Annotation Summary for Cell Line: IGR-37  

Cell line primary name: IGR-37
Cell line aliases:
Gender: M
Site Primary: skin
Histology: malignant_melanoma
Hist Subtype1: NS
Notes: Metastatic pair: IGR-37 and IGR-39 are from the same patient. IGR-37 is a metastasis
Source: DSMZ
Expression arrays: PARES_p_NCLE_RNA_Redo_HG-U133_Plus_2_E12_257716
SNP arrays: ARLES_p_NCLE_DNAAffy2_S_GenomeWideSNP_6_E07_256110
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in IGR-37

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
ABL2 1 179086419 179086420 IGR37_SKIN 37 Intron Ins - A rs72207641 uc001gmj.3 ABL2_uc010pnf.1... Hybrid_Cap...
ACACA 17 35766564 35766564 IGR37_SKIN 37 5'UTR Del A - uc002hno.2 ACACA_uc002hnn.... Hybrid_Cap...
ADAM28 p.D422N 8 24188823 24188823 IGR37_SKIN 37 Missense_Mutation SNP G A uc003xdy.2 ADAM28_uc003xdx... Hybrid_Cap... view
ADAM28 8 24211994 24211997 IGR37_SKIN 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
ADAMTS18 p.S1187F 16 77317959 77317959 IGR37_SKIN 37 Missense_Mutation SNP G A uc002ffc.3 Hybrid_Cap... view
AKAP9 p.Y3124N 7 91722422 91722422 IGR37_SKIN 37 Missense_Mutation SNP T A uc003ulg.2 AKAP9_uc003ulf.... Hybrid_Cap... view
ALPK2 p.A2094E 18 56165296 56165296 IGR37_SKIN 37 Missense_Mutation SNP G T uc002lhj.3 Hybrid_Cap... view
ALPK3 p.P648T 15 85383846 85383846 IGR37_SKIN 37 Missense_Mutation SNP C A uc002ble.2 Hybrid_Cap... view
AURKB p.F89L 17 8110628 8110628 IGR37_SKIN 37 Missense_Mutation SNP A T uc002gkn.2 AURKB_uc010cnu.... Hybrid_Cap... view
AURKC 19 57742494 57742507 IGR37_SKIN 37 5'UTR Del GGACG... - rs67926438;rs112039303;rs59094959 uc002qoe.2 AURKC_uc002qoc.... Hybrid_Cap...
BCL3 19 45262965 45262965 IGR37_SKIN 37 3'UTR Del C - uc010xxe.1 Hybrid_Cap...
BMPR2 p.S911A 2 203421119 203421119 IGR37_SKIN 37 Missense_Mutation SNP T G uc002uzf.3 BMPR2_uc010ftr.... Hybrid_Cap... view
BRAF p.V600E 7 140453136 140453136 IGR37_SKIN 37 Missense_Mutation SNP A T rs113488022 uc003vwc.3 Hybrid_Cap... view
CABC1 1 227171585 227171585 IGR37_SKIN 37 Intron Del T - uc001hqm.1 CABC1_uc001hqn.... Hybrid_Cap...
CABC1 1 227171736 227171737 IGR37_SKIN 37 Intron Ins - T rs1574184 uc001hqm.1 CABC1_uc001hqn.... Hybrid_Cap...
CACNB2 10 18828669 18828670 IGR37_SKIN 37 3'UTR Ins - C rs34022725;rs58830289 uc001ipr.2 CACNB2_uc009xjz... Hybrid_Cap...
CDK11B 1 1654066 1654068 IGR37_SKIN 37 Intron Del GCG - uc001agv.1 CDK11B_uc001aha... Hybrid_Cap...
CDK17 12 96674483 96674483 IGR37_SKIN 37 Intron SNP T C uc001tep.1 CDK17_uc009ztk.... Hybrid_Cap... view
CHD1 p.P1684del 5 98192165 98192167 IGR37_SKIN 37 In_Frame_Del Del AGG - rs79267787;rs61749618 uc003knf.2 CHD1_uc010jbn.2... Hybrid_Cap...
