Annotation Summary for Cell Line: LK-2  

Cell line primary name: LK-2
Cell line aliases:
Gender: M
Site Primary: lung
Histology: carcinoma
Hist Subtype1: squamous_cell_carcinoma
Notes:
Source: RIKEN
Expression arrays: METIS_p_NCLE_RNA1_Human_U133_Plus_2.0_D11_240942
SNP arrays: LIMPS_p_NCLE_DNA2N_GenomeWideSNP_6_C02_246660
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in LK-2

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
ADAM28 8 24211994 24211997 LK2_LUNG 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
AFF1 p.K296N 4 87968575 87968575 LK2_LUNG 37 Missense_Mutation SNP G T uc011ccz.1 AFF1_uc011ccx.1... Hybrid_Cap... view
APC p.W685* 5 112173346 112173346 LK2_LUNG 37 Nonsense_Mutation SNP G A uc010jby.2 APC_uc011cvt.1_... Hybrid_Cap... view
APC p.E1020K 5 112174349 112174349 LK2_LUNG 37 Missense_Mutation SNP G A uc010jby.2 APC_uc011cvt.1_... Hybrid_Cap... view
ARHGAP26 p.S589I 5 142513599 142513599 LK2_LUNG 37 Missense_Mutation SNP G T uc011dbj.1 ARHGAP26_uc003l... Hybrid_Cap... view
ARHGEF10 p.P180Q 8 1812596 1812596 LK2_LUNG 37 Missense_Mutation SNP C A uc003wpr.2 ARHGEF10_uc003w... Hybrid_Cap... view
ARHGEF7 p.Q564R 13 111932927 111932927 LK2_LUNG 37 Missense_Mutation SNP A G uc001vrs.2 ARHGEF7_uc001vr... Hybrid_Cap... view
AURKC 19 57742494 57742507 LK2_LUNG 37 5'UTR Del GGACG... - rs67926438;rs112039303;rs59094959 uc002qoe.2 AURKC_uc002qoc.... Hybrid_Cap...
BCL10 p.T162M 1 85733527 85733527 LK2_LUNG 37 Missense_Mutation SNP G A uc001dkz.2 Hybrid_Cap... view
BCL2L11 p.W147* 2 111907666 111907666 LK2_LUNG 37 Nonsense_Mutation SNP G A uc002tgv.1 BCL2L11_uc002tg... Hybrid_Cap... view
BCR 22 23631813 23631814 LK2_LUNG 37 Intron Ins - C rs66503844 uc002zww.2 BCR_uc002zwx.2_... Hybrid_Cap...
C15ORF2 p.P307A 15 24921933 24921933 LK2_LUNG 37 Missense_Mutation SNP C G uc001ywo.2 Hybrid_Cap... view
CACNB2 10 18828721 18828722 LK2_LUNG 37 3'UTR Ins - AA rs3841459 uc001ipr.2 CACNB2_uc009xjz... Hybrid_Cap...
CARD10 p.KE272del 22 37906309 37906314 LK2_LUNG 37 In_Frame_Del Del CTCCT... - uc003asx.1 CARD10_uc003ast... Hybrid_Cap...
CDK11A 1 1636297 1636297 LK2_LUNG 37 Intron SNP G A rs2377227 uc009vks.2 CDK11B_uc001ags... Hybrid_Cap... view
CDK4 p.K35K 12 58145396 58145396 LK2_LUNG 37 Silent SNP C T uc001spv.2 CDK4_uc010ssb.1... Hybrid_Cap... view
CDKN2A p.R139L 9 21971108 21971108 LK2_LUNG 37 Missense_Mutation SNP C A rs11552822 uc003zpl.2 MTAP_uc003zpi.1... Hybrid_Cap... view
CHRNA5 15 78885615 78885616 LK2_LUNG 37 3'UTR Ins - TA rs72534078 uc002bdy.2 CHRNA3_uc002bea... Hybrid_Cap...
CLTCL1 p.V1201_splice 22 19189003 19189004 LK2_LUNG 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
CREB3L2 p.T100del 7 137612914 137612916 LK2_LUNG 37 In_Frame_Del Del TGG - uc003vtw.2 CREB3L2_uc003vt... Hybrid_Cap...
