Annotation Summary for Cell Line: NCI-H1581  

Cell line primary name: NCI-H1581
Cell line aliases: H1581
Gender: M
Site Primary: lung
Histology: carcinoma
Hist Subtype1: large_cell_carcinoma
Notes:
Source: ATCC
Expression arrays: NIECE_p_NCLE_RNA3_HG-U133_Plus_2_F01_296110
SNP arrays: FASTS_p_NCLE_DNAAffy4_S_GenomeWideSNP_6_B07_335224
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in NCI-H1581

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
AAK1 p.541_542QQ>Q 2 69741754 69741756 NCIH1581_LUNG 37 In_Frame_Del Del TGT - rs55712143 uc002sfp.2 AAK1_uc010fdk.2... Hybrid_Cap...
ABCC3 p.L1441F 17 48764937 48764937 NCIH1581_LUNG 37 Missense_Mutation SNP C T uc002isl.2 ABCC3_uc002isn.... Hybrid_Cap... view
ADAM17 2 9630245 9630245 NCIH1581_LUNG 37 3'UTR Del T - uc002qzu.2 IAH1_uc010yiz.1... Hybrid_Cap...
ADAM28 8 24211994 24211997 NCIH1581_LUNG 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
ADAMTS20 p.I648_splice 12 43846215 43846215 NCIH1581_LUNG 37 Splice_Site_SNP SNP T G uc010skx.1 Hybrid_Cap... view
AKAP12 p.1531_1532insE 6 151674116 151674117 NCIH1581_LUNG 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
AKAP9 p.1335_1336insQ 7 91652178 91652179 NCIH1581_LUNG 37 In_Frame_Ins Ins - AAC rs34756483 uc003ulg.2 AKAP9_uc003ule.... Hybrid_Cap...
ANKK1 p.P148L 11 113264460 113264460 NCIH1581_LUNG 37 Missense_Mutation SNP C T uc001pny.2 Hybrid_Cap... view
APC p.R1105fs 5 112174604 112174605 NCIH1581_LUNG 37 Frame_Shift_Ins Ins - G uc010jby.2 APC_uc011cvt.1_... Hybrid_Cap...
ARID1A p.R1833C 1 27105886 27105886 NCIH1581_LUNG 37 Missense_Mutation SNP C T uc001bmv.1 ARID1A_uc001bmu... Hybrid_Cap... view
BAI3 p.L234V 6 69349267 69349267 NCIH1581_LUNG 37 Missense_Mutation SNP C G uc003pev.3 BAI3_uc010kak.2... Hybrid_Cap... view
BIRC5 17 76219784 76219785 NCIH1581_LUNG 37 3'UTR Ins - AA uc002jvf.2 BIRC5_uc002jvg.... Hybrid_Cap...
BTG1 12 92537706 92537707 NCIH1581_LUNG 37 3'UTR Ins - T rs33983967 uc001tby.3 BTG1_uc001tbv.1... Hybrid_Cap...
CDK11B 1 1654066 1654068 NCIH1581_LUNG 37 Intron Del GCG - uc001agv.1 CDK11B_uc001aha... Hybrid_Cap...
CDK16 X 47085900 47085900 NCIH1581_LUNG 37 Intron SNP G T uc011mll.1 CDK16_uc011mli.... Hybrid_Cap... view
CDK17 p.R504Q 12 96674609 96674609 NCIH1581_LUNG 37 Missense_Mutation SNP C T uc001tep.1 CDK17_uc009ztk.... Hybrid_Cap... view
CDKN2C 1 51435977 51435977 NCIH1581_LUNG 37 Intron SNP C T uc001csf.2 CDKN2C_uc001csg... Hybrid_Cap... view
CLTCL1 p.V1201_splice 22 19189003 19189004 NCIH1581_LUNG 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
COL18A1 p.P1260L 21 46916439 46916439 NCIH1581_LUNG 37 Missense_Mutation SNP C T uc011afs.1 COL18A1_uc002zh... Hybrid_Cap... view
CREB3L2 p.T100del 7 137612914 137612916 NCIH1581_LUNG 37 In_Frame_Del Del TGG - uc003vtw.2 CREB3L2_uc003vt... Hybrid_Cap...
DDX1 p.N235_splice 2 15746272 15746272 NCIH1581_LUNG 37 Splice_Site_SNP SNP A G uc002rce.2 DDX1_uc010yjq.1... Hybrid_Cap... view
DIP2C p.E961K 10 403791 403791 NCIH1581_LUNG 37 Missense_Mutation SNP C T uc001ifp.2 DIP2C_uc009xhi.... Hybrid_Cap... view
EP300 22 41488903 41488903 NCIH1581_LUNG 37 5'UTR SNP G A uc003azl.3 Hybrid_Cap... view
EP300 22 41574970 41574972 NCIH1581_LUNG 37 3'UTR Del GTA - rs76489032 uc003azl.3 Hybrid_Cap...
