Annotation Summary for Cell Line: NCI-H2228  

Cell line primary name: NCI-H2228
Cell line aliases: H2228
Gender: F
Site Primary: lung
Histology: carcinoma
Hist Subtype1: adenocarcinoma
Notes:
Source: ATCC
Expression arrays: BRAKE_p_NCLE_RNA2_HG-U133_Plus_2_C10_241108
SNP arrays: ARLES_p_NCLE_DNAAffy2_S_GenomeWideSNP_6_D06_256084
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in NCI-H2228

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
ABL2 1 179086419 179086420 NCIH2228_LUNG 37 Intron Ins - A rs72207641 uc001gmj.3 ABL2_uc010pnf.1... Hybrid_Cap...
ADAM17 2 9630245 9630245 NCIH2228_LUNG 37 3'UTR Del T - uc002qzu.2 IAH1_uc010yiz.1... Hybrid_Cap...
ADAM28 8 24211994 24211997 NCIH2228_LUNG 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
AKAP12 p.1531_1532insE 6 151674116 151674117 NCIH2228_LUNG 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
ALPK2 p.EDTST1006del 18 56204388 56204402 NCIH2228_LUNG 37 In_Frame_Del Del CAGTT... - rs60644017;rs117623369 uc002lhj.3 ALPK2_uc002lhk.... Hybrid_Cap...
ALS2 2 202587706 202587707 NCIH2228_LUNG 37 Intron Ins - A rs3219165 uc002uyo.2 ALS2_uc002uyp.3... Hybrid_Cap...
ATR p.P1914S 3 142215361 142215361 NCIH2228_LUNG 37 Missense_Mutation SNP G A uc003eux.3 Hybrid_Cap... view
ATR p.C1858R 3 142216021 142216021 NCIH2228_LUNG 37 Missense_Mutation SNP A G uc003eux.3 Hybrid_Cap... view
BCL11A 2 60687400 60687401 NCIH2228_LUNG 37 3'UTR Ins - TGTT rs34355930 uc002sae.1 BCL11A_uc002sab... Hybrid_Cap...
BIRC6 p.H3024Y 2 32726818 32726818 NCIH2228_LUNG 37 Missense_Mutation SNP C T uc010ezu.2 Hybrid_Cap... view
BMP4 14 54416601 54416602 NCIH2228_LUNG 37 3'UTR Ins - A rs74495140;rs76335800 uc001xal.3 BMP4_uc010aoh.2... Hybrid_Cap...
CABC1 1 227171736 227171737 NCIH2228_LUNG 37 Intron Ins - T rs1574184 uc001hqm.1 CABC1_uc001hqn.... Hybrid_Cap...
CACNB2 10 18828721 18828722 NCIH2228_LUNG 37 3'UTR Ins - AA rs3841459 uc001ipr.2 CACNB2_uc009xjz... Hybrid_Cap...
CCNB1 5 68463039 68463039 NCIH2228_LUNG 37 5'UTR SNP T C uc003jvm.2 CCNB1_uc011crd.... Hybrid_Cap... view
CDK1 p.G177R 10 62551687 62551687 NCIH2228_LUNG 37 Missense_Mutation SNP G A uc001jld.2 CDK1_uc001jle.2... Hybrid_Cap... view
CDK10 p.F114L 16 89758220 89758220 NCIH2228_LUNG 37 Missense_Mutation SNP C G uc010cio.2 CDK10_uc002foa.... Hybrid_Cap... view
CLTCL1 p.V1201_splice 22 19189003 19189004 NCIH2228_LUNG 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
CSF1R 5 149433400 149433401 NCIH2228_LUNG 37 3'UTR Ins - C rs66970099;rs78449650 uc003lrl.2 CSF1R_uc011dcd.... Hybrid_Cap...
DDR2 1 162750211 162750212 NCIH2228_LUNG 37 3'UTR Del TT - uc001gcf.2 DDR2_uc001gcg.2... Hybrid_Cap...
