Annotation Summary for Cell Line: NCI-H2066  

Cell line primary name: NCI-H2066
Cell line aliases: H2066
Gender: F
Site Primary: lung
Histology: carcinoma
Hist Subtype1: small_cell_carcinoma
Notes:
Source: ATCC
Expression arrays: AGENT_p_NCLE_RNA6_HG-U133_Plus_2_E03_436546
SNP arrays: LOBBY_p_NCLE_DNAAffy6_GenomeWideSNP_6_F07_437210
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in NCI-H2066

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
ABCC3 17 48757065 48757065 NCIH2066_LUNG 37 Intron SNP G A uc002isl.2 ABCC3_uc002isn.... Hybrid_Cap... view
ABL2 1 179086419 179086420 NCIH2066_LUNG 37 Intron Ins - A rs72207641 uc001gmj.3 ABL2_uc010pnf.1... Hybrid_Cap...
ADAM17 2 9630245 9630245 NCIH2066_LUNG 37 3'UTR Del T - uc002qzu.2 IAH1_uc010yiz.1... Hybrid_Cap...
ADAM28 8 24211994 24211997 NCIH2066_LUNG 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
AGAP2 p.Y544H 12 58126682 58126682 NCIH2066_LUNG 37 Missense_Mutation SNP A G uc001spq.2 AGAP2_uc001spp.... Hybrid_Cap... view
AKAP12 p.1531_1532insE 6 151674116 151674117 NCIH2066_LUNG 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
AKAP9 p.1335_1336insQ 7 91652178 91652179 NCIH2066_LUNG 37 In_Frame_Ins Ins - AAC rs34756483 uc003ulg.2 AKAP9_uc003ule.... Hybrid_Cap...
ALPK2 p.1388_1389FF>F 18 56203253 56203255 NCIH2066_LUNG 37 In_Frame_Del Del AAG - uc002lhj.3 ALPK2_uc002lhk.... Hybrid_Cap...
ARNT p.E9V 1 150830936 150830936 NCIH2066_LUNG 37 Missense_Mutation SNP T A uc001evr.1 ARNT_uc001evs.1... Hybrid_Cap... view
ATM p.E2118V 11 108190686 108190686 NCIH2066_LUNG 37 Missense_Mutation SNP A T uc001pkb.1 ATM_uc009yxr.1_... Hybrid_Cap... view
AURKC 19 57742494 57742507 NCIH2066_LUNG 37 5'UTR Del GGACG... - rs67926438;rs112039303;rs59094959 uc002qoe.2 AURKC_uc002qoc.... Hybrid_Cap...
BTK p.L278* X 100615601 100615601 NCIH2066_LUNG 37 Nonsense_Mutation SNP A T uc010nno.2 BTK_uc004ehf.2_... Hybrid_Cap... view
C15ORF2 p.G737C 15 24923223 24923223 NCIH2066_LUNG 37 Missense_Mutation SNP G T uc001ywo.2 Hybrid_Cap... view
CABC1 1 227171585 227171585 NCIH2066_LUNG 37 Intron Del T - uc001hqm.1 CABC1_uc001hqn.... Hybrid_Cap...
CACNA1F p.Q396E X 49083522 49083522 NCIH2066_LUNG 37 Missense_Mutation SNP G C uc004dnb.2 CACNA1F_uc010ni... Hybrid_Cap... view
CACNB2 10 18828721 18828722 NCIH2066_LUNG 37 3'UTR Ins - AA rs3841459 uc001ipr.2 CACNB2_uc009xjz... Hybrid_Cap...
CCDC56 17 40948775 40948775 NCIH2066_LUNG 37 De_novo_Start_OutOfFrame SNP G C uc010wgz.1 WNK4_uc002ibj.2... Hybrid_Cap... view
CDK13 p.R1253Q 7 40133798 40133798 NCIH2066_LUNG 37 Missense_Mutation SNP G A uc003thh.3 CDK13_uc003thi.... Hybrid_Cap... view
CLTCL1 p.V1201_splice 22 19189003 19189004 NCIH2066_LUNG 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
CLTCL1 p.I194M 22 19230397 19230397 NCIH2066_LUNG 37 Missense_Mutation SNP T C uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap... view
CNTN5 p.R819C 11 100169963 100169963 NCIH2066_LUNG 37 Missense_Mutation SNP C T uc001pga.2 CNTN5_uc001pfz.... Hybrid_Cap... view
CSF1R p.G80fs 5 149460397 149460397 NCIH2066_LUNG 37 Frame_Shift_Del Del C - uc003lrl.2 CSF1R_uc011dcd.... Hybrid_Cap...
