Annotation Summary for Cell Line: NCI-H1666  

Cell line primary name: NCI-H1666
Cell line aliases: H1666
Gender: F
Site Primary: lung
Histology: carcinoma
Hist Subtype1: bronchioloalveolar_adenocarcinoma
Notes:
Source: ATCC
Expression arrays: AGENT_p_NCLE_RNA6_HG-U133_Plus_2_G07_436502
SNP arrays: LOBBY_p_NCLE_DNAAffy6_GenomeWideSNP_6_F03_437202
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in NCI-H1666

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
AAK1 p.541_542QQ>Q 2 69741754 69741756 NCIH1666_LUNG 37 In_Frame_Del Del TGT - rs55712143 uc002sfp.2 AAK1_uc010fdk.2... Hybrid_Cap...
ADAM28 8 24211994 24211997 NCIH1666_LUNG 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
ADCK1 14 78390632 78390637 NCIH1666_LUNG 37 Intron Del AAACT... - rs78274857;rs74969652 uc001xui.2 ADCK1_uc010tvo.... Hybrid_Cap...
ADCK1 p.E326D 14 78390919 78390919 NCIH1666_LUNG 37 Missense_Mutation SNP G C uc001xui.2 ADCK1_uc010tvo.... Hybrid_Cap... view
AKAP12 p.1531_1532insE 6 151674116 151674117 NCIH1666_LUNG 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
AKAP9 p.1335_1336insQ 7 91652178 91652179 NCIH1666_LUNG 37 In_Frame_Ins Ins - AAC rs34756483 uc003ulg.2 AKAP9_uc003ule.... Hybrid_Cap...
ALPK2 p.1388_1389FF>F 18 56203253 56203255 NCIH1666_LUNG 37 In_Frame_Del Del AAG - uc002lhj.3 ALPK2_uc002lhk.... Hybrid_Cap...
APAF1 p.H942L 12 99102466 99102466 NCIH1666_LUNG 37 Missense_Mutation SNP A T uc001tfz.2 APAF1_uc001tfy.... Hybrid_Cap... view
ATM p.G2022V 11 108186608 108186608 NCIH1666_LUNG 37 Missense_Mutation SNP G T uc001pkb.1 ATM_uc009yxr.1_... Hybrid_Cap... view
AURKC 19 57742494 57742507 NCIH1666_LUNG 37 5'UTR Del GGACG... - rs67926438;rs112039303;rs59094959 uc002qoe.2 AURKC_uc002qoc.... Hybrid_Cap...
BCR 22 23631813 23631814 NCIH1666_LUNG 37 Intron Ins - C rs66503844 uc002zww.2 BCR_uc002zwx.2_... Hybrid_Cap...
BCR 22 23632777 23632778 NCIH1666_LUNG 37 Intron Ins - T uc002zww.2 BCR_uc002zwx.2_... Hybrid_Cap...
BMP4 14 54416601 54416602 NCIH1666_LUNG 37 3'UTR Ins - AT rs74495140;rs76335800 uc001xal.3 BMP4_uc010aoh.2... Hybrid_Cap...
BRAF p.G466V 7 140481411 140481411 NCIH1666_LUNG 37 Missense_Mutation SNP C A uc003vwc.3 Hybrid_Cap... view
BTK p.G81R X 100630134 100630134 NCIH1666_LUNG 37 Missense_Mutation SNP C G uc010nno.2 BTK_uc004ehg.2_... Hybrid_Cap... view
CABC1 1 227171585 227171585 NCIH1666_LUNG 37 Intron Del T - uc001hqm.1 CABC1_uc001hqn.... Hybrid_Cap...
CABC1 1 227171736 227171737 NCIH1666_LUNG 37 Intron Ins - T rs1574184 uc001hqm.1 CABC1_uc001hqn.... Hybrid_Cap...
CDK10 16 89759737 89759737 NCIH1666_LUNG 37 Intron SNP G T uc010cio.2 CDK10_uc010cip.... Hybrid_Cap... view
CDK11B 1 1654066 1654068 NCIH1666_LUNG 37 Intron Del GCG - uc001agv.1 CDK11B_uc001aha... Hybrid_Cap...
CDK6 p.H139Q 7 92355060 92355060 NCIH1666_LUNG 37 Missense_Mutation SNP G C uc011khw.1 CDK6_uc010lez.2... Hybrid_Cap... view
CLTCL1 p.V1201_splice 22 19189003 19189004 NCIH1666_LUNG 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
COL3A1 p.P443A 2 189859300 189859300 NCIH1666_LUNG 37 Missense_Mutation SNP C G uc002uqj.1 Hybrid_Cap... view
CREB3L2 p.T100del 7 137612914 137612916 NCIH1666_LUNG 37 In_Frame_Del Del TGG - uc003vtw.2 CREB3L2_uc003vt... Hybrid_Cap...
