Annotation Summary for Cell Line: NCI-H2122  

Cell line primary name: NCI-H2122
Cell line aliases: H2122
Gender: F
Site Primary: lung
Histology: carcinoma
Hist Subtype1: adenocarcinoma
Notes:
Source: ATCC
Expression arrays: METIS_p_NCLE_RNA1_Human_U133_Plus_2.0_G02_240996
SNP arrays: LIMPS_p_NCLE_DNA2N_GenomeWideSNP_6_C03_246662
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in NCI-H2122

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
ABL2 1 179086419 179086420 NCIH2122_LUNG 37 Intron Ins - A rs72207641 uc001gmj.3 ABL2_uc010pnf.1... Hybrid_Cap...
ADAM10 p.Q170H 15 58957371 58957371 NCIH2122_LUNG 37 Missense_Mutation SNP C G rs61751103 uc002afd.1 ADAM10_uc010bgc... Hybrid_Cap... view
ADAM17 2 9630245 9630245 NCIH2122_LUNG 37 3'UTR Del T - uc002qzu.2 IAH1_uc010yiz.1... Hybrid_Cap...
ADAM28 8 24211994 24211997 NCIH2122_LUNG 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
AKAP12 p.1531_1532insE 6 151674116 151674117 NCIH2122_LUNG 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
AKAP9 p.1335_1336insQ 7 91652178 91652179 NCIH2122_LUNG 37 In_Frame_Ins Ins - AAC rs34756483 uc003ulg.2 AKAP9_uc003ule.... Hybrid_Cap...
ALPK2 p.EDTST1006del 18 56204388 56204402 NCIH2122_LUNG 37 In_Frame_Del Del CAGTT... - rs60644017;rs117623369 uc002lhj.3 ALPK2_uc002lhk.... Hybrid_Cap...
ALS2 2 202587706 202587707 NCIH2122_LUNG 37 Intron Ins - A rs3219165 uc002uyo.2 ALS2_uc002uyp.3... Hybrid_Cap...
ASTN1 10 18828721 18828722 NCIH2122_LUNG 37 3'UTR Ins - AA rs3841459 uc001ipr.2 CACNB2_uc009xjz... Hybrid_Cap...
ASTN1 p.A1104S 15 34649519 34649519 NCIH2122_LUNG 37 Missense_Mutation SNP G T uc010ucc.1 C15orf55_uc010u... Hybrid_Cap... view
ATF2 p.R74K 2 175983076 175983076 NCIH2122_LUNG 37 Missense_Mutation SNP C T uc002ujl.2 ATF2_uc010fqv.2... Hybrid_Cap... view
BCKDK p.D404D 16 31123559 31123559 NCIH2122_LUNG 37 Silent SNP T C rs55939386 uc002eaw.3 BCKDK_uc002eav.... Hybrid_Cap... view
BCR 22 23632777 23632778 NCIH2122_LUNG 37 Intron Ins - T uc002zww.2 BCR_uc002zwx.2_... Hybrid_Cap...
BMP4 p.T100del 7 137612914 137612916 NCIH2122_LUNG 37 In_Frame_Del Del TGG - uc003vtw.2 CREB3L2_uc003vt... Hybrid_Cap...
BRD2 6 32948599 32948599 NCIH2122_LUNG 37 3'UTR Del C - uc010juh.2 BRD2_uc003ocn.3... Hybrid_Cap...
CDH1 p.PENEKG164del 16 68842427 68842444 NCIH2122_LUNG 37 In_Frame_Del Del GCCCA... - uc002ewg.1 CDH1_uc010vlj.1... Hybrid_Cap...
CDK11B 1 1654066 1654068 NCIH2122_LUNG 37 Intron Del GCG - uc001agv.1 CDK11B_uc001aha... Hybrid_Cap...
CDKL5 p.Q834K X 18646494 18646494 NCIH2122_LUNG 37 Missense_Mutation SNP C A uc004cym.2 CDKL5_uc004cyn.... Hybrid_Cap... view
CHD5 p.R523G 3 184040176 184040176 NCIH2122_LUNG 37 Missense_Mutation SNP C G uc010hxx.2 EIF4G1_uc003fno... Hybrid_Cap... view
CHD8 22 41574970 41574972 NCIH2122_LUNG 37 3'UTR Del GTA - rs76489032 uc003azl.3 Hybrid_Cap...
