Annotation Summary for Cell Line: NCI-H146  

Cell line primary name: NCI-H146
Cell line aliases: H146
Gender: M
Site Primary: lung
Histology: carcinoma
Hist Subtype1: small_cell_carcinoma
Notes:
Source: ATCC
Expression arrays: NIECE_p_NCLE_RNA3_HG-U133_Plus_2_G08_296148
SNP arrays: FASTS_p_NCLE_DNAAffy4_S_GenomeWideSNP_6_D01_335260
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in NCI-H146

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
ACACA 17 35766564 35766564 NCIH146_LUNG 37 5'UTR Del A - uc002hno.2 ACACA_uc002hnn.... Hybrid_Cap...
ACSL6 p.G364V 5 131309071 131309071 NCIH146_LUNG 37 Missense_Mutation SNP C A uc003kvx.1 ACSL6_uc003kvv.... Hybrid_Cap... view
ADAM12 10 127730650 127730650 NCIH146_LUNG 37 Intron SNP G A uc001ljk.2 ADAM12_uc010qul... Hybrid_Cap... view
ADAM17 2 9630245 9630245 NCIH146_LUNG 37 3'UTR Del T - uc002qzu.2 IAH1_uc010yiz.1... Hybrid_Cap...
ADAM28 8 24211994 24211997 NCIH146_LUNG 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
ADAMTS20 p.I1739K 12 43770043 43770043 NCIH146_LUNG 37 Missense_Mutation SNP A T uc010skx.1 Hybrid_Cap... view
ADAMTS20 p.G1539L 12 43777617 43777618 NCIH146_LUNG 37 Missense_Mutation DNP CC AA uc010skx.1 Hybrid_Cap...
ALPK2 p.EDTST1006del 18 56204388 56204402 NCIH146_LUNG 37 In_Frame_Del Del CAGTT... - rs60644017;rs117623369 uc002lhj.3 ALPK2_uc002lhk.... Hybrid_Cap...
ARHGAP26 p.R293W 5 142287313 142287313 NCIH146_LUNG 37 Missense_Mutation SNP C T uc011dbj.1 ARHGAP26_uc003l... Hybrid_Cap... view
ASPH p.A264_splice 8 62550924 62550925 NCIH146_LUNG 37 Splice_Site_Ins Ins - A rs5891816 uc003xuj.2 ASPH_uc011leg.1... Hybrid_Cap...
BMP2K p.QQQQ482del 4 79792137 79792148 NCIH146_LUNG 37 In_Frame_Del Del CAGCA... - rs17855588 uc003hlk.2 BMP2K_uc010ijl.... Hybrid_Cap...
BRD2 6 32948599 32948599 NCIH146_LUNG 37 3'UTR Del C - uc010juh.2 BRD2_uc003ocn.3... Hybrid_Cap...
BRIP1 p.C219R 17 59886091 59886091 NCIH146_LUNG 37 Missense_Mutation SNP A G uc002izk.1 Hybrid_Cap... view
BUB1B p.P544S 15 40494791 40494791 NCIH146_LUNG 37 Missense_Mutation SNP C T uc001zkx.3 BUB1B_uc010ucl.... Hybrid_Cap... view
CABC1 1 227171585 227171585 NCIH146_LUNG 37 Intron Del T - uc001hqm.1 CABC1_uc001hqn.... Hybrid_Cap...
CABC1 1 227171736 227171737 NCIH146_LUNG 37 Intron Ins - T rs1574184 uc001hqm.1 CABC1_uc001hqn.... Hybrid_Cap...
CACNB2 10 18828721 18828722 NCIH146_LUNG 37 3'UTR Ins - AA rs3841459 uc001ipr.2 CACNB2_uc009xjz... Hybrid_Cap...
CASC5 p.S1022I 15 40915449 40915449 NCIH146_LUNG 37 Missense_Mutation SNP G T uc010bbs.1 CASC5_uc010ucq.... Hybrid_Cap... view
CCDC6 10 61666223 61666223 NCIH146_LUNG 37 5'UTR SNP G A uc001jks.3 Hybrid_Cap... view
CCNT1 p.R483C 12 49087550 49087550 NCIH146_LUNG 37 Missense_Mutation SNP G A uc001rse.1 LOC144438_uc001... Hybrid_Cap... view
CDK1 10 62545644 62545644 NCIH146_LUNG 37 Intron SNP G C uc001jld.2 CDK1_uc010qii.1... Hybrid_Cap... view
CDK18 1 205495890 205495891 NCIH146_LUNG 37 Intron Del CT - uc001hcr.2 CDK18_uc010pri.... Hybrid_Cap...
