Annotation Summary for Cell Line: MDA-MB-436  

Cell line primary name: MDA-MB-436
Cell line aliases:
Gender: F
Site Primary: breast
Histology: carcinoma
Hist Subtype1: NS
Notes:
Source: ATCC
Expression arrays: CASED_p_NCLE_RNA4_HG-U133_Plus_2_C09_383596
SNP arrays: FASTS_p_NCLE_DNAAffy4_S_GenomeWideSNP_6_F10_335326
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in MDA-MB-436

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
AAK1 p.541_542QQ>Q 2 69741754 69741756 MDAMB436_BREAST 37 In_Frame_Del Del TGT - rs55712143 uc002sfp.2 AAK1_uc010fdk.2... Hybrid_Cap...
ABL1 p.C119G 9 133730232 133730232 MDAMB436_BREAST 37 Missense_Mutation SNP T G uc004bzv.2 ABL1_uc004bzw.2... Hybrid_Cap... view
ADAM17 2 9630241 9630245 MDAMB436_BREAST 37 3'UTR Del TTGAT - rs3833563 uc002qzu.2 IAH1_uc010yiz.1... Hybrid_Cap...
ADAM28 8 24211994 24211997 MDAMB436_BREAST 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
ADAM32 p.T38A 8 38975658 38975658 MDAMB436_BREAST 37 Missense_Mutation SNP A G uc003xmt.3 ADAM32_uc011lch... Hybrid_Cap... view
AKAP12 p.1531_1532insE 6 151674116 151674117 MDAMB436_BREAST 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
AKAP9 p.1335_1336insQ 7 91652178 91652179 MDAMB436_BREAST 37 In_Frame_Ins Ins - AAC rs34756483 uc003ulg.2 AKAP9_uc003ule.... Hybrid_Cap...
ALPK1 4 113347609 113347610 MDAMB436_BREAST 37 Intron Ins - T rs68137453 uc003iap.3 ALPK1_uc003ian.... Hybrid_Cap...
ALPK2 p.EDTST1006del 18 56204388 56204402 MDAMB436_BREAST 37 In_Frame_Del Del CAGTT... - rs60644017;rs117623369 uc002lhj.3 ALPK2_uc002lhk.... Hybrid_Cap...
ASPH p.K499N 8 62468522 62468522 MDAMB436_BREAST 37 Missense_Mutation SNP C A uc003xuj.2 ASPH_uc011leg.1... Hybrid_Cap... view
BCR 22 23631813 23631814 MDAMB436_BREAST 37 Intron Ins - C rs66503844 uc002zww.2 BCR_uc002zwx.2_... Hybrid_Cap...
BIRC6 p.P4812S 2 32842831 32842831 MDAMB436_BREAST 37 Missense_Mutation SNP C T uc010ezu.2 Hybrid_Cap... view
BRCA1 p.K1780_splice 17 41209068 41209068 MDAMB436_BREAST 37 Splice_Site_SNP SNP C T rs80358150 uc002ict.2 BRCA1_uc010whp.... Hybrid_Cap... view
BTK p.R167fs X 100617657 100617672 MDAMB436_BREAST 37 Frame_Shift_Del Del GATCA... - uc010nno.2 BTK_uc004ehg.2_... Hybrid_Cap...
CABC1 1 227171585 227171585 MDAMB436_BREAST 37 Intron Del T - uc001hqm.1 CABC1_uc001hqn.... Hybrid_Cap...
CACNB2 10 18629889 18629889 MDAMB436_BREAST 37 Intron SNP A C uc001ipr.2 CACNB2_uc009xjz... Hybrid_Cap... view
CACNB2 10 18828721 18828722 MDAMB436_BREAST 37 3'UTR Ins - AA rs3841459 uc001ipr.2 CACNB2_uc009xjz... Hybrid_Cap...
CARD10 p.KE272del 22 37906309 37906314 MDAMB436_BREAST 37 In_Frame_Del Del CTCCT... - uc003asx.1 CARD10_uc003ast... Hybrid_Cap...
