Annotation Summary for Cell Line: NCI-H522  

Cell line primary name: NCI-H522
Cell line aliases: H522
Gender: M
Site Primary: lung
Histology: carcinoma
Hist Subtype1: non_small_cell_carcinoma
Notes:
Source: ATCC
Expression arrays: NIECE_p_NCLE_RNA3_HG-U133_Plus_2_B08_296028
SNP arrays: FASTS_p_NCLE_DNAAffy4_S_GenomeWideSNP_6_B02_335214
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in NCI-H522

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
ABCA3 p.M847V 16 2339596 2339596 NCIH522_LUNG 37 Missense_Mutation SNP T C uc002cpy.1 ABCA3_uc010bsk.... Hybrid_Cap... view
ADAM17 2 9630245 9630245 NCIH522_LUNG 37 3'UTR Del T - uc002qzu.2 IAH1_uc010yiz.1... Hybrid_Cap...
ADAM28 8 24211994 24211997 NCIH522_LUNG 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
AKAP12 p.1531_1532insE 6 151674116 151674117 NCIH522_LUNG 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
ALPK1 4 113347609 113347610 NCIH522_LUNG 37 Intron Ins - T rs68137453 uc003iap.3 ALPK1_uc003ian.... Hybrid_Cap...
BIRC5 17 76219784 76219785 NCIH522_LUNG 37 3'UTR Ins - AA uc002jvf.2 BIRC5_uc002jvg.... Hybrid_Cap...
CABC1 1 227171585 227171585 NCIH522_LUNG 37 Intron Del T - uc001hqm.1 CABC1_uc001hqn.... Hybrid_Cap...
CABC1 1 227171736 227171737 NCIH522_LUNG 37 Intron Ins - T rs1574184 uc001hqm.1 CABC1_uc001hqn.... Hybrid_Cap...
CACNB2 10 18828721 18828722 NCIH522_LUNG 37 3'UTR Ins - AA rs3841459 uc001ipr.2 CACNB2_uc009xjz... Hybrid_Cap...
CASP4 11 104822788 104822788 NCIH522_LUNG 37 Intron SNP C T rs7924383 uc001pid.1 CASP4_uc001pib.... Hybrid_Cap... view
CD160 1 145696875 145696875 NCIH522_LUNG 37 Intron SNP C A uc001eol.1 NBPF10_uc001emp... Hybrid_Cap... view
CD40LG p.A130V X 135738557 135738557 NCIH522_LUNG 37 Missense_Mutation SNP C T uc004faa.2 CD40LG_uc010nsd... Hybrid_Cap... view
CDK11B 1 1654066 1654068 NCIH522_LUNG 37 Intron Del GCG - uc001agv.1 CDK11B_uc001aha... Hybrid_Cap...
CDK7 p.M196V 5 68558090 68558090 NCIH522_LUNG 37 Missense_Mutation SNP A G uc003jvs.3 CDK7_uc003jvt.3... Hybrid_Cap... view
CDKL5 p.V1002I X 18671575 18671575 NCIH522_LUNG 37 Missense_Mutation SNP G A uc004cym.2 CDKL5_uc004cyn.... Hybrid_Cap... view
CIT p.R2000C 12 120128144 120128144 NCIH522_LUNG 37 Missense_Mutation SNP G A uc001txj.1 CIT_uc001txh.1_... Hybrid_Cap... view
CLTCL1 p.V1201_splice 22 19189003 19189004 NCIH522_LUNG 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
CNTN6 3 1339681 1339686 NCIH522_LUNG 37 Intron Del GTTTT... - uc003boz.2 CNTN6_uc010hbo.... Hybrid_Cap...
CPAMD8 p.R218L 19 17119362 17119362 NCIH522_LUNG 37 Missense_Mutation SNP C A uc002nfb.2 Hybrid_Cap... view
CSPP1 p.Y555C 8 68030560 68030560 NCIH522_LUNG 37 Missense_Mutation SNP A G uc003xxi.2 CSPP1_uc003xxg.... Hybrid_Cap... view
CTNNA2 2 80816379 80816379 NCIH522_LUNG 37 Intron SNP C G uc010ysh.1 CTNNA2_uc010yse... Hybrid_Cap... view
CXCR4 p.S2Y 2 136873505 136873505 NCIH522_LUNG 37 Missense_Mutation SNP G T uc002tuy.2 CXCR4_uc010fnk.... Hybrid_Cap... view
DGKB p.Q460H 7 14647115 14647115 NCIH522_LUNG 37 Missense_Mutation SNP C A uc003ssz.2 DGKB_uc011jxt.1... Hybrid_Cap... view
DVL1 p.R151R 1 1277446 1277446 NCIH522_LUNG 37 Silent SNP C T uc001aer.3 DVL1_uc002quu.2... Hybrid_Cap... view
EDN1 6 12290729 12290729 NCIH522_LUNG 37 5'UTR Del A - uc003nae.3 EDN1_uc010jpb.2... Hybrid_Cap...
