Annotation Summary for Cell Line: MDA-MB-231  

Cell line primary name: MDA-MB-231
Cell line aliases:
Gender: F
Site Primary: breast
Histology: carcinoma
Hist Subtype1: NS
Notes:
Source: ATCC
Expression arrays: BRAKE_p_NCLE_RNA2_HG-U133_Plus_2_A01_241042
SNP arrays: LIMPS_p_NCLE_DNA2N_GenomeWideSNP_6_G12_246776
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in MDA-MB-231

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
AAK1 p.D724E 16 2347421 2347421 MDAMB231_BREAST 37 Missense_Mutation SNP G C uc002cpy.1 ABCA3_uc010bsk.... Hybrid_Cap... view
ADAM17 17 35766564 35766564 MDAMB231_BREAST 37 5'UTR Del A - uc002hno.2 ACACA_uc002hnn.... Hybrid_Cap...
ADAMTS18 2 9630245 9630245 MDAMB231_BREAST 37 3'UTR Del T - uc002qzu.2 IAH1_uc010yiz.1... Hybrid_Cap...
ADAMTS18 8 24211994 24211997 MDAMB231_BREAST 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
ADAMTS19 p.E1125K 5 129070703 129070703 MDAMB231_BREAST 37 Missense_Mutation SNP G A uc003kvb.1 ADAMTS19_uc010j... Hybrid_Cap... view
AKAP9 p.1335_1336insQ 7 91652178 91652179 MDAMB231_BREAST 37 In_Frame_Ins Ins - AAC rs34756483 uc003ulg.2 AKAP9_uc003ule.... Hybrid_Cap...
ALPK2 p.C1858Y 18 56191223 56191223 MDAMB231_BREAST 37 Missense_Mutation SNP C T uc002lhj.3 Hybrid_Cap... view
ALPK2 p.1531_1532insE 6 151674116 151674117 MDAMB231_BREAST 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
BAI3 p.R624I 6 69703796 69703796 MDAMB231_BREAST 37 Missense_Mutation SNP G T uc003pev.3 BAI3_uc010kak.2... Hybrid_Cap... view
BRAF p.G464V 7 140481417 140481417 MDAMB231_BREAST 37 Missense_Mutation SNP C A uc003vwc.3 Hybrid_Cap... view
BTG1 4 113347609 113347610 MDAMB231_BREAST 37 Intron Ins - T rs68137453 uc003iap.3 ALPK1_uc003ian.... Hybrid_Cap...
CACNB2 p.EDTST1006del 18 56204388 56204402 MDAMB231_BREAST 37 In_Frame_Del Del CAGTT... - rs60644017;rs117623369 uc002lhj.3 ALPK2_uc002lhk.... Hybrid_Cap...
CASP6 p.T105I 4 110615850 110615850 MDAMB231_BREAST 37 Missense_Mutation SNP G A uc003hzn.1 CASP6_uc003hzo.... Hybrid_Cap... view
CDC42BPA p.G1483A 1 227211026 227211026 MDAMB231_BREAST 37 Missense_Mutation SNP C G uc001hqr.2 CDC42BPA_uc001h... Hybrid_Cap... view
CDC42BPA p.A264_splice 8 62550924 62550925 MDAMB231_BREAST 37 Splice_Site_Ins Ins - A rs5891816 uc003xuj.2 ASPH_uc011leg.1... Hybrid_Cap...
CDK11B 1 1654066 1654068 MDAMB231_BREAST 37 Intron Del GCG - uc001agv.1 CDK11B_uc001aha... Hybrid_Cap...
CDK11B p.D752H 13 113510235 113510235 MDAMB231_BREAST 37 Missense_Mutation SNP G C uc001vsj.3 ATP11A_uc001vsi... Hybrid_Cap... view
CLTCL1 p.D1485N 22 19175222 19175222 MDAMB231_BREAST 37 Missense_Mutation SNP C T uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap... view
CLTCL1 p.V1201_splice 22 19189003 19189004 MDAMB231_BREAST 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
CNTN6 3 1339681 1339686 MDAMB231_BREAST 37 Intron Del GTTTT... - uc003boz.2 CNTN6_uc010hbo.... Hybrid_Cap...
CTBP2 10 18828721 18828722 MDAMB231_BREAST 37 3'UTR Ins - AA rs3841459 uc001ipr.2 CACNB2_uc009xjz... Hybrid_Cap...