CSMD3 p.E1572Q 8 113529305 113529305 NCIH2066_LUNG 37 Missense_Mutation SNP C G uc003ynu.2 CSMD3_uc003yns.... Hybrid_Cap... view
CSNK1G2 19 1980339 1980339 NCIH2066_LUNG 37 3'UTR SNP C G uc002lul.3 CSNK1G2_uc010ds... Hybrid_Cap... view
DAPK1 p.H483Y 9 90264854 90264854 NCIH2066_LUNG 37 Missense_Mutation SNP C T uc004apc.2 DAPK1_uc004ape.... Hybrid_Cap... view
EIF4E 4 99808137 99808141 NCIH2066_LUNG 37 Intron Del TTAAA - uc011ceb.1 EIF4E_uc011cea.... Hybrid_Cap...
EPHA6 3 97367230 97367231 NCIH2066_LUNG 37 Intron Ins - A rs115253553 uc010how.1 EPHA6_uc003drs.... Hybrid_Cap...
EPS15 1 51822220 51822220 NCIH2066_LUNG 37 3'UTR Del A - uc001csq.1 EPS15_uc009vyz.... Hybrid_Cap...
ETV1 7 14028708 14028708 NCIH2066_LUNG 37 5'UTR Del A - rs77190713 uc011jxq.1 ETV1_uc011jxn.1... Hybrid_Cap...
FANCM p.R769T 14 45642403 45642403 NCIH2066_LUNG 37 Missense_Mutation SNP G C uc001wwd.3 FANCM_uc010anf.... Hybrid_Cap... view
FGFR1OP 6 167453519 167453520 NCIH2066_LUNG 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
FGFR3 4 1809128 1809129 NCIH2066_LUNG 37 3'UTR Del GT - uc003gdu.2 FGFR3_uc003gdr.... Hybrid_Cap...
FLI1 11 128638217 128638217 NCIH2066_LUNG 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FLI1 11 128638222 128638223 NCIH2066_LUNG 37 Intron Ins - T uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FLNC p.Q1110* 7 128484847 128484847 NCIH2066_LUNG 37 Nonsense_Mutation SNP C T uc003vnz.3 FLNC_uc003voa.3... Hybrid_Cap... view
FLT4 p.W507C 5 180050962 180050962 NCIH2066_LUNG 37 Missense_Mutation SNP C G uc003mlz.3 FLT4_uc003mma.3... Hybrid_Cap... view
FN1 2 216244182 216244185 NCIH2066_LUNG 37 Intron Del GTAC - uc002vfa.2 FN1_uc002vfb.2_... Hybrid_Cap...
GLI3 p.P385L 7 42065886 42065886 NCIH2066_LUNG 37 Missense_Mutation SNP G A uc011kbh.1 GLI3_uc011kbg.1... Hybrid_Cap... view
GRIA3 X 122318386 122318387 NCIH2066_LUNG 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GUCY2C 12 14827464 14827466 NCIH2066_LUNG 37 Intron Del ATC - rs72525754;rs3083879 uc001rcd.2 GUCY2C_uc009zhz... Hybrid_Cap...
GUCY2C p.L167* 12 14836087 14836087 NCIH2066_LUNG 37 Nonsense_Mutation SNP A T uc001rcd.2 GUCY2C_uc009zhz... Hybrid_Cap... view
HDAC4 p.F888L 2 240002862 240002862 NCIH2066_LUNG 37 Missense_Mutation SNP G C uc002vyk.3 HDAC4_uc010fyy.... Hybrid_Cap... view
HIF1A 14 62213929 62213930 NCIH2066_LUNG 37 3'UTR Ins - T rs67890419 uc001xfs.2 HIF1A_uc001xfq.... Hybrid_Cap...
HIP1 p.E574* 7 75185437 75185437 NCIH2066_LUNG 37 Nonsense_Mutation SNP C A uc003uds.1 HIP1_uc011kfz.1... Hybrid_Cap... view
HIPK1 p.D606G 1 114500749 114500749 NCIH2066_LUNG 37 Missense_Mutation SNP A G uc001eem.2 HIPK1_uc001eel.... Hybrid_Cap... view
HNF1A 12 121434630 121434631 NCIH2066_LUNG 37 Intron Ins - TCATTCAT rs75100977 uc010szn.1 HNF1A_uc001tze.... Hybrid_Cap...
