Annotation Summary for Cell Line: NCI-H2081  

Cell line primary name: NCI-H2081
Cell line aliases: H2081
Gender: F
Site Primary: lung
Histology: carcinoma
Hist Subtype1: small_cell_carcinoma
Notes:
Source: ATCC
Expression arrays: CRAZY_p_NCLE_RNA10_HG-U133_Plus_2_D09_569554
SNP arrays: AWASH_p_NCLE_DNAAffy10_GenomeWideSNP_6_C01_542960
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in NCI-H2081

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
AAK1 p.541_542QQ>Q 2 69741754 69741756 NCIH2081_LUNG 37 In_Frame_Del Del TGT - rs55712143 uc002sfp.2 AAK1_uc010fdk.2... Hybrid_Cap...
ACACA 17 35766564 35766564 NCIH2081_LUNG 37 5'UTR Del A - uc002hno.2 ACACA_uc002hnn.... Hybrid_Cap...
ADAM28 8 24211994 24211997 NCIH2081_LUNG 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
AFF3 2 100623965 100623965 NCIH2081_LUNG 37 Intron SNP A G uc002taf.2 AFF3_uc002tag.2... Hybrid_Cap... view
AKAP12 p.1531_1532insE 6 151674116 151674117 NCIH2081_LUNG 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
ALDH7A1 p.K389N 5 125890012 125890012 NCIH2081_LUNG 37 Missense_Mutation SNP C G uc003ktx.2 ALDH7A1_uc003kt... Hybrid_Cap... view
ALPK1 4 113347609 113347610 NCIH2081_LUNG 37 Intron Ins - T rs68137453 uc003iap.3 ALPK1_uc003ian.... Hybrid_Cap...
ALPK2 p.EDTST1006del 18 56204388 56204402 NCIH2081_LUNG 37 In_Frame_Del Del CAGTT... - rs60644017;rs117623369 uc002lhj.3 ALPK2_uc002lhk.... Hybrid_Cap...
ALS2 2 202587706 202587707 NCIH2081_LUNG 37 Intron Ins - A rs3219165 uc002uyo.2 ALS2_uc002uyp.3... Hybrid_Cap...
ARAF p.A203A X 47426089 47426089 NCIH2081_LUNG 37 Silent SNP C A uc011mlq.1 ARAF_uc011mln.1... Hybrid_Cap... view
ASPH p.A264_splice 8 62550924 62550925 NCIH2081_LUNG 37 Splice_Site_Ins Ins - A rs5891816 uc003xuj.2 ASPH_uc011leg.1... Hybrid_Cap...
ATRX p.M1668I X 76888825 76888825 NCIH2081_LUNG 37 Missense_Mutation SNP C A uc004ecp.3 ATRX_uc004ecq.3... Hybrid_Cap... view
ATRX p.S1116C X 76937401 76937401 NCIH2081_LUNG 37 Missense_Mutation SNP G C uc004ecp.3 ATRX_uc004ecq.3... Hybrid_Cap... view
BIRC6 p.N586S 2 32640116 32640116 NCIH2081_LUNG 37 Missense_Mutation SNP A G uc010ezu.2 Hybrid_Cap... view
BLK 8 11418697 11418697 NCIH2081_LUNG 37 Intron SNP A G uc003wty.2 BLK_uc003wtz.2_... Hybrid_Cap... view
BMP2K p.K603I 4 79799902 79799902 NCIH2081_LUNG 37 Missense_Mutation SNP A T uc003hlk.2 BMP2K_uc003hlj.... Hybrid_Cap... view
BMP2K p.E604* 4 79799904 79799904 NCIH2081_LUNG 37 Nonsense_Mutation SNP G T uc003hlk.2 BMP2K_uc003hlj.... Hybrid_Cap... view
BMP4 14 54416601 54416602 NCIH2081_LUNG 37 3'UTR Del CT - rs74495140;rs76335800 uc001xal.3 BMP4_uc010aoh.2... Hybrid_Cap...
