Annotation Summary for Cell Line: NCI-H1876  

Cell line primary name: NCI-H1876
Cell line aliases: H1876
Gender: M
Site Primary: lung
Histology: carcinoma
Hist Subtype1: small_cell_carcinoma
Notes:
Source: ATCC
Expression arrays: CRAZY_p_NCLE_RNA10_HG-U133_Plus_2_E05_569520
SNP arrays: AWASH_p_NCLE_DNAAffy10_GenomeWideSNP_6_C10_542954
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in NCI-H1876

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
ACACA 17 35766564 35766564 NCIH1876_LUNG 37 5'UTR Del A - uc002hno.2 ACACA_uc002hnn.... Hybrid_Cap...
ACOXL p.G63C 2 111551254 111551254 NCIH1876_LUNG 37 Missense_Mutation SNP G T uc010yxk.1 ACOXL_uc010fkc.... Hybrid_Cap... view
ADAM17 2 9630245 9630245 NCIH1876_LUNG 37 3'UTR Del T - uc002qzu.2 IAH1_uc010yiz.1... Hybrid_Cap...
ADAM28 8 24211994 24211997 NCIH1876_LUNG 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
ADAM29 p.L691del 4 175898744 175898746 NCIH1876_LUNG 37 In_Frame_Del Del TTA - uc003iuc.2 ADAM29_uc003iud... Hybrid_Cap...
ADAMTS20 p.G865A 12 43828174 43828174 NCIH1876_LUNG 37 Missense_Mutation SNP C G uc010skx.1 ADAMTS20_uc001r... Hybrid_Cap... view
AIM1 p.A861V 6 106968889 106968889 NCIH1876_LUNG 37 Missense_Mutation SNP C T uc003prh.2 Hybrid_Cap... view
AKAP12 p.1531_1532insE 6 151674116 151674117 NCIH1876_LUNG 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
ALPK2 p.EDTST1006del 18 56204388 56204402 NCIH1876_LUNG 37 In_Frame_Del Del CAGTT... - rs60644017;rs117623369 uc002lhj.3 ALPK2_uc002lhk.... Hybrid_Cap...
ASTN1 p.W1265C 1 176833510 176833510 NCIH1876_LUNG 37 Missense_Mutation SNP C G uc001glc.2 ASTN1_uc001glb.... Hybrid_Cap... view
ATP13A5 p.S919C 3 193019020 193019020 NCIH1876_LUNG 37 Missense_Mutation SNP T A uc011bsq.1 Hybrid_Cap... view
AXIN1 16 337958 337958 NCIH1876_LUNG 37 3'UTR SNP G C uc002cgp.1 AXIN1_uc002cgq.... Hybrid_Cap... view
AXL p.V566A 19 41754711 41754711 NCIH1876_LUNG 37 Missense_Mutation SNP T C uc010ehj.2 CYP2F1_uc010xvw... Hybrid_Cap... view
BCR 22 23631813 23631814 NCIH1876_LUNG 37 Intron Ins - C rs66503844 uc002zww.2 BCR_uc002zwx.2_... Hybrid_Cap...
BRSK1 p.Q296R 19 55813518 55813518 NCIH1876_LUNG 37 Missense_Mutation SNP A G uc002qkf.2 BRSK1_uc002qkg.... Hybrid_Cap... view
C9ORF96 p.W95C 9 136251466 136251466 NCIH1876_LUNG 37 Missense_Mutation SNP G T uc004cdk.2 C9orf96_uc004cd... Hybrid_Cap... view
CASK X 41448854 41448854 NCIH1876_LUNG 37 Intron SNP C T uc004dfl.3 CASK_uc004dfj.3... Hybrid_Cap... view
CDK11B 1 1654066 1654068 NCIH1876_LUNG 37 Intron Del GCG - uc001agv.1 CDK11B_uc001aha... Hybrid_Cap...
CEP110 9 123939727 123939728 NCIH1876_LUNG 37 3'UTR Ins - A uc004bkx.1 CEP110_uc004blb... Hybrid_Cap...
CHD1 p.P1684del 5 98192165 98192167 NCIH1876_LUNG 37 In_Frame_Del Del AGG - rs79267787;rs61749618 uc003knf.2 CHD1_uc010jbn.2... Hybrid_Cap...
