Annotation Summary for Cell Line: NCI-H2196  

Cell line primary name: NCI-H2196
Cell line aliases: H2196
Gender: M
Site Primary: lung
Histology: carcinoma
Hist Subtype1: small_cell_carcinoma
Notes:
Source: ATCC
Expression arrays: PARES_p_NCLE_RNA_Redo_HG-U133_Plus_2_A10_257616
SNP arrays: HONEY_p_NCLE_DNAAffy3_S_GenomeWideSNP_6_F08_293414
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in NCI-H2196

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
AAK1 p.541_542QQ>Q 2 69741754 69741756 NCIH2196_LUNG 37 In_Frame_Del Del TGT - rs55712143 uc002sfp.2 AAK1_uc010fdk.2... Hybrid_Cap...
ACVR1B p.E483D 12 52385711 52385711 NCIH2196_LUNG 37 Missense_Mutation SNP A C uc010snn.1 ACVR1B_uc001rzm... Hybrid_Cap... view
ADAM17 2 9630245 9630245 NCIH2196_LUNG 37 3'UTR Del T - uc002qzu.2 IAH1_uc010yiz.1... Hybrid_Cap...
ADAM28 8 24211994 24211997 NCIH2196_LUNG 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
ADRBK2 p.M357I 22 26091092 26091092 NCIH2196_LUNG 37 Missense_Mutation SNP G T uc003abx.3 ADRBK2_uc010gux... Hybrid_Cap... view
AKAP12 p.1531_1532insE 6 151674116 151674117 NCIH2196_LUNG 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
ALS2 2 202587706 202587707 NCIH2196_LUNG 37 Intron Ins - A rs3219165 uc002uyo.2 ALS2_uc002uyp.3... Hybrid_Cap...
ALS2 2 202633670 202633670 NCIH2196_LUNG 37 Splice_Site_SNP SNP T C uc002uyo.2 ALS2_uc002uyp.3... Hybrid_Cap... view
AURKC 19 57742494 57742507 NCIH2196_LUNG 37 5'UTR Del GGACG... - rs67926438;rs112039303;rs59094959 uc002qoe.2 AURKC_uc002qoc.... Hybrid_Cap...
BAI3 p.W441L 6 69666042 69666042 NCIH2196_LUNG 37 Missense_Mutation SNP G T uc003pev.3 BAI3_uc010kak.2... Hybrid_Cap... view
BCR 22 23631813 23631814 NCIH2196_LUNG 37 Intron Ins - C rs66503844 uc002zww.2 BCR_uc002zwx.2_... Hybrid_Cap...
BCR 22 23632777 23632778 NCIH2196_LUNG 37 Intron Ins - T uc002zww.2 BCR_uc002zwx.2_... Hybrid_Cap...
BIRC2 11 102220484 102220484 NCIH2196_LUNG 37 5'UTR SNP A G uc001pgy.2 BIRC2_uc010ruq.... Hybrid_Cap... view
CACNB2 10 18828721 18828722 NCIH2196_LUNG 37 3'UTR Ins - AA rs3841459 uc001ipr.2 CACNB2_uc009xjz... Hybrid_Cap...
CCR5 p.E172A 3 46414908 46414908 NCIH2196_LUNG 37 Missense_Mutation SNP A C uc003cpo.3 CCR5_uc010hjd.2... Hybrid_Cap... view
CDC25A p.G75C 3 48228217 48228217 NCIH2196_LUNG 37 Missense_Mutation SNP C A uc003csh.1 CDC25A_uc003csi... Hybrid_Cap... view
CDK11B p.K127_splice 1 1647893 1647894 NCIH2196_LUNG 37 Splice_Site_Ins Ins - TTTCTT rs114930018 uc001agv.1 CDK11B_uc001ags... Hybrid_Cap...
CDK11B 1 1654066 1654068 NCIH2196_LUNG 37 Intron Del GCG - uc001agv.1 CDK11B_uc001aha... Hybrid_Cap...
CDK12 p.P564A 17 37627775 37627775 NCIH2196_LUNG 37 Missense_Mutation SNP C G uc010cvv.2 CDK12_uc010wef.... Hybrid_Cap... view
CHD1 5 98208016 98208017 NCIH2196_LUNG 37 Intron Ins - T uc003knf.2 CHD1_uc010jbn.2... Hybrid_Cap...