CACNB2 10 18828721 18828722 NCIH2081_LUNG 37 3'UTR Ins - AA rs3841459 uc001ipr.2 CACNB2_uc009xjz... Hybrid_Cap...
CAMKV p.A188_splice 3 49898612 49898612 NCIH2081_LUNG 37 Splice_Site_SNP SNP C A uc003cxt.1 CAMKV_uc011bcy.... Hybrid_Cap... view
CDC7 p.T252R 1 91978797 91978797 NCIH2081_LUNG 37 Missense_Mutation SNP C G uc001doe.2 CDC7_uc001dof.2... Hybrid_Cap... view
CDH1 p.E445A 16 68849431 68849431 NCIH2081_LUNG 37 Missense_Mutation SNP A C uc002ewg.1 CDH1_uc010vlj.1... Hybrid_Cap... view
CDH11 p.M241V 16 65025761 65025761 NCIH2081_LUNG 37 Missense_Mutation SNP T C uc002eoi.2 CDH11_uc010cdn.... Hybrid_Cap... view
CDK11B 1 1654066 1654068 NCIH2081_LUNG 37 Intron Del GCG - uc001agv.1 CDK11B_uc001aha... Hybrid_Cap...
CHRNA3 p.R41W 15 78911219 78911219 NCIH2081_LUNG 37 Missense_Mutation SNP G A uc002bec.2 CHRNA3_uc002bea... Hybrid_Cap... view
CLTCL1 p.V1201_splice 22 19189003 19189004 NCIH2081_LUNG 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
COL1A1 p.E630K 17 48270042 48270042 NCIH2081_LUNG 37 Missense_Mutation SNP C T uc002iqm.2 Hybrid_Cap... view
CXCL12 10 44873992 44873993 NCIH2081_LUNG 37 Intron Ins - CT rs117617571 uc001jbh.2 CXCL12_uc001jbf... Hybrid_Cap...
DACH1 13 72014625 72014626 NCIH2081_LUNG 37 3'UTR Ins - T rs117109529 uc010thn.1 DACH1_uc010tho.... Hybrid_Cap...
DDR2 1 162750211 162750212 NCIH2081_LUNG 37 3'UTR Del TT - uc001gcf.2 DDR2_uc001gcg.2... Hybrid_Cap...
DMPK 19 46273463 46273489 NCIH2081_LUNG 37 3'UTR Del CAGCA... - uc002pdi.1 SIX5_uc002pdb.2... Hybrid_Cap...
DOCK3 p.S176I 3 51112849 51112849 NCIH2081_LUNG 37 Missense_Mutation SNP G T uc011bds.1 Hybrid_Cap... view
DPYD p.T349A 1 98058857 98058857 NCIH2081_LUNG 37 Missense_Mutation SNP T C uc001drv.2 Hybrid_Cap... view
F8 p.T1891R X 154132714 154132714 NCIH2081_LUNG 37 Missense_Mutation SNP G C uc004fmt.2 F8_uc010nvi.1_M... Hybrid_Cap... view
FANCL p.N275K 2 58390175 58390175 NCIH2081_LUNG 37 Missense_Mutation SNP G T uc002rzx.3 FANCL_uc002rzw.... Hybrid_Cap... view
FGFR1OP p.L280R 6 167438302 167438302 NCIH2081_LUNG 37 Missense_Mutation SNP T G uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap... view
FLI1 11 128638217 128638217 NCIH2081_LUNG 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FLNA p.A2461G X 153578187 153578187 NCIH2081_LUNG 37 Missense_Mutation SNP G C uc004fkk.2 FLNA_uc004fki.2... Hybrid_Cap... view
FMN2 p.PPLPGAGIPPP939del 1 240370914 240370946 NCIH2081_LUNG 37 In_Frame_Del Del GCCCC... - rs4997328;rs4997329 uc010pye.1 FMN2_uc010pyd.1... Hybrid_Cap...