CHD5 p.P1555H 1 6184043 6184043 NCIH1876_LUNG 37 Missense_Mutation SNP G T uc001amb.1 CHD5_uc001alz.1... Hybrid_Cap... view
CIT 12 120125841 120125841 NCIH1876_LUNG 37 3'UTR SNP C A uc001txj.1 CIT_uc001txh.1_... Hybrid_Cap... view
CLPTM1L 5 1318457 1318457 NCIH1876_LUNG 37 3'UTR SNP C T uc003jch.2 CLPTM1L_uc003jc... Hybrid_Cap... view
CLTCL1 p.V1201_splice 22 19189003 19189004 NCIH1876_LUNG 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
CNTN6 3 1339681 1339686 NCIH1876_LUNG 37 Intron Del GTTTT... - uc003boz.2 CNTN6_uc010hbo.... Hybrid_Cap...
CREBBP p.K1086* 16 3808968 3808968 NCIH1876_LUNG 37 Nonsense_Mutation SNP T A uc002cvv.2 CREBBP_uc002cvw... Hybrid_Cap... view
CSMD3 p.G1308S 8 113585850 113585850 NCIH1876_LUNG 37 Missense_Mutation SNP C T uc003ynu.2 CSMD3_uc003yns.... Hybrid_Cap... view
CSMD3 p.Q1156K 8 113650985 113650985 NCIH1876_LUNG 37 Missense_Mutation SNP G T uc003ynu.2 CSMD3_uc003yns.... Hybrid_Cap... view
CXCL12 10 44873992 44873993 NCIH1876_LUNG 37 Intron Ins - CT rs117617571 uc001jbh.2 CXCL12_uc001jbf... Hybrid_Cap...
CYCS 7 25163105 25163105 NCIH1876_LUNG 37 3'UTR SNP C T uc003sxl.2 Hybrid_Cap... view
DDR2 1 162750211 162750212 NCIH1876_LUNG 37 3'UTR Del TT - uc001gcf.2 DDR2_uc001gcg.2... Hybrid_Cap...
DFNA5 p.G116fs 7 24784238 24784238 NCIH1876_LUNG 37 Frame_Shift_Del Del C - uc010kus.1 DFNA5_uc003swz.... Hybrid_Cap...
DLC1 p.E905* 8 12957133 12957133 NCIH1876_LUNG 37 Nonsense_Mutation SNP C A uc003wwm.2 DLC1_uc003wwk.1... Hybrid_Cap... view
DLL4 p.V91L 15 41222249 41222249 NCIH1876_LUNG 37 Missense_Mutation SNP G C uc001zng.1 Hybrid_Cap... view
DPYD p.S509_splice 1 97981498 97981498 NCIH1876_LUNG 37 Splice_Site_SNP SNP C T uc001drv.2 Hybrid_Cap... view
EDN1 6 12290729 12290729 NCIH1876_LUNG 37 5'UTR Del A - uc003nae.3 EDN1_uc010jpb.2... Hybrid_Cap...
EDNRB p.D396Y 13 78475207 78475207 NCIH1876_LUNG 37 Missense_Mutation SNP C A uc001vkp.1 EDNRB_uc001vkq.... Hybrid_Cap... view
EP300 p.D1485_splice 22 41568501 41568501 NCIH1876_LUNG 37 Splice_Site_SNP SNP A C uc003azl.3 Hybrid_Cap... view
EPHA4 p.W88L 2 222429011 222429011 NCIH1876_LUNG 37 Missense_Mutation SNP C A uc002vmq.2 EPHA4_uc002vmr.... Hybrid_Cap... view
EPHA6 p.T603T 3 97167489 97167489 NCIH1876_LUNG 37 Silent SNP C A uc010how.1 EPHA6_uc011bgo.... Hybrid_Cap... view
EPHA6 3 97367230 97367231 NCIH1876_LUNG 37 Intron Ins - A rs115253553 uc010how.1 EPHA6_uc003drs.... Hybrid_Cap...
ETV1 7 14028708 14028708 NCIH1876_LUNG 37 5'UTR Del A - rs77190713 uc011jxq.1 ETV1_uc011jxn.1... Hybrid_Cap...
EXT1 p.R528C 8 118830724 118830724 NCIH1876_LUNG 37 Missense_Mutation SNP G A uc003yok.1 Hybrid_Cap... view
FBXW7 p.T226I 4 153268131 153268131 NCIH1876_LUNG 37 Missense_Mutation SNP G A uc003ims.2 FBXW7_uc011cii.... Hybrid_Cap... view
FGFR1OP 6 167453519 167453520 NCIH1876_LUNG 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
FLI1 11 128638217 128638217 NCIH1876_LUNG 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FN1 2 216244182 216244185 NCIH1876_LUNG 37 Intron Del GTAC - uc002vfa.2 FN1_uc002vfb.2_... Hybrid_Cap...