CDK11B 1 1654066 1654068 MDAMB436_BREAST 37 Intron Del GCG - uc001agv.1 CDK11B_uc001aha... Hybrid_Cap...
CDKL3 p.A260V 5 133655062 133655062 MDAMB436_BREAST 37 Missense_Mutation SNP G A uc003kzf.3 CDKL3_uc011cxm.... Hybrid_Cap... view
CDKL3 p.N219fs 5 133655167 133655185 MDAMB436_BREAST 37 Frame_Shift_Del Del TGCAA... - uc003kzf.3 CDKL3_uc011cxm.... Hybrid_Cap...
CEP110 9 123939699 123939699 MDAMB436_BREAST 37 3'UTR Del T - rs75910820 uc004bkx.1 CEP110_uc004blb... Hybrid_Cap...
CLTCL1 p.V1201_splice 22 19189003 19189004 MDAMB436_BREAST 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
COL14A1 8 121279156 121279156 MDAMB436_BREAST 37 Intron SNP G C uc003yox.2 COL14A1_uc003yo... Hybrid_Cap... view
CSPG4 p.R477H 15 75981976 75981976 MDAMB436_BREAST 37 Missense_Mutation SNP C T uc002baw.2 Hybrid_Cap... view
EP300 22 41574970 41574972 MDAMB436_BREAST 37 3'UTR Del GTA - rs76489032 uc003azl.3 Hybrid_Cap...
EPHA3 p.L747V 3 89480402 89480402 MDAMB436_BREAST 37 Missense_Mutation SNP C G uc003dqy.2 EPHA3_uc010hon.... Hybrid_Cap... view
EPHA5 4 66189753 66189754 MDAMB436_BREAST 37 3'UTR Ins - T rs67487372 uc011cah.1 EPHA5_uc003hcx.... Hybrid_Cap...
EPHA6 3 97367230 97367231 MDAMB436_BREAST 37 Intron Ins - A rs115253553 uc010how.1 EPHA6_uc003drs.... Hybrid_Cap...
ERLIN2 p.D259N 8 37611003 37611003 MDAMB436_BREAST 37 Missense_Mutation SNP G A uc003xke.3 Hybrid_Cap... view
ETV1 7 14028708 14028708 MDAMB436_BREAST 37 5'UTR Del A - rs77190713 uc011jxq.1 ETV1_uc011jxn.1... Hybrid_Cap...
FANCI p.S812G 15 89837206 89837206 MDAMB436_BREAST 37 Missense_Mutation SNP A G uc010bnp.1 FANCI_uc002bnm.... Hybrid_Cap... view
FASTK 7 150774508 150774508 MDAMB436_BREAST 37 Intron SNP G A uc003wix.1 FASTK_uc003wiw.... Hybrid_Cap... view
FBN2 p.M1320I 5 127670875 127670875 MDAMB436_BREAST 37 Missense_Mutation SNP C T uc003kuu.2 FBN2_uc003kuv.2... Hybrid_Cap... view
FGFR1OP 6 167453519 167453520 MDAMB436_BREAST 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
FLNA p.R2334C X 153579972 153579972 MDAMB436_BREAST 37 Missense_Mutation SNP G A uc004fkk.2 FLNA_uc004fki.2... Hybrid_Cap... view
FLNA p.V923A X 153590405 153590405 MDAMB436_BREAST 37 Missense_Mutation SNP A G uc004fkk.2 FLNA_uc010nuu.1... Hybrid_Cap... view
FLT4 5 180035183 180035185 MDAMB436_BREAST 37 Intron Del AGT - uc003mlz.3 FLT4_uc003mma.3... Hybrid_Cap...
GRIA3 X 122318386 122318387 MDAMB436_BREAST 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GUCY2C 12 14827464 14827466 MDAMB436_BREAST 37 Intron Del ATC - rs72525754;rs3083879 uc001rcd.2 GUCY2C_uc009zhz... Hybrid_Cap...
HSP90B1 12 104341580 104341580 MDAMB436_BREAST 37 3'UTR Del A - uc001tkb.1 HSP90B1_uc010sw... Hybrid_Cap...