CLTCL1 p.V1201_splice 22 19189003 19189004 IGR37_SKIN 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
CPAMD8 p.R1221K 19 17036032 17036032 IGR37_SKIN 37 Missense_Mutation SNP C T uc002nfb.2 Hybrid_Cap... view
CREB3L2 p.T100del 7 137612914 137612916 IGR37_SKIN 37 In_Frame_Del Del TGG - uc003vtw.2 CREB3L2_uc003vt... Hybrid_Cap...
CSMD3 p.C2078S 8 113364667 113364667 IGR37_SKIN 37 Missense_Mutation SNP C G uc003ynu.2 CSMD3_uc003yns.... Hybrid_Cap... view
CTBP2 p.K974fs 10 126678123 126678123 IGR37_SKIN 37 Frame_Shift_Del Del T - uc001lie.3 CTBP2_uc009yak.... Hybrid_Cap...
CXCL12 10 44873992 44873993 IGR37_SKIN 37 Intron Ins - CT rs117617571 uc001jbh.2 CXCL12_uc001jbf... Hybrid_Cap...
DOCK3 p.R1722G 3 51399976 51399976 IGR37_SKIN 37 Missense_Mutation SNP A G uc011bds.1 Hybrid_Cap... view
DRD2 p.D2N 11 113295370 113295370 IGR37_SKIN 37 Missense_Mutation SNP C T uc001pnz.2 DRD2_uc010rwv.1... Hybrid_Cap... view
DYRK1A 21 38884966 38884967 IGR37_SKIN 37 3'UTR Ins - T rs72430212 uc002ywk.2 DYRK1A_uc002ywi... Hybrid_Cap...
EDN1 6 12295961 12295961 IGR37_SKIN 37 Intron SNP C T uc003nae.3 EDN1_uc003nad.2... Hybrid_Cap... view
EGFR 7 55270360 55270360 IGR37_SKIN 37 Intron SNP T G uc003tqk.2 EGFR_uc010kzg.1... Hybrid_Cap... view
EHBP1 2 62934175 62934175 IGR37_SKIN 37 5'UTR SNP G C uc002sby.2 EHBP1_uc010fcp.... Hybrid_Cap... view
EIF4E 4 99808137 99808141 IGR37_SKIN 37 Intron Del TTAAA - uc011ceb.1 EIF4E_uc011cea.... Hybrid_Cap...
EP300 22 41574970 41574972 IGR37_SKIN 37 3'UTR Del GTA - rs76489032 uc003azl.3 Hybrid_Cap...
EPHA6 3 97367230 97367231 IGR37_SKIN 37 Intron Ins - A rs115253553 uc010how.1 EPHA6_uc003drs.... Hybrid_Cap...
ERC1 p.H721Q 12 1299030 1299030 IGR37_SKIN 37 Missense_Mutation SNP T G uc001qjb.2 ERC1_uc001qiz.2... Hybrid_Cap... view
FANCI p.R602* 15 89828432 89828432 IGR37_SKIN 37 Nonsense_Mutation SNP C T uc010bnp.1 FANCI_uc002bnm.... Hybrid_Cap... view
FGFR1OP 6 167453519 167453520 IGR37_SKIN 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
FGFR3 4 1809128 1809129 IGR37_SKIN 37 3'UTR Del GT - uc003gdu.2 FGFR3_uc003gdr.... Hybrid_Cap...
FLT1 p.S437L 13 29001422 29001422 IGR37_SKIN 37 Missense_Mutation SNP G A uc001usb.3 FLT1_uc010aar.1... Hybrid_Cap... view
FMO4 p.P230L 1 171301909 171301909 IGR37_SKIN 37 Missense_Mutation SNP C T uc001gho.2 Hybrid_Cap... view
FN1 2 216244182 216244185 IGR37_SKIN 37 Intron Del GTAC - uc002vfa.2 FN1_uc002vfb.2_... Hybrid_Cap...
