.Rec.txt.gz | WHRadjBMI.C.Eur.Rec]]
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*[[Media:PublicRelease.WHRadjBMI.M.All.Add.txt.gz | WHRadjBMI.M.All.Add]]
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*[[Media:PublicRelease.WHRadjBMI.M.All.Rec.txt.gz | WHRadjBMI.M.All.Rec]]
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*[[Media:PublicRelease.WHRadjBMI.M.Eur.Add.txt.gz | WHRadjBMI.M.Eur.Add]]
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*[[Media:PublicRelease.WHRadjBMI.M.Eur.Rec.txt.gz|WHRadjBMI.M.Eur.Rec]]
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*[[Media:PublicRelease.WHRadjBMI.W.All.Add.txt.gz| WHRadjBMI.W.All.Add]]
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*[[Media:PublicRelease.WHRadjBMI.W.All.Rec.txt.gz | WHRadjBMI.W.All.Rec]]
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*[[Media:PublicRelease.WHRadjBMI.W.Eur.Add.txt.gz|WHRadjBMI.W.Eur.Add]]
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*[[Media:PublicRelease.WHRadjBMI.W.Eur.Rec.txt.gz|WHRadjBMI.W.Eur.Rec]]
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;MarkerName  :The [http://www.ncbi.nlm.nih.gov/SNP/ dbSNP] name of the genetic marker
 
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;Allele1      :The first allele, by definition the trait-increasing allele (hg18 + strand)
 
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;Allele2      :The second allele (hg18 + strand)
 
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;Freq.Allele1.HapMapCEU    :The allele frequency of Allele1 in the [http://www.hapmap.org HapMap] CEU population
 
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;p            :P value after meta-analysis using regression coefficients (beta and standard error), and after correction for inflation of test statistics using genomic control both at the individual study level and again after meta-analysis
 
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;N            :Number of observations
 
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==BMI Exome Array Summary Statistics==
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'''BMI Data Files:'''
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*[[Media:BMI_African_American.fmt.gzip|BMI_African_American gzip]]
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*[[Media:BMI_All_ancestry.fmt.gzip|BMI_All_Ancestry gzip]]
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*[[Media:BMI_Eastern_Asian.fmt.gzip| BMI_Eastern_Asian gzip]]
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*[[Media:BMI_European.fmt.gzip| BMI_European gzip]]
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*[[Media:BMI_Hispanic_American.fmt.gzip| BMI_Hispanic_American gzip]]
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*[[Media:BMI_South_Asian.fmt.gzip| BMI_South_Asian gzip]]
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== BMI ([[Media:GIANT_BMI_Speliotes2010_publicrelease_HapMapCeuFreq.txt.gz|download GZIP]]) ==
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If you use these data, please cite: Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, et al. (2018). Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2018 Jan;50(1):26-41. doi: 10.1038/s41588-017-0011-x. Epub 2017 Dec 22. PMID: 29273807
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<tt>MD5 ([[media:GIANT_BMI_Speliotes2010_publicrelease_HapMapCeuFreq.txt|GIANT_BMI_Speliotes2010_publicrelease_HapMapCeuFreq.txt]] -- 79 MB; 2,471,517 lines) = 38c836542807a3830101bcf48bb34472</tt>
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If you use these '''Body Mass Index''' data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=20935630 Speliotes, E.K., Willer, C.J., Berndt, S.I., Monda, K.L., Thorleifsson, G., Jackson, A.U., Allen, H.L., Lindgren, C.M., Luan, J., Magi, R., et al.] (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet <strong>42</strong>, 937-948.
 
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==Height Exome Array Summary Statistics==
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== Height ([[Media:GIANT_HEIGHT_LangoAllen2010_publicrelease_HapMapCeuFreq.txt.gz ‎|download GZIP]]) ==
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[[Media:Data_File_Description_2018_Exome_Array_Summary_Statistics_Height_Exome_Array_Summary_Statistics.docx‎ | Download Height Exome Array Data File Description]]
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<tt>MD5 ([[media:GIANT_HEIGHT_LangoAllen2010_publicrelease_HapMapCeuFreq.txt|GIANT_HEIGHT_LangoAllen2010_publicrelease_HapMapCeuFreq.txt]] -- 82 MB; 2,469,636 lines) = b51b4c4ff1f03bd33c4b2dfd6b10cb82</tt>
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If you use these '''height''' data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=20881960 Lango Allen, H., Estrada, K., Lettre, G., Berndt, S.I., Weedon, M.N., Rivadeneira, F., Willer, C.J., Jackson, A.U., Vedantam, S., Raychaudhuri, S., et al.] (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature <strong>467</strong>, 832-838.
 
