Annotation Summary for Cell Line: GMS-10  

Cell line primary name: GMS-10
Cell line aliases:
Gender: M
Site Primary: central_nervous_system
Histology: glioma
Hist Subtype1: astrocytoma_Grade_IV
Notes:
Source: DSMZ
Expression arrays: NIECE_p_NCLE_RNA3_HG-U133_Plus_2_A11_296010
SNP arrays: HONEY_p_NCLE_DNAAffy3_S_GenomeWideSNP_6_E10_293394
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in GMS-10

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
ACACA p.D1794E 17 35512670 35512670 GMS10_CENTRAL_N... 37 Missense_Mutation SNP A C uc002hno.2 ACACA_uc002hnk.... Hybrid_Cap... view
ADAM28 8 24211994 24211997 GMS10_CENTRAL_N... 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
AKAP12 p.F810C 6 151671955 151671955 GMS10_CENTRAL_N... 37 Missense_Mutation SNP T G uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap... view
AKAP12 p.1531_1532insE 6 151674116 151674117 GMS10_CENTRAL_N... 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
AKAP9 p.1335_1336insQ 7 91652178 91652179 GMS10_CENTRAL_N... 37 In_Frame_Ins Ins - AAC rs34756483 uc003ulg.2 AKAP9_uc003ule.... Hybrid_Cap...
ALPK2 p.EDTST1006del 18 56204388 56204402 GMS10_CENTRAL_N... 37 In_Frame_Del Del CAGTT... - rs60644017;rs117623369 uc002lhj.3 ALPK2_uc002lhk.... Hybrid_Cap...
ASPH p.V740M 8 62415977 62415977 GMS10_CENTRAL_N... 37 Missense_Mutation SNP C T uc003xuj.2 ASPH_uc011leg.1... Hybrid_Cap... view
ATR p.D836E 3 142272691 142272691 GMS10_CENTRAL_N... 37 Missense_Mutation SNP G T uc003eux.3 Hybrid_Cap... view
AURKC 19 57742494 57742507 GMS10_CENTRAL_N... 37 5'UTR Del GGACG... - rs67926438;rs112039303;rs59094959 uc002qoe.2 AURKC_uc002qoc.... Hybrid_Cap...
BMP4 14 54416601 54416602 GMS10_CENTRAL_N... 37 3'UTR Ins - AT rs74495140;rs76335800 uc001xal.3 BMP4_uc010aoh.2... Hybrid_Cap...
CACNB2 10 18828688 18828689 GMS10_CENTRAL_N... 37 3'UTR Ins - G rs76808867 uc001ipr.2 CACNB2_uc009xjz... Hybrid_Cap...
CHRNA3 p.H217Y 15 78894335 78894335 GMS10_CENTRAL_N... 37 Missense_Mutation SNP G A rs72650603 uc002bec.2 CHRNA3_uc002bea... Hybrid_Cap... view
CLTCL1 p.V1201_splice 22 19189003 19189004 GMS10_CENTRAL_N... 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
CTBP2 p.K974fs 10 126678123 126678123 GMS10_CENTRAL_N... 37 Frame_Shift_Del Del T - uc001lie.3 CTBP2_uc009yak.... Hybrid_Cap...
EDN1 6 12290729 12290729 GMS10_CENTRAL_N... 37 5'UTR Del A - uc003nae.3 EDN1_uc010jpb.2... Hybrid_Cap...
EIF2AK1 p.K609Q 7 6064372 6064372 GMS10_CENTRAL_N... 37 Missense_Mutation SNP T G uc003spp.2 EIF2AK1_uc003sp... Hybrid_Cap... view
EIF4G1 p.R251G 3 184039102 184039102 GMS10_CENTRAL_N... 37 Missense_Mutation SNP C G uc010hxx.2 EIF4G1_uc003fno... Hybrid_Cap... view
EP300 p.2209_2213NQFQQ>K 22 41574341 41574352 GMS10_CENTRAL_N... 37 In_Frame_Del Del ACCAG... - uc003azl.3 Hybrid_Cap...