EIF4G1 p.GEA479del 3 184039767 184039775 NCIH522_LUNG 37 In_Frame_Del Del AGGAG... - uc010hxx.2 EIF4G1_uc003fno... Hybrid_Cap...
EML4 p.S134C 2 42488323 42488323 NCIH522_LUNG 37 Missense_Mutation SNP C G uc002rsi.2 EML4_uc002rsh.3... Hybrid_Cap... view
EPHA6 3 97467610 97467611 NCIH522_LUNG 37 3'UTR Ins - CT uc010how.1 Hybrid_Cap...
EPS15 1 51822220 51822220 NCIH522_LUNG 37 3'UTR Del A - uc001csq.1 EPS15_uc009vyz.... Hybrid_Cap...
ERG 21 39947659 39947659 NCIH522_LUNG 37 5'UTR SNP C G uc010gnw.2 ERG_uc010gnv.2_... Hybrid_Cap... view
ETV1 7 14028708 14028708 NCIH522_LUNG 37 5'UTR Del A - rs77190713 uc011jxq.1 ETV1_uc011jxn.1... Hybrid_Cap...
FGFR1OP 6 167453519 167453520 NCIH522_LUNG 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
FLI1 11 128638217 128638217 NCIH522_LUNG 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FN1 2 216244182 216244185 NCIH522_LUNG 37 Intron Del GTAC - uc002vfa.2 FN1_uc002vfb.2_... Hybrid_Cap...
GLI2 p.E538G 2 121740386 121740386 NCIH522_LUNG 37 Missense_Mutation SNP A G uc010flp.2 GLI2_uc002tmq.1... Hybrid_Cap... view
GOPC p.Q97E 6 117900224 117900224 NCIH522_LUNG 37 Missense_Mutation SNP G C uc003pxu.2 GOPC_uc003pxv.2... Hybrid_Cap... view
GPR112 p.G1944* X 135431695 135431695 NCIH522_LUNG 37 Nonsense_Mutation SNP G T uc004ezu.1 GPR112_uc010nsb... Hybrid_Cap... view
GRIN2B p.Q1014H 12 13717130 13717130 NCIH522_LUNG 37 Missense_Mutation SNP C A uc001rbt.2 Hybrid_Cap... view
GUCY2C p.G944R 12 14772190 14772190 NCIH522_LUNG 37 Missense_Mutation SNP C T uc001rcd.2 Hybrid_Cap... view
GUCY2C 12 14827464 14827466 NCIH522_LUNG 37 Intron Del ATC - rs72525754;rs3083879 uc001rcd.2 GUCY2C_uc009zhz... Hybrid_Cap...
HNF1A 12 121434630 121434631 NCIH522_LUNG 37 Intron Ins - TCATTCAT rs75100977 uc010szn.1 HNF1A_uc001tze.... Hybrid_Cap...
ILK 11 6630029 6630029 NCIH522_LUNG 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
ITPR2 p.R470_splice 12 26834804 26834805 NCIH522_LUNG 37 Splice_Site_Ins Ins - ACTC rs66696203;rs59199365 uc001rhg.2 Hybrid_Cap...
KCNH2 p.T152fs 7 150656676 150656676 NCIH522_LUNG 37 Frame_Shift_Del Del G - uc003wic.2 KCNH2_uc011kux.... Hybrid_Cap...