IL6ST p.Q869H 5 55237060 55237060 NCIH2066_LUNG 37 Missense_Mutation SNP C A uc003jqq.2 IL6ST_uc010iwb.... Hybrid_Cap... view
ILK 11 6630029 6630029 NCIH2066_LUNG 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
ITPR2 p.R470_splice 12 26834804 26834805 NCIH2066_LUNG 37 Splice_Site_Ins Ins - ACTC rs66696203;rs59199365 uc001rhg.2 Hybrid_Cap...
JAK1 p.L423V 1 65325855 65325855 NCIH2066_LUNG 37 Missense_Mutation SNP G C uc001dbu.1 JAK1_uc009wam.1... Hybrid_Cap... view
KIAA1804 p.G762* 1 233515036 233515036 NCIH2066_LUNG 37 Nonsense_Mutation SNP G T uc001hvt.3 KIAA1804_uc001h... Hybrid_Cap... view
KLK7 19 51480672 51480675 NCIH2066_LUNG 37 3'UTR Del GGTT - uc002puo.2 KLK7_uc002pup.2... Hybrid_Cap...
LIFR p.S1059G 5 38481816 38481816 NCIH2066_LUNG 37 Missense_Mutation SNP T C uc010ive.1 LIFR_uc003jli.2... Hybrid_Cap... view
LIFR p.E921K 5 38482230 38482230 NCIH2066_LUNG 37 Missense_Mutation SNP C T uc010ive.1 LIFR_uc003jli.2... Hybrid_Cap... view
LMNB2 p.E398G 19 2434301 2434302 NCIH2066_LUNG 37 Missense_Mutation DNP CT GC uc002lwa.1 LMNB2_uc002lvy.... Hybrid_Cap...
LMNB2 p.R416* 19 2434060 2434060 NCIH2066_LUNG 37 Nonsense_Mutation SNP G A uc002lwa.1 LMNB2_uc002lvy.... Hybrid_Cap... view
LRGUK p.S740F 7 133943029 133943029 NCIH2066_LUNG 37 Missense_Mutation SNP C T rs35862526 uc003vrm.1 Hybrid_Cap... view
LRP1B p.D1208N 2 141660633 141660633 NCIH2066_LUNG 37 Missense_Mutation SNP C T uc002tvj.1 LRP1B_uc010fnl.... Hybrid_Cap... view
LRP6 12 12273908 12273908 NCIH2066_LUNG 37 3'UTR SNP A G uc001rah.3 BCL2L14_uc001ra... Hybrid_Cap... view
LRRK2 p.R1067G 12 40692147 40692147 NCIH2066_LUNG 37 Missense_Mutation SNP C G uc001rmg.3 LRRK2_uc001rmh.... Hybrid_Cap... view
MAML2 p.D714_splice 11 95724889 95724889 NCIH2066_LUNG 37 Splice_Site_SNP SNP T C uc001pfw.1 Hybrid_Cap... view
MAML2 p.604_607QQQQ>Q 11 95825375 95825383 NCIH2066_LUNG 37 In_Frame_Del Del TGCTG... - rs113349418 uc001pfw.1 Hybrid_Cap...
MAML3 p.Q767_splice 4 140651585 140651587 NCIH2066_LUNG 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP3K1 p.T949del 5 56177849 56177851 NCIH2066_LUNG 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAP3K14 p.R218_splice 17 43364293 43364294 NCIH2066_LUNG 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
MAPK14 6 36076345 36076354 NCIH2066_LUNG 37 3'UTR Del GTGTG... - rs80147786 uc003olp.2 MAPK14_uc003olq... Hybrid_Cap...
MCF2 p.W151F X 138713569 138713570 NCIH2066_LUNG 37 Missense_Mutation DNP CC AA uc011mwo.1 MCF2_uc004fau.2... Hybrid_Cap...
MLL3 p.Y816fs 7 151945071 151945072 NCIH2066_LUNG 37 Frame_Shift_Ins Ins - T uc003wla.2 Hybrid_Cap...
MSH3 p.PPA66del 5 79950742 79950750 NCIH2066_LUNG 37 In_Frame_Del Del CCCCC... - rs60484572;rs1047489 uc003kgz.2 DHFR_uc011ctl.1... Hybrid_Cap...
MTOR p.F140L 1 11317074 11317074 NCIH2066_LUNG 37 Missense_Mutation SNP A C uc001asd.2 Hybrid_Cap... view
NAV3 p.S2369fs 12 78604246 78604246 NCIH2066_LUNG 37 Frame_Shift_Del Del C - uc001syp.2 NAV3_uc001syo.2... Hybrid_Cap...