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'''Height Data Files:'''
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*[[Media:height_HA_add_SV.txt.gz| Download Height HA SV GZIP]]
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*[[Media:height_AA_add_SV.txt.gz| Download Height AA SV GZIP]]
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*[[Media:height_EA_add_SV.txt.gz| Download Height EA SV GZIP]]
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*[[Media:height_EAS_add_SV.txt.gz| Download Height EAS SV GZIP]]
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*[[Media:height_SA_add_SV.txt.gz| Download Height SA SV GZIP]]
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*[[Media:height_All_add_SV.txt.gz| Download Height All SV GZIP]]
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== WHRadjBMI ([[Media:GIANT WHRadjBMI Heid2010 publicrelease HapMapCeuFreq.txt.gz |download GZIP]]) ==
 
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<tt>MD5 ([[media:GIANT_WHRadjBMI_Heid2010_publicrelease_HapMapCeuFreq.txt|GIANT_WHRadjBMI_Heid2010_publicrelease_HapMapCeuFreq.txt]] -- 75 MB; 2,483,326 lines) = 8f7e2ca61c33a120db9e7bfe51e3c053</tt>
 
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If you use these '''waist-hip ratio adjusted for BMI''' data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=20935629 Heid, I.M., Jackson, A.U., Randall, J.C., Winkler, T.W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M.C., Speliotes, E.K., Magi, R., et al.] (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet <strong>42</strong>, 949-960.
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='''2018 GIANT and UK BioBank Meta-analysis'''=
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==WHR GIANT and UK BioBank Meta-analysis Summary Statistics==
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'''WHR UK BioBank Meta Analysis for Public Release:'''
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*[[Media: bmi.giant-ukbb.meta-analysis.males.23May2018.HapMap2_only.txt.gz | Download bmi.giant-ukbb.meta-analysis.males.23May2018.HapMap2_only.txt.gz]]
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*[[Media: bmi.giant-ukbb.meta-analysis.females.23May2018.HapMap2_only.txt.gz | Download bmi.giant-ukbb.meta-analysis.females.23May2018.HapMap2_only.txt.gz]]
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*[[Media: bmi.giant-ukbb.meta-analysis.combined.23May2018.HapMap2_only.txt.gz | Download bmi.giant-ukbb.meta-analysis.combined.23May2018.HapMap2_only.txt.gz]]
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*[[Media: whradjbmi.giant-ukbb.meta-analysis.combined.23May2018.HapMap2_only.txt.gz | Download whradjbmi.giant-ukbb.meta-analysis.combined.23May2018.HapMap2_only.txt.gz]]
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*[[Media: whradjbmi.giant-ukbb.meta-analysis.females.23May2018.HapMap2_only.txt.gz | Download whradjbmi.giant-ukbb.meta-analysis.females.23May2018.HapMap2_only.txt.gz]]
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*[[Media: whradjbmi.giant-ukbb.meta-analysis.males.23May2018.HapMap2_only.txt.gz | Download whradjbmi.giant-ukbb.meta-analysis.males.23May2018.HapMap2_only.txt.gz]]
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*[[Media: README_summary_statistics_Pulit_et_al_2018.txt | Download README_summary_statistics_Pulit_et_al_2018.txt]]
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==BMI==
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Access link for GWAS data for all ~27M sites: https://zenodo.org/record/1251813#.XCLJ7vZKhE4
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If you use these '''Body Mass Index''' data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22982992 Yang J, Loos RJ, Powell JE, Medland SE, Speliotes EK, Chasman DI, Rose LM, Thorleifsson G, Steinthorsdottir V, Mägi R, et al.] (2012). FTO genotype is associated with phenotypic variability of body mass index. Nature <strong>490</strong>, 267-272.
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DOI (10.5281/zenodo.1251813)
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==Sex Stratified Anthropometrics==
 
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==Anthropometric Traits==
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==BMI and Height GIANT and UK BioBank Meta-analysis Summary Statistics==
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Please Note: We discovered that the BMI files for the meta-analysis of UK Biobank and GIANT originally uploaded did not reflect the full sample size and have now been corrected.  If you downloaded these files prior to June 25, 2018, please download them again. Our apologies for any inconvenience.
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*[[Media: Meta-analysis_Locke_et_al+UKBiobank_2018_UPDATED.txt.gz | Download Updated Meta-analysis Locke et al + UKBiobank 2018 GZIP]]
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*[[Media: Meta-analysis_Wood_et_al+UKBiobank_2018.txt.gz | Download  Meta-analysis Wood et al + UKBiobank 2018 GZIP]]
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*[[Media: Meta-analysis_Locke_et_al+UKBiobank_2018_top_941_from_COJO_analysis_UPDATED.txt.gz | Download Updated Meta-analysis Lock et al + UKBiobank 2018 top 716 BMI SNPs from COJO analysis GZIP]]
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*[[Media: Meta-analysis_Wood_et_al+UKBiobank_2018_top_3290_from_COJO_analysis.txt.gz | Download  Meta-analysis Wood et al + UKBiobank 2018 top 3290 Height SNPs from COJO analysis GZIP]]
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*[[Media: README_summary_statistics_Yengo_et_al_2018.txt | Download  README Summary Statistics for Yengo et al 2018]]
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If you use these data, please cite: Yengo L, Sidorenko J, Kemper KE, Zheng Z, Wood AR, Weedon MN, Frayling TM, Hirschhorn J, Yang J, Visscher PM, GIANT Consortium. (2018). Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry. Biorxiv.
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='''2017 Gene x Environment Summary Statistics'''=
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==Summary Statistics for Models Adjusting for Smoking Status==
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[[Media:Data_File_Description_2017_Gene_x_Environment_Summary_Statistics_Summary_Statistics_for_Models_Adjusting_for_Smoking_Status.docx | Download Models Adjusting for Smoking Status Data File Description]]
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'''BMI:'''
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*[[Media: BMI.SNPadjSMK.zip | Download BMI.SNPadjSMK.zip]]
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'''WCadjBMI:'''
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*[[Media: WCadjBMI.SNPadjSMK.zip | Download WCadjBMI.SNPadjSMK.zip ]]
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'''WHRadjBMI:'''
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*[[Media: WHRadjBMI.SNPadjSMK.zip | Download WHRadjBMI GZIP]]
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==Summary Statistics for Smoking Stratified Models==
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[[Media:Data_File_Description_2017_Gene_x_Environment_Summary_Statistics_Summary_Statistics_for_Smoking_Stratified_Models.docx‎ | Download Smoking Stratified Models Data File Description]]
 +
 
