Annotation Summary for Cell Line: NCI-H524  

Cell line primary name: NCI-H524
Cell line aliases: H524
Gender: M
Site Primary: lung
Histology: carcinoma
Hist Subtype1: small_cell_carcinoma
Notes:
Source: ATCC
Expression arrays: METIS_p_NCLE_RNA1_Human_U133_Plus_2.0_A11_240870
SNP arrays: LIMPS_p_NCLE_DNA2N_GenomeWideSNP_6_E08_246720
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in NCI-H524

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
AAK1 p.541_542QQ>Q 2 69741754 69741756 NCIH524_LUNG 37 In_Frame_Del Del TGT - rs55712143 uc002sfp.2 AAK1_uc010fdk.2... Hybrid_Cap...
ABCC3 p.G624_splice 17 48746212 48746212 NCIH524_LUNG 37 Splice_Site_SNP SNP A T uc002isl.2 Hybrid_Cap... view
ADAM17 2 9630245 9630245 NCIH524_LUNG 37 3'UTR Del T - uc002qzu.2 IAH1_uc010yiz.1... Hybrid_Cap...
ADAM28 8 24211994 24211997 NCIH524_LUNG 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
AKAP12 p.1531_1532insE 6 151674116 151674117 NCIH524_LUNG 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
AKAP9 p.T336S 7 91630237 91630237 NCIH524_LUNG 37 Missense_Mutation SNP A T uc003ulg.2 AKAP9_uc003ule.... Hybrid_Cap... view
AKAP9 p.1335_1336insQ 7 91652178 91652179 NCIH524_LUNG 37 In_Frame_Ins Ins - AAC rs34756483 uc003ulg.2 AKAP9_uc003ule.... Hybrid_Cap...
ALPK2 p.EDTST1006del 18 56204388 56204402 NCIH524_LUNG 37 In_Frame_Del Del CAGTT... - rs60644017;rs117623369 uc002lhj.3 ALPK2_uc002lhk.... Hybrid_Cap...
ALPK3 p.P975S 15 85400286 85400286 NCIH524_LUNG 37 Missense_Mutation SNP C T rs116664409 uc002ble.2 Hybrid_Cap... view
ATM p.R337C 11 108117798 108117798 NCIH524_LUNG 37 Missense_Mutation SNP C T uc001pkb.1 ATM_uc009yxr.1_... Hybrid_Cap... view
ATR p.L1881I 3 142215952 142215952 NCIH524_LUNG 37 Missense_Mutation SNP G T uc003eux.3 Hybrid_Cap... view
BMP4 14 54416602 54416602 NCIH524_LUNG 37 3'UTR Del T - rs76335800 uc001xal.3 BMP4_uc010aoh.2... Hybrid_Cap...
CACNB2 10 18828721 18828722 NCIH524_LUNG 37 3'UTR Ins - AA rs3841459 uc001ipr.2 CACNB2_uc009xjz... Hybrid_Cap...
CAMK2G p.A339T 10 75585057 75585057 NCIH524_LUNG 37 Missense_Mutation SNP C T uc001jvv.1 CAMK2G_uc001jvm... Hybrid_Cap... view
CASP4 11 104819546 104819547 NCIH524_LUNG 37 Intron Ins - AGACACAC rs33910737;rs113139978 uc001pid.1 CASP4_uc001pib.... Hybrid_Cap...
CBFB 16 67132815 67132815 NCIH524_LUNG 37 3'UTR SNP A G uc002erb.2 CBFB_uc002era.2... Hybrid_Cap... view
CCNE1 p.R339S 19 30313417 30313417 NCIH524_LUNG 37 Missense_Mutation SNP G T uc002nsn.2 CCNE1_uc002nso.... Hybrid_Cap... view
CDH2 p.W161L 18 25591874 25591874 NCIH524_LUNG 37 Missense_Mutation SNP C A uc002kwg.2 CDH2_uc010xbn.1... Hybrid_Cap... view
CDK11B 1 1654066 1654068 NCIH524_LUNG 37 Intron Del GCG - uc001agv.1 CDK11B_uc001aha... Hybrid_Cap...
CDK15 p.S329fs 2 202719637 202719637 NCIH524_LUNG 37 Frame_Shift_Del Del C - uc002uyt.2 CDK15_uc010ftm.... Hybrid_Cap...