CSMD3 p.N1752K 8 113504740 113504740 NCIH1666_LUNG 37 Missense_Mutation SNP A T uc003ynu.2 CSMD3_uc003yns.... Hybrid_Cap... view
CYP1B1 2 38297654 38297655 NCIH1666_LUNG 37 3'UTR Ins - A rs9341258 uc002rqo.2 Hybrid_Cap...
DAB1 1 57476358 57476358 NCIH1666_LUNG 37 3'UTR SNP C A uc001cys.1 DAB1_uc001cyt.1... Hybrid_Cap... view
DACH1 13 72014625 72014626 NCIH1666_LUNG 37 3'UTR Ins - T rs117109529 uc010thn.1 DACH1_uc010tho.... Hybrid_Cap...
DDR2 1 162750211 162750212 NCIH1666_LUNG 37 3'UTR Del TT - uc001gcf.2 DDR2_uc001gcg.2... Hybrid_Cap...
DST p.V812G 6 56504812 56504812 NCIH1666_LUNG 37 Missense_Mutation SNP A C uc003pdf.2 DST_uc003pcz.3_... Hybrid_Cap... view
EPHA3 p.F135S 3 89259260 89259260 NCIH1666_LUNG 37 Missense_Mutation SNP T C uc003dqy.2 EPHA3_uc003dqx.... Hybrid_Cap... view
EPHA5 4 66189753 66189754 NCIH1666_LUNG 37 3'UTR Ins - T rs67487372 uc011cah.1 EPHA5_uc003hcx.... Hybrid_Cap...
EPHA6 3 97367230 97367231 NCIH1666_LUNG 37 Intron Ins - A rs115253553 uc010how.1 EPHA6_uc003drs.... Hybrid_Cap...
EPHB1 p.R390L 3 134851763 134851763 NCIH1666_LUNG 37 Missense_Mutation SNP G T uc003eqt.2 EPHB1_uc010htz.... Hybrid_Cap... view
FGFR1OP 6 167453519 167453520 NCIH1666_LUNG 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
FGFR3 4 1809128 1809129 NCIH1666_LUNG 37 3'UTR Del GT - uc003gdu.2 FGFR3_uc003gdr.... Hybrid_Cap...
FGFR4 5 176519897 176519897 NCIH1666_LUNG 37 Intron SNP G T uc003mfl.2 FGFR4_uc003mfm.... Hybrid_Cap... view
FLI1 11 128638217 128638217 NCIH1666_LUNG 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FLT4 p.N403N 5 180053160 180053160 NCIH1666_LUNG 37 Silent SNP G A uc003mlz.3 FLT4_uc003mma.3... Hybrid_Cap... view
FMN2 p.PPLPGAGIPPP939del 1 240370914 240370946 NCIH1666_LUNG 37 In_Frame_Del Del GCCCC... - rs4997328;rs4997329 uc010pye.1 FMN2_uc010pyd.1... Hybrid_Cap...
GLYATL2 p.P22H 11 58607021 58607021 NCIH1666_LUNG 37 Missense_Mutation SNP G T uc001nnd.3 GLYATL2_uc009ym... Hybrid_Cap... view
GPR112 X 135498723 135498724 NCIH1666_LUNG 37 3'UTR DNP AC GT uc004ezu.1 GPR112_uc010nsb... Hybrid_Cap...
GRIA3 X 122318386 122318387 NCIH1666_LUNG 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GRIN2B p.S1030del 12 13717082 13717084 NCIH1666_LUNG 37 In_Frame_Del Del GGA - uc001rbt.2 Hybrid_Cap...
HIF1A 14 62213929 62213930 NCIH1666_LUNG 37 3'UTR Ins - T rs67890419 uc001xfs.2 HIF1A_uc001xfq.... Hybrid_Cap...
HNF1A 12 121434630 121434631 NCIH1666_LUNG 37 Intron Ins - TCATTCAT rs75100977 uc010szn.1 HNF1A_uc001tze.... Hybrid_Cap...
ILK 11 6630029 6630029 NCIH1666_LUNG 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
INHBA 7 41740067 41740068 NCIH1666_LUNG 37 5'UTR Ins - T rs116230303 uc003thq.2 LOC285954_uc003... Hybrid_Cap...
ITPR2 p.R470_splice 12 26834804 26834805 NCIH1666_LUNG 37 Splice_Site_Ins Ins - ACTC rs66696203;rs59199365 uc001rhg.2 Hybrid_Cap...
