Annotation Summary for Cell Line: NCI-H69  

Cell line primary name: NCI-H69
Cell line aliases: H69
Gender: M
Site Primary: lung
Histology: carcinoma
Hist Subtype1: small_cell_carcinoma
Notes:
Source: ATCC
Expression arrays: MAKER_p_NCLE_RNA7_HG-U133_Plus_2_C02_454610
SNP arrays: PODIA_p_NCLE_DNAAffy7_GenomeWideSNP_6_D04_437520
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in NCI-H69

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
AAK1 p.541_542QQ>Q 2 69741754 69741756 NCIH69_LUNG 37 In_Frame_Del Del TGT - rs55712143 uc002sfp.2 AAK1_uc010fdk.2... Hybrid_Cap...
AATK p.F1298C 17 79093371 79093371 NCIH69_LUNG 37 Missense_Mutation SNP A C uc010dia.2 AATK_uc010dhz.2... Hybrid_Cap... view
ACACA p.K2068R 17 35478348 35478348 NCIH69_LUNG 37 Missense_Mutation SNP T C uc002hno.2 ACACA_uc002hnk.... Hybrid_Cap... view
ADAM28 8 24211994 24211997 NCIH69_LUNG 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
ADCK1 14 78390632 78390637 NCIH69_LUNG 37 Intron Del AAACT... - rs78274857;rs74969652 uc001xui.2 ADCK1_uc010tvo.... Hybrid_Cap...
ADRBK2 p.V433D 22 26100146 26100146 NCIH69_LUNG 37 Missense_Mutation SNP T A uc003abx.3 ADRBK2_uc010gux... Hybrid_Cap... view
AKAP12 p.1531_1532insE 6 151674116 151674117 NCIH69_LUNG 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
AKAP9 p.1335_1336insQ 7 91652178 91652179 NCIH69_LUNG 37 In_Frame_Ins Ins - AAC rs34756483 uc003ulg.2 AKAP9_uc003ule.... Hybrid_Cap...
ALPK2 p.1388_1389FF>F 18 56203253 56203255 NCIH69_LUNG 37 In_Frame_Del Del AAG - uc002lhj.3 ALPK2_uc002lhk.... Hybrid_Cap...
ARHGEF12 p.E587D 11 120319841 120319841 NCIH69_LUNG 37 Missense_Mutation SNP A C uc001pxl.1 ARHGEF12_uc009z... Hybrid_Cap... view
ARHGEF7 p.T214N 13 111870135 111870135 NCIH69_LUNG 37 Missense_Mutation SNP C A uc001vrs.2 ARHGEF7_uc001vr... Hybrid_Cap... view
ATM p.M1064I 11 108143487 108143487 NCIH69_LUNG 37 Missense_Mutation SNP G T uc001pkb.1 ATM_uc009yxr.1_... Hybrid_Cap... view
AURKC 19 57742494 57742507 NCIH69_LUNG 37 5'UTR Del GGACG... - rs67926438;rs112039303;rs59094959 uc002qoe.2 AURKC_uc002qoc.... Hybrid_Cap...
BCR 22 23631813 23631814 NCIH69_LUNG 37 Intron Ins - C rs66503844 uc002zww.2 BCR_uc002zwx.2_... Hybrid_Cap...
CABC1 1 227171585 227171585 NCIH69_LUNG 37 Intron Del T - uc001hqm.1 CABC1_uc001hqn.... Hybrid_Cap...
CABC1 1 227171736 227171737 NCIH69_LUNG 37 Intron Ins - T rs1574184 uc001hqm.1 CABC1_uc001hqn.... Hybrid_Cap...
CDKL5 p.Q219H X 18606176 18606176 NCIH69_LUNG 37 Missense_Mutation SNP A T uc004cym.2 CDKL5_uc004cyn.... Hybrid_Cap... view
CEP110 9 123939699 123939699 NCIH69_LUNG 37 3'UTR Del T - rs75910820 uc004bkx.1 CEP110_uc004blb... Hybrid_Cap...