KRAS p.Q767_splice 4 140651585 140651587 NCIH522_LUNG 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
KSR2 p.Y180C 12 118199176 118199176 NCIH522_LUNG 37 Missense_Mutation SNP T C uc001two.2 Hybrid_Cap... view
LCP1 p.A471E 13 46716517 46716517 NCIH522_LUNG 37 Missense_Mutation SNP G T uc001vaz.3 LCP1_uc010ack.2... Hybrid_Cap... view
LRP1B p.T706I 2 141773338 141773338 NCIH522_LUNG 37 Missense_Mutation SNP G A uc002tvj.1 LRP1B_uc010fnl.... Hybrid_Cap... view
LRP2 p.R1089C 2 170101368 170101368 NCIH522_LUNG 37 Missense_Mutation SNP G A uc002ues.2 LRP2_uc010zdf.1... Hybrid_Cap... view
MAF 16 79628537 79628537 NCIH522_LUNG 37 Intron Del T - uc002ffm.2 MAF_uc002ffn.2_... Hybrid_Cap...
MAP3K1 p.T949del 5 56177849 56177851 NCIH522_LUNG 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAPKAPK3 3 50685575 50685575 NCIH522_LUNG 37 3'UTR Del A - rs76026164 uc003day.1 MAPKAPK3_uc003d... Hybrid_Cap...
MSH2 p.D352H 2 47643546 47643546 NCIH522_LUNG 37 Missense_Mutation SNP G C uc002rvz.2 MSH2_uc010yoh.1... Hybrid_Cap... view
MTOR p.T1837N 1 11190689 11190689 NCIH522_LUNG 37 Missense_Mutation SNP G T uc001asd.2 MTOR_uc001asc.2... Hybrid_Cap... view
MTOR p.V1801G 1 11190797 11190797 NCIH522_LUNG 37 Missense_Mutation SNP A C uc001asd.2 MTOR_uc001asc.2... Hybrid_Cap... view
MYLK 3 123332875 123332876 NCIH522_LUNG 37 3'UTR Ins - T rs35930843;rs115544676 uc003ego.2 MYLK_uc003egl.2... Hybrid_Cap...
MYLK2 p.D323E 20 30412152 30412152 NCIH522_LUNG 37 Missense_Mutation SNP C A uc002wwq.2 MYLK2_uc002wws.... Hybrid_Cap... view
MYST4 p.E1104del 10 76781906 76781908 NCIH522_LUNG 37 In_Frame_Del Del GAA - rs79644703 uc001jwn.1 MYST4_uc001jwm.... Hybrid_Cap...
MYT1 20 62871860 62871861 NCIH522_LUNG 37 3'UTR Ins - CCGCA uc002yii.2 MYT1_uc002yij.2... Hybrid_Cap...
NCAM1 11 112832307 112832308 NCIH522_LUNG 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 NCIH522_LUNG 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCOA3 p.Q1276del 20 46279837 46279839 NCIH522_LUNG 37 In_Frame_Del Del CAG - rs2664555 uc002xtk.2 NCOA3_uc010ght.... Hybrid_Cap...
NEK3 p.K313_splice 13 52718050 52718051 NCIH522_LUNG 37 Splice_Site_Ins Ins - T rs72514762 uc001vgh.2 NEK3_uc001vgg.2... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881820 50881821 NCIH522_LUNG 37 In_Frame_Ins Ins - AAC rs66783852;rs112359270 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
OLFM4 p.D384Y 13 53624523 53624523 NCIH522_LUNG 37 Missense_Mutation SNP G T uc001vhl.2 OLFM4_uc001vhk.... Hybrid_Cap... view
PASK p.R880H 2 242065691 242065691 NCIH522_LUNG 37 Missense_Mutation SNP C T uc010fzl.1 PASK_uc010zol.1... Hybrid_Cap... view
PAX3 2 223158653 223158653 NCIH522_LUNG 37 Intron Del T - rs112753212 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PDE4DIP p.V486fs 1 144917828 144917828 NCIH522_LUNG 37 Frame_Shift_Del Del A - uc001elw.3 NBPF10_uc009wir... Hybrid_Cap...
