Annotation Summary for Cell Line: NCI-H1437  

Cell line primary name: NCI-H1437
Cell line aliases: H1437
Gender: M
Site Primary: lung
Histology: carcinoma
Hist Subtype1: adenocarcinoma
Notes:
Source: ATCC
Expression arrays: CASED_p_NCLE_RNA4_HG-U133_Plus_2_B11_383748
SNP arrays: FASTS_p_NCLE_DNAAffy4_S_GenomeWideSNP_6_E05_335292
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in NCI-H1437

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
ABCC4 p.D405Y 13 95847140 95847140 NCIH1437_LUNG 37 Missense_Mutation SNP C A uc001vmd.3 ABCC4_uc010afk.... Hybrid_Cap... view
ACVR2B p.P176R 3 38519870 38519870 NCIH1437_LUNG 37 Missense_Mutation SNP C G rs35882617 uc003cif.2 ACVR2B_uc003cig... Hybrid_Cap... view
ADAM17 2 9630245 9630245 NCIH1437_LUNG 37 3'UTR Del T - uc002qzu.2 IAH1_uc010yiz.1... Hybrid_Cap...
ADAM28 8 24211994 24211997 NCIH1437_LUNG 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
AKAP12 p.1531_1532insE 6 151674116 151674117 NCIH1437_LUNG 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
AKAP9 p.1335_1336insQ 7 91652178 91652179 NCIH1437_LUNG 37 In_Frame_Ins Ins - AAC rs34756483 uc003ulg.2 AKAP9_uc003ule.... Hybrid_Cap...
ALPK2 p.EDTST1006del 18 56204388 56204402 NCIH1437_LUNG 37 In_Frame_Del Del CAGTT... - rs60644017;rs117623369 uc002lhj.3 ALPK2_uc002lhk.... Hybrid_Cap...
ALPK2 18 56148904 56148904 NCIH1437_LUNG 37 3'UTR SNP T A uc002lhj.3 Hybrid_Cap... view
ARFGEF1 p.Q1001H 8 68151105 68151105 NCIH1437_LUNG 37 Missense_Mutation SNP C A uc003xxo.1 ARFGEF1_uc003xx... Hybrid_Cap... view
ATP13A5 p.Q544H 3 193042695 193042695 NCIH1437_LUNG 37 Missense_Mutation SNP C A uc011bsq.1 Hybrid_Cap... view
BCR 22 23631813 23631814 NCIH1437_LUNG 37 Intron Ins - C rs66503844 uc002zww.2 BCR_uc002zwx.2_... Hybrid_Cap...
CDC5L p.D514H 6 44392291 44392291 NCIH1437_LUNG 37 Missense_Mutation SNP G C uc003oxl.2 Hybrid_Cap... view
CHD1 p.P1684del 5 98192165 98192167 NCIH1437_LUNG 37 In_Frame_Del Del AGG - rs79267787;rs61749618 uc003knf.2 CHD1_uc010jbn.2... Hybrid_Cap...
CLTCL1 p.V1201_splice 22 19189003 19189004 NCIH1437_LUNG 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
CXCL12 10 44873992 44873993 NCIH1437_LUNG 37 Intron Ins - CT rs117617571 uc001jbh.2 CXCL12_uc001jbf... Hybrid_Cap...
DAB1 p.P487T 1 57476931 57476931 NCIH1437_LUNG 37 Missense_Mutation SNP G T uc001cys.1 DAB1_uc001cyt.1... Hybrid_Cap... view
DACH1 13 72014625 72014626 NCIH1437_LUNG 37 3'UTR Ins - T rs117109529 uc010thn.1 DACH1_uc010tho.... Hybrid_Cap...
DCLK1 13 36348688 36348688 NCIH1437_LUNG 37 3'UTR SNP G T uc001uvf.2 DCLK1_uc001uve.... Hybrid_Cap... view
DOCK3 p.R1678H 3 51399316 51399316 NCIH1437_LUNG 37 Missense_Mutation SNP G A uc011bds.1 Hybrid_Cap... view
DYRK1A 21 38884966 38884967 NCIH1437_LUNG 37 3'UTR Ins - T rs72430212 uc002ywk.2 DYRK1A_uc002ywi... Hybrid_Cap...