GPR112 p.D2657del X 135474445 135474447 NCIH1876_LUNG 37 In_Frame_Del Del GAT - rs3030295 uc004ezu.1 GPR112_uc010nsb... Hybrid_Cap...
GRAMD1B 11 123396824 123396824 NCIH1876_LUNG 37 5'UTR SNP G C uc001pyw.2 GRAMD1B_uc001py... Hybrid_Cap... view
GRIA3 X 122318386 122318387 NCIH1876_LUNG 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GUCY2C 12 14827464 14827466 NCIH1876_LUNG 37 Intron Del ATC - rs72525754;rs3083879 uc001rcd.2 GUCY2C_uc009zhz... Hybrid_Cap...
HEPH p.D794Y X 65427116 65427116 NCIH1876_LUNG 37 Missense_Mutation SNP G T uc011moz.1 HEPH_uc004dwn.2... Hybrid_Cap... view
HNF1A 12 121434630 121434631 NCIH1876_LUNG 37 Intron Ins - TCATTCAT rs75100977 uc010szn.1 HNF1A_uc001tze.... Hybrid_Cap...
HSP90B1 12 104341645 104341648 NCIH1876_LUNG 37 3'UTR Del ACTG - rs2307842 uc001tkb.1 HSP90B1_uc010sw... Hybrid_Cap...
IL21R 16 27441381 27441381 NCIH1876_LUNG 37 5'UTR SNP G T uc002doq.1 IL21R_uc002dor.... Hybrid_Cap... view
ILK 11 6630029 6630029 NCIH1876_LUNG 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
IRAK2 p.G248E 3 10255187 10255187 NCIH1876_LUNG 37 Missense_Mutation SNP G A uc003bve.1 Hybrid_Cap... view
ITPR2 p.I666N 12 26810953 26810953 NCIH1876_LUNG 37 Missense_Mutation SNP A T uc001rhg.2 Hybrid_Cap... view
ITPR2 p.R470_splice 12 26834804 26834805 NCIH1876_LUNG 37 Splice_Site_Ins Ins - ACTC rs66696203;rs59199365 uc001rhg.2 Hybrid_Cap...
KALRN p.E1310* 3 124181383 124181383 NCIH1876_LUNG 37 Nonsense_Mutation SNP G T uc003ehg.2 KALRN_uc010hrv.... Hybrid_Cap... view
KALRN p.R1400L 3 124201668 124201668 NCIH1876_LUNG 37 Missense_Mutation SNP G T uc003ehg.2 KALRN_uc010hrv.... Hybrid_Cap... view
LCP1 p.T399K 13 46718634 46718634 NCIH1876_LUNG 37 Missense_Mutation SNP G T uc001vaz.3 LCP1_uc010ack.2... Hybrid_Cap... view
LRP1B p.W4001R 2 141093299 141093299 NCIH1876_LUNG 37 Missense_Mutation SNP A T uc002tvj.1 Hybrid_Cap... view
LRP2 p.Y1934D 2 170072789 170072789 NCIH1876_LUNG 37 Missense_Mutation SNP A C uc002ues.2 Hybrid_Cap... view
MAF 16 79628537 79628537 NCIH1876_LUNG 37 Intron Del T - uc002ffm.2 MAF_uc002ffn.2_... Hybrid_Cap...
MAML2 p.604_607QQQQ>Q 11 95825375 95825383 NCIH1876_LUNG 37 In_Frame_Del Del TGCTG... - rs113349418 uc001pfw.1 Hybrid_Cap...
MAML3 p.Q767_splice 4 140651585 140651587 NCIH1876_LUNG 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP2K6 17 67516353 67516353 NCIH1876_LUNG 37 Intron SNP A T rs77138194 uc002jij.2 MAP2K6_uc002jii... Hybrid_Cap... view
MAP3K1 p.T949del 5 56177849 56177851 NCIH1876_LUNG 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAP3K14 p.R218_splice 17 43364293 43364294 NCIH1876_LUNG 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
MCM3APAS 21 47671275 47671276 NCIH1876_LUNG 37 3'UTR Ins - AAT rs67797185 uc002zin.2 MCM3APAS_uc002z... Hybrid_Cap...
MLL3 p.Y816fs 7 151945071 151945072 NCIH1876_LUNG 37 Frame_Shift_Ins Ins - T uc003wla.2 Hybrid_Cap...
MLLT3 9 20346377 20346378 NCIH1876_LUNG 37 3'UTR Ins - A rs66943046 uc003zoe.2 MLLT3_uc011lne.... Hybrid_Cap...