CDK4 p.M1I 12 58145498 58145498 NCIH524_LUNG 37 Missense_Mutation SNP C A uc001spv.2 CDK4_uc010ssb.1... Hybrid_Cap... view
CDKN2A 9 21974541 21974541 NCIH524_LUNG 37 Intron SNP C A uc003zpl.2 MTAP_uc003zpi.1... Hybrid_Cap... view
CEP110 p.A609S 9 123888014 123888014 NCIH524_LUNG 37 Missense_Mutation SNP G T uc004bkx.1 CEP110_uc004bky... Hybrid_Cap... view
CHL1 p.T766N 3 430984 430984 NCIH524_LUNG 37 Missense_Mutation SNP C A uc003bot.2 CHL1_uc003bou.2... Hybrid_Cap... view
CLTCL1 p.V1201_splice 22 19189003 19189004 NCIH524_LUNG 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
CSMD3 p.L1048H 8 113662440 113662440 NCIH524_LUNG 37 Missense_Mutation SNP A T uc003ynu.2 CSMD3_uc003yns.... Hybrid_Cap... view
CTBP2 p.K974fs 10 126678123 126678123 NCIH524_LUNG 37 Frame_Shift_Del Del T - uc001lie.3 CTBP2_uc009yak.... Hybrid_Cap...
CUBN p.C779S 10 17113937 17113937 NCIH524_LUNG 37 Missense_Mutation SNP A T uc001ioo.2 Hybrid_Cap... view
CYFIP1 p.V937F 15 22990189 22990189 NCIH524_LUNG 37 Missense_Mutation SNP G T uc001yus.2 CYFIP1_uc001yut... Hybrid_Cap... view
CYP2B6 p.S181Y 19 41512867 41512867 NCIH524_LUNG 37 Missense_Mutation SNP C A uc002opr.1 CYP2A7_uc002opo... Hybrid_Cap... view
CYP2B6 19 41522814 41522814 NCIH524_LUNG 37 3'UTR SNP A T uc002opr.1 CYP2A7_uc002opo... Hybrid_Cap... view
DAPK1 p.H657P 9 90283558 90283558 NCIH524_LUNG 37 Missense_Mutation SNP A C uc004apc.2 DAPK1_uc004apd.... Hybrid_Cap... view
DRD2 p.G242_splice 11 113285184 113285184 NCIH524_LUNG 37 Splice_Site_SNP SNP C G uc001pnz.2 DRD2_uc010rwv.1... Hybrid_Cap... view
DST p.I4234L 6 56373509 56373509 NCIH524_LUNG 37 Missense_Mutation SNP T A uc003pdf.2 DST_uc003pcz.3_... Hybrid_Cap... view
EP300 p.M693V 22 41542766 41542766 NCIH524_LUNG 37 Missense_Mutation SNP A G uc003azl.3 Hybrid_Cap... view
EP300 p.Y1503S 22 41568558 41568558 NCIH524_LUNG 37 Missense_Mutation SNP A C uc003azl.3 Hybrid_Cap... view
EPHA6 3 97367230 97367231 NCIH524_LUNG 37 Intron Ins - A rs115253553 uc010how.1 EPHA6_uc003drs.... Hybrid_Cap...
EPHA6 3 97467610 97467611 NCIH524_LUNG 37 3'UTR Ins - CT uc010how.1 Hybrid_Cap...
ETV1 7 14028708 14028708 NCIH524_LUNG 37 5'UTR Del A - rs77190713 uc011jxq.1 ETV1_uc011jxn.1... Hybrid_Cap...
EXT1 8 118811807 118811807 NCIH524_LUNG 37 3'UTR Del T - uc003yok.1 Hybrid_Cap...
FASN p.A2029V 17 80039962 80039962 NCIH524_LUNG 37 Missense_Mutation SNP G A uc002kdu.2 FASN_uc002kdv.1... Hybrid_Cap... view
FBN2 p.D2695N 5 127599226 127599226 NCIH524_LUNG 37 Missense_Mutation SNP C T uc003kuu.2 Hybrid_Cap... view
FGFR1OP 6 167453519 167453520 NCIH524_LUNG 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
FLI1 11 128638217 128638217 NCIH524_LUNG 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FN1 2 216244182 216244185 NCIH524_LUNG 37 Intron Del GTAC - uc002vfa.2 FN1_uc002vfb.2_... Hybrid_Cap...
