Annotation Summary for Cell Line: NCI-H2170  

Cell line primary name: NCI-H2170
Cell line aliases: H2170
Gender: M
Site Primary: lung
Histology: carcinoma
Hist Subtype1: squamous_cell_carcinoma
Notes:
Source: ATCC
Expression arrays: PARES_p_NCLE_RNA_Redo_HG-U133_Plus_2_D09_257686
SNP arrays: ARLES_p_NCLE_DNAAffy2_S_GenomeWideSNP_6_G02_256148
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in NCI-H2170

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
ABCA3 p.N124S 16 2374481 2374481 NCIH2170_LUNG 37 Missense_Mutation SNP T C uc002cpy.1 ABCA3_uc010bsk.... Hybrid_Cap... view
ACACA 17 35766564 35766564 NCIH2170_LUNG 37 5'UTR Del A - uc002hno.2 ACACA_uc002hnn.... Hybrid_Cap...
ACACB p.R1818W 12 109684134 109684134 NCIH2170_LUNG 37 Missense_Mutation SNP C T uc001tob.2 ACACB_uc001toc.... Hybrid_Cap... view
ADAM28 8 24211994 24211997 NCIH2170_LUNG 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
AFF3 p.A760S 2 100209920 100209920 NCIH2170_LUNG 37 Missense_Mutation SNP C A uc002taf.2 AFF3_uc002tag.2... Hybrid_Cap... view
AKAP12 p.1531_1532insE 6 151674116 151674117 NCIH2170_LUNG 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
ALPK2 p.EDTST1006del 18 56204388 56204402 NCIH2170_LUNG 37 In_Frame_Del Del CAGTT... - rs60644017;rs117623369 uc002lhj.3 ALPK2_uc002lhk.... Hybrid_Cap...
ALPK2 p.D361H 18 56246927 56246927 NCIH2170_LUNG 37 Missense_Mutation SNP C G uc002lhj.3 Hybrid_Cap... view
ATR p.R2190C 3 142186895 142186895 NCIH2170_LUNG 37 Missense_Mutation SNP G A uc003eux.3 ATR_uc003euy.1_... Hybrid_Cap... view
AURKC 19 57742494 57742507 NCIH2170_LUNG 37 5'UTR Del GGACG... - rs67926438;rs112039303;rs59094959 uc002qoe.2 AURKC_uc002qoc.... Hybrid_Cap...
BMF p.C139* 15 40396417 40396417 NCIH2170_LUNG 37 Nonsense_Mutation SNP G T uc001zkv.2 BMF_uc001zkt.2_... Hybrid_Cap... view
BRDT p.P448H 1 92446243 92446243 NCIH2170_LUNG 37 Missense_Mutation SNP C A uc010osz.1 BRDT_uc001dok.3... Hybrid_Cap... view
CACNB2 10 18828721 18828722 NCIH2170_LUNG 37 3'UTR Ins - AA rs3841459 uc001ipr.2 CACNB2_uc009xjz... Hybrid_Cap...
CASP9 1 15819626 15819626 NCIH2170_LUNG 37 Intron SNP A T uc001awn.2 CASP9_uc001awm.... Hybrid_Cap... view
CD160 1 145698809 145698809 NCIH2170_LUNG 37 Intron SNP C G uc001eol.1 NBPF10_uc001emp... Hybrid_Cap... view
CHD1 p.P1684del 5 98192165 98192167 NCIH2170_LUNG 37 In_Frame_Del Del AGG - rs79267787;rs61749618 uc003knf.2 CHD1_uc010jbn.2... Hybrid_Cap...
CHD8 14 21853630 21853630 NCIH2170_LUNG 37 3'UTR Del T - rs78520772 uc001was.1 CHD8_uc001war.1... Hybrid_Cap...
CHD9 p.R1988P 16 53337881 53337881 NCIH2170_LUNG 37 Missense_Mutation SNP G C uc002ehb.2 CHD9_uc002egy.2... Hybrid_Cap... view
CLTCL1 p.V1201_splice 22 19189003 19189004 NCIH2170_LUNG 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
CREB3L2 p.T100del 7 137612914 137612916 NCIH2170_LUNG 37 In_Frame_Del Del TGG - uc003vtw.2 CREB3L2_uc003vt... Hybrid_Cap...