CSMD3 p.V2327L 8 113348921 113348921 LK2_LUNG 37 Missense_Mutation SNP C G uc003ynu.2 CSMD3_uc003yns.... Hybrid_Cap... view
CUBN p.S1593* 10 16996465 16996465 LK2_LUNG 37 Nonsense_Mutation SNP G T uc001ioo.2 Hybrid_Cap... view
CXCL10 4 76943062 76943062 LK2_LUNG 37 3'UTR SNP C G uc003hjl.3 ART3_uc003hji.2... Hybrid_Cap... view
DAPK1 p.R54L 9 90219967 90219967 LK2_LUNG 37 Missense_Mutation SNP G T uc004apc.2 DAPK1_uc004ape.... Hybrid_Cap... view
DCLK3 p.W612L 3 36756931 36756931 LK2_LUNG 37 Missense_Mutation SNP C A uc003cgi.2 Hybrid_Cap... view
DNAH8 p.R3829H 6 38917235 38917235 LK2_LUNG 37 Missense_Mutation SNP G A uc003ooe.1 DNAH8_uc003oog.... Hybrid_Cap... view
DYRK3 1 206810247 206810247 LK2_LUNG 37 Intron Del A - uc001hej.2 DYRK3_uc001hek.... Hybrid_Cap...
EDNRB p.P342H 13 78477316 78477316 LK2_LUNG 37 Missense_Mutation SNP G T uc001vkp.1 EDNRB_uc001vkq.... Hybrid_Cap... view
ETV1 7 14028708 14028708 LK2_LUNG 37 5'UTR Del A - rs77190713 uc011jxq.1 ETV1_uc011jxn.1... Hybrid_Cap...
ETV6 p.P200P 12 12022494 12022494 LK2_LUNG 37 Silent SNP C T uc001qzz.2 ETV6_uc001raa.1... Hybrid_Cap... view
FGFR1OP 6 167453519 167453520 LK2_LUNG 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
FGFR2 10 123276734 123276734 LK2_LUNG 37 Intron SNP G C uc010qtj.1 FGFR2_uc010qtg.... Hybrid_Cap... view
FIGF X 15402140 15402140 LK2_LUNG 37 5'UTR SNP G A uc004cwt.1 Hybrid_Cap... view
FOXP1 3 71008341 71008342 LK2_LUNG 37 3'UTR Ins - T rs11433724;rs114233617 uc003dol.2 FOXP1_uc003dom.... Hybrid_Cap...
GOLGA5 p.L556F 14 93290938 93290938 LK2_LUNG 37 Missense_Mutation SNP G C uc001yaz.1 Hybrid_Cap... view
GPR112 p.A115V X 135405210 135405210 LK2_LUNG 37 Missense_Mutation SNP C T uc004ezu.1 GPR112_uc010nsb... Hybrid_Cap... view
GPR112 p.L1328F X 135429849 135429849 LK2_LUNG 37 Missense_Mutation SNP G T uc004ezu.1 GPR112_uc010nsb... Hybrid_Cap... view
GPR112 p.D2657del X 135474445 135474447 LK2_LUNG 37 In_Frame_Del Del GAT - rs3030295 uc004ezu.1 GPR112_uc010nsb... Hybrid_Cap...
GRIA3 X 122318386 122318387 LK2_LUNG 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GUCY2C 12 14827464 14827466 LK2_LUNG 37 Intron Del ATC - rs72525754;rs3083879 uc001rcd.2 GUCY2C_uc009zhz... Hybrid_Cap...
HDAC2 6 114262077 114262080 LK2_LUNG 37 3'UTR Del AAAC - rs3217728 uc003pwd.1 HDAC2_uc003pwc.... Hybrid_Cap...
HECW1 p.R202G 7 43436461 43436461 LK2_LUNG 37 Missense_Mutation SNP C G uc003tid.1 HECW1_uc011kbi.... Hybrid_Cap... view
IKZF1 7 50468333 50468333 LK2_LUNG 37 3'UTR SNP C T uc003tow.3 IKZF1_uc003tox.... Hybrid_Cap... view
ILK 11 6630029 6630029 LK2_LUNG 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
ITGB8 p.I716M 7 20449362 20449362 LK2_LUNG 37 Missense_Mutation SNP T G uc003suu.2 ITGB8_uc011jyh.... Hybrid_Cap... view
KALRN p.1084_1085NV>KF 3 124160851 124160852 LK2_LUNG 37 Missense_Mutation DNP CG AT uc003ehg.2 KALRN_uc010hrv.... Hybrid_Cap...
KIAA1409 p.W2015* 14 94121690 94121690 LK2_LUNG 37 Nonsense_Mutation SNP G A uc001ybv.1 KIAA1409_uc001y... Hybrid_Cap... view
LAMA1 p.D1086N 18 7013921 7013921 LK2_LUNG 37 Missense_Mutation SNP C T uc002knm.2 LAMA1_uc010wzj.... Hybrid_Cap... view
LATS2 13 21620222 21620223 LK2_LUNG 37 5'UTR Ins - A rs61240127;rs115723063 uc009zzs.2 LATS2_uc001unr.... Hybrid_Cap...
