Annotation Summary for Cell Line: NCI-H441  

Cell line primary name: NCI-H441
Cell line aliases: H441
Gender: M
Site Primary: lung
Histology: carcinoma
Hist Subtype1: adenocarcinoma
Notes:
Source: ATCC
Expression arrays: METIS_p_NCLE_RNA1_Human_U133_Plus_2.0_E05_240954
SNP arrays: HONEY_p_NCLE_DNAAffy3_S_GenomeWideSNP_6_B07_293316
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in NCI-H441

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
AAK1 p.541_542QQ>Q 2 69741754 69741756 NCIH441_LUNG 37 In_Frame_Del Del TGT - rs55712143 uc002sfp.2 AAK1_uc010fdk.2... Hybrid_Cap...
ABL2 1 179086419 179086420 NCIH441_LUNG 37 Intron Ins - A rs72207641 uc001gmj.3 ABL2_uc010pnf.1... Hybrid_Cap...
ADAM28 8 24211994 24211997 NCIH441_LUNG 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
AFF1 p.L768F 4 88036289 88036289 NCIH441_LUNG 37 Missense_Mutation SNP G C uc011ccz.1 AFF1_uc003hqj.3... Hybrid_Cap... view
AKAP12 p.1531_1532insE 6 151674116 151674117 NCIH441_LUNG 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
AKAP4 X 49955553 49955553 NCIH441_LUNG 37 3'UTR SNP G T uc004dow.1 AKAP4_uc004dov.... Hybrid_Cap... view
AKAP9 p.1335_1336insQ 7 91652178 91652179 NCIH441_LUNG 37 In_Frame_Ins Ins - AAC rs34756483 uc003ulg.2 AKAP9_uc003ule.... Hybrid_Cap...
ALPK2 p.1388_1389FF>F 18 56203253 56203255 NCIH441_LUNG 37 In_Frame_Del Del AAG - uc002lhj.3 ALPK2_uc002lhk.... Hybrid_Cap...
AMZ2 p.L311fs 17 66252960 66252964 NCIH441_LUNG 37 Frame_Shift_Del Del GGTGA - uc002jgs.1 ARSG_uc002jhc.2... Hybrid_Cap...
ATF2 2 175939578 175939578 NCIH441_LUNG 37 Intron Del G - uc002ujl.2 ATF2_uc010fqv.2... Hybrid_Cap...
BRD2 6 32948607 32948608 NCIH441_LUNG 37 3'UTR Ins - T rs1049414;rs114195059 uc010juh.2 BRD2_uc003ocn.3... Hybrid_Cap...
BUB1 p.V695F 2 111408243 111408243 NCIH441_LUNG 37 Missense_Mutation SNP C A uc002tgc.2 BUB1_uc010yxh.1... Hybrid_Cap... view
CABC1 1 227171585 227171585 NCIH441_LUNG 37 Intron Del T - uc001hqm.1 CABC1_uc001hqn.... Hybrid_Cap...
CABC1 1 227171736 227171737 NCIH441_LUNG 37 Intron Ins - T rs1574184 uc001hqm.1 CABC1_uc001hqn.... Hybrid_Cap...
CARD10 p.KE272del 22 37906309 37906314 NCIH441_LUNG 37 In_Frame_Del Del CTCCT... - uc003asx.1 CARD10_uc003ast... Hybrid_Cap...
CDK11B 1 1654066 1654068 NCIH441_LUNG 37 Intron Del GCG - uc001agv.1 CDK11B_uc001aha... Hybrid_Cap...
CDK13 p.T1445M 7 40134374 40134374 NCIH441_LUNG 37 Missense_Mutation SNP C T uc003thh.3 CDK13_uc003thi.... Hybrid_Cap... view
CHD1 p.S1683F 5 98192169 98192169 NCIH441_LUNG 37 Missense_Mutation SNP G A uc003knf.2 CHD1_uc010jbn.2... Hybrid_Cap... view
CHD8 14 21853630 21853630 NCIH441_LUNG 37 3'UTR Del T - rs78520772 uc001was.1 CHD8_uc001war.1... Hybrid_Cap...
CHD9 p.2164_2165SS>S 16 53338410 53338412 NCIH441_LUNG 37 In_Frame_Del Del TTC - uc002ehb.2 CHD9_uc002egy.2... Hybrid_Cap...
CHIC2 4 54876132 54876132 NCIH441_LUNG 37 3'UTR Del C - rs4437313 uc003haj.1 PDGFRA_uc003haa... Hybrid_Cap...