GRIA3 X 122318386 122318387 NCIH524_LUNG 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GUCY2C 12 14827464 14827466 NCIH524_LUNG 37 Intron Del ATC - rs72525754;rs3083879 uc001rcd.2 GUCY2C_uc009zhz... Hybrid_Cap...
HIF1A p.S35Y 14 62187165 62187165 NCIH524_LUNG 37 Missense_Mutation SNP C A uc001xfs.2 HIF1A_uc010tsc.... Hybrid_Cap... view
HIF1A 14 62213929 62213930 NCIH524_LUNG 37 3'UTR Ins - T rs67890419 uc001xfs.2 HIF1A_uc001xfq.... Hybrid_Cap...
HOXA9 7 27203151 27203151 NCIH524_LUNG 37 3'UTR SNP C T uc003syt.2 Hybrid_Cap... view
HSP90AA1 p.R467Q 14 102550849 102550849 NCIH524_LUNG 37 Missense_Mutation SNP C T uc001ykv.3 HSP90AA1_uc001y... Hybrid_Cap... view
ILK 11 6630029 6630029 NCIH524_LUNG 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
ITGAV p.Q986K 2 187541567 187541567 NCIH524_LUNG 37 Missense_Mutation SNP C A uc002upq.2 ITGAV_uc010frs.... Hybrid_Cap... view
ITPR2 p.R470_splice 12 26834804 26834805 NCIH524_LUNG 37 Splice_Site_Ins Ins - ACTC rs66696203;rs59199365 uc001rhg.2 Hybrid_Cap...
KLK7 19 51480672 51480675 NCIH524_LUNG 37 3'UTR Del GGTT - uc002puo.2 KLK7_uc002pup.2... Hybrid_Cap...
LIMK2 p.R295C 22 31662023 31662023 NCIH524_LUNG 37 Missense_Mutation SNP C T uc003akj.2 LIMK2_uc003akg.... Hybrid_Cap... view
LRRK2 p.D478Y 12 40653295 40653295 NCIH524_LUNG 37 Missense_Mutation SNP G T rs56001713 uc001rmg.3 LRRK2_uc001rmh.... Hybrid_Cap... view
LYN p.T276S 8 56879309 56879309 NCIH524_LUNG 37 Missense_Mutation SNP A T uc003xsk.3 LYN_uc003xsl.3_... Hybrid_Cap... view
MAF 16 79628537 79628537 NCIH524_LUNG 37 Intron Del T - uc002ffm.2 MAF_uc002ffn.2_... Hybrid_Cap...
MAML2 p.604_607QQQQ>Q 11 95825375 95825383 NCIH524_LUNG 37 In_Frame_Del Del TGCTG... - rs113349418 uc001pfw.1 Hybrid_Cap...
MAML3 p.Q767_splice 4 140651585 140651587 NCIH524_LUNG 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP3K1 p.T949del 5 56177849 56177851 NCIH524_LUNG 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAP3K14 p.R218_splice 17 43364293 43364294 NCIH524_LUNG 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
MAP3K4 p.A1199del 6 161519351 161519353 NCIH524_LUNG 37 In_Frame_Del Del CTG - uc003qtn.2 MAP3K4_uc010kkc... Hybrid_Cap...
MAST1 p.F441L 19 12969510 12969510 NCIH524_LUNG 37 Missense_Mutation SNP T A uc002mvm.2 MAST1_uc002mvk.... Hybrid_Cap... view
MCM3APAS 21 47671275 47671276 NCIH524_LUNG 37 3'UTR Ins - AAT rs67797185 uc002zin.2 MCM3APAS_uc002z... Hybrid_Cap...
MECOM 3 168862932 168862937 NCIH524_LUNG 37 Intron Del ACACA... - uc011bpj.1 MECOM_uc003ffj.... Hybrid_Cap...
MLL p.S3008Y 11 118375630 118375630 NCIH524_LUNG 37 Missense_Mutation SNP C A uc001ptb.2 MLL_uc001pta.2_... Hybrid_Cap... view
MLLT3 9 20346377 20346378 NCIH524_LUNG 37 3'UTR Ins - A rs66943046 uc003zoe.2 MLLT3_uc011lne.... Hybrid_Cap...
