Annotation Summary for Cell Line: NCI-H460  

Cell line primary name: NCI-H460
Cell line aliases: H460
Gender: M
Site Primary: lung
Histology: carcinoma
Hist Subtype1: large_cell_carcinoma
Notes:
Source: ATCC
Expression arrays: BRAKE_p_NCLE_RNA2_HG-U133_Plus_2_H05_241218
SNP arrays: FASTS_p_NCLE_DNAAffy4_S_GenomeWideSNP_6_B01_335212
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in NCI-H460

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
ADAM28 8 24211994 24211997 NCIH460_LUNG 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
ADAM29 p.G60S 4 175896854 175896854 NCIH460_LUNG 37 Missense_Mutation SNP G A uc003iuc.2 ADAM29_uc003iud... Hybrid_Cap... view
AKAP12 p.1531_1532insE 6 151674116 151674117 NCIH460_LUNG 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
AKAP9 p.1335_1336insQ 7 91652178 91652179 NCIH460_LUNG 37 In_Frame_Ins Ins - AAC rs34756483 uc003ulg.2 AKAP9_uc003ule.... Hybrid_Cap...
ALPK2 p.EDTST1006del 18 56204388 56204402 NCIH460_LUNG 37 In_Frame_Del Del CAGTT... - rs60644017;rs117623369 uc002lhj.3 ALPK2_uc002lhk.... Hybrid_Cap...
ARID1A p.LI2134del 1 27106789 27106794 NCIH460_LUNG 37 In_Frame_Del Del CTGAT... - uc001bmv.1 ARID1A_uc001bmu... Hybrid_Cap...
BRD3 9 136901535 136901535 NCIH460_LUNG 37 Intron SNP G T uc004cew.2 BRD3_uc004cex.2... Hybrid_Cap... view
C15ORF2 p.P573T 15 24922731 24922731 NCIH460_LUNG 37 Missense_Mutation SNP C A uc001ywo.2 Hybrid_Cap... view
C15ORF55 p.P362Q 15 34646656 34646656 NCIH460_LUNG 37 Missense_Mutation SNP C A uc010ucc.1 C15orf55_uc010u... Hybrid_Cap... view
CARD10 p.KE272del 22 37906309 37906314 NCIH460_LUNG 37 In_Frame_Del Del CTCCT... - uc003asx.1 CARD10_uc003ast... Hybrid_Cap...
CASP4 11 104820126 104820126 NCIH460_LUNG 37 Intron SNP C G uc001pid.1 CASP4_uc001pib.... Hybrid_Cap... view
CDH2 18 25532034 25532034 NCIH460_LUNG 37 3'UTR SNP T G uc002kwg.2 CDH2_uc010xbn.1... Hybrid_Cap... view
CDK11B 1 1654066 1654068 NCIH460_LUNG 37 Intron Del GCG - uc001agv.1 CDK11B_uc001aha... Hybrid_Cap...
CEP110 p.Q1000K 9 123906307 123906307 NCIH460_LUNG 37 Missense_Mutation SNP C A uc004bkx.1 CEP110_uc004bky... Hybrid_Cap... view
CLTCL1 p.V1201_splice 22 19189003 19189004 NCIH460_LUNG 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
COL14A1 p.P1467S 8 121313055 121313055 NCIH460_LUNG 37 Missense_Mutation SNP C T uc003yox.2 COL14A1_uc003yo... Hybrid_Cap... view
CREB3L2 p.T100del 7 137612914 137612916 NCIH460_LUNG 37 In_Frame_Del Del TGG - uc003vtw.2 CREB3L2_uc003vt... Hybrid_Cap...
CSNK2A1 p.P295fs 20 468160 468160 NCIH460_LUNG 37 Frame_Shift_Del Del G - uc002wdw.1 CSNK2A1_uc002wd... Hybrid_Cap...
CYB5R4 p.S119A 6 84618752 84618752 NCIH460_LUNG 37 Missense_Mutation SNP T G uc003pkf.2 Hybrid_Cap... view
DGKB p.G675R 7 14378242 14378242 NCIH460_LUNG 37 Missense_Mutation SNP C T uc003ssz.2 DGKB_uc011jxt.1... Hybrid_Cap... view
DIP2C p.R78L 10 518413 518414 NCIH460_LUNG 37 Missense_Mutation DNP CC AA uc001ifp.2 DIP2C_uc009xhk.... Hybrid_Cap...
