Citing Achilles

Publication Aviad Tsherniak, Francisca Vazquez, Phil G. Montgomery, Barbara A. Weir, et al., Defining a cancer Dependency Map. Cell. July 27, 2017. DOI: j.cell.2017.06.010
Aguirre, A.J., Meyers, R.M., Weir, B.A., Vazquez, F., Zhang, C.Z., et al. (2016). Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting. Cancer Discov 6, 914-929. June 3, 2016.
Cowley, G.S., Weir, B.A., Vazquez, F., Tamayo, P., et al. (2014) Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies. Nature Scientific Data 1, Article number: 140035. September 30, 2014.
Meyers R.M., Bryan J.G., McFarland J.M., Weir B.A., et al. (2017) Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells. Nat Genet 12, 1779-1784. doi: 10.1038/ng.3984. October 30, 2017.

Related Publications

Li, H et al. The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia. Blood. 2017 Jan 26;129(4):497-508. doi: 10.1182/blood-2016-05-714493. Epub 2016 Oct 18.

Paolella, BR, et al. Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability. Elife. 2017 Feb 8;6. pii: e23268. doi: 10.7554/eLife.23268.

Kim JW, et al. Characterizing genomic alterations in cancer by complementary functional associations. Nat Biotechnol. 2016 May;34(5):539-46. doi: 10.1038/nbt.3527. Epub 2016 Apr 18.

Kryukov, GV et al. MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells. Science. 2016 Mar 11;351(6278):1214-8. doi: 10.1126/science.aad5214. Epub 2016 Feb 11.

Gannon, HS et al. Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy. Mol Cancer Res. 2016 Feb;14(2):207-15. doi: 10.1158/1541-7786.MCR-15-0321. Epub 2015 Nov 18. PMCID: PMC4755909.

Kim KH, et al. SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2.. Nat Med. 2015 Dec;21(12):1491-6. doi: 10.1038/nm.3968. Epub 2015 Nov 9.

Pomerantz, MM et al. The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis.. Nat Genet. 2015 Nov;47(11):1346-51. doi: 10.1038/ng.3419. Epub 2015 Oct 12. PMCID: PMC4707683.

Chen, L et al. CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.. J Clin Invest. 2018 Jan 2;128(1):446-462. doi: 10.1172/JCI90793. Epub 2017 Dec 4.

Related Projects

GlassThe Cancer Dependency Map Project is an effort to comprehensively identify genetic and small molecule vulnerabilities and the molecular markers that predict their response across thousands of cancer cell lines. The goal of of the project is to identify the landscape of targets for therapeutic development.

The Cancer Cell Line Encyclopedia provides public access to genomic data, analysis and visualization for about 1000 cell lines.

The Cancer Therapeutics Response Portal enables analyses a genomic cancer cell-line profiling to identify more comprehensively relationships between genetic and lineage features of human cancer cell lines and small-molecule sensitivity.

CTD2 bridges the gap between the enormous volumes of data generated by genomic characterization studies and the ability to use these data for the development of human cancer therapeutics. It specializes in computational and functional genomics approaches critical for translating next-generation sequencing data.

We're moving! Go to the NEW DepMap Portal for all Project Achilles data and more. You will be automatically redirected to starting Winter 2018. Red_x

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