MSN p.L124V X 64949477 64949477 NCIH524_LUNG 37 Missense_Mutation SNP C G uc004dwf.2 Hybrid_Cap... view
MTMR11 p.P432L 1 149902853 149902853 NCIH524_LUNG 37 Missense_Mutation SNP G A uc001etl.3 SF3B4_uc001etk.... Hybrid_Cap... view
MYO18B p.G35W 22 26159261 26159261 NCIH524_LUNG 37 Missense_Mutation SNP G T uc003abz.1 MYO18B_uc003aca... Hybrid_Cap... view
NAV3 p.G1493V 12 78530993 78530993 NCIH524_LUNG 37 Missense_Mutation SNP G T uc001syp.2 NAV3_uc001syo.2... Hybrid_Cap... view
NCAM1 11 112832307 112832308 NCIH524_LUNG 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 NCIH524_LUNG 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 p.K63R 11 113076816 113076816 NCIH524_LUNG 37 Missense_Mutation SNP A G uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap... view
NEK3 p.K313_splice 13 52718050 52718051 NCIH524_LUNG 37 Splice_Site_Ins Ins - T rs72514762 uc001vgh.2 NEK3_uc001vgg.2... Hybrid_Cap...
NFIA 1 61921185 61921186 NCIH524_LUNG 37 3'UTR Ins - T rs57270124;rs76131997 uc010oos.1 NFIA_uc001czy.2... Hybrid_Cap...
NLRP10 p.F473S 11 7981741 7981741 NCIH524_LUNG 37 Missense_Mutation SNP A G uc001mfv.1 Hybrid_Cap... view
NOTCH1 9 139397590 139397590 NCIH524_LUNG 37 Intron Del C - uc004chz.2 NOTCH1_uc004cia... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881822 50881823 NCIH524_LUNG 37 In_Frame_Ins Ins - CAG rs61751954;rs1052533 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
PAX3 2 223158653 223158653 NCIH524_LUNG 37 Intron Del T - rs112753212 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PDE4DIP p.Q1665fs 1 144873963 144873963 NCIH524_LUNG 37 Frame_Shift_Del Del T - uc001elw.3 NBPF10_uc009wir... Hybrid_Cap...
PGGT1B 5 114548071 114548072 NCIH524_LUNG 37 3'UTR Ins - C uc003kqw.3 PGGT1B_uc003kqx... Hybrid_Cap...
PGR 11 100933598 100933599 NCIH524_LUNG 37 Intron Ins - AATGA rs35148438 uc001pgh.2 PGR_uc001pgg.2_... Hybrid_Cap...
PHIP p.T712P 6 79707198 79707198 NCIH524_LUNG 37 Missense_Mutation SNP T G uc003pir.2 PHIP_uc011dyp.1... Hybrid_Cap... view
PI4KA p.H1039L 22 21101944 21101944 NCIH524_LUNG 37 Missense_Mutation SNP T A uc002zsz.3 Hybrid_Cap... view
PIK3C2G p.P129del 12 18435399 18435401 NCIH524_LUNG 37 In_Frame_Del Del CCC - uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PKHD1 p.C1787* 6 51887618 51887618 NCIH524_LUNG 37 Nonsense_Mutation SNP G T uc003pah.1 PKHD1_uc003pai.... Hybrid_Cap... view
PLK2 5 57755014 57755014 NCIH524_LUNG 37 Intron Del A - uc003jrn.2 PLK2_uc011cql.1... Hybrid_Cap...
PRKCA 17 64298959 64298960 NCIH524_LUNG 37 5'UTR Ins - G rs71160558 uc002jfp.1 PRKCA_uc002jfo.... Hybrid_Cap...
PRKCB 16 24231224 24231224 NCIH524_LUNG 37 3'UTR SNP C A uc002dme.2 PRKCB_uc002dmd.... Hybrid_Cap... view
PRKCI p.R130C 3 169985726 169985726 NCIH524_LUNG 37 Missense_Mutation SNP C T rs56154494 uc003fgs.2 Hybrid_Cap... view
PRKDC p.L1244fs 8 48805816 48805817 NCIH524_LUNG 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
PRRX1 1 170705428 170705431 NCIH524_LUNG 37 3'UTR Del ACAA - uc001ghf.2 PRRX1_uc001ghe.... Hybrid_Cap...