DNAH8 p.I1074F 6 38793955 38793955 NCIH460_LUNG 37 Missense_Mutation SNP A T uc003ooe.1 Hybrid_Cap... view
EIF3A p.T295R 10 120829024 120829024 NCIH460_LUNG 37 Missense_Mutation SNP G C uc001ldu.2 EIF3A_uc010qsu.... Hybrid_Cap... view
EIF4B p.R246C 12 53421634 53421634 NCIH460_LUNG 37 Missense_Mutation SNP C T uc010snu.1 EIF4B_uc009zmp.... Hybrid_Cap... view
EP300 22 41574970 41574972 NCIH460_LUNG 37 3'UTR Del GTA - rs76489032 uc003azl.3 Hybrid_Cap...
EPHA7 p.P897fs 6 93956546 93956546 NCIH460_LUNG 37 Frame_Shift_Del Del G - uc003poe.2 EPHA7_uc003pof.... Hybrid_Cap...
FGFR1OP 6 167453519 167453520 NCIH460_LUNG 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
FLI1 11 128638217 128638217 NCIH460_LUNG 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FMN2 p.L690Q 1 240370169 240370169 NCIH460_LUNG 37 Missense_Mutation SNP T A uc010pye.1 FMN2_uc010pyd.1... Hybrid_Cap... view
FN1 2 216244182 216244185 NCIH460_LUNG 37 Intron Del GTAC - uc002vfa.2 FN1_uc002vfb.2_... Hybrid_Cap...
GAS7 p.P138T 17 9873053 9873053 NCIH460_LUNG 37 Missense_Mutation SNP G T uc002gmg.1 GAS7_uc010vvd.1... Hybrid_Cap... view
GPR112 p.V2324A X 135439906 135439906 NCIH460_LUNG 37 Missense_Mutation SNP T C uc004ezu.1 GPR112_uc010nsb... Hybrid_Cap... view
GPR112 p.D2657del X 135474445 135474447 NCIH460_LUNG 37 In_Frame_Del Del GAT - rs3030295 uc004ezu.1 GPR112_uc010nsb... Hybrid_Cap...
GRIA3 X 122318386 122318387 NCIH460_LUNG 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GRIN2A p.N1436S 16 9857094 9857094 NCIH460_LUNG 37 Missense_Mutation SNP T C rs77029288 uc002czo.3 GRIN2A_uc010uym... Hybrid_Cap... view
GUCY2C 12 14827464 14827466 NCIH460_LUNG 37 Intron Del ATC - rs72525754;rs3083879 uc001rcd.2 GUCY2C_uc009zhz... Hybrid_Cap...
HECW1 p.V120F 7 43360239 43360239 NCIH460_LUNG 37 Missense_Mutation SNP G T uc003tid.1 HECW1_uc011kbi.... Hybrid_Cap... view
HNF1A 12 121434630 121434631 NCIH460_LUNG 37 Intron Ins - TCATTCAT rs75100977 uc010szn.1 HNF1A_uc001tze.... Hybrid_Cap...
HSP90B1 p.E791del 12 104341188 104341190 NCIH460_LUNG 37 In_Frame_Del Del GAA - rs117491163 uc001tkb.1 HSP90B1_uc010sw... Hybrid_Cap...
ILK 11 6630029 6630029 NCIH460_LUNG 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
ITGB6 p.G56V 2 161052906 161052906 NCIH460_LUNG 37 Missense_Mutation SNP C A uc002ubh.2 ITGB6_uc010fow.... Hybrid_Cap... view
JAG1 p.F396Y 20 10630942 10630942 NCIH460_LUNG 37 Missense_Mutation SNP A T uc002wnw.2 JAG1_uc010gcd.1... Hybrid_Cap... view
KDR p.G1304C 4 55946269 55946269 NCIH460_LUNG 37 Missense_Mutation SNP C A uc003has.2 KDR_uc003hat.1_... Hybrid_Cap... view
KLK7 19 51480672 51480675 NCIH460_LUNG 37 3'UTR Del GGTT - uc002puo.2 KLK7_uc002pup.2... Hybrid_Cap...