CHD1 p.E669G 5 98228403 98228403 NCIH2196_LUNG 37 Missense_Mutation SNP T C rs61759467 uc003knf.2 Hybrid_Cap... view
CLTCL1 p.V1201_splice 22 19189003 19189004 NCIH2196_LUNG 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
CTBP2 p.K974fs 10 126678123 126678123 NCIH2196_LUNG 37 Frame_Shift_Del Del T - uc001lie.3 CTBP2_uc009yak.... Hybrid_Cap...
DAPK1 p.P732A 9 90296511 90296511 NCIH2196_LUNG 37 Missense_Mutation SNP C G uc004apc.2 DAPK1_uc004apd.... Hybrid_Cap... view
DGKB p.T163M 7 14741334 14741334 NCIH2196_LUNG 37 Missense_Mutation SNP G A uc003ssz.2 DGKB_uc011jxt.1... Hybrid_Cap... view
EIF4E 4 99808137 99808141 NCIH2196_LUNG 37 Intron Del TTAAA - uc011ceb.1 EIF4E_uc011cea.... Hybrid_Cap...
EP300 p.P2097A 22 41574004 41574004 NCIH2196_LUNG 37 Missense_Mutation SNP C G uc003azl.3 Hybrid_Cap... view
EP300 22 41574970 41574972 NCIH2196_LUNG 37 3'UTR Del GTA - rs76489032 uc003azl.3 Hybrid_Cap...
EPHA8 p.D873N 1 22927469 22927469 NCIH2196_LUNG 37 Missense_Mutation SNP G A uc001bfx.1 Hybrid_Cap... view
ETV1 7 14028708 14028708 NCIH2196_LUNG 37 5'UTR Del A - rs77190713 uc011jxq.1 ETV1_uc011jxn.1... Hybrid_Cap...
FGFR1OP 6 167453519 167453520 NCIH2196_LUNG 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
FLI1 11 128638217 128638217 NCIH2196_LUNG 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FN1 2 216244182 216244185 NCIH2196_LUNG 37 Intron Del GTAC - uc002vfa.2 FN1_uc002vfb.2_... Hybrid_Cap...
GPR112 p.D2657del X 135474445 135474447 NCIH2196_LUNG 37 In_Frame_Del Del GAT - rs3030295 uc004ezu.1 GPR112_uc010nsb... Hybrid_Cap...
GRIA3 X 122318386 122318387 NCIH2196_LUNG 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GUCY2C 12 14827464 14827466 NCIH2196_LUNG 37 Intron Del ATC - rs72525754;rs3083879 uc001rcd.2 GUCY2C_uc009zhz... Hybrid_Cap...
HIF1A 14 62213929 62213930 NCIH2196_LUNG 37 3'UTR Ins - T rs67890419 uc001xfs.2 HIF1A_uc001xfq.... Hybrid_Cap...
HNF1A 12 121434630 121434631 NCIH2196_LUNG 37 Intron Ins - TCATTCAT rs75100977 uc010szn.1 HNF1A_uc001tze.... Hybrid_Cap...
HOXD13 2 176959527 176959527 NCIH2196_LUNG 37 3'UTR SNP T A uc002ukf.1 Hybrid_Cap... view
ILK 11 6630029 6630029 NCIH2196_LUNG 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
ITGB8 7 20371644 20371644 NCIH2196_LUNG 37 Intron SNP C T uc003suu.2 ITGB8_uc011jyh.... Hybrid_Cap... view
ITPR2 p.G1053V 12 26775303 26775303 NCIH2196_LUNG 37 Missense_Mutation SNP C A uc001rhg.2 Hybrid_Cap... view
KIAA1549 p.P536L 7 138602765 138602765 NCIH2196_LUNG 37 Missense_Mutation SNP G A uc011kql.1 KIAA1549_uc003v... Hybrid_Cap... view
LPP 3 188426339 188426339 NCIH2196_LUNG 37 Intron SNP G A uc003frs.1 LPP_uc011bsg.1_... Hybrid_Cap... view
MAML2 p.604_607QQQQ>Q 11 95825375 95825383 NCIH2196_LUNG 37 In_Frame_Del Del TGCTG... - rs113349418 uc001pfw.1 Hybrid_Cap...
MAML3 p.Q767_splice 4 140651585 140651587 NCIH2196_LUNG 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP3K1 p.T949del 5 56177849 56177851 NCIH2196_LUNG 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAP3K14 p.R218_splice 17 43364293 43364294 NCIH2196_LUNG 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
MAP3K4 p.A1199del 6 161519351 161519353 NCIH2196_LUNG 37 In_Frame_Del Del CTG - uc003qtn.2 MAP3K4_uc010kkc... Hybrid_Cap...