EIF2AK2 p.L439V 2 37341936 37341936 NCIH1437_LUNG 37 Missense_Mutation SNP G C uc010ynh.1 EIF2AK2_uc010fa... Hybrid_Cap... view
EP300 22 41574970 41574972 NCIH1437_LUNG 37 3'UTR Del GTA - rs76489032 uc003azl.3 Hybrid_Cap...
EPHA6 3 97367230 97367231 NCIH1437_LUNG 37 Intron Ins - A rs115253553 uc010how.1 EPHA6_uc003drs.... Hybrid_Cap...
ETV1 7 14028708 14028708 NCIH1437_LUNG 37 5'UTR Del A - rs77190713 uc011jxq.1 ETV1_uc011jxn.1... Hybrid_Cap...
EXT1 8 118811807 118811807 NCIH1437_LUNG 37 3'UTR Del T - uc003yok.1 Hybrid_Cap...
FANCG p.S302I 9 35076740 35076740 NCIH1437_LUNG 37 Missense_Mutation SNP C A rs61757386 uc003zwb.1 FANCG_uc003zwa.... Hybrid_Cap... view
FANCL 2 58468480 58468480 NCIH1437_LUNG 37 5'UTR SNP C G uc002rzx.3 FANCL_uc002rzw.... Hybrid_Cap... view
FASTK p.V424L 7 150774418 150774418 NCIH1437_LUNG 37 Missense_Mutation SNP C G uc003wix.1 FASTK_uc003wiw.... Hybrid_Cap... view
FLI1 11 128638217 128638217 NCIH1437_LUNG 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
GRIA3 X 122318386 122318387 NCIH1437_LUNG 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GRK5 p.G339E 10 121201559 121201559 NCIH1437_LUNG 37 Missense_Mutation SNP G A uc001led.2 GRK5_uc009xzh.2... Hybrid_Cap... view
HDAC1 1 32793346 32793346 NCIH1437_LUNG 37 Intron SNP C G uc001bvb.1 HDAC1_uc010ohd.... Hybrid_Cap... view
HIF1A 14 62213929 62213930 NCIH1437_LUNG 37 3'UTR Ins - T rs67890419 uc001xfs.2 HIF1A_uc001xfq.... Hybrid_Cap...
HSP90B1 p.E791del 12 104341188 104341190 NCIH1437_LUNG 37 In_Frame_Del Del GAA - rs117491163 uc001tkb.1 HSP90B1_uc010sw... Hybrid_Cap...
ILK 11 6630029 6630029 NCIH1437_LUNG 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
IRAK2 p.S249L 3 10255190 10255190 NCIH1437_LUNG 37 Missense_Mutation SNP C T uc003bve.1 Hybrid_Cap... view
ITGA10 1 145528457 145528457 NCIH1437_LUNG 37 Intron SNP A G uc001eoa.2 NBPF10_uc001emp... Hybrid_Cap... view
KIAA1409 p.A1910E 14 94112986 94112986 NCIH1437_LUNG 37 Missense_Mutation SNP C A uc001ybv.1 KIAA1409_uc001y... Hybrid_Cap... view
KLK7 19 51480672 51480675 NCIH1437_LUNG 37 3'UTR Del GGTT - uc002puo.2 KLK7_uc002pup.2... Hybrid_Cap...
LAMA1 p.Q1257H 18 7010301 7010301 NCIH1437_LUNG 37 Missense_Mutation SNP T G uc002knm.2 LAMA1_uc010wzj.... Hybrid_Cap... view
LRGUK p.D199E 7 133832999 133832999 NCIH1437_LUNG 37 Missense_Mutation SNP T G uc003vrm.1 Hybrid_Cap... view
LRP1B p.G2770C 2 141267587 141267587 NCIH1437_LUNG 37 Missense_Mutation SNP C A uc002tvj.1 Hybrid_Cap... view
MAF 16 79628537 79628537 NCIH1437_LUNG 37 Intron Del T - uc002ffm.2 MAF_uc002ffn.2_... Hybrid_Cap...
MAML3 p.Q767_splice 4 140651585 140651587 NCIH1437_LUNG 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP2K1 p.Q56P 15 66727451 66727451 NCIH1437_LUNG 37 Missense_Mutation SNP A C uc010bhq.2 MAP2K1_uc010ujp... Hybrid_Cap... view
MAP3K1 p.T949del 5 56177849 56177851 NCIH1437_LUNG 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAP3K14 p.R218_splice 17 43364293 43364294 NCIH1437_LUNG 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
MAPKAPK3 3 50685575 50685575 NCIH1437_LUNG 37 3'UTR Del A - rs76026164 uc003day.1 MAPKAPK3_uc003d... Hybrid_Cap...