ILK 11 6630029 6630029 MDAMB436_BREAST 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
ITPR2 p.R470_splice 12 26834804 26834805 MDAMB436_BREAST 37 Splice_Site_Ins Ins - ACTC rs66696203;rs59199365 uc001rhg.2 Hybrid_Cap...
KDM6A p.L988F X 44936047 44936047 MDAMB436_BREAST 37 Missense_Mutation SNP G C uc011mkz.1 KDM6A_uc010nhk.... Hybrid_Cap... view
MAML3 p.Q767_splice 4 140651585 140651587 MDAMB436_BREAST 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP3K1 p.T949del 5 56177849 56177851 MDAMB436_BREAST 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAP3K14 p.R218_splice 17 43364293 43364294 MDAMB436_BREAST 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
MAP3K4 p.K563T 6 161470992 161470992 MDAMB436_BREAST 37 Missense_Mutation SNP A C uc003qtn.2 MAP3K4_uc010kkc... Hybrid_Cap... view
MAPK4 p.C372* 18 48255576 48255576 MDAMB436_BREAST 37 Nonsense_Mutation SNP C A uc002lev.2 MAPK4_uc010xdm.... Hybrid_Cap... view
MAST1 p.A1048S 19 12981865 12981865 MDAMB436_BREAST 37 Missense_Mutation SNP G T rs35052801 uc002mvm.2 Hybrid_Cap... view
MLL3 p.Y816fs 7 151945071 151945072 MDAMB436_BREAST 37 Frame_Shift_Ins Ins - T uc003wla.2 Hybrid_Cap...
MLLT3 9 20346377 20346378 MDAMB436_BREAST 37 3'UTR Ins - A rs66943046 uc003zoe.2 MLLT3_uc011lne.... Hybrid_Cap...
NCAM1 11 112832307 112832308 MDAMB436_BREAST 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 MDAMB436_BREAST 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCOA2 p.R19H 8 71128925 71128925 MDAMB436_BREAST 37 Missense_Mutation SNP C T uc003xyn.1 Hybrid_Cap... view
NEK3 p.K313_splice 13 52718050 52718051 MDAMB436_BREAST 37 Splice_Site_Ins Ins - T rs72514762 uc001vgh.2 NEK3_uc001vgg.2... Hybrid_Cap...
NFIA 1 61921185 61921186 MDAMB436_BREAST 37 3'UTR Ins - T rs57270124;rs76131997 uc010oos.1 NFIA_uc001czy.2... Hybrid_Cap...
NLRP10 p.K605R 11 7981345 7981345 MDAMB436_BREAST 37 Missense_Mutation SNP T C uc001mfv.1 Hybrid_Cap... view
NPM1 5 170837734 170837734 MDAMB436_BREAST 37 3'UTR Del T - uc011dex.1 NPM1_uc003mbi.2... Hybrid_Cap...
NPR1 1 153665919 153665920 MDAMB436_BREAST 37 3'UTR Ins - C rs66682713 uc001fcs.3 NPR1_uc010pdz.1... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881822 50881823 MDAMB436_BREAST 37 In_Frame_Ins Ins - CAG rs61751954;rs1052533 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
PAX3 2 223158653 223158653 MDAMB436_BREAST 37 Intron Del T - rs112753212 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PAX5 9 37034081 37034081 MDAMB436_BREAST 37 5'UTR SNP G T uc003zzo.1 PAX5_uc011lpw.1... Hybrid_Cap... view
PCM1 8 17813218 17813218 MDAMB436_BREAST 37 Intron Del T - uc003wyi.3 PCM1_uc011kyh.1... Hybrid_Cap...