CSMD3 p.T3012A 8 113301708 113301708 NCIH2170_LUNG 37 Missense_Mutation SNP T C uc003ynu.2 CSMD3_uc003yns.... Hybrid_Cap... view
CXCL12 10 44873992 44873993 NCIH2170_LUNG 37 Intron Ins - CT rs117617571 uc001jbh.2 CXCL12_uc001jbf... Hybrid_Cap...
DNAH8 p.K13N 6 38702329 38702329 NCIH2170_LUNG 37 Missense_Mutation SNP A T uc003ooe.1 DNAH8_uc003ood.... Hybrid_Cap... view
DNAH8 p.H478D 6 38747785 38747785 NCIH2170_LUNG 37 Missense_Mutation SNP C G uc003ooe.1 Hybrid_Cap... view
DPYD p.G224V 1 98164916 98164916 NCIH2170_LUNG 37 Missense_Mutation SNP C A uc001drv.2 DPYD_uc010oub.1... Hybrid_Cap... view
ECM1 1 150485989 150485989 NCIH2170_LUNG 37 3'UTR SNP G T uc001euu.2 ECM1_uc001eus.2... Hybrid_Cap... view
EIF4E 4 99808137 99808141 NCIH2170_LUNG 37 Intron Del TTAAA - uc011ceb.1 EIF4E_uc011cea.... Hybrid_Cap...
EP300 p.N1286S 22 41562653 41562653 NCIH2170_LUNG 37 Missense_Mutation SNP A G uc003azl.3 Hybrid_Cap... view
EP300 22 41574970 41574972 NCIH2170_LUNG 37 3'UTR Del GTA - rs76489032 uc003azl.3 Hybrid_Cap...
EPHA5 p.E279* 4 66467434 66467434 NCIH2170_LUNG 37 Nonsense_Mutation SNP C A uc011cah.1 EPHA5_uc003hcx.... Hybrid_Cap... view
EPHA6 3 97367230 97367231 NCIH2170_LUNG 37 Intron Ins - A rs115253553 uc010how.1 EPHA6_uc003drs.... Hybrid_Cap...
ETV1 7 14028708 14028708 NCIH2170_LUNG 37 5'UTR Del A - rs77190713 uc011jxq.1 ETV1_uc011jxn.1... Hybrid_Cap...
FBN2 p.N1218K 5 127671750 127671750 NCIH2170_LUNG 37 Missense_Mutation SNP G T uc003kuu.2 FBN2_uc003kuv.2... Hybrid_Cap... view
FGFR1OP 6 167453519 167453520 NCIH2170_LUNG 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
FGFR3 4 1809128 1809129 NCIH2170_LUNG 37 3'UTR Del GT - uc003gdu.2 FGFR3_uc003gdr.... Hybrid_Cap...
FMN2 p.PPPPLPGAAIP948del 1 240370942 240370974 NCIH2170_LUNG 37 In_Frame_Del Del CCTCC... - rs72444563 uc010pye.1 FMN2_uc010pyd.1... Hybrid_Cap...
FN1 2 216244182 216244185 NCIH2170_LUNG 37 Intron Del GTAC - uc002vfa.2 FN1_uc002vfb.2_... Hybrid_Cap...
GRIA3 X 122318386 122318387 NCIH2170_LUNG 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GRIN2B p.L1201M 12 13716571 13716571 NCIH2170_LUNG 37 Missense_Mutation SNP G T uc001rbt.2 Hybrid_Cap... view
GUCY2C 12 14827464 14827466 NCIH2170_LUNG 37 Intron Del ATC - rs72525754;rs3083879 uc001rcd.2 GUCY2C_uc009zhz... Hybrid_Cap...