FMN2 p.I1621M 1 240519201 240519201 NCIH2081_LUNG 37 Missense_Mutation SNP T G uc010pye.1 FMN2_uc010pyd.1... Hybrid_Cap... view
FN1 2 216244182 216244185 NCIH2081_LUNG 37 Intron Del GTAC - uc002vfa.2 FN1_uc002vfb.2_... Hybrid_Cap...
GRIA3 X 122318386 122318387 NCIH2081_LUNG 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GUCY2C 12 14827464 14827466 NCIH2081_LUNG 37 Intron Del ATC - rs72525754;rs3083879 uc001rcd.2 GUCY2C_uc009zhz... Hybrid_Cap...
GUCY2F p.A990V X 108628499 108628499 NCIH2081_LUNG 37 Missense_Mutation SNP G A uc004eod.3 GUCY2F_uc011msq... Hybrid_Cap... view
HIF1A 14 62213929 62213930 NCIH2081_LUNG 37 3'UTR Ins - T rs67890419 uc001xfs.2 HIF1A_uc001xfq.... Hybrid_Cap...
HNF1A 12 121434630 121434631 NCIH2081_LUNG 37 Intron Ins - TCATTCAT rs75100977 uc010szn.1 HNF1A_uc001tze.... Hybrid_Cap...
ILK 11 6630029 6630029 NCIH2081_LUNG 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
ITPR2 p.R470_splice 12 26834804 26834805 NCIH2081_LUNG 37 Splice_Site_Ins Ins - ACTC rs66696203;rs59199365 uc001rhg.2 Hybrid_Cap...
KIAA2022 p.Q639L X 73962476 73962476 NCIH2081_LUNG 37 Missense_Mutation SNP T A uc004eby.2 Hybrid_Cap... view
KIAA2022 p.I446N X 73963055 73963055 NCIH2081_LUNG 37 Missense_Mutation SNP A T uc004eby.2 Hybrid_Cap... view
LCP1 13 46718716 46718716 NCIH2081_LUNG 37 Intron SNP A T uc001vaz.3 LCP1_uc010ack.2... Hybrid_Cap... view
LPP 3 188426358 188426358 NCIH2081_LUNG 37 Intron SNP A G uc003frs.1 LPP_uc011bsg.1_... Hybrid_Cap... view
MAML2 p.604_607QQQQ>Q 11 95825375 95825383 NCIH2081_LUNG 37 In_Frame_Del Del TGCTG... - rs113349418 uc001pfw.1 Hybrid_Cap...
MAML3 p.Q767_splice 4 140651585 140651587 NCIH2081_LUNG 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP3K1 p.T949del 5 56177849 56177851 NCIH2081_LUNG 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAP3K14 p.R218_splice 17 43364293 43364294 NCIH2081_LUNG 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
MAPK14 6 36076345 36076354 NCIH2081_LUNG 37 3'UTR Del GTGTG... - rs80147786 uc003olp.2 MAPK14_uc003olq... Hybrid_Cap...
MCL1 1 150552008 150552008 NCIH2081_LUNG 37 5'UTR SNP G C uc001euz.2 MCL1_uc010pch.1... Hybrid_Cap... view
MCM3APAS 21 47671275 47671276 NCIH2081_LUNG 37 3'UTR Ins - AAT rs67797185 uc002zin.2 MCM3APAS_uc002z... Hybrid_Cap...
MRE11A 11 94153102 94153102 NCIH2081_LUNG 37 3'UTR SNP C T uc001peu.2 MRE11A_uc001pev... Hybrid_Cap... view
MYLK 3 123332875 123332876 NCIH2081_LUNG 37 3'UTR Ins - T rs35930843;rs115544676 uc003ego.2 MYLK_uc003egl.2... Hybrid_Cap...
MYST4 10 76790936 76790936 NCIH2081_LUNG 37 3'UTR Del A - uc001jwn.1 MYST4_uc001jwo.... Hybrid_Cap...