EPHA6 3 97367230 97367231 GMS10_CENTRAL_N... 37 Intron Ins - A rs115253553 uc010how.1 EPHA6_uc003drs.... Hybrid_Cap...
FANCC 9 97863893 97863893 GMS10_CENTRAL_N... 37 3'UTR SNP T C rs55687573 uc004avh.2 Hybrid_Cap... view
FGFR1OP 6 167453519 167453520 GMS10_CENTRAL_N... 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
FGFR3 4 1809128 1809129 GMS10_CENTRAL_N... 37 3'UTR Del GT - uc003gdu.2 FGFR3_uc003gdr.... Hybrid_Cap...
FLI1 11 128638217 128638217 GMS10_CENTRAL_N... 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FLNA X 153577132 153577133 GMS10_CENTRAL_N... 37 3'UTR Ins - CA rs10692455;rs71733538 uc004fkk.2 FLNA_uc004fki.2... Hybrid_Cap...
FMN2 p.PPLPGAGIPPP939del 1 240370914 240370946 GMS10_CENTRAL_N... 37 In_Frame_Del Del GCCCC... - rs4997328;rs4997329 uc010pye.1 FMN2_uc010pyd.1... Hybrid_Cap...
FN1 2 216244182 216244185 GMS10_CENTRAL_N... 37 Intron Del GTAC - uc002vfa.2 FN1_uc002vfb.2_... Hybrid_Cap...
GPR112 p.D2657del X 135474445 135474447 GMS10_CENTRAL_N... 37 In_Frame_Del Del GAT - rs3030295 uc004ezu.1 GPR112_uc010nsb... Hybrid_Cap...
GRAMD1B p.R729S 11 123493252 123493252 GMS10_CENTRAL_N... 37 Missense_Mutation SNP G T uc001pyw.2 GRAMD1B_uc001py... Hybrid_Cap... view
GRIA3 X 122318386 122318387 GMS10_CENTRAL_N... 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
HIF1A 14 62213929 62213930 GMS10_CENTRAL_N... 37 3'UTR Ins - T rs67890419 uc001xfs.2 HIF1A_uc001xfq.... Hybrid_Cap...
HNF1A 12 121434630 121434631 GMS10_CENTRAL_N... 37 Intron Ins - TCATTCAT rs75100977 uc010szn.1 HNF1A_uc001tze.... Hybrid_Cap...
HSP90B1 p.E791del 12 104341188 104341190 GMS10_CENTRAL_N... 37 In_Frame_Del Del GAA - rs117491163 uc001tkb.1 HSP90B1_uc010sw... Hybrid_Cap...
IGF1R 15 99192755 99192763 GMS10_CENTRAL_N... 37 5'UTR Del TTTTT... - uc002bul.2 IGF1R_uc010urq.... Hybrid_Cap...
ILK 11 6630029 6630029 GMS10_CENTRAL_N... 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
ITPR2 p.R470_splice 12 26834804 26834805 GMS10_CENTRAL_N... 37 Splice_Site_Ins Ins - ACTC rs66696203;rs59199365 uc001rhg.2 Hybrid_Cap...
KIAA1549 p.A768S 7 138602070 138602070 GMS10_CENTRAL_N... 37 Missense_Mutation SNP C A uc011kql.1 KIAA1549_uc003v... Hybrid_Cap... view
KLK7 19 51480672 51480675 GMS10_CENTRAL_N... 37 3'UTR Del GGTT - uc002puo.2 KLK7_uc002pup.2... Hybrid_Cap...
MAML3 p.Q767_splice 4 140651585 140651587 GMS10_CENTRAL_N... 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP3K1 p.T949del 5 56177849 56177851 GMS10_CENTRAL_N... 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAP3K14 p.R218_splice 17 43364293 43364294 GMS10_CENTRAL_N... 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
MAPKBP1 15 42111753 42111754 GMS10_CENTRAL_N... 37 Intron Ins - GC rs3034891 uc001zok.3 MAPKBP1_uc001zo... Hybrid_Cap...