MAX 14 65550948 65550948 NCIH1437_LUNG 37 Intron SNP T A uc001xif.1 MAX_uc001xic.1_... Hybrid_Cap... view
MCF2 p.N156K X 138713554 138713554 NCIH1437_LUNG 37 Missense_Mutation SNP A T uc011mwo.1 MCF2_uc004fau.2... Hybrid_Cap... view
MLL3 p.D1128N 7 151919709 151919709 NCIH1437_LUNG 37 Missense_Mutation SNP C T uc003wla.2 MLL3_uc003wkz.2... Hybrid_Cap... view
MLLT6 17 36881873 36881873 NCIH1437_LUNG 37 3'UTR Del C - uc002hqi.3 MLLT6_uc002hqk.... Hybrid_Cap...
MOS p.A123T 8 57026175 57026175 NCIH1437_LUNG 37 Missense_Mutation SNP C T uc011leb.1 Hybrid_Cap... view
MTMR11 p.W562* 1 149901771 149901771 NCIH1437_LUNG 37 Nonsense_Mutation SNP C T uc001etl.3 SF3B4_uc001etj.... Hybrid_Cap... view
MYO3A 10 26455151 26455151 NCIH1437_LUNG 37 Intron SNP G T uc001isn.2 MYO3A_uc009xko.... Hybrid_Cap... view
MYST4 p.EEEE1083del 10 76781852 76781863 NCIH1437_LUNG 37 In_Frame_Del Del GAGGA... - rs11001248 uc001jwn.1 MYST4_uc001jwm.... Hybrid_Cap...
NBN p.R215Q 8 90983459 90983459 NCIH1437_LUNG 37 Missense_Mutation SNP C T rs61753718 uc003yej.1 NBN_uc003yei.1_... Hybrid_Cap... view
NCAM1 11 112832135 112832135 NCIH1437_LUNG 37 5'UTR SNP G T uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap... view
NCAM1 11 112832307 112832308 NCIH1437_LUNG 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 NCIH1437_LUNG 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCOA3 p.Q1276del 20 46279837 46279839 NCIH1437_LUNG 37 In_Frame_Del Del CAG - rs2664555 uc002xtk.2 NCOA3_uc010ght.... Hybrid_Cap...
NEK1 p.A294P 4 170498219 170498219 NCIH1437_LUNG 37 Missense_Mutation SNP C G uc003isd.1 NEK1_uc003isb.1... Hybrid_Cap... view
NEK3 p.K313_splice 13 52718050 52718051 NCIH1437_LUNG 37 Splice_Site_Ins Ins - T rs72514762 uc001vgh.2 NEK3_uc001vgg.2... Hybrid_Cap...
NFIA 1 61921185 61921186 NCIH1437_LUNG 37 3'UTR Ins - T rs57270124;rs76131997 uc010oos.1 NFIA_uc001czy.2... Hybrid_Cap...
NFKB1 p.D917_splice 4 103534740 103534741 NCIH1437_LUNG 37 Splice_Site_Ins Ins - A rs35795162 uc011cep.1 NFKB1_uc011ceq.... Hybrid_Cap...
NIPBL p.S349C 5 36976054 36976054 NCIH1437_LUNG 37 Missense_Mutation SNP A T uc003jkl.3 NIPBL_uc003jkk.... Hybrid_Cap... view
NLRP1 p.W797R 17 5456845 5456845 NCIH1437_LUNG 37 Missense_Mutation SNP A T uc002gci.2 NLRP1_uc002gcg.... Hybrid_Cap... view
NR1H2 p.176_177insQ 19 50881820 50881821 NCIH1437_LUNG 37 In_Frame_Ins Ins - AAC rs66783852;rs112359270 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
PGR 11 100933598 100933599 NCIH1437_LUNG 37 Intron Ins - AATGA rs35148438 uc001pgh.2 PGR_uc001pgg.2_... Hybrid_Cap...