FZD1 p.93_94insP 7 90894459 90894460 IGR37_SKIN 37 In_Frame_Ins Ins - CCG uc003ula.2 Hybrid_Cap...
GCK p.L464P 7 44184745 44184745 IGR37_SKIN 37 Missense_Mutation SNP A G uc003tkk.1 GCK_uc003tkh.1_... Hybrid_Cap... view
GRIA3 X 122318386 122318387 IGR37_SKIN 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GUCY2C 12 14827464 14827466 IGR37_SKIN 37 Intron Del ATC - rs72525754;rs3083879 uc001rcd.2 GUCY2C_uc009zhz... Hybrid_Cap...
HNF1A 12 121434630 121434631 IGR37_SKIN 37 Intron Ins - TCATTCAT rs75100977 uc010szn.1 HNF1A_uc001tze.... Hybrid_Cap...
ILK 11 6630029 6630029 IGR37_SKIN 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
ITK p.H121Y 5 156641237 156641237 IGR37_SKIN 37 Missense_Mutation SNP C T uc003lwo.1 Hybrid_Cap... view
ITPR2 p.R470_splice 12 26834804 26834805 IGR37_SKIN 37 Splice_Site_Ins Ins - ACTC rs66696203;rs59199365 uc001rhg.2 Hybrid_Cap...
KDSR 18 60998954 60998954 IGR37_SKIN 37 3'UTR SNP C T uc010dpw.2 KDSR_uc010xem.1... Hybrid_Cap... view
LRP1B p.D61N 2 142567872 142567872 IGR37_SKIN 37 Missense_Mutation SNP C T uc002tvj.1 LRP1B_uc010fnl.... Hybrid_Cap... view
MAF 16 79628537 79628537 IGR37_SKIN 37 Intron Del T - uc002ffm.2 MAF_uc002ffn.2_... Hybrid_Cap...
MAML3 p.Q767_splice 4 140651585 140651587 IGR37_SKIN 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP2K1 15 66679649 66679650 IGR37_SKIN 37 5'UTR Ins - C rs67229745 uc010bhq.2 Hybrid_Cap...
MAP3K1 p.T949del 5 56177849 56177851 IGR37_SKIN 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAP3K14 p.R218_splice 17 43364293 43364294 IGR37_SKIN 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
MAPK14 6 36076345 36076354 IGR37_SKIN 37 3'UTR Del GTGTG... - rs80147786 uc003olp.2 MAPK14_uc003olq... Hybrid_Cap...
MAPKAPK3 3 50685575 50685575 IGR37_SKIN 37 3'UTR Del A - rs76026164 uc003day.1 MAPKAPK3_uc003d... Hybrid_Cap...
MAPKBP1 15 42111753 42111754 IGR37_SKIN 37 Intron Ins - C rs3034891 uc001zok.3 MAPKBP1_uc001zo... Hybrid_Cap...
MAST1 p.P61L 19 12951814 12951814 IGR37_SKIN 37 Missense_Mutation SNP C T uc002mvm.2 MAST1_uc002mvk.... Hybrid_Cap... view
MAST4 p.E355K 5 66414548 66414548 IGR37_SKIN 37 Missense_Mutation SNP G A uc003jut.1 MAST4_uc003juu.... Hybrid_Cap... view
MAST4 p.S1086F 5 66458473 66458473 IGR37_SKIN 37 Missense_Mutation SNP C T uc003jut.1 MAST4_uc003juw.... Hybrid_Cap... view
MEN1 p.D210E 11 64575402 64575402 IGR37_SKIN 37 Missense_Mutation SNP G T uc001obj.2 MEN1_uc001obk.2... Hybrid_Cap... view
MLLT1 p.S369F 19 6222136 6222136 IGR37_SKIN 37 Missense_Mutation SNP G A uc002mek.2 Hybrid_Cap... view
MYLK p.E1430_splice 3 123368043 123368044 IGR37_SKIN 37 Splice_Site_Ins Ins - G rs41431347 uc003ego.2 MYLK_uc010hrr.2... Hybrid_Cap...