NAV3 p.Y1135H 12 78513379 78513379 NCIH2081_LUNG 37 Missense_Mutation SNP T C uc001syp.2 NAV3_uc001syo.2... Hybrid_Cap... view
NCAM1 11 112832307 112832308 NCIH2081_LUNG 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 NCIH2081_LUNG 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NEK3 p.K313_splice 13 52718050 52718051 NCIH2081_LUNG 37 Splice_Site_Ins Ins - T rs72514762 uc001vgh.2 NEK3_uc001vgg.2... Hybrid_Cap...
NFIA 1 61921185 61921186 NCIH2081_LUNG 37 3'UTR Ins - T rs57270124;rs76131997 uc010oos.1 NFIA_uc001czy.2... Hybrid_Cap...
NIPBL p.V1670G 5 37019501 37019501 NCIH2081_LUNG 37 Missense_Mutation SNP T G uc003jkl.3 NIPBL_uc003jkk.... Hybrid_Cap... view
NLRP3 p.L248R 1 247587488 247587488 NCIH2081_LUNG 37 Missense_Mutation SNP T G uc001icr.2 NLRP3_uc001ics.... Hybrid_Cap... view
NPM1 5 170837734 170837734 NCIH2081_LUNG 37 3'UTR Del T - uc011dex.1 NPM1_uc003mbi.2... Hybrid_Cap...
NPR1 1 153665919 153665920 NCIH2081_LUNG 37 3'UTR Ins - C rs66682713 uc001fcs.3 NPR1_uc010pdz.1... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881820 50881821 NCIH2081_LUNG 37 In_Frame_Ins Ins - AAC rs66783852;rs112359270 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
PAX3 2 223158653 223158653 NCIH2081_LUNG 37 Intron Del T - rs112753212 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PAX5 9 37034095 37034095 NCIH2081_LUNG 37 5'UTR Del C - uc003zzo.1 PAX5_uc011lpw.1... Hybrid_Cap...
PGR 11 100933598 100933599 NCIH2081_LUNG 37 Intron Ins - AATGA rs35148438 uc001pgh.2 PGR_uc001pgg.2_... Hybrid_Cap...
PIK3C2G p.P129del 12 18435399 18435401 NCIH2081_LUNG 37 In_Frame_Del Del CCC - uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PIK3C2G 12 18800990 18800990 NCIH2081_LUNG 37 3'UTR Del A - rs16914368 uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PIK3CB p.M630R 3 138413631 138413631 NCIH2081_LUNG 37 Missense_Mutation SNP A C uc011bmq.1 PIK3CB_uc011bmn... Hybrid_Cap... view
PKHD1 p.P3552H 6 51524269 51524269 NCIH2081_LUNG 37 Missense_Mutation SNP G T uc003pah.1 Hybrid_Cap... view
PRKCA 17 64298959 64298960 NCIH2081_LUNG 37 5'UTR Ins - GG rs71160558 uc002jfp.1 PRKCA_uc002jfo.... Hybrid_Cap...
PRKDC p.L1244fs 8 48805816 48805817 NCIH2081_LUNG 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
PTEN p.C124F 10 89692887 89692887 NCIH2081_LUNG 37 Missense_Mutation SNP G T uc001kfb.2 Hybrid_Cap... view
PTPRT p.V45A 20 41514527 41514527 NCIH2081_LUNG 37 Missense_Mutation SNP A G uc010ggj.2 PTPRT_uc002xkg.... Hybrid_Cap... view
PTPRU p.Y777C 1 29616206 29616206 NCIH2081_LUNG 37 Missense_Mutation SNP A G uc001bru.2 PTPRU_uc001brv.... Hybrid_Cap... view
RAPGEF2 4 160189200 160189201 NCIH2081_LUNG 37 5'UTR Ins - T rs72011511 uc003iqg.3 Hybrid_Cap...
RAPGEF2 4 160189219 160189219 NCIH2081_LUNG 37 5'UTR SNP C T uc003iqg.3 Hybrid_Cap... view
RASGRF1 15 79277150 79277151 NCIH2081_LUNG 37 Intron Ins - C rs67045840;rs77640668 uc002beq.2 RASGRF1_uc002be... Hybrid_Cap...