HERC2 p.T4029I 15 28380768 28380768 NCIH2170_LUNG 37 Missense_Mutation SNP G A uc001zbj.2 Hybrid_Cap... view
HLF p.S118S 17 53345350 53345350 NCIH2170_LUNG 37 Silent SNP G A uc002iug.1 HLF_uc010dce.1_... Hybrid_Cap... view
HNF1A 12 121434630 121434631 NCIH2170_LUNG 37 Intron Ins - TCATTCAT rs75100977 uc010szn.1 HNF1A_uc001tze.... Hybrid_Cap...
HSPA1A p.K569V 6 31785238 31785239 NCIH2170_LUNG 37 Missense_Mutation DNP AA GT uc003nxj.2 HSPA1L_uc003nxh... Hybrid_Cap...
IRF4 6 397101 397101 NCIH2170_LUNG 37 Intron SNP C A uc003msz.3 IRF4_uc010jne.1... Hybrid_Cap... view
ITPR2 p.R470_splice 12 26834804 26834805 NCIH2170_LUNG 37 Splice_Site_Ins Ins - ACTC rs66696203;rs59199365 uc001rhg.2 Hybrid_Cap...
KIAA0802 p.R561W 18 8784791 8784791 NCIH2170_LUNG 37 Missense_Mutation SNP C T uc002knr.2 KIAA0802_uc002k... Hybrid_Cap... view
KLK7 19 51480672 51480675 NCIH2170_LUNG 37 3'UTR Del GGTT - uc002puo.2 KLK7_uc002pup.2... Hybrid_Cap...
KSR2 p.V742L 12 117923405 117923405 NCIH2170_LUNG 37 Missense_Mutation SNP C A uc001two.2 Hybrid_Cap... view
MAF 16 79628537 79628537 NCIH2170_LUNG 37 Intron Del T - uc002ffm.2 MAF_uc002ffn.2_... Hybrid_Cap...
MAF 16 79628325 79628325 NCIH2170_LUNG 37 3'UTR Del A - uc002ffm.2 MAF_uc002ffn.2_... Hybrid_Cap...
MAML3 p.Q767_splice 4 140651585 140651587 NCIH2170_LUNG 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP3K1 p.T949del 5 56177849 56177851 NCIH2170_LUNG 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAP3K14 p.R218_splice 17 43364293 43364294 NCIH2170_LUNG 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
MAPKAPK3 3 50685575 50685575 NCIH2170_LUNG 37 3'UTR Del A - rs76026164 uc003day.1 MAPKAPK3_uc003d... Hybrid_Cap...
MARK3 p.S734L 14 103969503 103969503 NCIH2170_LUNG 37 Missense_Mutation SNP C T uc001ymz.3 MARK3_uc001ymx.... Hybrid_Cap... view
MCF2 p.I76L X 138727732 138727732 NCIH2170_LUNG 37 Missense_Mutation SNP T G uc011mwo.1 MCF2_uc004fau.2... Hybrid_Cap... view
MGA p.E1642K 15 42035082 42035082 NCIH2170_LUNG 37 Missense_Mutation SNP G A uc010ucy.1 MGA_uc010ucz.1_... Hybrid_Cap... view
MN1 p.544_546QQQ>Q 22 28194895 28194900 NCIH2170_LUNG 37 In_Frame_Del Del TGCTG... - rs75719175 uc003adj.2 Hybrid_Cap...
MYT1 p.E291E 20 62839422 62839422 NCIH2170_LUNG 37 Silent SNP A G uc002yii.2 MYT1_uc002yih.2... Hybrid_Cap... view
NCAM1 11 112832307 112832308 NCIH2170_LUNG 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 NCIH2170_LUNG 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAPD3 p.L1349P 11 134027951 134027951 NCIH2170_LUNG 37 Missense_Mutation SNP A G uc001qhd.1 NCAPD3_uc010scm... Hybrid_Cap... view
NCOA3 p.QQQ1272del 20 46279815 46279823 NCIH2170_LUNG 37 In_Frame_Del Del GCAGC... - uc002xtk.2 NCOA3_uc010ght.... Hybrid_Cap...