CHN1 p.R304* 2 175676293 175676293 NCIH441_LUNG 37 Nonsense_Mutation SNP G A uc002uji.2 CHN1_uc010zeq.1... Hybrid_Cap... view
CIT 12 120125896 120125896 NCIH441_LUNG 37 3'UTR SNP C T uc001txj.1 CIT_uc001txh.1_... Hybrid_Cap... view
CLPTM1 19 45490776 45490776 NCIH441_LUNG 37 Intron SNP G A uc002pai.2 CLPTM1_uc010ejv... Hybrid_Cap... view
CLTCL1 p.V1201_splice 22 19189003 19189004 NCIH441_LUNG 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
CNTN6 3 1339681 1339686 NCIH441_LUNG 37 Intron Del GTTTT... - uc003boz.2 CNTN6_uc010hbo.... Hybrid_Cap...
CNTN6 p.Y942F 3 1444009 1444009 NCIH441_LUNG 37 Missense_Mutation SNP A T uc003boz.2 CNTN6_uc011asj.... Hybrid_Cap... view
COL14A1 p.E1024K 8 121279119 121279119 NCIH441_LUNG 37 Missense_Mutation SNP G A uc003yox.2 COL14A1_uc003yo... Hybrid_Cap... view
CPNE5 p.R276H 6 36730722 36730722 NCIH441_LUNG 37 Missense_Mutation SNP C T uc003omr.1 CPNE5_uc003oms.... Hybrid_Cap... view
CREB3L2 p.T100del 7 137612914 137612916 NCIH441_LUNG 37 In_Frame_Del Del TGG - uc003vtw.2 CREB3L2_uc003vt... Hybrid_Cap...
CSMD3 p.Y1608* 8 113518991 113518991 NCIH441_LUNG 37 Nonsense_Mutation SNP A T uc003ynu.2 CSMD3_uc003yns.... Hybrid_Cap... view
DACH1 13 72014625 72014626 NCIH441_LUNG 37 3'UTR Ins - T rs117109529 uc010thn.1 DACH1_uc010tho.... Hybrid_Cap...
DDR2 p.R668C 1 162745587 162745587 NCIH441_LUNG 37 Missense_Mutation SNP C T uc001gcf.2 DDR2_uc001gcg.2... Hybrid_Cap... view
DDR2 1 162750211 162750211 NCIH441_LUNG 37 3'UTR Del T - uc001gcf.2 DDR2_uc001gcg.2... Hybrid_Cap...
DLC1 p.A1424S 8 12946018 12946018 NCIH441_LUNG 37 Missense_Mutation SNP C A uc003wwm.2 DLC1_uc003wwk.1... Hybrid_Cap... view
EIF4B 12 53400089 53400089 NCIH441_LUNG 37 5'UTR SNP C A uc010snu.1 EIF4B_uc009zmp.... Hybrid_Cap... view
EPHA5 p.C319* 4 66361215 66361215 NCIH441_LUNG 37 Nonsense_Mutation SNP G T uc011cah.1 EPHA5_uc003hcx.... Hybrid_Cap... view
EPHA6 3 97367230 97367231 NCIH441_LUNG 37 Intron Ins - A rs115253553 uc010how.1 EPHA6_uc003drs.... Hybrid_Cap...
EPHB2 p.K487E 1 23219407 23219407 NCIH441_LUNG 37 Missense_Mutation SNP A G uc009vqj.1 EPHB2_uc001bge.... Hybrid_Cap... view
EPHB6 p.G567C 7 142564775 142564775 NCIH441_LUNG 37 Missense_Mutation SNP G T uc011kst.1 EPHB6_uc011ksu.... Hybrid_Cap... view
EPHB6 p.T678K 7 142566113 142566113 NCIH441_LUNG 37 Missense_Mutation SNP C A uc011kst.1 EPHB6_uc011ksu.... Hybrid_Cap... view
ERBB4 p.1246_1247SL>RM 2 212248528 212248529 NCIH441_LUNG 37 Missense_Mutation DNP GG TT uc002veg.1 ERBB4_uc002veh.... Hybrid_Cap...
ERCC5 p.R1180M 13 103528231 103528231 NCIH441_LUNG 37 Missense_Mutation SNP G T uc001vpw.2 Hybrid_Cap... view
EXT1 8 118811807 118811807 NCIH441_LUNG 37 3'UTR Del T - uc003yok.1 Hybrid_Cap...