MAPK14 6 36076345 36076354 NCIH2196_LUNG 37 3'UTR Del GTGTG... - rs80147786 uc003olp.2 MAPK14_uc003olq... Hybrid_Cap...
MAPKAPK3 3 50685575 50685575 NCIH2196_LUNG 37 3'UTR Del A - rs76026164 uc003day.1 MAPKAPK3_uc003d... Hybrid_Cap...
MBIP p.V51M 14 36785997 36785997 NCIH2196_LUNG 37 Missense_Mutation SNP C T uc001wtm.2 MBIP_uc001wto.2... Hybrid_Cap... view
MCM3APAS 21 47671275 47671276 NCIH2196_LUNG 37 3'UTR Ins - AAT rs67797185 uc002zin.2 MCM3APAS_uc002z... Hybrid_Cap...
MLLT3 9 20346377 20346378 NCIH2196_LUNG 37 3'UTR Ins - A rs66943046 uc003zoe.2 MLLT3_uc011lne.... Hybrid_Cap...
MN1 p.544_546QQQ>Q 22 28194895 28194900 NCIH2196_LUNG 37 In_Frame_Del Del TGCTG... - rs75719175 uc003adj.2 Hybrid_Cap...
NCAM1 11 112832307 112832308 NCIH2196_LUNG 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 NCIH2196_LUNG 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCOA3 p.Q1276del 20 46279837 46279839 NCIH2196_LUNG 37 In_Frame_Del Del CAG - rs2664555 uc002xtk.2 NCOA3_uc010ght.... Hybrid_Cap...
NCOA3 20 46282339 46282340 NCIH2196_LUNG 37 3'UTR Ins - AT uc002xtk.2 NCOA3_uc002xtl.... Hybrid_Cap...
NEK3 p.K313_splice 13 52718050 52718051 NCIH2196_LUNG 37 Splice_Site_Ins Ins - T rs72514762 uc001vgh.2 NEK3_uc001vgg.2... Hybrid_Cap...
NFIA 1 61921185 61921186 NCIH2196_LUNG 37 3'UTR Ins - T rs57270124;rs76131997 uc010oos.1 NFIA_uc001czy.2... Hybrid_Cap...
NPM1 5 170837734 170837734 NCIH2196_LUNG 37 3'UTR Del T - uc011dex.1 NPM1_uc003mbi.2... Hybrid_Cap...
NPR1 1 153665919 153665920 NCIH2196_LUNG 37 3'UTR Ins - C rs66682713 uc001fcs.3 NPR1_uc010pdz.1... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881822 50881823 NCIH2196_LUNG 37 In_Frame_Ins Ins - CAG rs61751954;rs1052533 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
PAPPA p.C1011F 9 119065114 119065114 NCIH2196_LUNG 37 Missense_Mutation SNP G T uc004bjn.2 PAPPA_uc011lxp.... Hybrid_Cap... view
PAX3 2 223158653 223158653 NCIH2196_LUNG 37 Intron Del T - rs112753212 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PCM1 8 17813218 17813218 NCIH2196_LUNG 37 Intron Del T - uc003wyi.3 PCM1_uc011kyh.1... Hybrid_Cap...
PDE4DIP 1 144892186 144892186 NCIH2196_LUNG 37 Intron SNP C T uc001elw.3 NBPF10_uc009wir... Hybrid_Cap... view
PDGFRA 4 55131002 55131002 NCIH2196_LUNG 37 Intron Del A - uc003han.3 PDGFRA_uc003haa... Hybrid_Cap...
PHIP 6 79650266 79650268 NCIH2196_LUNG 37 3'UTR Del TTT - rs13191571;rs74510728;rs77841178 uc003pir.2 PHIP_uc003piq.2... Hybrid_Cap...
PIK3C2G p.P129del 12 18435399 18435401 NCIH2196_LUNG 37 In_Frame_Del Del CCC - uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PIK3C2G 12 18801112 18801115 NCIH2196_LUNG 37 3'UTR Del TTGT - rs35889592 uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PKDCC p.G466V 2 42284743 42284743 NCIH2196_LUNG 37 Missense_Mutation SNP G T uc002rsg.2 Hybrid_Cap... view
PMS1 2 190670507 190670507 NCIH2196_LUNG 37 Intron SNP A G uc002urh.3 PMS1_uc010zga.1... Hybrid_Cap... view
PMS1 2 190670539 190670540 NCIH2196_LUNG 37 Intron Ins - A rs3214425 uc002urh.3 PMS1_uc010zga.1... Hybrid_Cap...