DLL1 p.P240T 6 170595339 170595339 NCIH2228_LUNG 37 Missense_Mutation SNP G T uc003qxm.2 Hybrid_Cap... view
EIF2AK2 p.G466A 2 37336419 37336419 NCIH2228_LUNG 37 Missense_Mutation SNP C G uc010ynh.1 EIF2AK2_uc010fa... Hybrid_Cap... view
EP300 p.A2251T 22 41574466 41574466 NCIH2228_LUNG 37 Missense_Mutation SNP G A uc003azl.3 Hybrid_Cap... view
EPHA5 4 66189753 66189754 NCIH2228_LUNG 37 3'UTR Ins - T rs67487372 uc011cah.1 EPHA5_uc003hcx.... Hybrid_Cap...
EPHA6 3 97367230 97367231 NCIH2228_LUNG 37 Intron Ins - A rs115253553 uc010how.1 EPHA6_uc003drs.... Hybrid_Cap...
FBN2 p.H618R 5 127712543 127712543 NCIH2228_LUNG 37 Missense_Mutation SNP T C uc003kuu.2 FBN2_uc003kuv.2... Hybrid_Cap... view
FGFR1OP 6 167453519 167453520 NCIH2228_LUNG 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
FGFR3 4 1809128 1809129 NCIH2228_LUNG 37 3'UTR Del GT - uc003gdu.2 FGFR3_uc003gdr.... Hybrid_Cap...
FLI1 11 128638217 128638217 NCIH2228_LUNG 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FN1 2 216244182 216244185 NCIH2228_LUNG 37 Intron Del GTAC - uc002vfa.2 FN1_uc002vfb.2_... Hybrid_Cap...
GLG1 p.E1107K 16 74490600 74490600 NCIH2228_LUNG 37 Missense_Mutation SNP C T uc002fcx.2 GLG1_uc002fcy.3... Hybrid_Cap... view
GRIA3 X 122318386 122318387 NCIH2228_LUNG 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
HIF1A 14 62213929 62213930 NCIH2228_LUNG 37 3'UTR Ins - T rs67890419 uc001xfs.2 HIF1A_uc001xfq.... Hybrid_Cap...
HNF1A 12 121434630 121434631 NCIH2228_LUNG 37 Intron Ins - TCATTCAT rs75100977 uc010szn.1 HNF1A_uc001tze.... Hybrid_Cap...
ILK 11 6630029 6630029 NCIH2228_LUNG 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
ITPR2 p.R470_splice 12 26834804 26834805 NCIH2228_LUNG 37 Splice_Site_Ins Ins - ACTC rs66696203;rs59199365 uc001rhg.2 Hybrid_Cap...
KLF6 p.E246K 10 3822362 3822362 NCIH2228_LUNG 37 Missense_Mutation SNP C T uc001iha.2 KLF6_uc010qaj.1... Hybrid_Cap... view
KLK7 19 51480672 51480675 NCIH2228_LUNG 37 3'UTR Del GGTT - uc002puo.2 KLK7_uc002pup.2... Hybrid_Cap...
LCP1 13 46718660 46718660 NCIH2228_LUNG 37 Intron SNP A G uc001vaz.3 LCP1_uc010ack.2... Hybrid_Cap... view
MAML3 p.Q767_splice 4 140651585 140651587 NCIH2228_LUNG 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP2K1 15 66679649 66679650 NCIH2228_LUNG 37 5'UTR Ins - C rs67229745 uc010bhq.2 Hybrid_Cap...
MAP3K1 p.T949del 5 56177849 56177851 NCIH2228_LUNG 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAP3K11 11 65374361 65374361 NCIH2228_LUNG 37 Intron SNP C T uc001oew.2 MAP3K11_uc001oe... Hybrid_Cap... view
MAP3K14 p.R218_splice 17 43364293 43364294 NCIH2228_LUNG 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
MAPKAPK3 3 50685575 50685575 NCIH2228_LUNG 37 3'UTR Del A - rs76026164 uc003day.1 MAPKAPK3_uc003d... Hybrid_Cap...