CLTCL1 p.V1201_splice 22 19189003 19189004 NCIH2122_LUNG 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
CNTN5 2 216244182 216244185 NCIH2122_LUNG 37 Intron Del GTAC - uc002vfa.2 FN1_uc002vfb.2_... Hybrid_Cap...
CNTN6 3 1339681 1339686 NCIH2122_LUNG 37 Intron Del GTTTT... - uc003boz.2 CNTN6_uc010hbo.... Hybrid_Cap...
CSNK1E p.R256L 22 38694909 38694909 NCIH2122_LUNG 37 Missense_Mutation SNP C A uc003avj.2 CSNK1E_uc003avk... Hybrid_Cap... view
DACH1 13 72014625 72014626 NCIH2122_LUNG 37 3'UTR Ins - T rs117109529 uc010thn.1 DACH1_uc010tho.... Hybrid_Cap...
DICER1 12 121434630 121434631 NCIH2122_LUNG 37 Intron Ins - TCATTCAT rs75100977 uc010szn.1 HNF1A_uc001tze.... Hybrid_Cap...
EIF4E 4 99808137 99808141 NCIH2122_LUNG 37 Intron Del TTAAA - uc011ceb.1 EIF4E_uc011cea.... Hybrid_Cap...
EPHA10 16 79628537 79628537 NCIH2122_LUNG 37 Intron Del T - uc002ffm.2 MAF_uc002ffn.2_... Hybrid_Cap...
EPHA3 3 89448705 89448705 NCIH2122_LUNG 37 Intron SNP T A uc003dqy.2 EPHA3_uc003dqx.... Hybrid_Cap... view
FGFR4 p.P712T 5 176523723 176523723 NCIH2122_LUNG 37 Missense_Mutation SNP C A uc003mfl.2 FGFR4_uc003mfm.... Hybrid_Cap... view
FLI1 11 128638217 128638217 NCIH2122_LUNG 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FLI1 p.S4R 12 69202267 69202267 NCIH2122_LUNG 37 Missense_Mutation SNP A C uc001sui.2 MDM2_uc009zri.2... Hybrid_Cap... view
FMN2 p.QQQ1272del 20 46279815 46279823 NCIH2122_LUNG 37 In_Frame_Del Del GCAGC... - uc002xtk.2 NCOA3_uc010ght.... Hybrid_Cap...
FMN2 11 112832340 112832340 NCIH2122_LUNG 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
GLI1 p.176_177insQ 19 50881822 50881823 NCIH2122_LUNG 37 In_Frame_Ins Ins - CAG rs61751954;rs1052533 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
GPR112 p.D2657del X 135474445 135474447 NCIH2122_LUNG 37 In_Frame_Del Del GAT - rs3030295 uc004ezu.1 GPR112_uc010nsb... Hybrid_Cap...
GPR183 p.E234K 13 99947700 99947700 NCIH2122_LUNG 37 Missense_Mutation SNP C T uc001vog.2 UBAC2_uc001voa.... Hybrid_Cap... view
GRAMD1B p.E243fs 1 144923729 144923729 NCIH2122_LUNG 37 Frame_Shift_Del Del T - uc001elw.3 NBPF10_uc009wir... Hybrid_Cap...
GRIA3 X 122318386 122318387 NCIH2122_LUNG 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GRIN2A p.P679H 16 9916253 9916253 NCIH2122_LUNG 37 Missense_Mutation SNP G T uc002czo.3 GRIN2A_uc010uym... Hybrid_Cap... view
GUCY2C p.L1244fs 8 48805816 48805817 NCIH2122_LUNG 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
HEPH p.G705F X 65423232 65423233 NCIH2122_LUNG 37 Missense_Mutation DNP GG TT uc011moz.1 HEPH_uc004dwn.2... Hybrid_Cap...
HERC2 p.M1531K 15 28478375 28478375 NCIH2122_LUNG 37 Missense_Mutation SNP A T rs61755660 uc001zbj.2 Hybrid_Cap... view
HIF1A 17 58024224 58024225 NCIH2122_LUNG 37 3'UTR Ins - AA rs67846207 uc002ixy.2 RPS6KB1_uc010dd... Hybrid_Cap...
HIF1A 14 62213929 62213930 NCIH2122_LUNG 37 3'UTR Ins - T rs67890419 uc001xfs.2 HIF1A_uc001xfq.... Hybrid_Cap...