KRAS p.Q61H 12 25380275 25380275 NCIH460_LUNG 37 Missense_Mutation SNP T A rs17851045 uc001rgp.1 KRAS_uc001rgq.1... Hybrid_Cap... view
LDHA p.V80G 11 18421003 18421003 NCIH460_LUNG 37 Missense_Mutation SNP T G uc010rdd.1 LDHA_uc001mok.3... Hybrid_Cap... view
LRP2 p.I1876V 2 170076986 170076986 NCIH460_LUNG 37 Missense_Mutation SNP T C uc002ues.2 Hybrid_Cap... view
MAML2 p.604_607QQQQ>Q 11 95825375 95825383 NCIH460_LUNG 37 In_Frame_Del Del TGCTG... - rs113349418 uc001pfw.1 Hybrid_Cap...
MAML3 p.Q767_splice 4 140651585 140651587 NCIH460_LUNG 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP2K1 p.Y134C 15 66729193 66729193 NCIH460_LUNG 37 Missense_Mutation SNP A G uc010bhq.2 MAP2K1_uc010ujp... Hybrid_Cap... view
MAP3K1 p.T949del 5 56177849 56177851 NCIH460_LUNG 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAP3K14 p.R218_splice 17 43364293 43364294 NCIH460_LUNG 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
MAP3K4 p.A1199del 6 161519351 161519353 NCIH460_LUNG 37 In_Frame_Del Del CTG - uc003qtn.2 MAP3K4_uc010kkc... Hybrid_Cap...
MCM3APAS 21 47671275 47671276 NCIH460_LUNG 37 3'UTR Ins - AAT rs67797185 uc002zin.2 MCM3APAS_uc002z... Hybrid_Cap...
MEF2A p.P435del 15 100252742 100252744 NCIH460_LUNG 37 In_Frame_Del Del GCC - uc010urw.1 MEF2A_uc010urv.... Hybrid_Cap...
MMP2 p.A408T 16 55525754 55525754 NCIH460_LUNG 37 Missense_Mutation SNP G A uc002ehz.3 MMP2_uc010vhd.1... Hybrid_Cap... view
MYH11 16 15808707 15808707 NCIH460_LUNG 37 Intron SNP C T uc002ddx.2 MYH11_uc002ddv.... Hybrid_Cap... view
MYH11 p.D764E 16 15841567 15841567 NCIH460_LUNG 37 Missense_Mutation SNP G T uc002ddx.2 MYH11_uc002ddv.... Hybrid_Cap... view
NBN p.G224A 8 90983432 90983432 NCIH460_LUNG 37 Missense_Mutation SNP C G uc003yej.1 NBN_uc003yei.1_... Hybrid_Cap... view
NCAM1 11 112832307 112832308 NCIH460_LUNG 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 NCIH460_LUNG 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCOA3 p.Q1276del 20 46279837 46279839 NCIH460_LUNG 37 In_Frame_Del Del CAG - rs2664555 uc002xtk.2 NCOA3_uc010ght.... Hybrid_Cap...
NEK3 p.K313_splice 13 52718050 52718051 NCIH460_LUNG 37 Splice_Site_Ins Ins - T rs72514762 uc001vgh.2 NEK3_uc001vgg.2... Hybrid_Cap...
NIN p.L351S 14 51238116 51238116 NCIH460_LUNG 37 Missense_Mutation SNP A G uc001wyi.2 NIN_uc001wyj.2_... Hybrid_Cap... view
NPM1 5 170837734 170837734 NCIH460_LUNG 37 3'UTR Del T - uc011dex.1 NPM1_uc003mbi.2... Hybrid_Cap...
NPR1 1 153665919 153665920 NCIH460_LUNG 37 3'UTR Ins - C rs66682713 uc001fcs.3 NPR1_uc010pdz.1... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881820 50881821 NCIH460_LUNG 37 In_Frame_Ins Ins - AAC rs66783852;rs112359270 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
NR2F1 5 92929582 92929582 NCIH460_LUNG 37 3'UTR Del A - uc003kkj.2 Hybrid_Cap...
NUP210 p.E224D 3 13429815 13429815 NCIH460_LUNG 37 Missense_Mutation SNP C A uc003bxv.1 Hybrid_Cap... view
PDE4DIP p.Q1665fs 1 144873963 144873963 NCIH460_LUNG 37 Frame_Shift_Del Del T - uc001elw.3 NBPF10_uc009wir... Hybrid_Cap...
PIK3CA p.E545K 3 178936091 178936091 NCIH460_LUNG 37 Missense_Mutation SNP G A rs104886003 uc003fjk.2 Hybrid_Cap... view
PRKCG p.E561* 19 54407913 54407913 NCIH460_LUNG 37 Nonsense_Mutation SNP G T uc010yeg.1 PRKCG_uc002qcq.... Hybrid_Cap... view
PRKD3 2 37480319 37480320 NCIH460_LUNG 37 Stop_Codon_Ins Ins - T rs79875666 uc002rqd.2 Hybrid_Cap...