MASTL 10 27444240 27444241 NCIH2228_LUNG 37 5'UTR Ins - G uc001itm.2 YME1L1_uc001iti... Hybrid_Cap...
MCM3APAS 21 47671275 47671276 NCIH2228_LUNG 37 3'UTR Ins - AAT rs67797185 uc002zin.2 MCM3APAS_uc002z... Hybrid_Cap...
MLL3 p.E3724K 7 151859492 151859492 NCIH2228_LUNG 37 Missense_Mutation SNP C T uc003wla.2 MLL3_uc003wkz.2... Hybrid_Cap... view
NCAM1 11 112832307 112832308 NCIH2228_LUNG 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 NCIH2228_LUNG 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCOA3 p.Q1276del 20 46279864 46279866 NCIH2228_LUNG 37 In_Frame_Del Del CAA - rs1132443;rs28529067 uc002xtk.2 NCOA3_uc010ght.... Hybrid_Cap...
NEK3 p.K313_splice 13 52718050 52718051 NCIH2228_LUNG 37 Splice_Site_Ins Ins - T rs72514762 uc001vgh.2 NEK3_uc001vgg.2... Hybrid_Cap...
NPR1 1 153665919 153665920 NCIH2228_LUNG 37 3'UTR Ins - C rs66682713 uc001fcs.3 NPR1_uc010pdz.1... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881820 50881821 NCIH2228_LUNG 37 In_Frame_Ins Ins - AAC rs66783852;rs112359270 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
PAK7 p.Q687* 20 9520210 9520210 NCIH2228_LUNG 37 Nonsense_Mutation SNP G A uc002wnl.2 PAK7_uc002wnk.2... Hybrid_Cap... view
PAX3 2 223158653 223158653 NCIH2228_LUNG 37 Intron Del T - rs112753212 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PIK3C2G p.P129del 12 18435399 18435401 NCIH2228_LUNG 37 In_Frame_Del Del CCC - uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PRKDC p.L1244fs 8 48805816 48805817 NCIH2228_LUNG 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
PTPRT p.H418Y 20 41101104 41101104 NCIH2228_LUNG 37 Missense_Mutation SNP G A uc010ggj.2 PTPRT_uc002xkg.... Hybrid_Cap... view
RAD21 p.P298A 8 117868450 117868450 NCIH2228_LUNG 37 Missense_Mutation SNP G C uc003yod.2 Hybrid_Cap... view
RB1 p.G203_splice 13 48934152 48934152 NCIH2228_LUNG 37 Splice_Site_Del Del G - uc001vcb.2 RB1_uc010acs.1_... Hybrid_Cap...
RECQL4 p.R766fs 8 145738768 145738768 NCIH2228_LUNG 37 Frame_Shift_Del Del G - uc003zdj.2 Hybrid_Cap...
RIOK3 18 21061375 21061375 NCIH2228_LUNG 37 3'UTR SNP T G uc002kui.3 RIOK3_uc010dls.... Hybrid_Cap... view
ROBO2 p.R734H 3 77623867 77623867 NCIH2228_LUNG 37 Missense_Mutation SNP G A uc003dpz.2 ROBO2_uc003dpy.... Hybrid_Cap... view
SCYL1 p.T58A 11 65293105 65293105 NCIH2228_LUNG 37 Missense_Mutation SNP A G uc001oea.1 SCYL1_uc009yqk.... Hybrid_Cap... view
SS18 p.P8P 18 23670510 23670510 NCIH2228_LUNG 37 Silent SNP C T uc002kvm.2 SS18_uc002kvn.2... Hybrid_Cap... view
STK25 2 242435659 242435662 NCIH2228_LUNG 37 Intron Del AAGG - rs3215138;rs75497042 uc002wbm.2 STK25_uc002wbk.... Hybrid_Cap...