 +
 
 +
'''BMI:'''
 +
*[[Media: BMI.Stratified.zip | Download BMI.Stratified.zip]]
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'''WCadjBMI:'''
 +
*[[Media: WCadjBMI.Stratified.zip | Download WCadjBMI.Stratified.zip]]
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'''WHRadjBMI:'''
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*[[Media: WHRadjBMI.Stratified.zip | Download WHRadjBMI.Stratified.zip]]
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==Summary Statistics for Gene x Physical Activity==
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[[Media:Data_File_Description_2017_Gene_x_Environment_Summary_Statistics_Summary_Statistics_for_Gene_x_Physical_Activity.docx | Download Gene x Physical Activity Data File Description]]
 +
 
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'''BMI Data Files:'''
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*BMI Active
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**[[Media: BMI.ACTIVE.ALL.AllAncestry.txt.gz | Download All AllAncestry GZIP]]
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**[[Media: BMI.ACTIVE.ALL.European.txt.gz | Download All European Ancestry GZIP]]
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**[[Media: BMI.ACTIVE.MEN.AllAncestry.txt.gz | Download Men AllAncestry GZIP]]
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**[[Media: BMI.ACTIVE.MEN.European.txt.gz | Download Men European Ancestry GZIP]]
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**[[Media: BMI.ACTIVE.WOMEN.AllAncestry.txt.gz | Download Women AllAncestry GZIP]]
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**[[Media: BMI.ACTIVE.WOMEN.European.txt.gz | Download Women European Ancestry GZIP]]
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*BMI Inactive
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**[[Media: BMI.INACTIVE.ALL.AllAncestry.txt.gz | Download All AllAncestry GZIP]]
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**[[Media: BMI.INACTIVE.ALL.European.txt.gz | Download All European Ancestry GZIP]]
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**[[Media: BMI.INACTIVE.MEN.AllAncestry.txt.gz | Download Men AllAncestry GZIP]]
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**[[Media: BMI.INACTIVE.MEN.European.txt.gz | Download Men European Ancestry GZIP]]
 +
**[[Media: BMI.INACTIVE.WOMEN.AllAncestry.txt.gz | Download Women AllAncestry GZIP]]
 +
**[[Media: BMI.INACTIVE.WOMEN.European.txt.gz | Download Women European Ancestry GZIP]]
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*BMI SNPadjPA
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**[[Media: BMI.SNPadjPA.ALL.AllAncestry.txt.gz | Download All AllAncestry GZIP]]
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**[[Media: BMI.SNPadjPA.ALL.European.txt.gz | Download All European Ancestry GZIP]]
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**[[Media: BMI.SNPadjPA.MEN.AllAncestry.txt.gz | Download Men AllAncestry GZIP]]
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**[[Media: BMI.SNPadjPA.MEN.European.txt.gz | Download Men European Ancestry GZIP]]
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**[[Media: BMI.SNPadjPA.WOMEN.AllAncestry.txt.gz | Download Women AllAncestry GZIP]]
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**[[Media: BMI.SNPadjPA.WOMEN.European.txt.gz | Download Women European Ancestry GZIP]]
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'''WAISTadjBMI Data Files:'''
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*WAISTadjBMI Active
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**[[Media: WAISTadjBMI.ACTIVE.ALL.AllAncestry.txt.gz | Download All AllAncestry GZIP]]
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**[[Media: WAISTadjBMI.ACTIVE.ALL.European.txt.gz | Download All European Ancestry GZIP]]
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**[[Media: WAISTadjBMI.ACTIVE.MEN.AllAncestry.txt.gz | Download Men AllAncestry GZIP]]
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**[[Media: WAISTadjBMI.ACTIVE.MEN.European.txt.gz | Download Men European Ancestry GZIP]]
 +
**[[Media: WAISTadjBMI.ACTIVE.WOMEN.AllAncestry.txt.gz | Download Women AllAncestry GZIP]]
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**[[Media: WAISTadjBMI.ACTIVE.WOMEN.European.txt.gz | Download Women European Ancestry GZIP]]
 +
*WAISTadjBMI Inactive
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**[[Media: WAISTadjBMI.INACTIVE.ALL.AllAncestry.txt.gz | Download All AllAncestry GZIP]]
 +
**[[Media: WAISTadjBMI.INACTIVE.ALL.European.txt.gz | Download All European Ancestry GZIP]]
 +
**[[Media: WAISTadjBMI.INACTIVE.MEN.AllAncestry.txt.gz | Download Men AllAncestry GZIP]]
 +
**[[Media: WAISTadjBMI.INACTIVE.MEN.European.txt.gz | Download Men European Ancestry GZIP]]
 +
**[[Media: WAISTadjBMI.INACTIVE.WOMEN.AllAncestry.txt.gz | Download Women AllAncestry GZIP]]
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**[[Media: WAISTadjBMI.INACTIVE.WOMEN.European.txt.gz | Download Women European Ancestry GZIP]]
 +
*WAISTadjBMI SNPadjPA
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**[[Media: WAISTadjBMI.SNPadjPA.ALL.AllAncestry.txt.gz | Download All AllAncestry GZIP]]
 +
**[[Media: WAISTadjBMI.SNPadjPA.ALL.European.txt.gz | Download All European Ancestry GZIP]]
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**[[Media: WAISTadjBMI.SNPadjPA.MEN.AllAncestry.txt.gz | Download Men AllAncestry GZIP]]
 +
**[[Media: WAISTadjBMI.SNPadjPA.MEN.European.txt.gz | Download Men European Ancestry GZIP]]
 +
**[[Media: WAISTadjBMI.SNPadjPA.WOMEN.AllAncestry.txt.gz | Download Women AllAncestry GZIP]]
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**[[Media: WAISTadjBMI.SNPadjPA.WOMEN.European.txt.gz | Download Women European Ancestry GZIP]]
 +
 