NBN p.I455M 8 90967543 90967543 NCIH2066_LUNG 37 Missense_Mutation SNP G C uc003yej.1 NBN_uc003yei.1_... Hybrid_Cap... view
NCAM1 11 112832307 112832308 NCIH2066_LUNG 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 NCIH2066_LUNG 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCOA1 p.G662C 2 24930323 24930323 NCIH2066_LUNG 37 Missense_Mutation SNP G T uc002rfk.2 NCOA1_uc010eye.... Hybrid_Cap... view
NCOA2 8 71129001 71129001 NCIH2066_LUNG 37 Splice_Site_SNP SNP T A uc003xyn.1 Hybrid_Cap... view
NEK3 p.K313_splice 13 52718050 52718051 NCIH2066_LUNG 37 Splice_Site_Ins Ins - T rs72514762 uc001vgh.2 NEK3_uc001vgg.2... Hybrid_Cap...
NFIA 1 61921185 61921186 NCIH2066_LUNG 37 3'UTR Ins - T rs57270124;rs76131997 uc010oos.1 NFIA_uc001czy.2... Hybrid_Cap...
NFKB1 p.G446C 4 103517330 103517330 NCIH2066_LUNG 37 Missense_Mutation SNP G T uc011cep.1 NFKB1_uc011ceq.... Hybrid_Cap... view
NPR1 p.E378D 1 153654278 153654278 NCIH2066_LUNG 37 Missense_Mutation SNP G T uc001fcs.3 NPR1_uc010pdz.1... Hybrid_Cap... view
NPR1 1 153665919 153665920 NCIH2066_LUNG 37 3'UTR Ins - C rs66682713 uc001fcs.3 NPR1_uc010pdz.1... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881820 50881821 NCIH2066_LUNG 37 In_Frame_Ins Ins - AAC rs66783852;rs112359270 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
NR3C1 5 142780419 142780419 NCIH2066_LUNG 37 Splice_Site_SNP SNP T A uc003lmy.2 NR3C1_uc003lmz.... Hybrid_Cap... view
OBSCN p.R2797W 1 228469825 228469825 NCIH2066_LUNG 37 Missense_Mutation SNP C T rs77737906 uc009xez.1 OBSCN_uc001hsn.... Hybrid_Cap... view
OLFM4 p.T459K 13 53624749 53624749 NCIH2066_LUNG 37 Missense_Mutation SNP C A uc001vhl.2 OLFM4_uc001vhk.... Hybrid_Cap... view
ORMDL3 p.G4A 17 38080446 38080446 NCIH2066_LUNG 37 Missense_Mutation SNP C G uc002htj.1 ORMDL3_uc002hti... Hybrid_Cap... view
PAX3 2 223158653 223158653 NCIH2066_LUNG 37 Intron Del T - rs112753212 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PGGT1B 5 114548071 114548072 NCIH2066_LUNG 37 3'UTR Ins - C uc003kqw.3 PGGT1B_uc003kqx... Hybrid_Cap...
PIK3C2G p.P129del 12 18435399 18435401 NCIH2066_LUNG 37 In_Frame_Del Del CCC - uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PIK3C2G 12 18800990 18800990 NCIH2066_LUNG 37 3'UTR Del A - rs16914368 uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PKN2 p.S375R 1 89250461 89250461 NCIH2066_LUNG 37 Missense_Mutation SNP T A uc001dmn.2 PKN2_uc001dmm.1... Hybrid_Cap... view
PLD1 p.R245I 3 171442510 171442510 NCIH2066_LUNG 37 Missense_Mutation SNP C A uc003fhs.2 PLD1_uc003fht.2... Hybrid_Cap... view
PMS1 2 190670539 190670540 NCIH2066_LUNG 37 Intron Ins - A rs3214425 uc002urh.3 PMS1_uc010zga.1... Hybrid_Cap...