MYLK p.P750S 3 123426743 123426743 IGR37_SKIN 37 Missense_Mutation SNP G A uc003ego.2 MYLK_uc011bjw.1... Hybrid_Cap... view
NCAM1 11 112832307 112832308 IGR37_SKIN 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 IGR37_SKIN 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCOA3 p.Q1276del 20 46279837 46279839 IGR37_SKIN 37 In_Frame_Del Del CAG - rs2664555 uc002xtk.2 NCOA3_uc010ght.... Hybrid_Cap...
NFKB1 p.D917_splice 4 103534740 103534741 IGR37_SKIN 37 Splice_Site_Ins Ins - A rs35795162 uc011cep.1 NFKB1_uc011ceq.... Hybrid_Cap...
NIN p.E2100del 14 51190283 51190285 IGR37_SKIN 37 In_Frame_Del Del CTC - uc001wyi.2 NIN_uc001wyj.2_... Hybrid_Cap...
NIPBL p.E2636del 5 37063925 37063927 IGR37_SKIN 37 In_Frame_Del Del GAA - uc003jkl.3 NIPBL_uc003jkk.... Hybrid_Cap...
NOTCH4 p.15_16LL>L 6 32191659 32191661 IGR37_SKIN 37 In_Frame_Del Del AGC - uc003obb.2 NOTCH4_uc011dpu... Hybrid_Cap...
NPR1 1 153665919 153665920 IGR37_SKIN 37 3'UTR Ins - C rs66682713 uc001fcs.3 NPR1_uc010pdz.1... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881820 50881821 IGR37_SKIN 37 In_Frame_Ins Ins - AAC rs66783852;rs112359270 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
NR3C1 5 142780419 142780419 IGR37_SKIN 37 Splice_Site_SNP SNP T A uc003lmy.2 NR3C1_uc003lmz.... Hybrid_Cap... view
NRK p.S101F X 105132336 105132336 IGR37_SKIN 37 Missense_Mutation SNP C T uc004emd.2 NRK_uc010npc.1_... Hybrid_Cap... view
NTSR1 p.Q95E 20 61340842 61340842 IGR37_SKIN 37 Missense_Mutation SNP C G uc002ydf.2 Hybrid_Cap... view
NUP214 9 134067556 134067557 IGR37_SKIN 37 Intron Ins - T rs66652901 uc004cag.2 NUP214_uc004cah... Hybrid_Cap...
NUP214 9 134108982 134108982 IGR37_SKIN 37 3'UTR SNP T A uc004cag.2 NUP214_uc004cah... Hybrid_Cap... view
PAX3 2 223158653 223158653 IGR37_SKIN 37 Intron Del T - rs112753212 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PAX7 p.K175N 1 18962804 18962804 IGR37_SKIN 37 Missense_Mutation SNP G C uc001bay.2 PAX7_uc001baz.2... Hybrid_Cap... view
PIK3C2G p.D8N 12 18435037 18435037 IGR37_SKIN 37 Missense_Mutation SNP G A uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap... view
PIK3C2G p.P129del 12 18435399 18435401 IGR37_SKIN 37 In_Frame_Del Del CCC - uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PNCK X 152936684 152936684 IGR37_SKIN 37 Intron SNP C T uc011myu.1 PNCK_uc011myt.1... Hybrid_Cap... view
PPP3R1 p.F15_splice 2 68415824 68415824 IGR37_SKIN 37 Splice_Site_SNP SNP T A uc002sei.1 Hybrid_Cap... view
PRKDC p.L1244fs 8 48805816 48805817 IGR37_SKIN 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
PTCH2 p.S752F 1 45293190 45293190 IGR37_SKIN 37 Missense_Mutation SNP G A uc010olf.1 PTCH2_uc010olg.... Hybrid_Cap... view
PTK6 20 62168676 62168677 IGR37_SKIN 37 5'UTR Ins - GCGC uc002yfg.2 PTK6_uc011aay.1... Hybrid_Cap...