EIF2AK4 2 27466471 27466471 MDAMB231_BREAST 37 3'UTR SNP A T uc002rji.2 CAD_uc010eyw.2_... Hybrid_Cap... view
EIF4EBP1 8 37917561 37917561 MDAMB231_BREAST 37 3'UTR SNP C T uc003xks.2 Hybrid_Cap... view
ERCC6 p.V549M 18 25568584 25568584 MDAMB231_BREAST 37 Missense_Mutation SNP C T uc002kwg.2 CDH2_uc010xbn.1... Hybrid_Cap... view
FGFR1OP 6 167453519 167453520 MDAMB231_BREAST 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
GRIA3 X 122318386 122318387 MDAMB231_BREAST 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GRK6 5 176868973 176868973 MDAMB231_BREAST 37 3'UTR SNP G T uc011dfz.1 Hybrid_Cap... view
GUCY2C 12 14827464 14827466 MDAMB231_BREAST 37 Intron Del ATC - rs72525754;rs3083879 uc001rcd.2 GUCY2C_uc009zhz... Hybrid_Cap...
HMMR p.A664fs 5 162917425 162917426 MDAMB231_BREAST 37 Frame_Shift_Ins Ins - A uc003lzh.2 HMMR_uc003lzf.2... Hybrid_Cap...
ICK 6 52880774 52880774 MDAMB231_BREAST 37 Intron SNP T C uc003pbh.2 ICK_uc003pbi.2_... Hybrid_Cap... view
ILK 11 6630029 6630029 MDAMB231_BREAST 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
ILK p.V224F 12 68051357 68051357 MDAMB231_BREAST 37 Missense_Mutation SNP G T uc001str.3 DYRK2_uc001sts.... Hybrid_Cap... view
ILK 13 72014625 72014626 MDAMB231_BREAST 37 3'UTR Ins - T rs117109529 uc010thn.1 DACH1_uc010tho.... Hybrid_Cap...
ITPR2 3 97367230 97367231 MDAMB231_BREAST 37 Intron Ins - A rs115253553 uc010how.1 EPHA6_uc003drs.... Hybrid_Cap...
KLK7 19 51480672 51480675 MDAMB231_BREAST 37 3'UTR Del GGTT - uc002puo.2 KLK7_uc002pup.2... Hybrid_Cap...
KRAS p.G13D 12 25398281 25398281 MDAMB231_BREAST 37 Missense_Mutation SNP C T rs112445441 uc001rgp.1 KRAS_uc001rgq.1... Hybrid_Cap... view
KRAS 7 14028708 14028708 MDAMB231_BREAST 37 5'UTR Del A - rs77190713 uc011jxq.1 ETV1_uc011jxn.1... Hybrid_Cap...
LRP1B p.L306P 8 101153565 101153565 MDAMB231_BREAST 37 Missense_Mutation SNP A G uc003yjd.2 FBXO43_uc003yje... Hybrid_Cap... view
LRRK2 p.I2323S 12 40753186 40753186 MDAMB231_BREAST 37 Missense_Mutation SNP T G uc001rmg.3 LRRK2_uc009zjw.... Hybrid_Cap... view
MAF 16 79628537 79628537 MDAMB231_BREAST 37 Intron Del T - uc002ffm.2 MAF_uc002ffn.2_... Hybrid_Cap...
MAML2 11 128638217 128638217 MDAMB231_BREAST 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
MAP3K14 14 62213929 62213930 MDAMB231_BREAST 37 3'UTR Ins - T rs67890419 uc001xfs.2 HIF1A_uc001xfq.... Hybrid_Cap...
MAP3K9 p.S1093N 14 71197176 71197176 MDAMB231_BREAST 37 Missense_Mutation SNP C T uc001xml.2 MAP3K9_uc010ttk... Hybrid_Cap... view
MMP1 p.P371R 11 102662148 102662148 MDAMB231_BREAST 37 Missense_Mutation SNP G C uc001phi.2 MMP1_uc010ruv.1... Hybrid_Cap... view
MMP1 p.R470_splice 12 26834804 26834805 MDAMB231_BREAST 37 Splice_Site_Ins Ins - ACTC rs66696203;rs59199365 uc001rhg.2 Hybrid_Cap...