CHD9 p.W730* 16 53262915 53262915 NCIH69_LUNG 37 Nonsense_Mutation SNP G A uc002ehb.2 CHD9_uc002egy.2... Hybrid_Cap... view
CHL1 p.I100L 3 369950 369950 NCIH69_LUNG 37 Missense_Mutation SNP A T uc003bot.2 CHL1_uc003bou.2... Hybrid_Cap... view
CLTCL1 p.V1201_splice 22 19189003 19189004 NCIH69_LUNG 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
CREB3L2 p.T100del 7 137612914 137612916 NCIH69_LUNG 37 In_Frame_Del Del TGG - uc003vtw.2 CREB3L2_uc003vt... Hybrid_Cap...
CTBP2 p.K974fs 10 126678123 126678123 NCIH69_LUNG 37 Frame_Shift_Del Del T - uc001lie.3 CTBP2_uc009yak.... Hybrid_Cap...
CUBN p.G388V 10 17147523 17147523 NCIH69_LUNG 37 Missense_Mutation SNP C A uc001ioo.2 Hybrid_Cap... view
DDX10 11 108788786 108788786 NCIH69_LUNG 37 Intron SNP C G uc001pkm.2 DDX10_uc001pkl.... Hybrid_Cap... view
EIF2S1 p.I27T 14 67831564 67831564 NCIH69_LUNG 37 Missense_Mutation SNP T C uc001xjg.2 Hybrid_Cap... view
EPHA5 4 66189753 66189754 NCIH69_LUNG 37 3'UTR Ins - T rs67487372 uc011cah.1 EPHA5_uc003hcx.... Hybrid_Cap...
EPHA6 3 97367230 97367231 NCIH69_LUNG 37 Intron Ins - A rs115253553 uc010how.1 EPHA6_uc003drs.... Hybrid_Cap...
ETV1 7 14028708 14028708 NCIH69_LUNG 37 5'UTR Del A - rs77190713 uc011jxq.1 ETV1_uc011jxn.1... Hybrid_Cap...
FLI1 11 128638217 128638217 NCIH69_LUNG 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FLI1 11 128638222 128638223 NCIH69_LUNG 37 Intron Ins - T uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FLI1 p.S197_splice 11 128651852 128651852 NCIH69_LUNG 37 Splice_Site_SNP SNP G T uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap... view
FLNC p.C1680Y 7 128489472 128489472 NCIH69_LUNG 37 Missense_Mutation SNP G A uc003vnz.3 FLNC_uc003voa.3... Hybrid_Cap... view
FN1 2 216244182 216244185 NCIH69_LUNG 37 Intron Del GTAC - uc002vfa.2 FN1_uc002vfb.2_... Hybrid_Cap...
GH1 p.G152W 17 61995122 61995122 NCIH69_LUNG 37 Missense_Mutation SNP C A uc002jdj.2 GH1_uc002jdi.2_... Hybrid_Cap... view
GPR112 p.D2657del X 135474445 135474447 NCIH69_LUNG 37 In_Frame_Del Del GAT - rs3030295 uc004ezu.1 GPR112_uc010nsb... Hybrid_Cap...
GRIA3 X 122318386 122318387 NCIH69_LUNG 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GUCY2C 12 14827464 14827466 NCIH69_LUNG 37 Intron Del ATC - rs72525754;rs3083879 uc001rcd.2 GUCY2C_uc009zhz... Hybrid_Cap...
HNF1A 12 121434630 121434631 NCIH69_LUNG 37 Intron Ins - TCATTCAT rs75100977 uc010szn.1 HNF1A_uc001tze.... Hybrid_Cap...
HSP90AA1 p.E430del 14 102551075 102551077 NCIH69_LUNG 37 In_Frame_Del Del CTC - uc001ykv.3 HSP90AA1_uc001y... Hybrid_Cap...
ILK 11 6630029 6630029 NCIH69_LUNG 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
INHBA 7 41740067 41740068 NCIH69_LUNG 37 5'UTR Ins - T rs116230303 uc003thq.2 LOC285954_uc003... Hybrid_Cap...
ITPR2 p.R470_splice 12 26834804 26834805 NCIH69_LUNG 37 Splice_Site_Ins Ins - ACTC rs66696203;rs59199365 uc001rhg.2 Hybrid_Cap...
KALRN p.E2000* 3 124376615 124376615 NCIH69_LUNG 37 Nonsense_Mutation SNP G T uc003ehg.2 KALRN_uc003ehi.... Hybrid_Cap... view
KLK7 19 51480672 51480675 NCIH69_LUNG 37 3'UTR Del GGTT - uc002puo.2 KLK7_uc002pup.2... Hybrid_Cap...