HNF1A 14 75373626 75373627 NCIH2122_LUNG 37 3'UTR Ins - TGAT uc001xqx.1 RPS6KL1_uc001xq... Hybrid_Cap...
HSP90AB1 p.R82C 6 44217210 44217210 NCIH2122_LUNG 37 Missense_Mutation SNP C T rs61753592 uc003oxa.1 HSP90AB1_uc011d... Hybrid_Cap... view
IL2RA 4 1739519 1739527 NCIH2122_LUNG 37 Intron Del GCCAT... - rs114226356 uc003gdo.2 TACC3_uc010ibz.... Hybrid_Cap...
ILK 11 6630029 6630029 NCIH2122_LUNG 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
ILK 4 48139307 48139310 NCIH2122_LUNG 37 3'UTR Del TTAT - rs79098351 uc003gxz.2 Hybrid_Cap...
INHBA 7 41729121 41729122 NCIH2122_LUNG 37 3'UTR Ins - T uc003thq.2 INHBA_uc003thr.... Hybrid_Cap...
INSRR 11 102269398 102269398 NCIH2122_LUNG 37 3'UTR Del G - uc001pha.2 TMEM123_uc009yx... Hybrid_Cap...
ITGB1 p.C176F 17 7578403 7578403 NCIH2122_LUNG 37 Missense_Mutation SNP C A uc002gim.2 TP53_uc002gig.1... Hybrid_Cap... view
ITPR2 p.Q16L 17 7579866 7579866 NCIH2122_LUNG 37 Missense_Mutation SNP T A uc002gim.2 TP53_uc002gig.1... Hybrid_Cap... view
ITPR2 p.R470_splice 12 26834804 26834805 NCIH2122_LUNG 37 Splice_Site_Ins Ins - ACTC rs66696203;rs59199365 uc001rhg.2 Hybrid_Cap...
KDM5A 1 114940215 114940216 NCIH2122_LUNG 37 3'UTR Ins - G rs68133208 uc001eew.2 TRIM33_uc010owr... Hybrid_Cap...
KLK7 19 51480672 51480675 NCIH2122_LUNG 37 3'UTR Del GGTT - uc002puo.2 KLK7_uc002pup.2... Hybrid_Cap...
KRAS p.G12C 12 25398285 25398285 NCIH2122_LUNG 37 Missense_Mutation SNP C A uc001rgp.1 KRAS_uc001rgq.1... Hybrid_Cap... view
KRAS 8 116635872 116635873 NCIH2122_LUNG 37 5'UTR Ins - A rs76893349 uc003yny.2 TRPS1_uc011lhy.... Hybrid_Cap...
LAMA1 18 6955644 6955644 NCIH2122_LUNG 37 Intron SNP C T uc002knm.2 LAMA1_uc002knk.... Hybrid_Cap... view
LRRK2 p.S419_splice 4 177605082 177605084 NCIH2122_LUNG 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
MAF 16 79628325 79628325 NCIH2122_LUNG 37 3'UTR Del A - uc002ffm.2 MAF_uc002ffn.2_... Hybrid_Cap...
MAML2 p.604_607QQQQ>Q 11 95825375 95825383 NCIH2122_LUNG 37 In_Frame_Del Del TGCTG... - rs113349418 uc001pfw.1 Hybrid_Cap...
MAML3 p.Q767_splice 4 140651585 140651587 NCIH2122_LUNG 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP2K1 15 66679649 66679650 NCIH2122_LUNG 37 5'UTR Ins - C rs67229745 uc010bhq.2 Hybrid_Cap...
MAP3K1 p.T949del 5 56177849 56177851 NCIH2122_LUNG 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAP3K9 p.R497Q 14 71209145 71209145 NCIH2122_LUNG 37 Missense_Mutation SNP C T rs56196343 uc001xml.2 MAP3K9_uc010ttk... Hybrid_Cap... view
MAPKBP1 p.E1411_splice 15 42116260 42116260 NCIH2122_LUNG 37 Splice_Site_SNP SNP G C uc001zok.3 MAPKBP1_uc001zo... Hybrid_Cap... view
NCAM1 11 112832307 112832308 NCIH2122_LUNG 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NLRP10 p.S287F 11 7982299 7982299 NCIH2122_LUNG 37 Missense_Mutation SNP G A uc001mfv.1 Hybrid_Cap... view
NPM1 5 170837734 170837734 NCIH2122_LUNG 37 3'UTR Del T - uc011dex.1 NPM1_uc003mbi.2... Hybrid_Cap...