MST4 p.E37D X 131188727 131188727 NCIH1876_LUNG 37 Missense_Mutation SNP A T uc011mux.1 MST4_uc004ewk.1... Hybrid_Cap... view
MTUS2 p.D537H 13 29600414 29600414 NCIH1876_LUNG 37 Missense_Mutation SNP G C uc001usl.3 Hybrid_Cap... view
NCAM1 11 112832307 112832308 NCIH1876_LUNG 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 NCIH1876_LUNG 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCOA3 p.Q1276del 20 46279837 46279839 NCIH1876_LUNG 37 In_Frame_Del Del CAG - rs2664555 uc002xtk.2 NCOA3_uc010ght.... Hybrid_Cap...
NEDD9 p.Y112F 6 11213638 11213638 NCIH1876_LUNG 37 Missense_Mutation SNP T A uc003mzv.2 NEDD9_uc010joz.... Hybrid_Cap... view
NEK3 p.K313_splice 13 52718050 52718051 NCIH1876_LUNG 37 Splice_Site_Ins Ins - T rs72514762 uc001vgh.2 NEK3_uc001vgg.2... Hybrid_Cap...
NFATC1 p.Q593H 18 77211692 77211692 NCIH1876_LUNG 37 Missense_Mutation SNP G C uc010xfg.1 NFATC1_uc002lnc... Hybrid_Cap... view
NLRP1 p.W475* 17 5462592 5462592 NCIH1876_LUNG 37 Nonsense_Mutation SNP C T uc002gci.2 NLRP1_uc002gcg.... Hybrid_Cap... view
NPR1 1 153665919 153665920 NCIH1876_LUNG 37 3'UTR Ins - C rs66682713 uc001fcs.3 NPR1_uc010pdz.1... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881820 50881821 NCIH1876_LUNG 37 In_Frame_Ins Ins - AAC rs66783852;rs112359270 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
NRK p.C1305F X 105183980 105183980 NCIH1876_LUNG 37 Missense_Mutation SNP G T uc004emd.2 NRK_uc010npc.1_... Hybrid_Cap... view
NUP214 9 134067556 134067557 NCIH1876_LUNG 37 Intron Ins - T rs66652901 uc004cag.2 NUP214_uc004cah... Hybrid_Cap...
OBSCN p.R1612Q 1 228452066 228452066 NCIH1876_LUNG 37 Missense_Mutation SNP G A uc009xez.1 OBSCN_uc001hsn.... Hybrid_Cap... view
ODZ1 p.S1621I X 123554281 123554281 NCIH1876_LUNG 37 Missense_Mutation SNP C A uc010nqy.2 ODZ1_uc011muj.1... Hybrid_Cap... view
PAX3 2 223158653 223158653 NCIH1876_LUNG 37 Intron Del T - rs112753212 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PCDH15 p.E1018* 10 55719577 55719577 NCIH1876_LUNG 37 Nonsense_Mutation SNP C A uc010qhy.1 PCDH15_uc010qhq... Hybrid_Cap... view
PCDH15 p.H758Q 10 55782919 55782919 NCIH1876_LUNG 37 Missense_Mutation SNP G C uc010qhy.1 PCDH15_uc010qhq... Hybrid_Cap... view
PIK3C2G 12 18801112 18801115 NCIH1876_LUNG 37 3'UTR Del TTGT - rs35889592 uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PIP4K2A p.H87Y 10 22896936 22896936 NCIH1876_LUNG 37 Missense_Mutation SNP G A uc001irl.3 Hybrid_Cap... view
PMS1 2 190670539 190670540 NCIH1876_LUNG 37 Intron Ins - A rs3214425 uc002urh.3 PMS1_uc010zga.1... Hybrid_Cap...
PRKAA2 p.R227L 1 57161724 57161724 NCIH1876_LUNG 37 Missense_Mutation SNP G T uc001cyk.3 Hybrid_Cap... view
PRKCA p.V410fs 17 64731780 64731780 NCIH1876_LUNG 37 Frame_Shift_Del Del G - uc002jfp.1 PRKCA_uc002jfo.... Hybrid_Cap...
PRKDC p.L1244fs 8 48805816 48805817 NCIH1876_LUNG 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
PTPRT p.G206R 20 41400143 41400143 NCIH1876_LUNG 37 Missense_Mutation SNP C T uc010ggj.2 PTPRT_uc002xkg.... Hybrid_Cap... view
RAPGEF2 4 160189200 160189201 NCIH1876_LUNG 37 5'UTR Ins - T rs72011511 uc003iqg.3 Hybrid_Cap...