PIK3C2B p.D964E 1 204412701 204412701 MDAMB436_BREAST 37 Missense_Mutation SNP G T uc001haw.2 PIK3C2B_uc010pq... Hybrid_Cap... view
PIP5K1B p.L519F 9 71606110 71606110 MDAMB436_BREAST 37 Missense_Mutation SNP G C uc004agu.2 PIP5K1B_uc011lr... Hybrid_Cap... view
PRKDC p.L1825F 8 48777215 48777215 MDAMB436_BREAST 37 Missense_Mutation SNP G A uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap... view
PRKDC p.L1244fs 8 48805816 48805817 MDAMB436_BREAST 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
PTK2B p.C395Y 8 27292068 27292068 MDAMB436_BREAST 37 Missense_Mutation SNP G A uc003xfn.1 PTK2B_uc003xfo.... Hybrid_Cap... view
RECQL4 p.R766fs 8 145738768 145738768 MDAMB436_BREAST 37 Frame_Shift_Del Del G - uc003zdj.2 Hybrid_Cap...
RPS6KL1 14 75373626 75373627 MDAMB436_BREAST 37 3'UTR Ins - TGAT uc001xqx.1 RPS6KL1_uc001xq... Hybrid_Cap...
SORL1 p.A1310V 11 121458843 121458843 MDAMB436_BREAST 37 Missense_Mutation SNP C T uc001pxx.2 SORL1_uc010rzp.... Hybrid_Cap... view
SSX1 p.P69H X 48117992 48117992 MDAMB436_BREAST 37 Missense_Mutation SNP C A uc004djb.1 Hybrid_Cap... view
STAT6 p.V487M 12 57496273 57496273 MDAMB436_BREAST 37 Missense_Mutation SNP C T uc009zpg.2 STAT6_uc009zpe.... Hybrid_Cap... view
STK17A p.M278I 7 43663401 43663401 MDAMB436_BREAST 37 Missense_Mutation SNP G T uc003tih.2 C7orf44_uc003ti... Hybrid_Cap... view
SULF1 p.P366T 8 70515461 70515461 MDAMB436_BREAST 37 Missense_Mutation SNP C A uc010lza.1 SULF1_uc003xyd.... Hybrid_Cap... view
TBX22 p.G488S X 79286509 79286509 MDAMB436_BREAST 37 Missense_Mutation SNP G A uc010nmg.1 TBX22_uc004edi.... Hybrid_Cap... view
TEC 4 48139307 48139310 MDAMB436_BREAST 37 3'UTR Del TTAT - rs79098351 uc003gxz.2 Hybrid_Cap...
TLK1 2 171850178 171850179 MDAMB436_BREAST 37 3'UTR Ins - AA rs71008739 uc002ugo.2 TLK1_uc002ugn.2... Hybrid_Cap...
TMEM123 11 102269398 102269398 MDAMB436_BREAST 37 3'UTR Del G - uc001pha.2 TMEM123_uc009yx... Hybrid_Cap...
TP63 3 189507518 189507519 MDAMB436_BREAST 37 Intron Ins - AGAG rs62702062;rs79714037 uc003fry.2 TP63_uc003frx.2... Hybrid_Cap...
TPH1 p.D413G 11 18042635 18042635 MDAMB436_BREAST 37 Missense_Mutation SNP T C uc001mnp.2 TPH1_uc009yhe.2... Hybrid_Cap... view
TRPS1 p.T1266M 8 116426339 116426339 MDAMB436_BREAST 37 Missense_Mutation SNP G A uc003yny.2 TRPS1_uc011lhy.... Hybrid_Cap... view
TRPS1 p.N68S 8 116632122 116632122 MDAMB436_BREAST 37 Missense_Mutation SNP T C uc003yny.2 TRPS1_uc011lhy.... Hybrid_Cap... view
TTN 2 179391639 179391640 MDAMB436_BREAST 37 3'UTR Ins - T rs36037175 uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap...
TTN p.E22073V 2 179436937 179436937 MDAMB436_BREAST 37 Missense_Mutation SNP T A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TYK2 p.G1010_splice 19 10463758 10463781 MDAMB436_BREAST 37 Splice_Site_Del Del TGCAG... - uc002moc.3 TYK2_uc010dxe.2... Hybrid_Cap...
VEGFC p.S419_splice 4 177605082 177605084 MDAMB436_BREAST 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...