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'''WHRadjBMI Data Files:'''
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*WHRadjBMI Active
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**[[Media: WHRadjBMI.ACTIVE.ALL.AllAncestry.txt.gz | Download All AllAncestry GZIP]]
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**[[Media: WHRadjBMI.ACTIVE.ALL.European.txt.gz | Download All European Ancestry GZIP]]
 +
**[[Media: WHRadjBMI.ACTIVE.MEN.AllAncestry.txt.gz | Download Men AllAncestry GZIP]]
 +
**[[Media: WHRadjBMI.ACTIVE.MEN.European.txt.gz | Download Men European Ancestry GZIP]]
 +
**[[Media: WHRadjBMI.ACTIVE.WOMEN.AllAncestry.txt.gz | Download Women AllAncestry GZIP]]
 +
**[[Media: WHRadjBMI.ACTIVE.WOMEN.European.txt.gz | Download Women European Ancestry GZIP]]
 +
*WHRadjBMI Inactive
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**[[Media: WHRadjBMI.INACTIVE.ALL.AllAncestry.txt.gz | Download All AllAncestry GZIP]]
 +
**[[Media: WHRadjBMI.INACTIVE.ALL.European.txt.gz | Download All European Ancestry GZIP]]
 +
**[[Media: WHRadjBMI.INACTIVE.MEN.AllAncestry.txt.gz | Download Men AllAncestry GZIP]]
 +
**[[Media: WHRadjBMI.INACTIVE.MEN.European.txt.gz | Download Men European Ancestry GZIP]]
 +
**[[Media: WHRadjBMI.INACTIVE.WOMEN.AllAncestry.txt.gz | Download Women AllAncestry GZIP]]
 +
**[[Media: WHRadjBMI.INACTIVE.WOMEN.European.txt.gz | Download Women European Ancestry GZIP]]
 +
*WHRadjBMI SNPadjPA
 +
**[[Media: WHRadjBMI.SNPadjPA.ALL.AllAncestry.txt.gz | Download All AllAncestry GZIP]]
 +
**[[Media: WHRadjBMI.SNPadjPA.ALL.European.txt.gz | Download All European Ancestry GZIP]]
 +
**[[Media: WHRadjBMI.SNPadjPA.MEN.AllAncestry.txt.gz | Download Men AllAncestry GZIP]]
 +
**[[Media: WHRadjBMI.SNPadjPA.MEN.European.txt.gz | Download Men European Ancestry GZIP]]
 +
**[[Media: WHRadjBMI.SNPadjPA.WOMEN.AllAncestry.txt.gz | Download Women AllAncestry GZIP]]
 +
**[[Media: WHRadjBMI.SNPadjPA.WOMEN.European.txt.gz | Download Women European Ancestry GZIP]]
 +
 