PRKDC p.L1244fs 8 48805816 48805817 NCIH460_LUNG 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
PSKH2 p.R366M 8 87060752 87060752 NCIH460_LUNG 37 Missense_Mutation SNP C A uc011lfy.1 Hybrid_Cap... view
PTK2 p.I1005T 8 141669776 141669776 NCIH460_LUNG 37 Missense_Mutation SNP A G uc003yvt.2 PTK2_uc011ljp.1... Hybrid_Cap... view
RAD21 p.D118V 8 117874101 117874101 NCIH460_LUNG 37 Missense_Mutation SNP T A uc003yod.2 Hybrid_Cap... view
ROBO2 p.P368H 3 77600000 77600000 NCIH460_LUNG 37 Missense_Mutation SNP C A uc003dpz.2 ROBO2_uc003dpy.... Hybrid_Cap... view
ROCK2 p.D854V 2 11342236 11342236 NCIH460_LUNG 37 Missense_Mutation SNP T A uc002rbd.1 Hybrid_Cap... view
RPTOR p.D451E 17 78829302 78829302 NCIH460_LUNG 37 Missense_Mutation SNP C A uc002jyt.1 RPTOR_uc010wuf.... Hybrid_Cap... view
SMURF2 p.N567fs 17 62551021 62551022 NCIH460_LUNG 37 Frame_Shift_Ins Ins - T uc002jep.1 SMURF2_uc002jeq... Hybrid_Cap...
SPEG 2 220315838 220315838 NCIH460_LUNG 37 Intron SNP G A uc010fwg.2 SPEG_uc002vlm.2... Hybrid_Cap... view
STK31 7 23872024 23872025 NCIH460_LUNG 37 3'UTR Ins - TTTG rs66787534 uc003sws.3 STK31_uc003swt.... Hybrid_Cap...
TEC 4 48139307 48139310 NCIH460_LUNG 37 3'UTR Del TTAT - rs79098351 uc003gxz.2 Hybrid_Cap...
TIAM1 p.G1283fs 21 32508286 32508286 NCIH460_LUNG 37 Frame_Shift_Del Del C - uc002yow.1 TIAM1_uc011adk.... Hybrid_Cap...
TMEM123 11 102269398 102269398 NCIH460_LUNG 37 3'UTR Del G - uc001pha.2 TMEM123_uc009yx... Hybrid_Cap...
TNFAIP3 p.R136C 6 138196092 138196092 NCIH460_LUNG 37 Missense_Mutation SNP C T uc003qhr.2 TNFAIP3_uc003qh... Hybrid_Cap... view
TRIM33 1 114940212 114940212 NCIH460_LUNG 37 3'UTR Del T - uc001eew.2 TRIM33_uc010owr... Hybrid_Cap...
TRPM7 p.T860M 15 50901779 50901779 NCIH460_LUNG 37 Missense_Mutation SNP G A uc001zyt.3 TRPM7_uc010bew.... Hybrid_Cap... view
TRPS1 8 116635872 116635873 NCIH460_LUNG 37 5'UTR Ins - A rs76893349 uc003yny.2 TRPS1_uc011lhy.... Hybrid_Cap...
TSSK2 p.R237H 22 19119622 19119622 NCIH460_LUNG 37 Missense_Mutation SNP G A uc002zow.2 DGCR14_uc002zot... Hybrid_Cap... view
TTN 2 179391639 179391640 NCIH460_LUNG 37 3'UTR Ins - T rs36037175 uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap...
TTN p.A29874G 2 179407158 179407158 NCIH460_LUNG 37 Missense_Mutation SNP G C uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.A21775T 2 179437832 179437832 NCIH460_LUNG 37 Missense_Mutation SNP C T rs72646895 uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
VEGFC p.S419_splice 4 177605082 177605084 NCIH460_LUNG 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
WEE2 7 141430290 141430290 NCIH460_LUNG 37 3'UTR SNP C T uc003vwn.2 FLJ40852_uc011k... Hybrid_Cap... view
ZNF217 p.A699fs 20 52193208 52193208 NCIH460_LUNG 37 Frame_Shift_Del Del C - uc002xwq.3 ZNF217_uc010gij... Hybrid_Cap...