LAMA1 p.R169Q 18 7050775 7050775 NCIH69_LUNG 37 Missense_Mutation SNP C T uc002knm.2 LAMA1_uc010wzj.... Hybrid_Cap... view
LRP1B 2 140990663 140990663 NCIH69_LUNG 37 3'UTR SNP G T uc002tvj.1 Hybrid_Cap... view
MAF 16 79628537 79628537 NCIH69_LUNG 37 Intron Del T - uc002ffm.2 MAF_uc002ffn.2_... Hybrid_Cap...
MAML2 p.604_607QQQQ>Q 11 95825375 95825383 NCIH69_LUNG 37 In_Frame_Del Del TGCTG... - rs113349418 uc001pfw.1 Hybrid_Cap...
MAML3 p.Q767_splice 4 140651585 140651587 NCIH69_LUNG 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP2K4 p.G78V 17 11958290 11958290 NCIH69_LUNG 37 Missense_Mutation SNP G T uc002gnk.2 MAP2K4_uc002gnj... Hybrid_Cap... view
MAP3K1 p.T949del 5 56177849 56177851 NCIH69_LUNG 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAP3K14 p.R218_splice 17 43364293 43364294 NCIH69_LUNG 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
MAPKAPK3 3 50685575 50685575 NCIH69_LUNG 37 3'UTR Del A - rs76026164 uc003day.1 MAPKAPK3_uc003d... Hybrid_Cap...
MAPKAPK5 p.Q272E 12 112321538 112321538 NCIH69_LUNG 37 Missense_Mutation SNP C G uc001tta.2 MAPKAPK5_uc001t... Hybrid_Cap... view
MAST1 p.T506N 19 12975871 12975872 NCIH69_LUNG 37 Missense_Mutation DNP CC AT uc002mvm.2 Hybrid_Cap...
MECOM 3 169381262 169381262 NCIH69_LUNG 37 5'UTR SNP G C rs10581416 uc011bpj.1 MECOM_uc011bpk.... Hybrid_Cap... view
MYC p.G123E 8 128750831 128750831 NCIH69_LUNG 37 Missense_Mutation SNP G A uc003ysi.2 MYC_uc003ysh.1_... Hybrid_Cap... view
NCAM1 11 112832307 112832308 NCIH69_LUNG 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 NCIH69_LUNG 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NEK3 p.K313_splice 13 52718050 52718051 NCIH69_LUNG 37 Splice_Site_Ins Ins - T rs72514762 uc001vgh.2 NEK3_uc001vgg.2... Hybrid_Cap...
NFIA 1 61921185 61921186 NCIH69_LUNG 37 3'UTR Ins - T rs57270124;rs76131997 uc010oos.1 NFIA_uc001czy.2... Hybrid_Cap...
NIPBL p.H870Q 5 36985892 36985892 NCIH69_LUNG 37 Missense_Mutation SNP C A uc003jkl.3 NIPBL_uc003jkk.... Hybrid_Cap... view
NPR1 1 153665919 153665920 NCIH69_LUNG 37 3'UTR Ins - C rs66682713 uc001fcs.3 NPR1_uc010pdz.1... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881820 50881821 NCIH69_LUNG 37 In_Frame_Ins Ins - AAC rs66783852;rs112359270 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881822 50881823 NCIH69_LUNG 37 In_Frame_Ins Ins - CAG rs61751954;rs1052533 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
NTRK2 p.A586V 9 87549200 87549200 NCIH69_LUNG 37 Missense_Mutation SNP C T uc004anz.1 NTRK2_uc004any.... Hybrid_Cap... view
PAX5 9 36840382 36840382 NCIH69_LUNG 37 3'UTR SNP G T uc003zzo.1 PAX5_uc011lpt.1... Hybrid_Cap... view
PAX5 9 37034095 37034095 NCIH69_LUNG 37 5'UTR Del C - uc003zzo.1 PAX5_uc011lpw.1... Hybrid_Cap...
PIK3C2G p.P129del 12 18435399 18435401 NCIH69_LUNG 37 In_Frame_Del Del CCC - uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PIK3CA p.GNR106del 3 178916929 178916937 NCIH69_LUNG 37 In_Frame_Del Del GGCAA... - uc003fjk.2 Hybrid_Cap...