KCNH2 p.G800_splice 7 150647255 150647255 NCIH1666_LUNG 37 Splice_Site_SNP SNP C A uc003wic.2 KCNH2_uc003wib.... Hybrid_Cap... view
KCNH2 p.A536P 7 150648875 150648875 NCIH1666_LUNG 37 Missense_Mutation SNP C G uc003wic.2 KCNH2_uc003wib.... Hybrid_Cap... view
MAML3 p.Q767_splice 4 140651585 140651587 NCIH1666_LUNG 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP3K1 p.T949del 5 56177849 56177851 NCIH1666_LUNG 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MARK4 p.Q174P 19 45769511 45769511 NCIH1666_LUNG 37 Missense_Mutation SNP A C uc002pba.1 MARK4_uc002paz.... Hybrid_Cap... view
MCM3APAS 21 47671275 47671276 NCIH1666_LUNG 37 3'UTR Ins - AAT rs67797185 uc002zin.2 MCM3APAS_uc002z... Hybrid_Cap...
MECOM 3 169381317 169381317 NCIH1666_LUNG 37 5'UTR SNP T C uc011bpj.1 MECOM_uc011bpk.... Hybrid_Cap... view
MKRN3 p.N325K 15 23811904 23811904 NCIH1666_LUNG 37 Missense_Mutation SNP T A uc001ywh.3 MKRN3_uc001ywi.... Hybrid_Cap... view
MLLT3 9 20346377 20346378 NCIH1666_LUNG 37 3'UTR Ins - A rs66943046 uc003zoe.2 MLLT3_uc011lne.... Hybrid_Cap...
MLLT6 17 36881873 36881873 NCIH1666_LUNG 37 3'UTR Del C - uc002hqi.3 MLLT6_uc002hqk.... Hybrid_Cap...
MUSK p.S172C 9 113459633 113459633 NCIH1666_LUNG 37 Missense_Mutation SNP C G uc004bey.2 MUSK_uc004bex.2... Hybrid_Cap... view
MYH9 p.R867I 22 36697610 36697611 NCIH1666_LUNG 37 Missense_Mutation DNP CC AA uc003apg.2 MYH9_uc003aph.1... Hybrid_Cap...
MYLK p.E1430_splice 3 123368043 123368044 NCIH1666_LUNG 37 Splice_Site_Ins Ins - G rs41431347 uc003ego.2 MYLK_uc010hrr.2... Hybrid_Cap...
NCAM1 11 112832307 112832308 NCIH1666_LUNG 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 NCIH1666_LUNG 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NEK10 3 27152624 27152624 NCIH1666_LUNG 37 3'UTR SNP A G uc010hfk.2 NEK10_uc010hfj.... Hybrid_Cap... view
NEK3 p.K313_splice 13 52718050 52718051 NCIH1666_LUNG 37 Splice_Site_Ins Ins - T rs72514762 uc001vgh.2 NEK3_uc001vgg.2... Hybrid_Cap...
NFIA p.47_48insY 1 61548466 61548467 NCIH1666_LUNG 37 In_Frame_Ins Ins - TAT uc010oos.1 NFIA_uc001czy.2... Hybrid_Cap...
NFIA 1 61921185 61921186 NCIH1666_LUNG 37 3'UTR Ins - T rs57270124;rs76131997 uc010oos.1 NFIA_uc001czy.2... Hybrid_Cap...
NFKB1 4 103537812 103537812 NCIH1666_LUNG 37 3'UTR SNP C G uc011cep.1 NFKB1_uc011ceq.... Hybrid_Cap... view
NPR1 1 153665919 153665920 NCIH1666_LUNG 37 3'UTR Ins - C rs66682713 uc001fcs.3 NPR1_uc010pdz.1... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881820 50881821 NCIH1666_LUNG 37 In_Frame_Ins Ins - AAC rs66783852;rs112359270 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
PCM1 p.T1305P 8 17830166 17830166 NCIH1666_LUNG 37 Missense_Mutation SNP A C uc003wyi.3 PCM1_uc011kyh.1... Hybrid_Cap... view
PDE4DIP 1 144863860 144863861 NCIH1666_LUNG 37 Intron Ins - T rs33949841 uc001elw.3 NBPF10_uc009wir... Hybrid_Cap...
PDGFRB p.A11A 5 149516578 149516578 NCIH1666_LUNG 37 Silent SNP G T uc003lro.2 PDGFRB_uc010jhd... Hybrid_Cap... view
PGR 11 100933598 100933599 NCIH1666_LUNG 37 Intron Ins - AATGA rs35148438 uc001pgh.2 PGR_uc001pgg.2_... Hybrid_Cap...