NPR1 1 153665919 153665920 NCIH2122_LUNG 37 3'UTR Ins - C rs66682713 uc001fcs.3 NPR1_uc010pdz.1... Hybrid_Cap...
PARP1 p.G913fs 1 226551692 226551692 NCIH2122_LUNG 37 Frame_Shift_Del Del C - uc001hqd.3 Hybrid_Cap...
PAX3 2 223158653 223158653 NCIH2122_LUNG 37 Intron Del T - rs112753212 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PI4K2A p.V298M 10 99416701 99416701 NCIH2122_LUNG 37 Missense_Mutation SNP G A uc001kog.1 PI4K2A_uc010qoy... Hybrid_Cap... view
PIK3C2B p.N232del 1 204438235 204438237 NCIH2122_LUNG 37 In_Frame_Del Del ATT - uc001haw.2 PIK3C2B_uc010pq... Hybrid_Cap...
RAGE p.T367fs 14 102695876 102695877 NCIH2122_LUNG 37 Frame_Shift_Del Del GT - uc001ylm.2 RAGE_uc010txv.1... Hybrid_Cap...
REM1 20 30064232 30064233 NCIH2122_LUNG 37 5'UTR Ins - C uc002wwa.2 Hybrid_Cap...
RGL3 p.G18S 19 11529442 11529442 NCIH2122_LUNG 37 Missense_Mutation SNP C T uc002mro.2 RGL3_uc002mrn.2... Hybrid_Cap... view
SCD 10 102120756 102120756 NCIH2122_LUNG 37 3'UTR SNP A G uc001kqy.2 Hybrid_Cap... view
STAG3 p.F660L 7 99798511 99798511 NCIH2122_LUNG 37 Missense_Mutation SNP C A uc003utx.1 STAG3_uc010lgs.... Hybrid_Cap... view
STK11 p.G279fs 19 1221314 1221314 NCIH2122_LUNG 37 Frame_Shift_Del Del C - uc002lrl.1 Hybrid_Cap...
STK31 7 23872024 23872025 NCIH2122_LUNG 37 3'UTR Ins - TTTG rs66787534 uc003sws.3 STK31_uc003swt.... Hybrid_Cap...
TP63 3 189507518 189507519 NCIH2122_LUNG 37 Intron Ins - AGAG rs62702062;rs79714037 uc003fry.2 TP63_uc003frx.2... Hybrid_Cap...
TRIP13 p.L239F 5 908147 908147 NCIH2122_LUNG 37 Missense_Mutation SNP G T uc003jbr.2 TRIP13_uc010ite... Hybrid_Cap... view
TSC1 p.T1047I 9 135771977 135771977 NCIH2122_LUNG 37 Missense_Mutation SNP G A uc004cca.2 TSC1_uc004ccb.3... Hybrid_Cap... view
TSC2 16 2138671 2138672 NCIH2122_LUNG 37 3'UTR Del AA - uc002con.2 TSC2_uc010bsd.2... Hybrid_Cap...
TTBK1 p.E771del 6 43250726 43250728 NCIH2122_LUNG 37 In_Frame_Del Del GAA - uc003ouq.1 Hybrid_Cap...
TTN p.H7126N 2 179582493 179582493 NCIH2122_LUNG 37 Missense_Mutation SNP G T uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
USP6 17 5076345 5076345 NCIH2122_LUNG 37 3'UTR SNP G C uc002gau.1 USP6_uc002gav.1... Hybrid_Cap... view
VEGFA 6 43746423 43746423 NCIH2122_LUNG 37 Intron SNP A G rs3025048 uc003owh.2 VEGFA_uc003owc.... Hybrid_Cap... view
ZAP70 2 98351655 98351655 NCIH2122_LUNG 37 Intron Del G - uc002syd.1 ZAP70_uc010yvf.... Hybrid_Cap...
ZNF331 p.K222T 19 54080479 54080479 NCIH2122_LUNG 37 Missense_Mutation SNP A C uc002qbx.1 ZNF331_uc002qby... Hybrid_Cap... view