EPHA6 3 97367230 97367231 NCIH1581_LUNG 37 Intron Ins - A rs115253553 uc010how.1 EPHA6_uc003drs.... Hybrid_Cap...
EPHB6 7 142568771 142568771 NCIH1581_LUNG 37 3'UTR Del C - uc011kst.1 EPHB6_uc011ksu.... Hybrid_Cap...
EPO 7 100318570 100318570 NCIH1581_LUNG 37 5'UTR SNP C A uc003uwi.2 EPO_uc011kkc.1_... Hybrid_Cap... view
ERLIN2 p.D87N 8 37601895 37601895 NCIH1581_LUNG 37 Missense_Mutation SNP G A uc003xke.3 ERLIN2_uc003xkc... Hybrid_Cap... view
ERLIN2 p.E90K 8 37601904 37601904 NCIH1581_LUNG 37 Missense_Mutation SNP G A uc003xke.3 ERLIN2_uc003xkc... Hybrid_Cap... view
ERLIN2 8 37603167 37603167 NCIH1581_LUNG 37 Intron SNP C T uc003xke.3 ERLIN2_uc003xkc... Hybrid_Cap... view
ETV1 p.R37S 7 14027733 14027733 NCIH1581_LUNG 37 Missense_Mutation SNP T A uc011jxq.1 ETV1_uc011jxn.1... Hybrid_Cap... view
FBN2 p.C1323S 5 127670867 127670867 NCIH1581_LUNG 37 Missense_Mutation SNP C G uc003kuu.2 FBN2_uc003kuv.2... Hybrid_Cap... view
FGF4 11 69587987 69587987 NCIH1581_LUNG 37 3'UTR SNP A G uc001opg.1 FGF4_uc010rqj.1... Hybrid_Cap... view
FGFR1OP 6 167453519 167453520 NCIH1581_LUNG 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
FLI1 11 128638217 128638217 NCIH1581_LUNG 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FLNC p.F2649S 7 128498227 128498227 NCIH1581_LUNG 37 Missense_Mutation SNP T C uc003vnz.3 FLNC_uc003voa.3... Hybrid_Cap... view
GPR112 p.D2657del X 135474445 135474447 NCIH1581_LUNG 37 In_Frame_Del Del GAT - rs3030295 uc004ezu.1 GPR112_uc010nsb... Hybrid_Cap...
GRIA3 X 122318386 122318387 NCIH1581_LUNG 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GUCY2C 12 14827464 14827466 NCIH1581_LUNG 37 Intron Del ATC - rs72525754;rs3083879 uc001rcd.2 GUCY2C_uc009zhz... Hybrid_Cap...
HNF1A 12 121434630 121434631 NCIH1581_LUNG 37 Intron Ins - TCATTCAT rs75100977 uc010szn.1 HNF1A_uc001tze.... Hybrid_Cap...
HSP90B1 p.E791del 12 104341188 104341190 NCIH1581_LUNG 37 In_Frame_Del Del GAA - rs117491163 uc001tkb.1 HSP90B1_uc010sw... Hybrid_Cap...
IGF1R 15 99192755 99192763 NCIH1581_LUNG 37 5'UTR Del TTTTT... - uc002bul.2 IGF1R_uc010urq.... Hybrid_Cap...
ILK 11 6630029 6630029 NCIH1581_LUNG 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
INHBA 7 41729121 41729122 NCIH1581_LUNG 37 3'UTR Ins - T uc003thq.2 INHBA_uc003thr.... Hybrid_Cap...
INPP4B p.W521L 4 143081512 143081512 NCIH1581_LUNG 37 Missense_Mutation SNP C A uc003iix.3 INPP4B_uc003iiw... Hybrid_Cap... view
ITPR2 p.R470_splice 12 26834804 26834805 NCIH1581_LUNG 37 Splice_Site_Ins Ins - ACTC rs66696203;rs59199365 uc001rhg.2 Hybrid_Cap...
JAG1 p.A833V 20 10623210 10623210 NCIH1581_LUNG 37 Missense_Mutation SNP G A uc002wnw.2 JAG1_uc010gcd.1... Hybrid_Cap... view
KLK7 19 51480672 51480675 NCIH1581_LUNG 37 3'UTR Del GGTT - uc002puo.2 KLK7_uc002pup.2... Hybrid_Cap...