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 +
='''GIANT Consortium 2012-2015 GWAS Summary Statistics'''=
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 +
 
 +
 
 +
[[Media:Data_File_Description_2012-2015_GIANT_GWAS_Summary_Statistics.docx | Download 2012-2015 GIANT GWAS Summary Statistics Data File Description]]
 +
 
 +
 
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==GWAS Age-/Sex-Stratified 2015 BMI and WHR Summary Statistics==
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*[[Media:BMI.MEN.GT50.publicrelease.txt.gz | Download BMI Men >=50y GZIP]]
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*[[Media:BMI.MEN.LE50.publicrelease.txt.gz | Download BMI Men <=50y GZIP]]
 +
 
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*[[Media:BMI.WOMEN.GT50.publicrelease.txt.gz | Download BMI Women >=50y GZIP]]
 +
 
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*[[Media:BMI.WOMEN.LE50.publicrelease.txt.gz | Download BMI Women <=50y GZIP]]
 +
 
 +
*[[Media:WHRADJ.MEN.GT50.publicrelease.txt.gz | Download WHRadjBMI Men >=50y GZIP]]
 +
 
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*[[Media:WHRADJ.MEN.LE50.publicrelease.txt.gz | Download WHRadjBMI Men <=50y GZIP]]
 +
 
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*[[Media:WHRADJ.WOMEN.GT50.publicrelease.txt.gz | Download WHRadjBMI Women >=50y GZIP]]
 +
 
 +
*[[Media: WHRADJ.WOMEN.LE50.publicrelease.txt.gz | Download WHRadjBMI Women <=50y GZIP]]
 +
 
 +
If you use these data, please cite: Winkler TW*, Justice AE*, Graff M*, Barata L*, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R et al. (2015). The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study. PLoS Genetics. In press.
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==GWAS Anthropometric 2015 BMI Summary Statistics==
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*[[Media:Men_SNP_gwas_mc_merge_nogc.tbl.uniq.gz|Download BMI Men Only GZIP]]
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*[[Media:Women_SNP_gwas_mc_merge_nogc.tbl.uniq.gz|Download BMI Women Only GZIP]]
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*[[Media:SNP_gwas_mc_merge_nogc.tbl.uniq.gz|Download BMI EUR Ancestry GZIP]]
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*[[Media:All_ancestries_SNP_gwas_mc_merge_nogc.tbl.uniq.gz|Download BMI All Ancestries GZIP]]
 +
 
 +
If you use these '''BMI''' data, please cite: Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T et al. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature 518, 197-206.
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==GWAS Anthropometric 2015 Waist Summary Statistics==
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'''HIP:'''
 +
*[[Media:GIANT_2015_HIP_MALES_EUR.txt.gz| Download HIP Males EUR GZIP]]
 +
*[[Media:GIANT_2015_HIP_MALES_AllAncestries.txt.gz| Download HIP Males All Ancestries GZIP ]]
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*[[Media:GIANT_2015_HIP_FEMALES_EUR.txt.gz| Download HIP Females EUR GZIP ]]
 +
*[[Media:GIANT_2015_HIP_FEMALES_AllAncestries.txt.gz| Download HIP Females All Ancestries GZIP ]]
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*[[Media:GIANT_2015_HIP_COMBINED_EUR.txt.gz| Download HIP Combined EUR GZIP ]]
 +
*[[Media:GIANT_2015_HIP_COMBINED_AllAncestries.txt.gz| Download HIP Combined All Ancestries GZIP]]
 +
 
 +
'''HIPadjBMI:'''
 +
*[[Media:GIANT_2015_HIPadjBMI_MALES_EUR.txt.gz| Download HIPadjBMI Males EUR GZIP]]
 +
*[[Media:GIANT_2015_HIPadjBMI_MALES_AllAncestries.txt.gz| Download HIPadjBMI Males All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_HIPadjBMI_FEMALES_EUR.txt.gz| Download HIPadjBMI Females EUR GZIP]]
 +
*[[Media:GIANT_2015_HIPadjBMI_FEMALES_AllAncestries.txt.gz| Download HIPadjBMI Females All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_HIPadjBMI_COMBINED_EUR.txt.gz| Download HIPadjBMI Combined EUR GZIP]]
 +
*[[Media:GIANT_2015_HIPadjBMI_COMBINED_AllAncestries.txt.gz| Download HIPadjBMI Combined All Ancestries GZIP]]
 +
 
 +
'''WC:'''
 +
*[[Media:GIANT_2015_WC_MALES_EUR.txt.gz| Download WC Males EUR GZIP]]
 +
*[[Media:GIANT_2015_WC_MALES_AllAncestries.txt.gz| Download WC Males All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_WC_FEMALES_EUR.txt.gz| Download WC Females EUR GZIP]]
 +
*[[Media:GIANT_2015_WC_FEMALES_AllAncestries.txt.gz| Download WC Females All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_WC_COMBINED_EUR.txt.gz| Download WC Combined EUR GZIP]]
 +
*[[Media:GIANT_2015_WC_COMBINED_AllAncestries.txt.gz| Download WC Combined All Ancestries GZIP]]
 +
 