PMS2 p.G779R 7 6017329 6017329 NCIH2196_LUNG 37 Missense_Mutation SNP C T uc003spl.2 PMS2_uc003spj.2... Hybrid_Cap... view
PRKDC p.L1244fs 8 48805816 48805817 NCIH2196_LUNG 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
PRPF4B p.S422N 6 4037657 4037657 NCIH2196_LUNG 37 Missense_Mutation SNP G A uc003mvv.2 PRPF4B_uc003mvw... Hybrid_Cap... view
PTCH1 p.P252R 9 98242862 98242862 NCIH2196_LUNG 37 Missense_Mutation SNP G C uc004avk.3 PTCH1_uc010mro.... Hybrid_Cap... view
PTPRT p.R1343L 20 40714369 40714369 NCIH2196_LUNG 37 Missense_Mutation SNP C A uc010ggj.2 PTPRT_uc002xkg.... Hybrid_Cap... view
RB1 p.T738_splice 13 49039128 49039134 NCIH2196_LUNG 37 Splice_Site_Del Del CCTCA... - uc001vcb.2 Hybrid_Cap...
RBBP8 18 20516758 20516758 NCIH2196_LUNG 37 5'UTR SNP T C uc002kua.2 RBBP8_uc002ktw.... Hybrid_Cap... view
RECQL4 p.R766fs 8 145738768 145738768 NCIH2196_LUNG 37 Frame_Shift_Del Del G - uc003zdj.2 Hybrid_Cap...
RPS6KL1 14 75373626 75373627 NCIH2196_LUNG 37 3'UTR Ins - TGAT uc001xqx.1 RPS6KL1_uc001xq... Hybrid_Cap...
STRADA 17 61781331 61781332 NCIH2196_LUNG 37 Intron Ins - AGAACC rs66701913 uc002jbm.2 STRADA_uc002jbn... Hybrid_Cap...
TCL6 14 96135014 96135014 NCIH2196_LUNG 37 Intron SNP T C uc001yeq.2 TCL6_uc001yep.1... Hybrid_Cap... view
TEC 4 48139307 48139310 NCIH2196_LUNG 37 3'UTR Del TTAT - rs79098351 uc003gxz.2 Hybrid_Cap...
TFR2 p.E222D 7 100230912 100230912 NCIH2196_LUNG 37 Missense_Mutation SNP C G uc003uvv.1 TFR2_uc010lhc.1... Hybrid_Cap... view
TMEM123 11 102269398 102269398 NCIH2196_LUNG 37 3'UTR Del G - uc001pha.2 TMEM123_uc009yx... Hybrid_Cap...
TNN p.S229R 1 175048746 175048746 NCIH2196_LUNG 37 Missense_Mutation SNP C A uc001gkl.1 TNN_uc010pmx.1_... Hybrid_Cap... view
TNNI3K p.G573_splice 1 74834889 74834889 NCIH2196_LUNG 37 Splice_Site_SNP SNP A T uc001dge.1 TNNI3K_uc001dgc... Hybrid_Cap... view
TP53 p.V157F 17 7578461 7578461 NCIH2196_LUNG 37 Missense_Mutation SNP C A uc002gim.2 TP53_uc002gig.1... Hybrid_Cap... view
TRPS1 8 116635872 116635873 NCIH2196_LUNG 37 5'UTR Ins - A rs76893349 uc003yny.2 TRPS1_uc011lhy.... Hybrid_Cap...
TTN p.Y23991C 2 179431183 179431183 NCIH2196_LUNG 37 Missense_Mutation SNP T C uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
VEGFC p.S419_splice 4 177605082 177605084 NCIH2196_LUNG 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
XPO4 p.Q255* 13 21401283 21401283 NCIH2196_LUNG 37 Nonsense_Mutation SNP G A uc001unq.3 Hybrid_Cap... view
YSK4 p.P92fs 2 135757546 135757546 NCIH2196_LUNG 37 Frame_Shift_Del Del G - uc002tue.1 YSK4_uc010fne.1... Hybrid_Cap...