PICALM p.K339K 11 85712078 85712078 NCIH522_LUNG 37 Silent SNP C T uc001pbm.2 PICALM_uc001pbl... Hybrid_Cap... view
PIK3C2G p.P129del 12 18435399 18435401 NCIH522_LUNG 37 In_Frame_Del Del CCC - uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PLCB2 p.P436T 15 40589739 40589739 NCIH522_LUNG 37 Missense_Mutation SNP G T uc001zld.2 PLCB2_uc010bbo.... Hybrid_Cap... view
PNCK X 152938417 152938417 NCIH522_LUNG 37 Intron SNP C A uc011myu.1 PNCK_uc011myt.1... Hybrid_Cap... view
PRKDC p.L1244fs 8 48805816 48805817 NCIH522_LUNG 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
RAC1 7 6442161 6442161 NCIH522_LUNG 37 3'UTR SNP A C uc003spw.2 RAC1_uc003spx.2... Hybrid_Cap... view
RAG1 p.V895A 11 36597538 36597538 NCIH522_LUNG 37 Missense_Mutation SNP T C uc001mwu.3 RAG1_uc001mwt.2... Hybrid_Cap... view
RASGRF1 p.K50N 11 116827730 116827730 NCIH522_LUNG 37 Missense_Mutation SNP C G uc001ppy.2 SIK3_uc001ppz.2... Hybrid_Cap... view
RIMS2 p.R194* 8 104898073 104898073 NCIH522_LUNG 37 Nonsense_Mutation SNP C T uc003yls.2 RIMS2_uc003ylp.... Hybrid_Cap... view
RPS6KA5 14 91360733 91360734 NCIH522_LUNG 37 Intron Ins - T rs77438853 uc001xys.2 RPS6KA5_uc010tw... Hybrid_Cap...
RPS6KA6 X 83319196 83319196 NCIH522_LUNG 37 3'UTR SNP G T uc004eej.1 RPS6KA6_uc011mq... Hybrid_Cap... view
RPS6KB1 17 58024224 58024225 NCIH522_LUNG 37 3'UTR Ins - AA rs67846207 uc002ixy.2 RPS6KB1_uc010dd... Hybrid_Cap...
SMARCA4 p.P269fs 19 11097625 11097626 NCIH522_LUNG 37 Frame_Shift_Del Del CC - uc010dxo.2 SMARCA4_uc002mq... Hybrid_Cap...
SPEN p.E1271A 1 16256547 16256547 NCIH522_LUNG 37 Missense_Mutation SNP A C uc001axk.1 SPEN_uc010obp.1... Hybrid_Cap... view
SRPK1 6 35803037 35803037 NCIH522_LUNG 37 3'UTR SNP C A uc003olj.2 SRPK1_uc011dtg.... Hybrid_Cap... view
STAT1 2 191840353 191840353 NCIH522_LUNG 37 Intron Del T - uc002usj.2 STAT1_uc010fse.... Hybrid_Cap...
STK31 7 23872024 23872025 NCIH522_LUNG 37 3'UTR Ins - TTTG rs66787534 uc003sws.3 STK31_uc003swt.... Hybrid_Cap...
TP53 p.P191fs 17 7578277 7578277 NCIH522_LUNG 37 Frame_Shift_Del Del G - uc002gim.2 TP53_uc002gig.1... Hybrid_Cap...
TRIP11 p.R1028Q 14 92471237 92471237 NCIH522_LUNG 37 Missense_Mutation SNP C T uc001xzy.2 TRIP11_uc010auf... Hybrid_Cap... view
TRPM6 p.S78C 9 77457180 77457180 NCIH522_LUNG 37 Missense_Mutation SNP T A uc004ajl.1 TRPM6_uc004ajk.... Hybrid_Cap... view
TRPS1 8 116635872 116635873 NCIH522_LUNG 37 5'UTR Ins - A rs76893349 uc003yny.2 TRPS1_uc011lhy.... Hybrid_Cap...
TTBK1 p.E771del 6 43250726 43250728 NCIH522_LUNG 37 In_Frame_Del Del GAA - uc003ouq.1 Hybrid_Cap...
TTN p.R29799H 2 179407481 179407481 NCIH522_LUNG 37 Missense_Mutation SNP C T uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.D6289V 2 179586792 179586792 NCIH522_LUNG 37 Missense_Mutation SNP T A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
VEGFC p.S419_splice 4 177605082 177605084 NCIH522_LUNG 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
WNK2 p.P892R 9 96021505 96021505 NCIH522_LUNG 37 Missense_Mutation SNP C G uc004ati.1 WNK2_uc011lud.1... Hybrid_Cap... view
XPO4 p.Y908C 13 21370289 21370289 NCIH522_LUNG 37 Missense_Mutation SNP T C uc001unq.3 Hybrid_Cap... view
ZBTB16 11 114121371 114121372 NCIH522_LUNG 37 3'UTR Ins - A uc001pop.2 ZBTB16_uc001poq... Hybrid_Cap...