CHIC2 4 54876204 54876204 NCIH146_LUNG 37 3'UTR SNP A C uc003haj.1 PDGFRA_uc003haa... Hybrid_Cap... view
CIT p.E973* 12 120180257 120180257 NCIH146_LUNG 37 Nonsense_Mutation SNP C A uc001txj.1 CIT_uc001txh.1_... Hybrid_Cap... view
CLTCL1 p.V1201_splice 22 19189003 19189004 NCIH146_LUNG 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
CNTN5 p.K915N 11 100211209 100211209 NCIH146_LUNG 37 Missense_Mutation SNP A C uc001pga.2 CNTN5_uc001pgb.... Hybrid_Cap... view
CNTN6 3 1339681 1339686 NCIH146_LUNG 37 Intron Del GTTTT... - uc003boz.2 CNTN6_uc010hbo.... Hybrid_Cap...
CSMD3 p.E1692K 8 113516028 113516028 NCIH146_LUNG 37 Missense_Mutation SNP C T uc003ynu.2 CSMD3_uc003yns.... Hybrid_Cap... view
CYFIP1 p.P853L 15 22969332 22969332 NCIH146_LUNG 37 Missense_Mutation SNP C T uc001yus.2 CYFIP1_uc001yut... Hybrid_Cap... view
EDN1 6 12290729 12290729 NCIH146_LUNG 37 5'UTR Del A - uc003nae.3 EDN1_uc010jpb.2... Hybrid_Cap...
EIF2AK3 p.T528M 2 88885426 88885426 NCIH146_LUNG 37 Missense_Mutation SNP G A uc002stc.3 Hybrid_Cap... view
EIF2AK3 p.F335_splice 2 88890125 88890125 NCIH146_LUNG 37 Splice_Site_SNP SNP T A uc002stc.3 Hybrid_Cap... view
EIF2B5 p.I282M 3 183858208 183858208 NCIH146_LUNG 37 Missense_Mutation SNP C G uc003fmp.2 EIF2B5_uc003fmq... Hybrid_Cap... view
EP300 22 41574970 41574972 NCIH146_LUNG 37 3'UTR Del GTA - rs76489032 uc003azl.3 Hybrid_Cap...
EPHA6 3 97367230 97367231 NCIH146_LUNG 37 Intron Ins - A rs115253553 uc010how.1 EPHA6_uc003drs.... Hybrid_Cap...
ERBB3 12 56492071 56492075 NCIH146_LUNG 37 Intron Del CTGTA - uc001sjh.2 ERBB3_uc009zoj.... Hybrid_Cap...
ETV1 7 14028708 14028708 NCIH146_LUNG 37 5'UTR Del A - rs77190713 uc011jxq.1 ETV1_uc011jxn.1... Hybrid_Cap...
FGFR1OP 6 167453519 167453520 NCIH146_LUNG 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
FGFR3 4 1809128 1809129 NCIH146_LUNG 37 3'UTR Del GT - uc003gdu.2 FGFR3_uc003gdr.... Hybrid_Cap...
FGFR4 p.C101Y 5 176517601 176517601 NCIH146_LUNG 37 Missense_Mutation SNP G A uc003mfl.2 FGFR4_uc003mfm.... Hybrid_Cap... view
FLI1 11 128638217 128638217 NCIH146_LUNG 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FLT1 p.E1230K 13 28883012 28883012 NCIH146_LUNG 37 Missense_Mutation SNP C T uc001usb.3 FLT1_uc010aap.2... Hybrid_Cap... view
FN1 2 216244182 216244185 NCIH146_LUNG 37 Intron Del GTAC - uc002vfa.2 FN1_uc002vfb.2_... Hybrid_Cap...
FNBP1 p.G484V 9 132662804 132662804 NCIH146_LUNG 37 Missense_Mutation SNP C A uc004byw.1 FNBP1_uc011mbv.... Hybrid_Cap... view
GPR112 p.D2657del X 135474445 135474447 NCIH146_LUNG 37 In_Frame_Del Del GAT - rs3030295 uc004ezu.1 GPR112_uc010nsb... Hybrid_Cap...
GRIA3 X 122318386 122318387 NCIH146_LUNG 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GRIN2B p.P1409L 12 13715946 13715946 NCIH146_LUNG 37 Missense_Mutation SNP G A uc001rbt.2 Hybrid_Cap... view
GRK7 p.G203E 3 141497734 141497734 NCIH146_LUNG 37 Missense_Mutation SNP G A uc011bnd.1 Hybrid_Cap... view
GUCY2C 12 14827464 14827466 NCIH146_LUNG 37 Intron Del ATC - rs72525754;rs3083879 uc001rcd.2 GUCY2C_uc009zhz... Hybrid_Cap...