PTPRD p.R561Q 9 8504401 8504401 IGR37_SKIN 37 Missense_Mutation SNP C T uc003zkk.2 PTPRD_uc003zkp.... Hybrid_Cap... view
SLC6A8 X 152957656 152957657 IGR37_SKIN 37 Intron Ins - A uc004fib.3 SLC6A8_uc004fic... Hybrid_Cap...
SNX19 p.E80Q 11 130785597 130785597 IGR37_SKIN 37 Missense_Mutation SNP C G uc001qgk.3 SNX19_uc010sce.... Hybrid_Cap... view
STK31 7 23872024 23872025 IGR37_SKIN 37 3'UTR Ins - TTTG rs66787534 uc003sws.3 STK31_uc003swt.... Hybrid_Cap...
THBS3 p.P325fs 1 155172174 155172175 IGR37_SKIN 37 Frame_Shift_Del Del AG - uc001fix.2 RAG1AP1_uc010pe... Hybrid_Cap...
TIE1 p.F975_splice 1 43784905 43784905 IGR37_SKIN 37 Splice_Site_SNP SNP G A uc001ciu.2 TIE1_uc010oke.1... Hybrid_Cap... view
TP53 p.C229fs 17 7577594 7577595 IGR37_SKIN 37 Frame_Shift_Del Del AC - uc002gim.2 TP53_uc002gig.1... Hybrid_Cap...
TRIM33 1 114940215 114940216 IGR37_SKIN 37 3'UTR Ins - G rs68133208 uc001eew.2 TRIM33_uc010owr... Hybrid_Cap...
TRIP13 5 908720 908720 IGR37_SKIN 37 Intron SNP C T uc003jbr.2 TRIP13_uc010ite... Hybrid_Cap... view
TRPM6 p.P1951L 9 77343238 77343238 IGR37_SKIN 37 Missense_Mutation SNP G A uc004ajl.1 TRPM6_uc004ajk.... Hybrid_Cap... view
TRPM6 p.L219P 9 77448927 77448927 IGR37_SKIN 37 Missense_Mutation SNP A G uc004ajl.1 TRPM6_uc004ajk.... Hybrid_Cap... view
TTN 2 179391639 179391640 IGR37_SKIN 37 3'UTR Ins - T rs36037175 uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap...
TTN p.G13568V 2 179480421 179480421 IGR37_SKIN 37 Missense_Mutation SNP C A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.C13567* 2 179480423 179480424 IGR37_SKIN 37 Nonsense_Mutation DNP AC TT uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap...
TTN p.E13451K 2 179481561 179481561 IGR37_SKIN 37 Missense_Mutation SNP C T uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.G12566E 2 179486044 179486044 IGR37_SKIN 37 Missense_Mutation SNP C T uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.G12098E 2 179495778 179495778 IGR37_SKIN 37 Missense_Mutation SNP C T uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.P9598S 2 179549663 179549663 IGR37_SKIN 37 Missense_Mutation SNP G A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.E1933K 2 179640794 179640794 IGR37_SKIN 37 Missense_Mutation SNP C T uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
VDR 12 48238260 48238260 IGR37_SKIN 37 3'UTR SNP A G uc001rql.2 VDR_uc001rqm.2_... Hybrid_Cap... view
VEGFC p.S419_splice 4 177605082 177605084 IGR37_SKIN 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
VRK3 p.F331F 19 50492999 50492999 IGR37_SKIN 37 Silent SNP G A uc002prg.2 VRK3_uc002prh.1... Hybrid_Cap... view
XPO4 p.S498_splice 13 21382722 21382722 IGR37_SKIN 37 Splice_Site_SNP SNP T A uc001unq.3 Hybrid_Cap... view
ZNF497 p.G382C 19 58867858 58867859 IGR37_SKIN 37 Missense_Mutation DNP CC AT uc002qsh.1 A1BG_uc002qsd.3... Hybrid_Cap...