FBN2 p.C251S 5 127800491 127800491 NCIH441_LUNG 37 Missense_Mutation SNP C G uc003kuu.2 FBN2_uc003kuv.2... Hybrid_Cap... view
FGFR1OP 6 167453519 167453520 NCIH441_LUNG 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
FLI1 11 128638217 128638217 NCIH441_LUNG 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FLNC p.W135C 7 128475432 128475432 NCIH441_LUNG 37 Missense_Mutation SNP G T uc003vnz.3 FLNC_uc003voa.3... Hybrid_Cap... view
FMN2 p.PPPPLPGAAIP948del 1 240370942 240370974 NCIH441_LUNG 37 In_Frame_Del Del CCTCC... - rs72444563 uc010pye.1 FMN2_uc010pyd.1... Hybrid_Cap...
FN1 2 216244182 216244185 NCIH441_LUNG 37 Intron Del GTAC - uc002vfa.2 FN1_uc002vfb.2_... Hybrid_Cap...
FZD1 p.C554S 7 90895855 90895855 NCIH441_LUNG 37 Missense_Mutation SNP T A uc003ula.2 Hybrid_Cap... view
GLG1 p.M347V 16 74528669 74528669 NCIH441_LUNG 37 Missense_Mutation SNP T C uc002fcx.2 GLG1_uc002fcy.3... Hybrid_Cap... view
GRIA3 X 122318386 122318387 NCIH441_LUNG 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GRIN2A 16 9856949 9856949 NCIH441_LUNG 37 3'UTR SNP C T uc002czo.3 GRIN2A_uc010uym... Hybrid_Cap... view
HGF p.P457S 7 81346584 81346584 NCIH441_LUNG 37 Missense_Mutation SNP G A uc003uhl.2 HGF_uc003uhm.2_... Hybrid_Cap... view
HIF1A p.S232* 14 62194292 62194292 NCIH441_LUNG 37 Nonsense_Mutation SNP C G uc001xfs.2 HIF1A_uc001xfq.... Hybrid_Cap... view
HIF1A 14 62213929 62213930 NCIH441_LUNG 37 3'UTR Ins - T rs67890419 uc001xfs.2 HIF1A_uc001xfq.... Hybrid_Cap...
HNF1A 12 121434630 121434631 NCIH441_LUNG 37 Intron Ins - TCATTCAT rs75100977 uc010szn.1 HNF1A_uc001tze.... Hybrid_Cap...
IKBKE p.I703I 1 206667316 206667316 NCIH441_LUNG 37 Silent SNP C A uc001hdz.1 IKBKE_uc009xbv.... Hybrid_Cap... view
IL1A 2 113532638 113532638 NCIH441_LUNG 37 3'UTR SNP C G uc002tig.2 Hybrid_Cap... view
ILK 11 6630029 6630029 NCIH441_LUNG 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
ITGB4 p.G1035V 17 73739935 73739935 NCIH441_LUNG 37 Missense_Mutation SNP G T uc002jpg.2 ITGB4_uc002jph.... Hybrid_Cap... view
ITPR2 p.R470_splice 12 26834804 26834805 NCIH441_LUNG 37 Splice_Site_Ins Ins - ACTC rs66696203;rs59199365 uc001rhg.2 Hybrid_Cap...
KLK7 19 51480672 51480675 NCIH441_LUNG 37 3'UTR Del GGTT - uc002puo.2 KLK7_uc002pup.2... Hybrid_Cap...
KRAS p.G12V 12 25398284 25398284 NCIH441_LUNG 37 Missense_Mutation SNP C A uc001rgp.1 KRAS_uc001rgq.1... Hybrid_Cap... view
LCP1 13 46701580 46701580 NCIH441_LUNG 37 3'UTR SNP G T uc001vaz.3 LCP1_uc010ack.2... Hybrid_Cap... view
LRP1B p.D3545Y 2 141135754 141135754 NCIH441_LUNG 37 Missense_Mutation SNP C A uc002tvj.1 Hybrid_Cap... view
LRP1B p.G3525V 2 141135813 141135813 NCIH441_LUNG 37 Missense_Mutation SNP C A uc002tvj.1 Hybrid_Cap... view
LRRC7 p.S1248I 1 70505364 70505364 NCIH441_LUNG 37 Missense_Mutation SNP G T uc001dep.2 LRRC7_uc009wbg.... Hybrid_Cap... view
MAML3 p.Q767_splice 4 140651585 140651587 NCIH441_LUNG 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP2K6 17 67410918 67410918 NCIH441_LUNG 37 5'UTR SNP G C uc002jij.2 MAP2K6_uc002jii... Hybrid_Cap... view
MAP2K7 p.L308fs 19 7976202 7976202 NCIH441_LUNG 37 Frame_Shift_Del Del T - uc002miv.2 MAP2K7_uc010xka... Hybrid_Cap...