LAMA1 p.R1213L 18 7011348 7011348 NCIH1581_LUNG 37 Missense_Mutation SNP C A uc002knm.2 LAMA1_uc010wzj.... Hybrid_Cap... view
MAML3 p.Q767_splice 4 140651585 140651587 NCIH1581_LUNG 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP3K1 p.T949del 5 56177849 56177851 NCIH1581_LUNG 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAP3K14 p.R218_splice 17 43364293 43364294 NCIH1581_LUNG 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
MAPK8 p.I157V 10 49628216 49628216 NCIH1581_LUNG 37 Missense_Mutation SNP A G uc009xnz.2 MAPK8_uc001jgl.... Hybrid_Cap... view
MCM3APAS 21 47671275 47671276 NCIH1581_LUNG 37 3'UTR Ins - AAT rs67797185 uc002zin.2 MCM3APAS_uc002z... Hybrid_Cap...
MECOM 3 168862932 168862937 NCIH1581_LUNG 37 Intron Del ACACA... - uc011bpj.1 MECOM_uc003ffj.... Hybrid_Cap...
MED13L p.L191F 12 116460313 116460313 NCIH1581_LUNG 37 Missense_Mutation SNP C G uc001tvw.2 Hybrid_Cap... view
MLF1 p.H38D 3 158310239 158310239 NCIH1581_LUNG 37 Missense_Mutation SNP C G uc003fcc.2 MLF1_uc003fbz.2... Hybrid_Cap... view
MLLT3 9 20346377 20346378 NCIH1581_LUNG 37 3'UTR Ins - A rs66943046 uc003zoe.2 MLLT3_uc011lne.... Hybrid_Cap...
MLLT6 17 36881873 36881873 NCIH1581_LUNG 37 3'UTR Del C - uc002hqi.3 MLLT6_uc002hqk.... Hybrid_Cap...
MN1 p.533_533Q>QQ 22 28194933 28194934 NCIH1581_LUNG 37 In_Frame_Ins Ins - TGC rs45480998 uc003adj.2 Hybrid_Cap...
NCAM1 11 112832307 112832308 NCIH1581_LUNG 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 NCIH1581_LUNG 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCOA1 p.T73I 2 24888746 24888746 NCIH1581_LUNG 37 Missense_Mutation SNP C T uc002rfk.2 NCOA1_uc010eye.... Hybrid_Cap... view
NCOA3 p.Q1276del 20 46279837 46279839 NCIH1581_LUNG 37 In_Frame_Del Del CAG - rs2664555 uc002xtk.2 NCOA3_uc010ght.... Hybrid_Cap...
NOS3 p.R234C 7 150695652 150695652 NCIH1581_LUNG 37 Missense_Mutation SNP C T uc003wif.2 NOS3_uc011kuy.1... Hybrid_Cap... view
NOTCH4 p.15_16LL>L 6 32191659 32191661 NCIH1581_LUNG 37 In_Frame_Del Del AGC - uc003obb.2 NOTCH4_uc011dpu... Hybrid_Cap...
NPR1 1 153665919 153665920 NCIH1581_LUNG 37 3'UTR Ins - C rs66682713 uc001fcs.3 NPR1_uc010pdz.1... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881820 50881821 NCIH1581_LUNG 37 In_Frame_Ins Ins - AAC rs66783852;rs112359270 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
NUP214 9 134067556 134067557 NCIH1581_LUNG 37 Intron Ins - T rs66652901 uc004cag.2 NUP214_uc004cah... Hybrid_Cap...
NUP214 9 134108962 134108962 NCIH1581_LUNG 37 3'UTR SNP G A uc004cag.2 NUP214_uc004cah... Hybrid_Cap... view
PDE4DIP 1 144931483 144931483 NCIH1581_LUNG 37 Intron SNP T C uc001elw.3 NBPF10_uc009wir... Hybrid_Cap... view
PDGFRA 4 55130162 55130162 NCIH1581_LUNG 37 Intron Del T - uc003han.3 PDGFRA_uc003haa... Hybrid_Cap...
PER1 p.P474L 17 8050864 8050864 NCIH1581_LUNG 37 Missense_Mutation SNP G A uc002gkd.2 PER1_uc010vuq.1... Hybrid_Cap... view
PGR 11 100933598 100933599 NCIH1581_LUNG 37 Intron Ins - AATGA rs35148438 uc001pgh.2 PGR_uc001pgg.2_... Hybrid_Cap...