 +
'''WCadjBMI:'''
 +
*[[Media:GIANT_2015_WCadjBMI_MALES_EUR.txt.gz| Download WCadjBMI Males EUR GZIP]]
 +
*[[Media:GIANT_2015_WCadjBMI_MALES_AllAncestries.txt.gz| Download WCadjBMI Males All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_WCadjBMI_FEMALES_EUR.txt.gz| Download WCadjBMI Females EUR GZIP]]
 +
*[[Media:GIANT_2015_WCadjBMI_FEMALES_AllAncestries.txt.gz| Download WCadjBMI Females All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_WCadjBMI_COMBINED_EUR.txt.gz| Download WCadjBMI Combined EUR GZIP]]
 +
*[[Media:GIANT_2015_WCadjBMI_COMBINED_AllAncestries.txt.gz| Download WCadjBMI Combined All Ancestries GZIP]]
 +
 
 +
'''WHR:'''
 +
*[[Media:GIANT_2015_WHR_MALES_EUR.txt.gz| Download WHR Males EUR GZIP]]
 +
*[[Media:GIANT_2015_WHR_MALES_AllAncestries.txt.gz| Download WHR Males All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_WHR_FEMALES_EUR.txt.gz| Download WHR Females EUR GZIP]]
 +
*[[Media:GIANT_2015_WHR_FEMALES_AllAncestries.txt.gz| Download WHR Females All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_WHR_COMBINED_EUR.txt.gz| Download WHR Combined EUR GZIP]]
 +
*[[Media:GIANT_2015_WHR_COMBINED_AllAncestries.txt.gz| Download WHR Combined All Ancestries GZIP]]
 +
 
 +
'''WHRadjBMI:'''
 +
*[[Media:GIANT_2015_WHRadjBMI_MALES_EUR.txt.gz| Download WHRadjBMI Males EUR GZIP]]
 +
*[[Media:GIANT_2015_WHRadjBMI_MALES_AllAncestries.txt.gz| Download WHRadjBMI Males All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_WHRadjBMI_FEMALES_EUR.txt.gz| Download WHRadjBMI Females EUR GZIP]]
 +
*[[Media:GIANT_2015_WHRadjBMI_FEMALES_AllAncestries.txt.gz| Download WHRadjBMI Females All Ancestries GZIP]]
 +
*[[Media:GIANT_2015_WHRadjBMI_COMBINED_EUR.txt.gz| Download WHRadjBMI Combined EUR GZIP]]
 +
*[[Media:GIANT_2015_WHRadjBMI_COMBINED_AllAncestries.txt.gz| Download WHRadjBMI Combined All Ancestries GZIP]]
 +
 
 +
If you use these '''Waist''' data, please cite: Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Magi R, Strawbridge R, Pers TH, Fischer K, Justice AE, Workalemahu T, Wu JM, et al. (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature <strong>518</strong>: 187-196.
 +
 
 +
 
 +
==GWAS Anthropometric 2014 Height Summary Statistics==
 +
 
 +
*[[Media:GIANT_HEIGHT_Wood_et_al_2014_publicrelease_HapMapCeuFreq.txt.gz|Download Height GZIP]]
 +
 +
*[[Media:GIANT_HEIGHT_Wood_et_al_2014_depict_gene_set_enrichment.txt.gz|Download full set of DEPICT gene set enrichment results GZIP]]
 +
 
 +
If you use these '''Height''' data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=25282103 Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S et al.] (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics <strong>11</strong>:1173-86.
 +
 
 +
 
 +
==Variability in BMI and Height Summary Statistics==
 +
 
 +
*[[Media:GIANT_Yang2012Nature_publicrelease_HapMapCeuFreq_BMI.txt.gz|Download BMI GZIP]]
 +
 
 +
*[[Media:GIANT_Yang2012Nature_publicrelease_HapMapCeuFreq_Height.txt.gz|Download Height GZIP]]
 +
 
 +
If you use these '''Body Mass Index''' or '''Height''' data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22982992 Yang J, Loos RJ, Powell JE, Medland SE, Speliotes EK, Chasman DI, Rose LM, Thorleifsson G, Steinthorsdottir V, Mägi R, et al.] (2012). FTO genotype is associated with phenotypic variability of body mass index. Nature <strong>490</strong>:267-272.
 +
 
 +
 
 +
==Sex Stratified Anthropometrics Summary Statistics==
 +
 
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_BMI_MEN_N.txt|Download BMI Men]]
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_BMI_WOMEN_N.txt|Download BMI Women]]
 +
 
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HEIGHT_MEN_N.txt|Download HEIGHT Men]]
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HEIGHT_WOMEN_N.txt| Download HEIGHT Women]]
 +
 