PIK3C2G p.P129del 12 18435399 18435401 NCIH1437_LUNG 37 In_Frame_Del Del CCC - uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PLCG1 p.R197W 20 39791168 39791168 NCIH1437_LUNG 37 Missense_Mutation SNP C T uc002xjo.1 PLCG1_uc002xjp.... Hybrid_Cap... view
PPP1R3A p.S848Y 7 113518604 113518604 NCIH1437_LUNG 37 Missense_Mutation SNP G T uc010ljy.1 Hybrid_Cap... view
PRKCA 17 64298959 64298960 NCIH1437_LUNG 37 5'UTR Ins - G rs71160558 uc002jfp.1 PRKCA_uc002jfo.... Hybrid_Cap...
PRKDC p.L1244fs 8 48805816 48805817 NCIH1437_LUNG 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
RAG1 p.K621N 11 36596717 36596717 NCIH1437_LUNG 37 Missense_Mutation SNP G T uc001mwu.3 RAG1_uc001mwt.2... Hybrid_Cap... view
RECQL4 p.R766fs 8 145738768 145738768 NCIH1437_LUNG 37 Frame_Shift_Del Del G - uc003zdj.2 Hybrid_Cap...
RHOH 4 40244875 40244875 NCIH1437_LUNG 37 5'UTR SNP C A uc003guz.2 Hybrid_Cap... view
RPS6KA5 14 91360733 91360734 NCIH1437_LUNG 37 Intron Ins - T rs77438853 uc001xys.2 RPS6KA5_uc010tw... Hybrid_Cap...
STAT5A 17 40462797 40462800 NCIH1437_LUNG 37 3'UTR Del TGTG - uc002hzj.1 STAT5A_uc010cya... Hybrid_Cap...
STK16 p.E100K 2 220111455 220111455 NCIH1437_LUNG 37 Missense_Mutation SNP G A rs35947471 uc002vkq.2 GLB1L_uc002vkm.... Hybrid_Cap... view
STK31 7 23872024 23872025 NCIH1437_LUNG 37 3'UTR Ins - TTTG rs66787534 uc003sws.3 STK31_uc003swt.... Hybrid_Cap...
TCF12 p.E95* 15 57384047 57384047 NCIH1437_LUNG 37 Nonsense_Mutation SNP G T uc002aea.2 TCF12_uc010ugm.... Hybrid_Cap... view
TCL6 p.G78R 14 96135928 96135928 NCIH1437_LUNG 37 Missense_Mutation SNP G A uc001yeq.2 TCL6_uc001yep.1... Hybrid_Cap... view
TGFB2 1 218519928 218519929 NCIH1437_LUNG 37 5'UTR Ins - AAAC uc001hln.2 TGFB2_uc001hll.... Hybrid_Cap...
TGFBR1 p.R487W 9 101911534 101911534 NCIH1437_LUNG 37 Missense_Mutation SNP C T rs111426349 uc004azc.2 TGFBR1_uc004azd... Hybrid_Cap... view
TP53 p.R267P 17 7577138 7577138 NCIH1437_LUNG 37 Missense_Mutation SNP C G uc002gim.2 TP53_uc002gig.1... Hybrid_Cap... view
TP63 3 189349245 189349245 NCIH1437_LUNG 37 5'UTR SNP A G uc003fry.2 TP63_uc003frx.2... Hybrid_Cap... view
TRPS1 8 116635872 116635873 NCIH1437_LUNG 37 5'UTR Ins - A rs76893349 uc003yny.2 TRPS1_uc011lhy.... Hybrid_Cap...
TTN p.R12782I 2 179485198 179485199 NCIH1437_LUNG 37 Missense_Mutation DNP TC AA uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap...
UBE2O p.R569L 17 74394995 74394995 NCIH1437_LUNG 37 Missense_Mutation SNP C A uc002jrm.3 UBE2O_uc002jrn.... Hybrid_Cap... view
UBR5 p.V968I 8 103316323 103316323 NCIH1437_LUNG 37 Missense_Mutation SNP C T uc003ykr.1 UBR5_uc003yks.1... Hybrid_Cap... view
VEGFC p.S419_splice 4 177605082 177605084 NCIH1437_LUNG 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
WHSC1L1 p.P361S 8 38187396 38187396 NCIH1437_LUNG 37 Missense_Mutation SNP G A rs61746935 uc003xli.2 WHSC1L1_uc011lb... Hybrid_Cap... view
ZNF608 p.S1428N 5 123979217 123979217 NCIH1437_LUNG 37 Missense_Mutation SNP C T uc003ktq.1 ZNF608_uc003ktr... Hybrid_Cap... view