LNX2 p.R150K 13 28143372 28143372 LK2_LUNG 37 Missense_Mutation SNP C T uc001url.3 LNX2_uc001urm.1... Hybrid_Cap... view
LRP2 p.Q3036K 2 170044702 170044702 LK2_LUNG 37 Missense_Mutation SNP G T uc002ues.2 Hybrid_Cap... view
LRRK1 p.E325K 15 101549252 101549252 LK2_LUNG 37 Missense_Mutation SNP G A uc002bwr.2 LRRK1_uc010usb.... Hybrid_Cap... view
MAML3 p.Q767_splice 4 140651585 140651587 LK2_LUNG 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP3K14 p.R218_splice 17 43364293 43364294 LK2_LUNG 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
MAP3K9 p.R497Q 14 71209145 71209145 LK2_LUNG 37 Missense_Mutation SNP C T rs56196343 uc001xml.2 MAP3K9_uc010ttk... Hybrid_Cap... view
MAPKAPK2 p.H322Y 1 206905056 206905056 LK2_LUNG 37 Missense_Mutation SNP C T uc001hem.1 MAPKAPK2_uc001h... Hybrid_Cap... view
MAPKBP1 15 42111746 42111746 LK2_LUNG 37 Intron Del G - uc001zok.3 MAPKBP1_uc001zo... Hybrid_Cap...
MLF1 3 158289182 158289182 LK2_LUNG 37 Intron SNP T C uc003fcc.2 MLF1_uc003fbz.2... Hybrid_Cap... view
MLLT4 p.A134S 6 168271164 168271164 LK2_LUNG 37 Missense_Mutation SNP G T uc003qwd.2 MLLT4_uc003qwb.... Hybrid_Cap... view
MYH11 p.H148H 16 15917170 15917170 LK2_LUNG 37 Silent SNP G A uc002ddx.2 MYH11_uc002ddv.... Hybrid_Cap... view
MYLK p.E1066del 3 123419117 123419119 LK2_LUNG 37 In_Frame_Del Del TTC - rs72491150 uc003ego.2 MYLK_uc011bjw.1... Hybrid_Cap...
MYLK2 20 30421790 30421790 LK2_LUNG 37 3'UTR SNP G A uc002wwq.2 MYLK2_uc002wws.... Hybrid_Cap... view
MYLK4 p.D190V 6 2683373 2683373 LK2_LUNG 37 Missense_Mutation SNP T A uc003mty.3 Hybrid_Cap... view
MYST3 8 41906606 41906606 LK2_LUNG 37 5'UTR SNP C T uc010lxb.2 MYST3_uc010lxc.... Hybrid_Cap... view
MYST4 p.E1104del 10 76781906 76781908 LK2_LUNG 37 In_Frame_Del Del GAA - rs79644703 uc001jwn.1 MYST4_uc001jwm.... Hybrid_Cap...
NCAM1 11 112832307 112832308 LK2_LUNG 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 LK2_LUNG 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NEK3 p.K313_splice 13 52718050 52718051 LK2_LUNG 37 Splice_Site_Ins Ins - T rs72514762 uc001vgh.2 NEK3_uc001vgg.2... Hybrid_Cap...
NIPBL p.S1280F 5 37003433 37003433 LK2_LUNG 37 Missense_Mutation SNP C T uc003jkl.3 NIPBL_uc003jkk.... Hybrid_Cap... view
NPR1 1 153665919 153665920 LK2_LUNG 37 3'UTR Ins - C rs66682713 uc001fcs.3 NPR1_uc010pdz.1... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881820 50881821 LK2_LUNG 37 In_Frame_Ins Ins - AAC rs66783852;rs112359270 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
NRK p.E786* X 105159728 105159728 LK2_LUNG 37 Nonsense_Mutation SNP G T uc004emd.2 NRK_uc010npc.1_... Hybrid_Cap... view
OBSCN 1 228471657 228471657 LK2_LUNG 37 Intron SNP G A uc009xez.1 OBSCN_uc001hsn.... Hybrid_Cap... view
PAX3 2 223066017 223066018 LK2_LUNG 37 Intron Ins - C rs115619343 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PAXIP1 7 154759521 154759521 LK2_LUNG 37 Intron SNP C G uc003wlp.2 PAXIP1_uc003wlq... Hybrid_Cap... view
PDK4 7 95221928 95221928 LK2_LUNG 37 Intron Del A - uc003uoa.2 PDK4_uc003unz.2... Hybrid_Cap...
PIK3C2G 12 18800990 18800990 LK2_LUNG 37 3'UTR Del A - rs16914368 uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PIP5K1B p.K47M 9 71478823 71478823 LK2_LUNG 37 Missense_Mutation SNP A T uc004agu.2 PIP5K1B_uc011lr... Hybrid_Cap... view
PREX2 8 69143713 69143714 LK2_LUNG 37 3'UTR Del TT - uc003xxv.1 Hybrid_Cap...