PMS2 p.L594fs 7 6026614 6026614 NCIH69_LUNG 37 Frame_Shift_Del Del T - rs63750593 uc003spl.2 PMS2_uc003spj.2... Hybrid_Cap...
PPP3CA p.A61S 4 102117151 102117151 NCIH69_LUNG 37 Missense_Mutation SNP C A uc011cen.1 PPP3CA_uc003hvu... Hybrid_Cap... view
PRKDC p.L1244fs 8 48805816 48805817 NCIH69_LUNG 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
PTCH2 p.V1019M 1 45291981 45291981 NCIH69_LUNG 37 Missense_Mutation SNP C T rs11573591 uc010olf.1 PTCH2_uc010olg.... Hybrid_Cap... view
RASGRF2 p.E1174K 5 80513260 80513260 NCIH69_LUNG 37 Missense_Mutation SNP G A uc003kha.1 RNU5E_uc011cto.... Hybrid_Cap... view
RB1 p.E748* 13 49039164 49039164 NCIH69_LUNG 37 Nonsense_Mutation SNP G T uc001vcb.2 Hybrid_Cap... view
RBM15 p.S435Y 1 110883331 110883331 NCIH69_LUNG 37 Missense_Mutation SNP C A uc001dzl.1 RBM15_uc001dzm.... Hybrid_Cap... view
ROR2 p.C389R 9 94493210 94493210 NCIH69_LUNG 37 Missense_Mutation SNP A G uc004arj.1 ROR2_uc004ari.1... Hybrid_Cap... view
ROS1 p.S2299Y 6 117609803 117609803 NCIH69_LUNG 37 Missense_Mutation SNP G T uc003pxp.1 ROS1_uc011ebi.1... Hybrid_Cap... view
RPS6KA5 14 91360733 91360734 NCIH69_LUNG 37 Intron Ins - T rs77438853 uc001xys.2 RPS6KA5_uc010tw... Hybrid_Cap...
SEPT9 17 75494787 75494788 NCIH69_LUNG 37 3'UTR Ins - C rs5822173 uc002jts.3 SEPT9_uc010wtk.... Hybrid_Cap...
SPEN p.R1303M 1 16256643 16256643 NCIH69_LUNG 37 Missense_Mutation SNP G T uc001axk.1 SPEN_uc010obp.1... Hybrid_Cap... view
STAT5A 17 40462797 40462800 NCIH69_LUNG 37 3'UTR Del TGTG - uc002hzj.1 STAT5A_uc010cya... Hybrid_Cap...
STK25 2 242435659 242435662 NCIH69_LUNG 37 Intron Del AAGG - rs3215138;rs75497042 uc002wbm.2 STK25_uc002wbk.... Hybrid_Cap...
TAF1 p.E1244K X 70618471 70618471 NCIH69_LUNG 37 Missense_Mutation SNP G A uc004dzt.3 BCYRN1_uc011mpt... Hybrid_Cap... view
TAF15 p.G336C 17 34169463 34169463 NCIH69_LUNG 37 Missense_Mutation SNP G T uc002hkd.2 TAF15_uc010ctw.... Hybrid_Cap... view
TP53 p.E171* 17 7578419 7578419 NCIH69_LUNG 37 Nonsense_Mutation SNP C A uc002gim.2 TP53_uc002gig.1... Hybrid_Cap... view
TPR p.E1132K 1 186313530 186313530 NCIH69_LUNG 37 Missense_Mutation SNP C T uc001grv.2 Hybrid_Cap... view
TRPS1 8 116635872 116635873 NCIH69_LUNG 37 5'UTR Ins - A rs76893349 uc003yny.2 TRPS1_uc011lhy.... Hybrid_Cap...
TRRAP p.P521L 7 98507890 98507890 NCIH69_LUNG 37 Missense_Mutation SNP C T uc003upp.2 TRRAP_uc011kis.... Hybrid_Cap... view
UBR5 p.N935K 8 103317335 103317335 NCIH69_LUNG 37 Missense_Mutation SNP A T uc003ykr.1 UBR5_uc003yks.1... Hybrid_Cap... view
VEGFC p.S419_splice 4 177605082 177605084 NCIH69_LUNG 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
WRN p.M1I 8 30915966 30915966 NCIH69_LUNG 37 Missense_Mutation SNP G C uc003xio.3 Hybrid_Cap... view