PIK3C2G p.P129del 12 18435399 18435401 NCIH1581_LUNG 37 In_Frame_Del Del CCC - uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PIK3C2G p.L588F 12 18524127 18524127 NCIH1581_LUNG 37 Missense_Mutation SNP C T uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap... view
PRKAA1 p.S509W 5 40763079 40763079 NCIH1581_LUNG 37 Missense_Mutation SNP G C uc003jmb.2 PRKAA1_uc003jmc... Hybrid_Cap... view
PRKDC p.L1244fs 8 48805816 48805817 NCIH1581_LUNG 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
RECQL4 p.R766fs 8 145738768 145738768 NCIH1581_LUNG 37 Frame_Shift_Del Del G - uc003zdj.2 Hybrid_Cap...
RIF1 p.P2294L 2 152325210 152325210 NCIH1581_LUNG 37 Missense_Mutation SNP C T uc002txm.2 RIF1_uc002txl.2... Hybrid_Cap... view
RPS6KA5 14 91360733 91360734 NCIH1581_LUNG 37 Intron Ins - T rs77438853 uc001xys.2 RPS6KA5_uc010tw... Hybrid_Cap...
RPS6KL1 14 75373626 75373627 NCIH1581_LUNG 37 3'UTR Ins - TGAT uc001xqx.1 RPS6KL1_uc001xq... Hybrid_Cap...
SEPT5 p.G142S 22 19707904 19707904 NCIH1581_LUNG 37 Missense_Mutation SNP G A uc002zpv.1 SEPT5_uc002zpw.... Hybrid_Cap... view
STAT5A 17 40462797 40462798 NCIH1581_LUNG 37 3'UTR Del TG - uc002hzj.1 STAT5A_uc010cya... Hybrid_Cap...
STK31 7 23872024 23872025 NCIH1581_LUNG 37 3'UTR Ins - TTTG rs66787534 uc003sws.3 STK31_uc003swt.... Hybrid_Cap...
TAOK1 17 27838073 27838074 NCIH1581_LUNG 37 Intron Ins - A uc002hdz.1 TAOK1_uc010wbe.... Hybrid_Cap...
TFR2 p.D680fs 7 100224483 100224484 NCIH1581_LUNG 37 Frame_Shift_Ins Ins - C uc003uvv.1 TFR2_uc010lhc.1... Hybrid_Cap...
TMEM123 11 102269398 102269398 NCIH1581_LUNG 37 3'UTR Del G - uc001pha.2 TMEM123_uc009yx... Hybrid_Cap...
TNKS2 10 93622951 93622959 NCIH1581_LUNG 37 3'UTR Del GTTTT... - rs115539654 uc001khp.2 Hybrid_Cap...
TP53 p.Q144* 17 7578500 7578500 NCIH1581_LUNG 37 Nonsense_Mutation SNP G A uc002gim.2 TP53_uc002gig.1... Hybrid_Cap... view
TP63 3 189507518 189507519 NCIH1581_LUNG 37 Intron Ins - AG rs62702062;rs79714037 uc003fry.2 TP63_uc003frx.2... Hybrid_Cap...
TRIM42 p.S69P 3 140397276 140397276 NCIH1581_LUNG 37 Missense_Mutation SNP T C uc003eto.1 Hybrid_Cap... view
TRPM6 p.T1311I 9 77377655 77377655 NCIH1581_LUNG 37 Missense_Mutation SNP G A uc004ajl.1 TRPM6_uc004ajk.... Hybrid_Cap... view
TRPM8 p.R278W 2 234854632 234854632 NCIH1581_LUNG 37 Missense_Mutation SNP C T uc002vvh.2 TRPM8_uc010fyj.... Hybrid_Cap... view
TRPS1 8 116635872 116635873 NCIH1581_LUNG 37 5'UTR Ins - A rs76893349 uc003yny.2 TRPS1_uc011lhy.... Hybrid_Cap...
TTN 2 179391639 179391640 NCIH1581_LUNG 37 3'UTR Ins - T rs36037175 uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap...
TTN p.R19720L 2 179445243 179445243 NCIH1581_LUNG 37 Missense_Mutation SNP C A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.W15751C 2 179467172 179467172 NCIH1581_LUNG 37 Missense_Mutation SNP C A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.N7140Y 2 179582451 179582451 NCIH1581_LUNG 37 Missense_Mutation SNP T A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.S3954Y 2 179598523 179598523 NCIH1581_LUNG 37 Missense_Mutation SNP G T uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
VEGFC p.S419_splice 4 177605082 177605084 NCIH1581_LUNG 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
WDHD1 14 55408116 55408117 NCIH1581_LUNG 37 3'UTR Del AT - uc001xbm.1 WDHD1_uc010aom.... Hybrid_Cap...