PIK3C2G p.P129del 12 18435399 18435401 NCIH1666_LUNG 37 In_Frame_Del Del CCC - uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PRKAR1A p.E103E 17 66519028 66519028 NCIH1666_LUNG 37 Silent SNP G A uc002jhg.2 PRKAR1A_uc002jh... Hybrid_Cap... view
PRKCA 17 64298959 64298960 NCIH1666_LUNG 37 5'UTR Ins - G rs71160558 uc002jfp.1 PRKCA_uc002jfo.... Hybrid_Cap...
RECQL4 p.R766fs 8 145738768 145738768 NCIH1666_LUNG 37 Frame_Shift_Del Del G - uc003zdj.2 Hybrid_Cap...
RGL3 19 11527163 11527163 NCIH1666_LUNG 37 Intron SNP A G uc002mro.2 RGL3_uc002mrn.2... Hybrid_Cap... view
RICTOR 5 38942186 38942186 NCIH1666_LUNG 37 3'UTR SNP G T uc003jlo.2 RICTOR_uc003jlp... Hybrid_Cap... view
ROCK1 p.S482C 18 18588121 18588121 NCIH1666_LUNG 37 Missense_Mutation SNP G C uc002kte.2 Hybrid_Cap... view
RPS6KB1 17 58024224 58024225 NCIH1666_LUNG 37 3'UTR Ins - AA rs67846207 uc002ixy.2 RPS6KB1_uc010dd... Hybrid_Cap...
RPS6KL1 14 75373626 75373627 NCIH1666_LUNG 37 3'UTR Ins - TGAT uc001xqx.1 RPS6KL1_uc001xq... Hybrid_Cap...
SLC6A8 X 152957656 152957657 NCIH1666_LUNG 37 Intron Ins - A uc004fib.3 SLC6A8_uc004fic... Hybrid_Cap...
SMG1 p.E2397K 16 18849684 18849684 NCIH1666_LUNG 37 Missense_Mutation SNP C T uc002dfm.2 SMG1_uc010bwb.2... Hybrid_Cap... view
SPEN p.E1271A 1 16256547 16256547 NCIH1666_LUNG 37 Missense_Mutation SNP A C uc001axk.1 SPEN_uc010obp.1... Hybrid_Cap... view
STK32A 5 146728339 146728339 NCIH1666_LUNG 37 Intron SNP C T uc011dbw.1 STK32A_uc003lol... Hybrid_Cap... view
TCF21 6 134210497 134210498 NCIH1666_LUNG 37 5'UTR Ins - TCTC rs35199378 uc003qei.3 TCF21_uc003qej.... Hybrid_Cap...
TEC 4 48139307 48139310 NCIH1666_LUNG 37 3'UTR Del TTAT - rs79098351 uc003gxz.2 Hybrid_Cap...
TGFB2 1 218519928 218519929 NCIH1666_LUNG 37 5'UTR Ins - AAAC uc001hln.2 TGFB2_uc001hll.... Hybrid_Cap...
TMEM123 11 102269398 102269398 NCIH1666_LUNG 37 3'UTR Del G - uc001pha.2 TMEM123_uc009yx... Hybrid_Cap...
TMEM123 11 102269461 102269461 NCIH1666_LUNG 37 3'UTR Del G - uc001pha.2 TMEM123_uc009yx... Hybrid_Cap...
TNKS2 10 93622951 93622959 NCIH1666_LUNG 37 3'UTR Del GTTTT... - rs115539654 uc001khp.2 Hybrid_Cap...
TOP2B 3 25639733 25639734 NCIH1666_LUNG 37 3'UTR Ins - AGAC uc003cdj.2 TOP2B_uc011awm.... Hybrid_Cap...
TP63 3 189507518 189507519 NCIH1666_LUNG 37 Intron Ins - AGAG rs62702062;rs79714037 uc003fry.2 TP63_uc003frx.2... Hybrid_Cap...
TRIM33 1 114940215 114940216 NCIH1666_LUNG 37 3'UTR Ins - G rs68133208 uc001eew.2 TRIM33_uc010owr... Hybrid_Cap...
TRPS1 8 116635872 116635873 NCIH1666_LUNG 37 5'UTR Ins - A rs76893349 uc003yny.2 TRPS1_uc011lhy.... Hybrid_Cap...
TTBK1 p.E771del 6 43250726 43250728 NCIH1666_LUNG 37 In_Frame_Del Del GAA - uc003ouq.1 Hybrid_Cap...
TTN 2 179391639 179391640 NCIH1666_LUNG 37 3'UTR Ins - T rs36037175 uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap...
VEGFC p.S419_splice 4 177605082 177605084 NCIH1666_LUNG 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
ZAK 2 174131511 174131512 NCIH1666_LUNG 37 3'UTR Ins - AA rs75896701 uc002uhz.2 Hybrid_Cap...