RB1 p.Y756* 13 49039190 49039190 NCIH2081_LUNG 37 Nonsense_Mutation SNP T A uc001vcb.2 Hybrid_Cap... view
RICTOR 5 38942186 38942186 NCIH2081_LUNG 37 3'UTR SNP G T uc003jlo.2 RICTOR_uc003jlp... Hybrid_Cap... view
SEPT9 17 75494787 75494788 NCIH2081_LUNG 37 3'UTR Ins - C rs5822173 uc002jts.3 SEPT9_uc010wtk.... Hybrid_Cap...
STAT1 2 191840353 191840353 NCIH2081_LUNG 37 Intron Del T - uc002usj.2 STAT1_uc010fse.... Hybrid_Cap...
STK31 7 23872024 23872025 NCIH2081_LUNG 37 3'UTR Ins - TTTG rs66787534 uc003sws.3 STK31_uc003swt.... Hybrid_Cap...
STK39 p.K280_splice 2 168996798 168996798 NCIH2081_LUNG 37 Splice_Site_SNP SNP C A uc002uea.2 Hybrid_Cap... view
SULF2 p.M294T 20 46313182 46313182 NCIH2081_LUNG 37 Missense_Mutation SNP A G uc002xto.2 SULF2_uc002xtr.... Hybrid_Cap... view
TCF21 6 134210497 134210498 NCIH2081_LUNG 37 5'UTR Ins - TCTC rs35199378 uc003qei.3 TCF21_uc003qej.... Hybrid_Cap...
TEC 4 48139307 48139310 NCIH2081_LUNG 37 3'UTR Del TTAT - rs79098351 uc003gxz.2 Hybrid_Cap...
TLK1 2 171850178 171850179 NCIH2081_LUNG 37 3'UTR Ins - AA rs71008739 uc002ugo.2 TLK1_uc002ugn.2... Hybrid_Cap...
TMEM123 11 102269398 102269398 NCIH2081_LUNG 37 3'UTR Del G - uc001pha.2 TMEM123_uc009yx... Hybrid_Cap...
TPO p.G803C 2 1507740 1507740 NCIH2081_LUNG 37 Missense_Mutation SNP G T uc002qww.2 TPO_uc010ewj.2_... Hybrid_Cap... view
TRIM33 1 114940212 114940212 NCIH2081_LUNG 37 3'UTR Del T - uc001eew.2 TRIM33_uc010owr... Hybrid_Cap...
TRPS1 8 116635872 116635873 NCIH2081_LUNG 37 5'UTR Ins - A rs76893349 uc003yny.2 TRPS1_uc011lhy.... Hybrid_Cap...
TTK p.A205_splice 6 80721150 80721150 NCIH2081_LUNG 37 Splice_Site_SNP SNP G T uc003pjc.2 TTK_uc003pjb.3_... Hybrid_Cap... view
TTN p.P14414S 2 179475912 179475912 NCIH2081_LUNG 37 Missense_Mutation SNP G A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.A11086S 2 179501494 179501494 NCIH2081_LUNG 37 Missense_Mutation SNP C A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
UHMK1 p.Q371E 1 162487978 162487978 NCIH2081_LUNG 37 Missense_Mutation SNP C G uc001gcc.1 UHMK1_uc001gcb.... Hybrid_Cap... view
ULK4 p.K20R 3 41996193 41996193 NCIH2081_LUNG 37 Missense_Mutation SNP T C uc003ckv.3 ULK4_uc003ckw.2... Hybrid_Cap... view
VEGFC p.S419_splice 4 177605082 177605084 NCIH2081_LUNG 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
WNK3 p.Y162H X 54359623 54359623 NCIH2081_LUNG 37 Missense_Mutation SNP A G uc004dtc.1 WNK3_uc004dtd.1... Hybrid_Cap... view