MAP3K1 p.T949del 5 56177849 56177851 NCIH441_LUNG 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAPK7 p.D387Y 17 19284681 19284681 NCIH441_LUNG 37 Missense_Mutation SNP G T uc002gvn.2 MAPK7_uc002gvo.... Hybrid_Cap... view
MAPKAPK3 3 50685575 50685575 NCIH441_LUNG 37 3'UTR Del A - rs76026164 uc003day.1 MAPKAPK3_uc003d... Hybrid_Cap...
MPL p.V368L 1 43812237 43812237 NCIH441_LUNG 37 Missense_Mutation SNP G T uc001ciw.2 MPL_uc001civ.2_... Hybrid_Cap... view
MRE11A p.E248K 11 94204843 94204843 NCIH441_LUNG 37 Missense_Mutation SNP C T uc001peu.2 MRE11A_uc001pev... Hybrid_Cap... view
NCAM1 11 112832307 112832308 NCIH441_LUNG 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 NCIH441_LUNG 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCOA3 p.Q1276del 20 46279837 46279839 NCIH441_LUNG 37 In_Frame_Del Del CAG - rs2664555 uc002xtk.2 NCOA3_uc010ght.... Hybrid_Cap...
NIN 14 51290098 51290098 NCIH441_LUNG 37 Intron SNP C G uc001wyi.2 NIN_uc001wyj.2_... Hybrid_Cap... view
NOS2 p.A850S 17 26091051 26091051 NCIH441_LUNG 37 Missense_Mutation SNP C A uc002gzu.2 Hybrid_Cap... view
NPM1 5 170837734 170837734 NCIH441_LUNG 37 3'UTR Del T - uc011dex.1 NPM1_uc003mbi.2... Hybrid_Cap...
NPR1 1 153652951 153652951 NCIH441_LUNG 37 Intron SNP C G uc001fcs.3 NPR1_uc010pdz.1... Hybrid_Cap... view
NR1H2 p.176_177insQ 19 50881820 50881821 NCIH441_LUNG 37 In_Frame_Ins Ins - AAC rs66783852;rs112359270 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
NUP210 p.S1213A 3 13378334 13378334 NCIH441_LUNG 37 Missense_Mutation SNP A C uc003bxv.1 Hybrid_Cap... view
NYNRIN p.K679* 14 24879035 24879035 NCIH441_LUNG 37 Nonsense_Mutation SNP A T uc001wpf.3 Hybrid_Cap... view
OBSCN p.V3655L 1 228481149 228481149 NCIH441_LUNG 37 Missense_Mutation SNP G T uc009xez.1 OBSCN_uc001hsn.... Hybrid_Cap... view
PALB2 p.Q343* 16 23646840 23646840 NCIH441_LUNG 37 Nonsense_Mutation SNP G A uc002dlx.1 Hybrid_Cap... view
PAX3 2 223158653 223158653 NCIH441_LUNG 37 Intron Del T - rs112753212 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PDGFRA 4 55131002 55131002 NCIH441_LUNG 37 Intron Del A - uc003han.3 PDGFRA_uc003haa... Hybrid_Cap...
PEX5L p.Q355E 3 179533669 179533669 NCIH441_LUNG 37 Missense_Mutation SNP G C uc003fki.1 PEX5L_uc011bqd.... Hybrid_Cap... view
PEX5L p.D39N 3 179616013 179616013 NCIH441_LUNG 37 Missense_Mutation SNP C T uc003fki.1 PEX5L_uc011bqd.... Hybrid_Cap... view
PGR 11 100933598 100933599 NCIH441_LUNG 37 Intron Ins - AATGA rs35148438 uc001pgh.2 PGR_uc001pgg.2_... Hybrid_Cap...