STK31 p.Q23* 7 23751734 23751734 NCIH2228_LUNG 37 Nonsense_Mutation SNP C T uc003sws.3 STK31_uc003swt.... Hybrid_Cap... view
STK31 7 23872024 23872025 NCIH2228_LUNG 37 3'UTR Ins - TTTG rs66787534 uc003sws.3 STK31_uc003swt.... Hybrid_Cap...
STK33 p.R369G 11 8457082 8457082 NCIH2228_LUNG 37 Missense_Mutation SNP T C uc001mgi.1 STK33_uc001mgj.... Hybrid_Cap... view
TAF1 p.D1170G X 70617145 70617145 NCIH2228_LUNG 37 Missense_Mutation SNP A G uc004dzt.3 BCYRN1_uc011mpt... Hybrid_Cap... view
TLK1 2 171850178 171850179 NCIH2228_LUNG 37 3'UTR Ins - AA rs71008739 uc002ugo.2 TLK1_uc002ugn.2... Hybrid_Cap...
TMEM123 11 102269398 102269398 NCIH2228_LUNG 37 3'UTR Del G - uc001pha.2 TMEM123_uc009yx... Hybrid_Cap...
TMPO p.S355fs 12 98927100 98927101 NCIH2228_LUNG 37 Frame_Shift_Ins Ins - A uc001tfh.1 TMPO_uc001tfi.1... Hybrid_Cap...
TNK2 3 195610221 195610221 NCIH2228_LUNG 37 Intron SNP G A uc003fvt.1 TNK2_uc003fvs.1... Hybrid_Cap... view
TNN p.T832P 1 175087804 175087804 NCIH2228_LUNG 37 Missense_Mutation SNP A C uc001gkl.1 Hybrid_Cap... view
TNRC6B p.Q1328del 22 40697177 40697179 NCIH2228_LUNG 37 In_Frame_Del Del GCA - rs114291931 uc011aor.1 TNRC6B_uc003aym... Hybrid_Cap...
TP53 p.Q331* 17 7576855 7576855 NCIH2228_LUNG 37 Nonsense_Mutation SNP G A uc002gim.2 TP53_uc002gig.1... Hybrid_Cap... view
TTL p.A166V 2 113258810 113258810 NCIH2228_LUNG 37 Missense_Mutation SNP C T uc002thu.2 TTL_uc010fkm.1_... Hybrid_Cap... view
TTN 2 179391640 179391640 NCIH2228_LUNG 37 3'UTR Del T - uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap...
TTN p.T32799M 2 179395242 179395242 NCIH2228_LUNG 37 Missense_Mutation SNP G A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.M25646V 2 179426219 179426219 NCIH2228_LUNG 37 Missense_Mutation SNP T C rs72648221 uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.I22300V 2 179436257 179436257 NCIH2228_LUNG 37 Missense_Mutation SNP T C rs72646898 uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.D11273N 2 179500777 179500777 NCIH2228_LUNG 37 Missense_Mutation SNP C T uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
UNC13C p.D307N 15 54306019 54306019 NCIH2228_LUNG 37 Missense_Mutation SNP G A uc002ack.2 Hybrid_Cap... view
VEGFC p.S419_splice 4 177605082 177605084 NCIH2228_LUNG 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
WHSC1L1 p.S443fs 8 38187148 38187149 NCIH2228_LUNG 37 Frame_Shift_Ins Ins - A uc003xli.2 WHSC1L1_uc011lb... Hybrid_Cap...
ZNF423 p.S621L 16 49671201 49671201 NCIH2228_LUNG 37 Missense_Mutation SNP G A uc002efs.2 ZNF423_uc010vgn... Hybrid_Cap... view