HNF1A 12 121434630 121434631 NCIH146_LUNG 37 Intron Ins - TCATTCAT rs75100977 uc010szn.1 HNF1A_uc001tze.... Hybrid_Cap...
HSP90B1 p.E791del 12 104341188 104341190 NCIH146_LUNG 37 In_Frame_Del Del GAA - rs117491163 uc001tkb.1 HSP90B1_uc010sw... Hybrid_Cap...
ILK 11 6630029 6630029 NCIH146_LUNG 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
IRF4 p.H278N 6 401509 401510 NCIH146_LUNG 37 Missense_Mutation DNP CC AA rs61732392 uc003msz.3 IRF4_uc010jne.1... Hybrid_Cap...
ITK p.R44C 5 156608118 156608118 NCIH146_LUNG 37 Missense_Mutation SNP C T uc003lwo.1 Hybrid_Cap... view
ITPR2 p.R470_splice 12 26834804 26834805 NCIH146_LUNG 37 Splice_Site_Ins Ins - ACTC rs66696203;rs59199365 uc001rhg.2 Hybrid_Cap...
LRP1B p.G4577* 2 140990826 140990826 NCIH146_LUNG 37 Nonsense_Mutation SNP C A uc002tvj.1 Hybrid_Cap... view
LRP1B p.P3372S 2 141202192 141202192 NCIH146_LUNG 37 Missense_Mutation SNP G A uc002tvj.1 Hybrid_Cap... view
LRRK1 p.Q1544L 15 101598298 101598298 NCIH146_LUNG 37 Missense_Mutation SNP A T uc002bwr.2 LRRK1_uc010usb.... Hybrid_Cap... view
MAML3 p.Q767_splice 4 140651585 140651587 NCIH146_LUNG 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP3K1 p.T949del 5 56177849 56177851 NCIH146_LUNG 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAP3K14 p.R218_splice 17 43364293 43364294 NCIH146_LUNG 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
MAPK7 p.H27Y 17 19282292 19282292 NCIH146_LUNG 37 Missense_Mutation SNP C T uc002gvn.2 B9D1_uc010cqm.1... Hybrid_Cap... view
MYLK2 p.T505A 20 30419594 30419594 NCIH146_LUNG 37 Missense_Mutation SNP A G uc002wwq.2 MYLK2_uc002wws.... Hybrid_Cap... view
MYO3A p.M1236L 10 26462899 26462899 NCIH146_LUNG 37 Missense_Mutation SNP A T uc001isn.2 MYO3A_uc009xkp.... Hybrid_Cap... view
MYST3 p.G1999V 8 41789742 41789742 NCIH146_LUNG 37 Missense_Mutation SNP C A uc010lxb.2 MYST3_uc010lxc.... Hybrid_Cap... view
NCAM1 11 112832307 112832308 NCIH146_LUNG 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 NCIH146_LUNG 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAPD3 p.K1479Q 11 134022901 134022901 NCIH146_LUNG 37 Missense_Mutation SNP T G uc001qhd.1 NCAPD3_uc010scm... Hybrid_Cap... view
NEK3 p.K313_splice 13 52718050 52718051 NCIH146_LUNG 37 Splice_Site_Ins Ins - T rs72514762 uc001vgh.2 NEK3_uc001vgg.2... Hybrid_Cap...
NFIA 1 61921185 61921186 NCIH146_LUNG 37 3'UTR Ins - T rs57270124;rs76131997 uc010oos.1 NFIA_uc001czy.2... Hybrid_Cap...
NPR1 1 153665919 153665920 NCIH146_LUNG 37 3'UTR Ins - C rs66682713 uc001fcs.3 NPR1_uc010pdz.1... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881822 50881823 NCIH146_LUNG 37 In_Frame_Ins Ins - CAG rs61751954;rs1052533 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
PAX3 2 223158653 223158653 NCIH146_LUNG 37 Intron Del T - rs112753212 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PDE4DIP p.Q1665fs 1 144873963 144873963 NCIH146_LUNG 37 Frame_Shift_Del Del T - uc001elw.3 NBPF10_uc009wir... Hybrid_Cap...
PDE4DIP p.V486fs 1 144917828 144917828 NCIH146_LUNG 37 Frame_Shift_Del Del A - uc001elw.3 NBPF10_uc009wir... Hybrid_Cap...
PDGFRA 4 55131002 55131002 NCIH146_LUNG 37 Intron Del A - uc003han.3 PDGFRA_uc003haa... Hybrid_Cap...