PKHD1 p.K3886Q 6 51497372 51497372 NCIH441_LUNG 37 Missense_Mutation SNP T G uc003pah.1 Hybrid_Cap... view
PLCG2 16 81991670 81991670 NCIH441_LUNG 37 3'UTR SNP C T uc002fgt.2 Hybrid_Cap... view
PLCG2 p.V824F 16 81960739 81960739 NCIH441_LUNG 37 Missense_Mutation SNP G T uc002fgt.2 Hybrid_Cap... view
PRKACA p.W223L 19 14208270 14208270 NCIH441_LUNG 37 Missense_Mutation SNP C A uc002myc.2 PRKACA_uc002myb... Hybrid_Cap... view
RAPGEF2 p.R158T 4 160243601 160243601 NCIH441_LUNG 37 Missense_Mutation SNP G C uc003iqg.3 Hybrid_Cap... view
RGS22 8 101117728 101117728 NCIH441_LUNG 37 Intron SNP A G uc003yjb.1 RGS22_uc003yja.... Hybrid_Cap... view
RGS22 8 101117795 101117795 NCIH441_LUNG 37 Intron SNP T C uc003yjb.1 RGS22_uc003yja.... Hybrid_Cap... view
RIMS2 p.P673T 8 104955136 104955136 NCIH441_LUNG 37 Missense_Mutation SNP C A uc003yls.2 RIMS2_uc003ylp.... Hybrid_Cap... view
RIPK3 14 24807900 24807900 NCIH441_LUNG 37 Intron SNP G A uc001wpb.2 RIPK3_uc001wpa.... Hybrid_Cap... view
RPS6KB1 17 58024224 58024225 NCIH441_LUNG 37 3'UTR Ins - AA rs67846207 uc002ixy.2 RPS6KB1_uc010dd... Hybrid_Cap...
SCD5 4 83552478 83552478 NCIH441_LUNG 37 3'UTR SNP G T uc003hna.2 Hybrid_Cap... view
SEPT9 p.D348Y 17 75483634 75483634 NCIH441_LUNG 37 Missense_Mutation SNP G T uc002jts.3 SEPT9_uc010wtk.... Hybrid_Cap... view
SGK1 6 134495748 134495748 NCIH441_LUNG 37 Intron SNP A C uc003qeo.3 SGK1_uc011ect.1... Hybrid_Cap... view
SHH 7 155604884 155604884 NCIH441_LUNG 37 5'UTR SNP G C rs111495739 uc003wmk.1 Hybrid_Cap... view
SLC14A1 p.Q104* 18 43310427 43310427 NCIH441_LUNG 37 Nonsense_Mutation SNP C T uc010dnk.2 SLC14A1_uc010xc... Hybrid_Cap... view
SP110 p.L52V 2 231079827 231079827 NCIH441_LUNG 37 Missense_Mutation SNP G C uc002vqg.3 SP110_uc002vqh.... Hybrid_Cap... view
STK31 7 23872024 23872025 NCIH441_LUNG 37 3'UTR Ins - TTTG rs66787534 uc003sws.3 STK31_uc003swt.... Hybrid_Cap...
TAF1L p.H1057N 9 32632409 32632409 NCIH441_LUNG 37 Missense_Mutation SNP G T uc003zrg.1 Hybrid_Cap... view
TMEM123 11 102269398 102269398 NCIH441_LUNG 37 3'UTR Del G - uc001pha.2 TMEM123_uc009yx... Hybrid_Cap...
TNN p.P1010T 1 175096204 175096204 NCIH441_LUNG 37 Missense_Mutation SNP C A uc001gkl.1 Hybrid_Cap... view
TNRC6B p.G361C 22 40661315 40661315 NCIH441_LUNG 37 Missense_Mutation SNP G T uc011aor.1 TNRC6B_uc003aym... Hybrid_Cap... view
TP53 p.R158L 17 7578457 7578457 NCIH441_LUNG 37 Missense_Mutation SNP C A uc002gim.2 TP53_uc002gig.1... Hybrid_Cap... view
TP63 3 189507518 189507519 NCIH441_LUNG 37 Intron Ins - AGAG rs62702062;rs79714037 uc003fry.2 TP63_uc003frx.2... Hybrid_Cap...
TRPS1 8 116635872 116635873 NCIH441_LUNG 37 5'UTR Ins - A rs76893349 uc003yny.2 TRPS1_uc011lhy.... Hybrid_Cap...
TRRAP p.R144M 7 98491485 98491485 NCIH441_LUNG 37 Missense_Mutation SNP G T uc003upp.2 TRRAP_uc011kis.... Hybrid_Cap... view
TTN p.V28018F 2 179414809 179414809 NCIH441_LUNG 37 Missense_Mutation SNP C A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN 2 179616036 179616036 NCIH441_LUNG 37 Intron SNP C A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TYK2 p.E315K 19 10476261 10476261 NCIH441_LUNG 37 Missense_Mutation SNP C T uc002moc.3 TYK2_uc010dxe.2... Hybrid_Cap... view
VEGFC p.S419_splice 4 177605082 177605084 NCIH441_LUNG 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
XPC p.R715W 3 14190421 14190421 NCIH441_LUNG 37 Missense_Mutation SNP G A uc011ave.1 XPC_uc011avf.1_... Hybrid_Cap... view
ZNF423 16 49525115 49525115 NCIH441_LUNG 37 3'UTR SNP A G uc002efs.2 ZNF423_uc010vgn... Hybrid_Cap... view