MECOM 3 169381200 169381201 GMS10_CENTRAL_N... 37 5'UTR Ins - T uc011bpj.1 MECOM_uc011bpk.... Hybrid_Cap...
MERTK p.T795A 2 112779868 112779868 GMS10_CENTRAL_N... 37 Missense_Mutation SNP A G uc002thk.1 MERTK_uc002thl.... Hybrid_Cap... view
MGA p.L664F 15 41989198 41989198 GMS10_CENTRAL_N... 37 Missense_Mutation SNP C T uc010ucy.1 MGA_uc001zog.1_... Hybrid_Cap... view
MLH1 3 37092174 37092176 GMS10_CENTRAL_N... 37 3'UTR Del TTC - uc003cgl.2 MLH1_uc011aye.1... Hybrid_Cap...
MLL p.M2602V 11 118374411 118374411 GMS10_CENTRAL_N... 37 Missense_Mutation SNP A G uc001ptb.2 MLL_uc001pta.2_... Hybrid_Cap... view
MLL3 p.R3398Q 7 151860469 151860469 GMS10_CENTRAL_N... 37 Missense_Mutation SNP C T uc003wla.2 MLL3_uc003wkz.2... Hybrid_Cap... view
MLLT3 9 20346377 20346378 GMS10_CENTRAL_N... 37 3'UTR Ins - A rs66943046 uc003zoe.2 MLLT3_uc011lne.... Hybrid_Cap...
NCAM1 11 112832307 112832308 GMS10_CENTRAL_N... 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 GMS10_CENTRAL_N... 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCOA3 p.Q1276del 20 46279837 46279839 GMS10_CENTRAL_N... 37 In_Frame_Del Del CAG - rs2664555 uc002xtk.2 NCOA3_uc010ght.... Hybrid_Cap...
NEK3 p.K313_splice 13 52718050 52718051 GMS10_CENTRAL_N... 37 Splice_Site_Ins Ins - T rs72514762 uc001vgh.2 NEK3_uc001vgg.2... Hybrid_Cap...
NEK9 14 75572824 75572824 GMS10_CENTRAL_N... 37 Intron SNP C T uc001xrl.2 NEK9_uc001xrk.2... Hybrid_Cap... view
NOTCH4 p.15_16LL>L 6 32191659 32191661 GMS10_CENTRAL_N... 37 In_Frame_Del Del AGC - uc003obb.2 NOTCH4_uc011dpu... Hybrid_Cap...
NPR1 1 153665919 153665920 GMS10_CENTRAL_N... 37 3'UTR Ins - C rs66682713 uc001fcs.3 NPR1_uc010pdz.1... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881822 50881823 GMS10_CENTRAL_N... 37 In_Frame_Ins Ins - CAG rs61751954;rs1052533 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
NUP214 9 134067556 134067557 GMS10_CENTRAL_N... 37 Intron Ins - TT rs66652901 uc004cag.2 NUP214_uc004cah... Hybrid_Cap...
PAX3 2 223066017 223066018 GMS10_CENTRAL_N... 37 Intron Ins - C rs115619343 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PAX3 2 223158653 223158653 GMS10_CENTRAL_N... 37 Intron Del T - rs112753212 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PGGT1B 5 114548071 114548072 GMS10_CENTRAL_N... 37 3'UTR Ins - C uc003kqw.3 PGGT1B_uc003kqx... Hybrid_Cap...
PIK3CB p.A515T 3 138423323 138423323 GMS10_CENTRAL_N... 37 Missense_Mutation SNP C T uc011bmq.1 PIK3CB_uc011bmn... Hybrid_Cap... view
PMS1 2 190670539 190670540 GMS10_CENTRAL_N... 37 Intron Ins - A rs3214425 uc002urh.3 PMS1_uc010zga.1... Hybrid_Cap...