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HIP_MEN_N.txt|Download HIP Men]]
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HIP_WOMEN_N.txt|Download HIP Women]]
 +
 
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HIPadjBMI_MEN_N.txt|Download HIPadjBMI Men]]
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HIPadjBMI_WOMEN_N.txt|Download HIPadjBMI Women]]
 +
 
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WC_MEN_N.txt|Download WC Men]]
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WC_WOMEN_N.txt|Download WC Women]]
 +
 
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WCadjBMI_MEN_N.txt| Download WCadjBMI Men]]
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WCadjBMI_WOMEN_N.txt|Download WCadjBMI Women]]
 +
 
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WEIGHT_MEN_N.txt|Download WEIGHT Men]]
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WEIGHT_WOMEN_N.txt|Download WEIGHT Women]]
 +
 
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WHR_MEN_N.txt|Download WHR Men]]
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WHR_WOMEN_N.txt|Download WHR Women]]
 +
 
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WHRadjBMI_MEN_N.txt|Download WHRadjBMI Men]]
 +
*[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WHRadjBMI_WOMEN_N.txt|Download WHRadjBMI Women]]
 +
 
 +
If you use these data, please cite: [http://www.ncbi.nlm.nih.gov/pubmed/23754948?dopt=Citation Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, et al.] (2013). Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet <strong>9</strong>: e1003500.
 +
 
 +
 
 +
==Extremes of Anthropometric Traits Summary Statistics==
 +
 
 +
*[[Media:GIANT_EXTREME_BMI_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz|Download Extreme BMI Stage 1 GZIP]]
 +
 
 +
*[[Media:GIANT_EXTREME_HEIGHT_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz| Download Extreme Height Stage 1 GZIP]]
 +
 
 +
*[[Media: GIANT_EXTREME_WHR_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz | Download Extreme WHR Stage 1 GZIP]]
 +
 
 +
*[[Media:GIANT_OBESITY_CLASS1_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz | Download Obesity Class 1 Stage 1 GZIP]]
 +
 
 +
*[[Media:GIANT_OBESITY_CLASS2_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz | Download Obesity Class 2 Stage1 GZIP]]
 +
 
 +
*[[Media:GIANT_OBESITY_CLASS3_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz | Download Obesity Class 3 Stage1 GZIP]]
 +
 
 +
*[[Media:GIANT_OVERWEIGHT_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz | Download Overweight Stage 1 GZIP]]
 +
 
 +
If you use these data, please cite: [http://www.ncbi.nlm.nih.gov/pubmed/23563607?dopt=Citation Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, et al.] (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics <strong>45</strong>:501-512.
 +
 
 +
 
 +
 
 +
='''GIANT Consortium 2010 GWAS Summary Statistics'''=
 +
 
 +
 
 +
 
 +
[[Media:Data_File_Description_2010_GIANT_Consortium_2010_GWAS_Summary_Statistics.docx | Download GIANT Consortium 2010 GWAS Summary Statistics Data File Description]]
 +
 
 +
 
 +
 
 +
==GWAS 2010 BMI Summary Statistics==
 +
 
 +
*[[Media:GIANT_BMI_Speliotes2010_publicrelease_HapMapCeuFreq.txt.gz|Download BMI GWAS Summary Statistics GZIP]]
 +
 
 +
If you use these '''Body Mass Index''' data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=20935630 Speliotes, E.K., Willer, C.J., Berndt, S.I., Monda, K.L., Thorleifsson, G., Jackson, A.U., Allen, H.L., Lindgren, C.M., Luan, J., Magi, R., et al.] (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet <strong>42</strong>, 937-948.
 +
 
 +
 
 +
==GWAS 2010 Height Summary Statistics==
 +
 
 +
*[[Media:GIANT_HEIGHT_LangoAllen2010_publicrelease_HapMapCeuFreq.txt.gz ‎|Download Height for BMI Summary Statistics GZIP]]
 +
 
 +
If you use these '''Height''' data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=20881960 Lango Allen, H., Estrada, K., Lettre, G., Berndt, S.I., Weedon, M.N., Rivadeneira, F., Willer, C.J., Jackson, A.U., Vedantam, S., Raychaudhuri, S., et al.] (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature <strong>467</strong>, 832-838.
 +
 
 +
 
 +
==GWAS 2010 WHRadjBMI Summary Statistics==
 +
*[[Media:GIANT WHRadjBMI Heid2010 publicrelease HapMapCeuFreq.txt.gz |Download WHRadjBMI Summary Statistics GZIP]]
 +
 
 +
If you use these '''waist-hip ratio adjusted for BMI''' data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=20935629 Heid, I.M., Jackson, A.U., Randall, J.C., Winkler, T.W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M.C., Speliotes, E.K., Magi, R., et al.] (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet <strong>42</strong>, 949-960.

Latest revision as of 21:10, 2 May 2019

We are releasing the summary data from our meta-analyses of Genome-Wide Association Studies (GWAS) in order to enable other researchers to examine particular variants or loci for their evidence of association with anthropometric traits. The files include p-values and direction of effect at over 2 million directly genotyped or imputed single nucleotide polymorphisms (SNPs). To prevent the possibility of identification of individuals from these summary results, we are not releasing allele frequency data from our samples.