NEK1 4 170523831 170523831 NCIH2170_LUNG 37 Splice_Site_SNP SNP T A uc003isd.1 NEK1_uc003isb.1... Hybrid_Cap... view
NEK3 p.K313_splice 13 52718050 52718051 NCIH2170_LUNG 37 Splice_Site_Ins Ins - T rs72514762 uc001vgh.2 NEK3_uc001vgg.2... Hybrid_Cap...
NPM1 5 170837734 170837734 NCIH2170_LUNG 37 3'UTR Del T - uc011dex.1 NPM1_uc003mbi.2... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881820 50881821 NCIH2170_LUNG 37 In_Frame_Ins Ins - AAC rs66783852;rs112359270 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881822 50881823 NCIH2170_LUNG 37 In_Frame_Ins Ins - CAG rs61751954;rs1052533 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
NR3C1 5 142780419 142780419 NCIH2170_LUNG 37 Splice_Site_SNP SNP T A uc003lmy.2 NR3C1_uc003lmz.... Hybrid_Cap... view
PAX3 2 223158653 223158653 NCIH2170_LUNG 37 Intron Del T - rs112753212 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PDE4DIP 1 144994874 144994874 NCIH2170_LUNG 37 5'UTR SNP C T uc001elw.3 NBPF10_uc009wir... Hybrid_Cap... view
PDZRN4 12 41831799 41831799 NCIH2170_LUNG 37 Intron SNP T A uc010skn.1 PDZRN4_uc001rmq... Hybrid_Cap... view
PDZRN4 p.R439L 12 41966494 41966494 NCIH2170_LUNG 37 Missense_Mutation SNP G T uc010skn.1 PDZRN4_uc001rmq... Hybrid_Cap... view
PIK3CG p.H693Q 7 106513175 106513175 NCIH2170_LUNG 37 Missense_Mutation SNP C G uc003vdv.3 PIK3CG_uc003vdu... Hybrid_Cap... view
POLG 15 89859569 89859569 NCIH2170_LUNG 37 3'UTR SNP A T uc002bns.3 FANCI_uc010bnp.... Hybrid_Cap... view
PPP3R1 p.F15_splice 2 68415824 68415824 NCIH2170_LUNG 37 Splice_Site_SNP SNP T A uc002sei.1 Hybrid_Cap... view
PRKDC p.L1244fs 8 48805816 48805817 NCIH2170_LUNG 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
RAPGEF2 4 160189224 160189224 NCIH2170_LUNG 37 5'UTR SNP A T uc003iqg.3 Hybrid_Cap... view
RECQL4 p.R766fs 8 145738768 145738768 NCIH2170_LUNG 37 Frame_Shift_Del Del G - uc003zdj.2 Hybrid_Cap...
RHOA p.S26N 3 49412946 49412946 NCIH2170_LUNG 37 Missense_Mutation SNP C T uc003cwu.2 RHOA_uc010hku.2... Hybrid_Cap... view
ROR2 p.S907R 9 94486055 94486055 NCIH2170_LUNG 37 Missense_Mutation SNP G C uc004arj.1 ROR2_uc004ari.1... Hybrid_Cap... view
ROR2 p.V593M 9 94486999 94486999 NCIH2170_LUNG 37 Missense_Mutation SNP C T uc004arj.1 ROR2_uc004ari.1... Hybrid_Cap... view
RPS6KL1 14 75373623 75373623 NCIH2170_LUNG 37 3'UTR SNP C T uc001xqx.1 RPS6KL1_uc001xq... Hybrid_Cap... view
SGK196 8 42978200 42978201 NCIH2170_LUNG 37 3'UTR Ins - T uc003xpw.2 Hybrid_Cap...
SIK3 p.Q461E 11 116744645 116744645 NCIH2170_LUNG 37 Missense_Mutation SNP G C uc001ppy.2 SIK3_uc001ppz.2... Hybrid_Cap... view
SLC6A8 X 152957656 152957657 NCIH2170_LUNG 37 Intron Ins - A uc004fib.3 SLC6A8_uc004fic... Hybrid_Cap...