PRKCA 17 64298959 64298960 GMS10_CENTRAL_N... 37 5'UTR Ins - G rs71160558 uc002jfp.1 PRKCA_uc002jfo.... Hybrid_Cap...
PRKDC p.L1244fs 8 48805816 48805817 GMS10_CENTRAL_N... 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
PTEN p.I101T 10 89692818 89692818 GMS10_CENTRAL_N... 37 Missense_Mutation SNP T C uc001kfb.2 Hybrid_Cap... view
PTK6 20 62168676 62168677 GMS10_CENTRAL_N... 37 5'UTR Ins - GCGC uc002yfg.2 PTK6_uc011aay.1... Hybrid_Cap...
PXN p.S188R 12 120660483 120660483 GMS10_CENTRAL_N... 37 Missense_Mutation SNP G T rs61748078 uc001txt.2 PXN_uc001txv.2_... Hybrid_Cap... view
RAD50 p.N598I 5 131927726 131927726 GMS10_CENTRAL_N... 37 Missense_Mutation SNP A T uc003kxi.2 RAD50_uc003kxh.... Hybrid_Cap... view
RASGRF1 15 79277150 79277151 GMS10_CENTRAL_N... 37 Intron Ins - C rs67045840;rs77640668 uc002beq.2 RASGRF1_uc002be... Hybrid_Cap...
RB1 p.R320* 13 48941648 48941648 GMS10_CENTRAL_N... 37 Nonsense_Mutation SNP C T uc001vcb.2 RB1_uc010act.1_... Hybrid_Cap... view
RECQL4 p.R766fs 8 145738768 145738768 GMS10_CENTRAL_N... 37 Frame_Shift_Del Del G - uc003zdj.2 Hybrid_Cap...
RIPK4 p.T601M 21 43161551 43161551 GMS10_CENTRAL_N... 37 Missense_Mutation SNP G A uc002yzn.1 Hybrid_Cap... view
RPS6KA5 14 91360733 91360734 GMS10_CENTRAL_N... 37 Intron Ins - T rs77438853 uc001xys.2 RPS6KA5_uc010tw... Hybrid_Cap...
SETDB1 1 150917633 150917633 GMS10_CENTRAL_N... 37 Intron SNP A G uc001evu.2 SETDB1_uc009wmf... Hybrid_Cap... view
STK31 7 23872024 23872025 GMS10_CENTRAL_N... 37 3'UTR Ins - TTTG rs66787534 uc003sws.3 STK31_uc003swt.... Hybrid_Cap...
SULF1 8 70570945 70570945 GMS10_CENTRAL_N... 37 3'UTR SNP T A uc010lza.1 SULF1_uc003xyd.... Hybrid_Cap... view
TEC 4 48139307 48139310 GMS10_CENTRAL_N... 37 3'UTR Del TTAT - rs79098351 uc003gxz.2 Hybrid_Cap...
TFG p.A274G 3 100466993 100466993 GMS10_CENTRAL_N... 37 Missense_Mutation SNP C G uc003due.2 TFG_uc003duf.2_... Hybrid_Cap... view
TNRC6B p.P1120Q 22 40676095 40676095 GMS10_CENTRAL_N... 37 Missense_Mutation SNP C A uc011aor.1 TNRC6B_uc003aym... Hybrid_Cap... view
TP53 p.Y236C 17 7577574 7577574 GMS10_CENTRAL_N... 37 Missense_Mutation SNP T C uc002gim.2 TP53_uc002gig.1... Hybrid_Cap... view
TP73 p.S477S 1 3647576 3647576 GMS10_CENTRAL_N... 37 Silent SNP G A uc001akp.2 TP73_uc001akq.2... Hybrid_Cap... view
TRIM33 p.V176_splice 1 115007012 115007012 GMS10_CENTRAL_N... 37 Splice_Site_SNP SNP T A uc001eew.2 TRIM33_uc010ows... Hybrid_Cap... view
VEGFC p.S419_splice 4 177605082 177605084 GMS10_CENTRAL_N... 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...