Contents

2018 Exome Array Summary Statistics

WHR Exome Array Summary Statistics

Download WHR Exome Array Data File Description


WHR Data Files:


BMI Exome Array Summary Statistics

BMI Data Files:

If you use these data, please cite: Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, et al. (2018). Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2018 Jan;50(1):26-41. doi: 10.1038/s41588-017-0011-x. Epub 2017 Dec 22. PMID: 29273807


Height Exome Array Summary Statistics

Download Height Exome Array Data File Description


Height Data Files:


2018 GIANT and UK BioBank Meta-analysis

WHR GIANT and UK BioBank Meta-analysis Summary Statistics

WHR UK BioBank Meta Analysis for Public Release:

Access link for GWAS data for all ~27M sites: https://zenodo.org/record/1251813#.XCLJ7vZKhE4 DOI (10.5281/zenodo.1251813)


BMI and Height GIANT and UK BioBank Meta-analysis Summary Statistics

Please Note: We discovered that the BMI files for the meta-analysis of UK Biobank and GIANT originally uploaded did not reflect the full sample size and have now been corrected. If you downloaded these files prior to June 25, 2018, please download them again. Our apologies for any inconvenience.

If you use these data, please cite: Yengo L, Sidorenko J, Kemper KE, Zheng Z, Wood AR, Weedon MN, Frayling TM, Hirschhorn J, Yang J, Visscher PM, GIANT Consortium. (2018). Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry. Biorxiv.


2017 Gene x Environment Summary Statistics

Summary Statistics for Models Adjusting for Smoking Status

Download Models Adjusting for Smoking Status Data File Description


BMI:


WCadjBMI:


WHRadjBMI:


Summary Statistics for Smoking Stratified Models

Download Smoking Stratified Models Data File Description


BMI:


WCadjBMI:


WHRadjBMI:


Summary Statistics for Gene x Physical Activity

Download Gene x Physical Activity Data File Description


BMI Data Files:


WAISTadjBMI Data Files:


WHRadjBMI Data Files:


GIANT Consortium 2012-2015 GWAS Summary Statistics

Download 2012-2015 GIANT GWAS Summary Statistics Data File Description


GWAS Age-/Sex-Stratified 2015 BMI and WHR Summary Statistics

If you use these data, please cite: Winkler TW*, Justice AE*, Graff M*, Barata L*, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R et al. (2015). The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study. PLoS Genetics. In press.


GWAS Anthropometric 2015 BMI Summary Statistics

If you use these BMI data, please cite: Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T et al. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature 518, 197-206.


GWAS Anthropometric 2015 Waist Summary Statistics

HIP:

HIPadjBMI:

WC:

WCadjBMI:

WHR:

WHRadjBMI:

If you use these Waist data, please cite: Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Magi R, Strawbridge R, Pers TH, Fischer K, Justice AE, Workalemahu T, Wu JM, et al. (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature 518: 187-196.


GWAS Anthropometric 2014 Height Summary Statistics

If you use these Height data, please cite: Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S et al. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics 11:1173-86.


Variability in BMI and Height Summary Statistics

If you use these Body Mass Index or Height data, please cite: Yang J, Loos RJ, Powell JE, Medland SE, Speliotes EK, Chasman DI, Rose LM, Thorleifsson G, Steinthorsdottir V, Mägi R, et al. (2012). FTO genotype is associated with phenotypic variability of body mass index. Nature 490:267-272.


Sex Stratified Anthropometrics Summary Statistics

If you use these data, please cite: Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, et al. (2013). Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet 9: e1003500.


Extremes of Anthropometric Traits Summary Statistics

If you use these data, please cite: Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, et al. (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics 45:501-512.


GIANT Consortium 2010 GWAS Summary Statistics

Download GIANT Consortium 2010 GWAS Summary Statistics Data File Description


GWAS 2010 BMI Summary Statistics

If you use these Body Mass Index data, please cite: Speliotes, E.K., Willer, C.J., Berndt, S.I., Monda, K.L., Thorleifsson, G., Jackson, A.U., Allen, H.L., Lindgren, C.M., Luan, J., Magi, R., et al. (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42, 937-948.


GWAS 2010 Height Summary Statistics

If you use these Height data, please cite: Lango Allen, H., Estrada, K., Lettre, G., Berndt, S.I., Weedon, M.N., Rivadeneira, F., Willer, C.J., Jackson, A.U., Vedantam, S., Raychaudhuri, S., et al. (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467, 832-838.


GWAS 2010 WHRadjBMI Summary Statistics

If you use these waist-hip ratio adjusted for BMI data, please cite: Heid, I.M., Jackson, A.U., Randall, J.C., Winkler, T.W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M.C., Speliotes, E.K., Magi, R., et al. (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 42, 949-960.

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