MSH3 p.G896R 5 80109433 80109433 MDAMB231_BREAST 37 Missense_Mutation SNP G A uc003kgz.2 Hybrid_Cap... view
MST1R p.F400L 3 49939843 49939843 MDAMB231_BREAST 37 Missense_Mutation SNP G T uc003cxy.3 MST1R_uc011bdd.... Hybrid_Cap... view
MYCL1 p.E226K 1 40363463 40363463 MDAMB231_BREAST 37 Missense_Mutation SNP C T uc001cer.1 MYCL1_uc001ces.... Hybrid_Cap... view
NCAM1 11 112832307 112832308 MDAMB231_BREAST 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 MDAMB231_BREAST 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 p.N451S 12 117993053 117993053 MDAMB231_BREAST 37 Missense_Mutation SNP T C uc001two.2 Hybrid_Cap... view
NCAPD3 p.R110L 11 134086883 134086883 MDAMB231_BREAST 37 Missense_Mutation SNP C A uc001qhd.1 NCAPD3_uc010scm... Hybrid_Cap... view
NCOA3 p.Q1276del 20 46279837 46279839 MDAMB231_BREAST 37 In_Frame_Del Del CAG - rs2664555 uc002xtk.2 NCOA3_uc010ght.... Hybrid_Cap...
NF1 p.L466fs 17 29541474 29541475 MDAMB231_BREAST 37 Frame_Shift_Ins Ins - C uc002hgg.2 NF1_uc002hge.1_... Hybrid_Cap...
NF2 p.E231* 22 30057209 30057209 MDAMB231_BREAST 37 Nonsense_Mutation SNP G T uc003age.3 NF2_uc003afy.3_... Hybrid_Cap... view
NLRP1 p.R191I 2 142004815 142004815 MDAMB231_BREAST 37 Missense_Mutation SNP C A uc002tvj.1 LRP1B_uc010fnl.... Hybrid_Cap... view
NOTCH3 p.T368S 19 15300174 15300174 MDAMB231_BREAST 37 Missense_Mutation SNP T A uc002nan.2 NOTCH3_uc002nao... Hybrid_Cap... view
NPM1 5 170837734 170837734 MDAMB231_BREAST 37 3'UTR Del T - uc011dex.1 NPM1_uc003mbi.2... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881822 50881823 MDAMB231_BREAST 37 In_Frame_Ins Ins - CAG rs61751954;rs1052533 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
PAX3 2 223158653 223158653 MDAMB231_BREAST 37 Intron Del T - rs112753212 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PCDH15 p.Q1471H 10 55583094 55583094 MDAMB231_BREAST 37 Missense_Mutation SNP T A uc010qhy.1 PCDH15_uc010qhq... Hybrid_Cap... view
PCSK7 p.P52R 11 117100406 117100406 MDAMB231_BREAST 37 Missense_Mutation SNP G C uc001pqr.2 RNF214_uc001pqt... Hybrid_Cap... view
PDE4DIP p.Q1665fs 1 144873963 144873963 MDAMB231_BREAST 37 Frame_Shift_Del Del T - uc001elw.3 NBPF10_uc009wir... Hybrid_Cap...
PDE4DIP 1 144931101 144931101 MDAMB231_BREAST 37 Intron SNP G A uc001elw.3 NBPF10_uc009wir... Hybrid_Cap... view
PDGFRA p.Y172F 4 55129981 55129981 MDAMB231_BREAST 37 Missense_Mutation SNP A T uc003han.3 PDGFRA_uc003haa... Hybrid_Cap... view
PDGFRA 4 55131002 55131002 MDAMB231_BREAST 37 Intron Del A - uc003han.3 PDGFRA_uc003haa... Hybrid_Cap...
PER1 p.E189D 17 8053157 8053157 MDAMB231_BREAST 37 Missense_Mutation SNP C A uc002gkd.2 PER1_uc010vuq.1... Hybrid_Cap... view
PGR 11 100933598 100933599 MDAMB231_BREAST 37 Intron Ins - AATGA rs35148438 uc001pgh.2 PGR_uc001pgg.2_... Hybrid_Cap...
PIK3C2G p.P129del 12 18435399 18435401 MDAMB231_BREAST 37 In_Frame_Del Del CCC - uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PMS1 2 190670539 190670540 MDAMB231_BREAST 37 Intron Ins - A rs3214425 uc002urh.3 PMS1_uc010zga.1... Hybrid_Cap...
PRKDC p.L1244fs 8 48805816 48805817 MDAMB231_BREAST 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
RBL1 p.P246L 20 35695236 35695236 MDAMB231_BREAST 37 Missense_Mutation SNP G A uc002xgi.2 RBL1_uc010zvt.1... Hybrid_Cap... view
RECQL4 p.R766fs 8 145738768 145738768 MDAMB231_BREAST 37 Frame_Shift_Del Del G - uc003zdj.2 Hybrid_Cap...
RPS6KA5 14 91360733 91360734 MDAMB231_BREAST 37 Intron Ins - T rs77438853 uc001xys.2 RPS6KA5_uc010tw... Hybrid_Cap...