PRKCE p.E149K 2 46203600 46203600 LK2_LUNG 37 Missense_Mutation SNP G A uc002rut.2 Hybrid_Cap... view
PRKDC p.L1244fs 8 48805816 48805817 LK2_LUNG 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
PTEN 10 89725256 89725256 LK2_LUNG 37 3'UTR SNP C T uc001kfb.2 Hybrid_Cap... view
RECQL4 p.R766fs 8 145738768 145738768 LK2_LUNG 37 Frame_Shift_Del Del G - uc003zdj.2 Hybrid_Cap...
SERPINB4 18 61304931 61304931 LK2_LUNG 37 3'UTR SNP T C uc002ljf.2 SERPINB4_uc002l... Hybrid_Cap... view
SGK3 p.G246V 8 67748305 67748305 LK2_LUNG 37 Missense_Mutation SNP G T uc003xwr.2 SGK3_uc003xwp.2... Hybrid_Cap... view
SLC6A8 X 152957656 152957657 LK2_LUNG 37 Intron Ins - A uc004fib.3 SLC6A8_uc004fic... Hybrid_Cap...
SMURF2 p.E575K 17 62550999 62550999 LK2_LUNG 37 Missense_Mutation SNP C T uc002jep.1 SMURF2_uc002jeq... Hybrid_Cap... view
SPEN p.R1079S 1 16255972 16255972 LK2_LUNG 37 Missense_Mutation SNP G T uc001axk.1 SPEN_uc010obp.1... Hybrid_Cap... view
STARD3 p.L22L 17 37809848 37809848 LK2_LUNG 37 Silent SNP C T uc002hsd.2 STARD3_uc010weg... Hybrid_Cap... view
STAT5B 17 40370115 40370115 LK2_LUNG 37 Intron SNP T C uc002hzh.2 STAT5B_uc002hzi... Hybrid_Cap... view
STK17B p.M1L 2 197028107 197028107 LK2_LUNG 37 Missense_Mutation SNP T G uc002utk.2 STK17B_uc010fsh... Hybrid_Cap... view
STK31 7 23872024 23872025 LK2_LUNG 37 3'UTR Ins - TTTG rs66787534 uc003sws.3 STK31_uc003swt.... Hybrid_Cap...
TCF21 6 134210498 134210499 LK2_LUNG 37 5'UTR Del TC - uc003qei.3 TCF21_uc003qej.... Hybrid_Cap...
TG p.T2537I 8 134125703 134125703 LK2_LUNG 37 Missense_Mutation SNP C T uc003ytw.2 TG_uc010mdw.2_M... Hybrid_Cap... view
TLR4 p.G96W 9 120474692 120474692 LK2_LUNG 37 Missense_Mutation SNP G T uc004bjz.2 TLR4_uc004bka.2... Hybrid_Cap... view
TNFRSF17 p.A153T 16 12061606 12061606 LK2_LUNG 37 Missense_Mutation SNP G A uc002dbv.2 TNFRSF17_uc010b... Hybrid_Cap... view
TNNI3K 1 74701100 74701100 LK2_LUNG 37 Intron SNP A G uc001dge.1 TNNI3K_uc001dgc... Hybrid_Cap... view
TP53 p.V272M 17 7577124 7577124 LK2_LUNG 37 Missense_Mutation SNP C T uc002gim.2 TP53_uc002gig.1... Hybrid_Cap... view
TRIM36 5 114515868 114515868 LK2_LUNG 37 5'UTR SNP G A uc003kqs.2 TRIM36_uc003kqt... Hybrid_Cap... view
TRPS1 8 116635872 116635873 LK2_LUNG 37 5'UTR Ins - A rs76893349 uc003yny.2 TRPS1_uc011lhy.... Hybrid_Cap...
TTN 2 179391639 179391640 LK2_LUNG 37 3'UTR Ins - T rs36037175 uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap...
TTN p.R15335C 2 179470315 179470315 LK2_LUNG 37 Missense_Mutation SNP G A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.P5892Q 2 179588420 179588420 LK2_LUNG 37 Missense_Mutation SNP G T uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
UNC13C 15 54919333 54919333 LK2_LUNG 37 3'UTR SNP A G uc002ack.2 UNC13C_uc002acm... Hybrid_Cap... view
VEGFC p.S419_splice 4 177605082 177605084 LK2_LUNG 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
ZFYVE9 p.S1027R 1 52759178 52759178 LK2_LUNG 37 Missense_Mutation SNP A C uc001cto.2 ZFYVE9_uc001ctp... Hybrid_Cap... view