RABEP1 p.A598S 17 5271671 5271671 NCIH524_LUNG 37 Missense_Mutation SNP G T uc002gbm.3 RABEP1_uc010clc... Hybrid_Cap... view
RAGE p.V69E 14 102732166 102732166 NCIH524_LUNG 37 Missense_Mutation SNP A T uc001ylm.2 RAGE_uc010txv.1... Hybrid_Cap... view
RAPGEF2 4 160189200 160189201 NCIH524_LUNG 37 5'UTR Ins - T rs72011511 uc003iqg.3 Hybrid_Cap...
RB1 p.S576* 13 49027160 49027160 NCIH524_LUNG 37 Nonsense_Mutation SNP C G uc001vcb.2 Hybrid_Cap... view
RB1 13 49054240 49054240 NCIH524_LUNG 37 3'UTR SNP C A uc001vcb.2 Hybrid_Cap... view
RGS22 p.I1226F 8 100975146 100975146 NCIH524_LUNG 37 Missense_Mutation SNP T A uc003yjb.1 RGS22_uc003yja.... Hybrid_Cap... view
ROR1 1 64608393 64608393 NCIH524_LUNG 37 Intron SNP C A uc001dbj.2 ROR1_uc001dbi.3... Hybrid_Cap... view
SEMA5B p.R645G 3 122634342 122634342 NCIH524_LUNG 37 Missense_Mutation SNP G C uc003efz.1 SEMA5B_uc011bju... Hybrid_Cap... view
STAT5A 17 40462797 40462798 NCIH524_LUNG 37 3'UTR Del TG - uc002hzj.1 STAT5A_uc010cya... Hybrid_Cap...
STK31 7 23872024 23872025 NCIH524_LUNG 37 3'UTR Ins - TTTG rs66787534 uc003sws.3 STK31_uc003swt.... Hybrid_Cap...
TAOK1 p.R495* 17 27835058 27835058 NCIH524_LUNG 37 Nonsense_Mutation SNP A T uc002hdz.1 TAOK1_uc010wbe.... Hybrid_Cap... view
TEC 4 48139307 48139310 NCIH524_LUNG 37 3'UTR Del TTAT - rs79098351 uc003gxz.2 Hybrid_Cap...
TLK1 2 171850178 171850179 NCIH524_LUNG 37 3'UTR Ins - AA rs71008739 uc002ugo.2 TLK1_uc002ugn.2... Hybrid_Cap...
TMEM123 11 102269398 102269398 NCIH524_LUNG 37 3'UTR Del G - uc001pha.2 TMEM123_uc009yx... Hybrid_Cap...
TNIK p.Q386H 3 170875312 170875312 NCIH524_LUNG 37 Missense_Mutation SNP C A uc003fhh.2 TNIK_uc003fhi.2... Hybrid_Cap... view
TP53 p.T155N 17 7578466 7578466 NCIH524_LUNG 37 Missense_Mutation SNP G T uc002gim.2 TP53_uc002gig.1... Hybrid_Cap... view
TP63 3 189507518 189507519 NCIH524_LUNG 37 Intron Ins - AG rs62702062;rs79714037 uc003fry.2 TP63_uc003frx.2... Hybrid_Cap...
TPM3 1 154155477 154155477 NCIH524_LUNG 37 Intron SNP C A uc001fec.1 TPM3_uc010pei.1... Hybrid_Cap... view
TPO p.W672V 2 1499768 1499769 NCIH524_LUNG 37 Missense_Mutation DNP TG GT uc002qww.2 TPO_uc010ewj.2_... Hybrid_Cap...
TRAF2 9 139820463 139820463 NCIH524_LUNG 37 3'UTR SNP T G uc010nbu.2 TRAF2_uc004cjv.... Hybrid_Cap... view
TRPS1 8 116635872 116635873 NCIH524_LUNG 37 5'UTR Ins - A rs76893349 uc003yny.2 TRPS1_uc011lhy.... Hybrid_Cap...
TTN p.A20548S 2 179441716 179441716 NCIH524_LUNG 37 Missense_Mutation SNP C A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.D8508N 2 179571347 179571347 NCIH524_LUNG 37 Missense_Mutation SNP C T uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.M7759I 2 179577852 179577852 NCIH524_LUNG 37 Missense_Mutation SNP C A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.E913D 2 179648833 179648833 NCIH524_LUNG 37 Missense_Mutation SNP T A uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view