RPS6KL1 14 75373626 75373627 MDAMB231_BREAST 37 3'UTR Ins - TGAT uc001xqx.1 RPS6KL1_uc001xq... Hybrid_Cap...
RPS6KL1 p.R522C 14 75373803 75373803 MDAMB231_BREAST 37 Missense_Mutation SNP G A uc010tux.1 RPS6KL1_uc001xq... Hybrid_Cap... view
SACS p.K3116N 13 23908667 23908667 MDAMB231_BREAST 37 Missense_Mutation SNP C G uc001uon.2 SACS_uc001uoo.2... Hybrid_Cap... view
SORL1 11 121500400 121500401 MDAMB231_BREAST 37 3'UTR Ins - A rs73020651 uc001pxx.2 SORL1_uc010rzp.... Hybrid_Cap...
SOS1 p.Q767_splice 4 140651585 140651587 MDAMB231_BREAST 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
STK38 p.I457T 6 36463589 36463589 MDAMB231_BREAST 37 Missense_Mutation SNP A G uc003omg.2 STK38_uc003omh.... Hybrid_Cap... view
TCERG1L p.R218_splice 17 43364293 43364294 MDAMB231_BREAST 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
TCF21 6 134210497 134210498 MDAMB231_BREAST 37 5'UTR Ins - TCTC rs35199378 uc003qei.3 TCF21_uc003qej.... Hybrid_Cap...
TEC 4 48139307 48139310 MDAMB231_BREAST 37 3'UTR Del TTAT - rs79098351 uc003gxz.2 Hybrid_Cap...
TLK1 2 171850178 171850179 MDAMB231_BREAST 37 3'UTR Ins - AA rs71008739 uc002ugo.2 TLK1_uc002ugn.2... Hybrid_Cap...
TLN1 p.Q1793L 9 35706092 35706092 MDAMB231_BREAST 37 Missense_Mutation SNP T A uc003zxt.2 Hybrid_Cap... view
TMEM123 11 102269398 102269398 MDAMB231_BREAST 37 3'UTR Del G - uc001pha.2 TMEM123_uc009yx... Hybrid_Cap...
TNFRSF1B p.L140L 1 12251943 12251943 MDAMB231_BREAST 37 Silent SNP G C uc001att.2 TNFRSF1B_uc001a... Hybrid_Cap... view
TP53 p.R280K 17 7577099 7577099 MDAMB231_BREAST 37 Missense_Mutation SNP C T uc002gim.2 TP53_uc002gig.1... Hybrid_Cap... view
TP63 3 189507518 189507519 MDAMB231_BREAST 37 Intron Ins - AGAG rs62702062;rs79714037 uc003fry.2 TP63_uc003frx.2... Hybrid_Cap...
TPR p.D1959Y 1 186296606 186296606 MDAMB231_BREAST 37 Missense_Mutation SNP C A uc001grv.2 Hybrid_Cap... view
TRIM33 15 42111753 42111754 MDAMB231_BREAST 37 Intron Ins - C rs3034891 uc001zok.3 MAPKBP1_uc001zo... Hybrid_Cap...
TRIM37 p.S270_splice 17 57141768 57141769 MDAMB231_BREAST 37 Splice_Site_Ins Ins - A uc002iwy.3 TRIM37_uc002iwz... Hybrid_Cap...
TRIO p.L600V 5 14330953 14330953 MDAMB231_BREAST 37 Missense_Mutation SNP C G uc003jff.2 TRIO_uc003jfg.2... Hybrid_Cap... view
TRIO p.K2789E 5 14502720 14502720 MDAMB231_BREAST 37 Missense_Mutation SNP A G uc003jff.2 TRIO_uc003jfg.2... Hybrid_Cap... view
TTN p.L9678V 2 179548768 179548768 MDAMB231_BREAST 37 Missense_Mutation SNP G C uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.D8936H 2 179566767 179566767 MDAMB231_BREAST 37 Missense_Mutation SNP C G uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
VEGFC p.S419_splice 4 177605082 177605084 MDAMB231_BREAST 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
WNK1 p.R561I 12 970240 970240 MDAMB231_BREAST 37 Missense_Mutation SNP G T uc001qio.3 WNK1_uc001qip.3... Hybrid_Cap... view
YSK4 p.L639R 2 135744526 135744526 MDAMB231_BREAST 37 Missense_Mutation SNP A C uc002tue.1 YSK4_uc002tuf.1... Hybrid_Cap... view
ZNF423 p.H1010Q 16 49670033 49670033 MDAMB231_BREAST 37 Missense_Mutation SNP G T uc002efs.2 ZNF423_uc010vgn... Hybrid_Cap... view