PIK3C2G p.P129del 12 18435399 18435401 NCIH146_LUNG 37 In_Frame_Del Del CCC - uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PIK3C3 18 39535204 39535205 NCIH146_LUNG 37 5'UTR Ins - T uc002lap.2 PIK3C3_uc010xcl... Hybrid_Cap...
PIK3CB p.M68I 3 138474789 138474789 NCIH146_LUNG 37 Missense_Mutation SNP C A uc011bmq.1 Hybrid_Cap... view
PIM1 6 37138217 37138217 NCIH146_LUNG 37 5'UTR SNP A G uc003onk.2 PIM1_uc011dtw.1... Hybrid_Cap... view
PRKDC p.L1244fs 8 48805816 48805817 NCIH146_LUNG 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
PRPF4B p.A708V 6 4050062 4050062 NCIH146_LUNG 37 Missense_Mutation SNP C T uc003mvv.2 PRPF4B_uc003mvw... Hybrid_Cap... view
PTPN1 20 49199355 49199356 NCIH146_LUNG 37 3'UTR Ins - G rs16989673 uc002xvl.2 PTPN1_uc010zys.... Hybrid_Cap...
PTPN11 p.N275T 12 112910815 112910815 NCIH146_LUNG 37 Missense_Mutation SNP A C uc001ttx.2 PTPN11_uc001ttw... Hybrid_Cap... view
RB1 p.Q850* 13 49050864 49050864 NCIH146_LUNG 37 Nonsense_Mutation SNP C T uc001vcb.2 Hybrid_Cap... view
RPN1 3 128339072 128339072 NCIH146_LUNG 37 3'UTR Del G - uc003ekr.1 RPN1_uc011bkq.1... Hybrid_Cap...
SGK196 8 42978201 42978201 NCIH146_LUNG 37 3'UTR Del T - uc003xpw.2 Hybrid_Cap...
SIRT1 p.Q632H 10 69672769 69672769 NCIH146_LUNG 37 Missense_Mutation SNP G T uc001jnd.2 SIRT1_uc010qis.... Hybrid_Cap... view
SMAD7 18 46476894 46476894 NCIH146_LUNG 37 5'UTR SNP G T uc002ldg.2 SMAD7_uc010xde.... Hybrid_Cap... view
SMURF2 p.R114R 17 62587260 62587260 NCIH146_LUNG 37 Silent SNP C T uc002jep.1 SMURF2_uc002jeq... Hybrid_Cap... view
SOX10 p.W455L 22 38369539 38369539 NCIH146_LUNG 37 Missense_Mutation SNP C A uc003aun.1 POLR2F_uc003aum... Hybrid_Cap... view
STK31 7 23872024 23872025 NCIH146_LUNG 37 3'UTR Ins - TTTG rs66787534 uc003sws.3 STK31_uc003swt.... Hybrid_Cap...
TAOK3 12 118588761 118588762 NCIH146_LUNG 37 3'UTR Ins - T rs116872184 uc001twx.2 TAOK3_uc001twv.... Hybrid_Cap...
TNRC6B p.Q1328del 22 40697177 40697179 NCIH146_LUNG 37 In_Frame_Del Del GCA - rs114291931 uc011aor.1 TNRC6B_uc003aym... Hybrid_Cap...
TRIM28 p.H386Q 19 59059717 59059717 NCIH146_LUNG 37 Missense_Mutation SNP T G uc002qtg.1 TRIM28_uc010eut... Hybrid_Cap... view
UNC13C p.S83R 15 54305349 54305349 NCIH146_LUNG 37 Missense_Mutation SNP T A uc002ack.2 Hybrid_Cap... view
VEGFC p.S419_splice 4 177605082 177605084 NCIH146_LUNG 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
WEE1 11 9598827 9598827 NCIH146_LUNG 37 Intron SNP T A uc001mhs.2 WEE1_uc001mht.2... Hybrid_Cap... view
WNK3 p.T1392S X 54263825 54263825 NCIH146_LUNG 37 Missense_Mutation SNP T A uc004dtc.1 WNK3_uc004dtd.1... Hybrid_Cap... view
XPC p.E34del 3 14219966 14219968 NCIH146_LUNG 37 In_Frame_Del Del CCT - rs72561774 uc011ave.1 XPC_uc011avf.1_... Hybrid_Cap...
XPO4 p.S498_splice 13 21382722 21382722 NCIH146_LUNG 37 Splice_Site_SNP SNP T A uc001unq.3 Hybrid_Cap... view
YSK4 2 135749072 135749072 NCIH146_LUNG 37 Intron SNP A T uc002tue.1 YSK4_uc010fne.1... Hybrid_Cap... view