PPP1R3A p.S220* 7 113558393 113558393 NCIH2066_LUNG 37 Nonsense_Mutation SNP G C uc010ljy.1 Hybrid_Cap... view
PRKDC p.V4004M 8 48690279 48690279 NCIH2066_LUNG 37 Missense_Mutation SNP C T uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap... view
PRKDC p.L1244fs 8 48805816 48805817 NCIH2066_LUNG 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
RET p.S853T 10 43615143 43615143 NCIH2066_LUNG 37 Missense_Mutation SNP T A uc001jal.2 RET_uc001jak.1_... Hybrid_Cap... view
RICTOR p.L1660P 5 38944554 38944554 NCIH2066_LUNG 37 Missense_Mutation SNP A G uc003jlo.2 RICTOR_uc003jlp... Hybrid_Cap... view
RIPK4 p.G215S 21 43169344 43169344 NCIH2066_LUNG 37 Missense_Mutation SNP C T uc002yzn.1 Hybrid_Cap... view
ROS1 p.D2058Y 6 117632244 117632244 NCIH2066_LUNG 37 Missense_Mutation SNP C A uc003pxp.1 ROS1_uc011ebi.1... Hybrid_Cap... view
RPS6KA2 p.E291D 6 166904179 166904179 NCIH2066_LUNG 37 Missense_Mutation SNP C A uc003qvd.1 RPS6KA2_uc011eg... Hybrid_Cap... view
RPS6KA5 14 91360733 91360734 NCIH2066_LUNG 37 Intron Ins - T rs77438853 uc001xys.2 RPS6KA5_uc010tw... Hybrid_Cap...
RPS6KL1 14 75373626 75373627 NCIH2066_LUNG 37 3'UTR Ins - TGAT uc001xqx.1 RPS6KL1_uc001xq... Hybrid_Cap...
SACS p.D1261N 13 23914234 23914234 NCIH2066_LUNG 37 Missense_Mutation SNP C T uc001uon.2 SACS_uc001uoo.2... Hybrid_Cap... view
SERPINB4 p.M212I 18 61306551 61306551 NCIH2066_LUNG 37 Missense_Mutation SNP C A uc002ljf.2 SERPINB4_uc002l... Hybrid_Cap... view
SLC14A1 p.R170W 18 43311168 43311168 NCIH2066_LUNG 37 Missense_Mutation SNP A T uc010dnk.2 SLC14A1_uc010xc... Hybrid_Cap... view
SLC6A8 X 152957656 152957657 NCIH2066_LUNG 37 Intron Ins - A uc004fib.3 SLC6A8_uc004fic... Hybrid_Cap...
SPEG p.G1793E 2 220346034 220346034 NCIH2066_LUNG 37 Missense_Mutation SNP G A uc010fwg.2 Hybrid_Cap... view
SRPK1 p.R649L 6 35803102 35803103 NCIH2066_LUNG 37 Missense_Mutation DNP CC AA rs35124200 uc003olj.2 SRPK1_uc011dtg.... Hybrid_Cap...
STK19 6 31940060 31940060 NCIH2066_LUNG 37 Intron SNP T C uc003nyv.2 DOM3Z_uc003nyo.... Hybrid_Cap... view
STK25 2 242435659 242435662 NCIH2066_LUNG 37 Intron Del AAGG - rs3215138;rs75497042 uc002wbm.2 STK25_uc002wbk.... Hybrid_Cap...
STK38L p.K224_splice 12 27467592 27467592 NCIH2066_LUNG 37 Splice_Site_SNP SNP G A uc001rhr.2 STK38L_uc001rhs... Hybrid_Cap... view
TAOK1 p.Q538R 17 27837919 27837919 NCIH2066_LUNG 37 Missense_Mutation SNP A G uc002hdz.1 TAOK1_uc010wbe.... Hybrid_Cap... view
TP53 p.V157F 17 7578461 7578461 NCIH2066_LUNG 37 Missense_Mutation SNP C A uc002gim.2 TP53_uc002gig.1... Hybrid_Cap... view
TP63 3 189507518 189507519 NCIH2066_LUNG 37 Intron Ins - AGAG rs62702062;rs79714037 uc003fry.2 TP63_uc003frx.2... Hybrid_Cap...
TRIO p.A436T 5 14297310 14297310 NCIH2066_LUNG 37 Missense_Mutation SNP G A uc003jff.2 TRIO_uc003jfg.2... Hybrid_Cap... view
TTN p.E6084Q 2 179587644 179587644 NCIH2066_LUNG 37 Missense_Mutation SNP C G uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.C3528W 2 179602864 179602864 NCIH2066_LUNG 37 Missense_Mutation SNP G C uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
UNC13C p.R640L 15 54307019 54307019 NCIH2066_LUNG 37 Missense_Mutation SNP G T uc002ack.2 Hybrid_Cap... view
VDR 12 48272741 48272742 NCIH2066_LUNG 37 Intron Ins - A uc001rql.2 VDR_uc001rqm.2_... Hybrid_Cap...
VEGFC p.S419_splice 4 177605082 177605084 NCIH2066_LUNG 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
WRN p.D511H 8 30945391 30945391 NCIH2066_LUNG 37 Missense_Mutation SNP G C uc003xio.3 WRN_uc011lbe.1_... Hybrid_Cap... view