SRPK1 p.D58H 6 35858693 35858693 NCIH2170_LUNG 37 Missense_Mutation SNP C G uc003olj.2 SRPK1_uc011dtg.... Hybrid_Cap... view
STK25 2 242435659 242435662 NCIH2170_LUNG 37 Intron Del AAGG - rs3215138;rs75497042 uc002wbm.2 STK25_uc002wbk.... Hybrid_Cap...
STK31 7 23872024 23872025 NCIH2170_LUNG 37 3'UTR Ins - TTTG rs66787534 uc003sws.3 STK31_uc003swt.... Hybrid_Cap...
TACC3 4 1739519 1739527 NCIH2170_LUNG 37 Intron Del GCCAT... - rs114226356 uc003gdo.2 TACC3_uc010ibz.... Hybrid_Cap...
TERT 5 1282819 1282819 NCIH2170_LUNG 37 Intron SNP G T uc003jcb.1 TERT_uc003jbz.1... Hybrid_Cap... view
TFEB p.55_55Q>QQ 6 41658829 41658830 NCIH2170_LUNG 37 In_Frame_Ins Ins - TGC uc003oqu.1 TFEB_uc003oqs.1... Hybrid_Cap...
TLE1 9 84202844 84202845 NCIH2170_LUNG 37 Intron Ins - CATCCC uc004alz.2 TLE1_uc004aly.2... Hybrid_Cap...
TLK1 2 171850178 171850179 NCIH2170_LUNG 37 3'UTR Ins - AA rs71008739 uc002ugo.2 TLK1_uc002ugn.2... Hybrid_Cap...
TMEM123 11 102269398 102269398 NCIH2170_LUNG 37 3'UTR Del G - uc001pha.2 TMEM123_uc009yx... Hybrid_Cap...
TNIK p.S1021L 3 170802051 170802051 NCIH2170_LUNG 37 Missense_Mutation SNP G A uc003fhh.2 TNIK_uc003fhi.2... Hybrid_Cap... view
TP53 p.R158G 17 7578458 7578458 NCIH2170_LUNG 37 Missense_Mutation SNP G C uc002gim.2 TP53_uc002gig.1... Hybrid_Cap... view
TP63 3 189507518 189507519 NCIH2170_LUNG 37 Intron Ins - AGAG rs62702062;rs79714037 uc003fry.2 TP63_uc003frx.2... Hybrid_Cap...
TPM3 1 154140301 154140301 NCIH2170_LUNG 37 3'UTR SNP T C uc001fec.1 TPM3_uc001fdx.1... Hybrid_Cap... view
TRIM28 p.H386Q 19 59059717 59059717 NCIH2170_LUNG 37 Missense_Mutation SNP T G uc002qtg.1 TRIM28_uc010eut... Hybrid_Cap... view
TRPS1 8 116635872 116635873 NCIH2170_LUNG 37 5'UTR Ins - A rs76893349 uc003yny.2 TRPS1_uc011lhy.... Hybrid_Cap...
TTN 2 179391639 179391640 NCIH2170_LUNG 37 3'UTR Ins - T rs36037175 uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap...
TTN p.L30686F 2 179402174 179402174 NCIH2170_LUNG 37 Missense_Mutation SNP G A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.R28674H 2 179412628 179412628 NCIH2170_LUNG 37 Missense_Mutation SNP C T uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.T16275S 2 179463993 179463993 NCIH2170_LUNG 37 Missense_Mutation SNP T A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.R13204L 2 179482763 179482763 NCIH2170_LUNG 37 Missense_Mutation SNP C A rs72677233 uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
ULK4 3 41288395 41288395 NCIH2170_LUNG 37 3'UTR SNP G A uc003ckv.3 ULK4_uc003cku.3... Hybrid_Cap... view
VEGFC p.S419_splice 4 177605082 177605084 NCIH2170_LUNG 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
WNK3 p.H1679R X 54228461 54228461 NCIH2170_LUNG 37 Missense_Mutation SNP T C uc004dtc.1 WNK3_uc004dtd.1... Hybrid_Cap... view
ZBTB16 11 114121371 114121371 NCIH2170_LUNG 37 3'UTR SNP G A uc001pop.2 ZBTB16_uc001poq... Hybrid_Cap... view