RB1 p.S127_splice 13 48916851 48916851 NCIH1876_LUNG 37 Splice_Site_SNP SNP G A uc001vcb.2 RB1_uc010acs.1_... Hybrid_Cap... view
RBPJ 4 26431822 26431822 NCIH1876_LUNG 37 Intron Del A - rs76214390 uc003grx.1 RBPJ_uc003gry.1... Hybrid_Cap...
ROCK1 p.T351_splice 18 18608897 18608897 NCIH1876_LUNG 37 Splice_Site_SNP SNP C G uc002kte.2 Hybrid_Cap... view
SOX2 p.M173I 3 181430667 181430667 NCIH1876_LUNG 37 Missense_Mutation SNP G A uc003fkx.2 SOX2OT_uc003fkv... Hybrid_Cap... view
SP140 p.D482Y 2 231134668 231134668 NCIH1876_LUNG 37 Missense_Mutation SNP G T uc002vql.2 SP140_uc010zma.... Hybrid_Cap... view
STK31 7 23872024 23872025 NCIH1876_LUNG 37 3'UTR Ins - TTTG rs66787534 uc003sws.3 STK31_uc003swt.... Hybrid_Cap...
TAF1L p.V1432F 9 32631284 32631284 NCIH1876_LUNG 37 Missense_Mutation SNP C A uc003zrg.1 Hybrid_Cap... view
TBCK p.D508Y 4 107154212 107154212 NCIH1876_LUNG 37 Missense_Mutation SNP C A uc010ilv.2 TBCK_uc003hyb.2... Hybrid_Cap... view
TCEA1 p.R132W 8 54900746 54900746 NCIH1876_LUNG 37 Missense_Mutation SNP G A uc003xru.2 TCEA1_uc003xrv.... Hybrid_Cap... view
TMEM123 11 102269398 102269398 NCIH1876_LUNG 37 3'UTR Del G - uc001pha.2 TMEM123_uc009yx... Hybrid_Cap...
TMEM74 p.W255fs 8 109796563 109796563 NCIH1876_LUNG 37 Frame_Shift_Del Del C - uc003ymy.1 TMEM74_uc003ymx... Hybrid_Cap...
TMEM74 p.A181T 8 109796787 109796787 NCIH1876_LUNG 37 Missense_Mutation SNP C T uc003ymy.1 TMEM74_uc003ymx... Hybrid_Cap... view
TP53 p.R273L 17 7577120 7577120 NCIH1876_LUNG 37 Missense_Mutation SNP C A rs28934576 uc002gim.2 TP53_uc002gig.1... Hybrid_Cap... view
TPO 2 1546310 1546311 NCIH1876_LUNG 37 3'UTR Ins - CAAA uc002qww.2 TPO_uc010ewj.2_... Hybrid_Cap...
TRIM33 1 114948014 114948014 NCIH1876_LUNG 37 Intron SNP C A uc001eew.2 TRIM33_uc010owr... Hybrid_Cap... view
TRIM36 p.E550V 5 114466472 114466472 NCIH1876_LUNG 37 Missense_Mutation SNP T A uc003kqs.2 TRIM36_uc011cwc... Hybrid_Cap... view
TRRAP p.S3592C 7 98606063 98606063 NCIH1876_LUNG 37 Missense_Mutation SNP C G uc003upp.2 TRRAP_uc011kis.... Hybrid_Cap... view
TTN p.R27010C 2 179419342 179419342 NCIH1876_LUNG 37 Missense_Mutation SNP G A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.S21247* 2 179439415 179439415 NCIH1876_LUNG 37 Nonsense_Mutation SNP G T uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.V9896A 2 179544782 179544782 NCIH1876_LUNG 37 Missense_Mutation SNP A G uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.G1511D 2 179642260 179642260 NCIH1876_LUNG 37 Missense_Mutation SNP C T uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.T992I 2 179647658 179647658 NCIH1876_LUNG 37 Missense_Mutation SNP G A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TXK p.R241S 4 48091830 48091830 NCIH1876_LUNG 37 Missense_Mutation SNP G T uc003gxx.3 TXK_uc003gxy.1_... Hybrid_Cap... view
UNC13C p.T1204S 15 54556527 54556527 NCIH1876_LUNG 37 Missense_Mutation SNP A T uc002ack.2 UNC13C_uc002acl... Hybrid_Cap... view
VEGFC p.S419_splice 4 177605082 177605084 NCIH1876_LUNG 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...