Annotation Summary for Cell Line: SCC-4  

Cell line primary name: SCC-4
Cell line aliases:
Gender: M
Site Primary: upper_aerodigestive_tract
Histology: carcinoma
Hist Subtype1: squamous_cell_carcinoma
Notes:
Source: ATCC
Expression arrays: CASED_p_NCLE_RNA4_HG-U133_Plus_2_G07_383650
SNP arrays: FIEFS_p_NCLE_DNA_Affy5_GenomeWideSNP_6_E11_410996
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in SCC-4

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
ADAM17 2 9630245 9630245 SCC4_UPPER_AERO... 37 3'UTR Del T - uc002qzu.2 IAH1_uc010yiz.1... Hybrid_Cap...
ADAM28 8 24211994 24211997 SCC4_UPPER_AERO... 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
AKAP12 p.1531_1532insE 6 151674116 151674117 SCC4_UPPER_AERO... 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
AKAP9 p.1335_1336insQ 7 91652178 91652179 SCC4_UPPER_AERO... 37 In_Frame_Ins Ins - AAC rs34756483 uc003ulg.2 AKAP9_uc003ule.... Hybrid_Cap...
ALPK1 4 113347609 113347610 SCC4_UPPER_AERO... 37 Intron Ins - T rs68137453 uc003iap.3 ALPK1_uc003ian.... Hybrid_Cap...
ALPK2 p.1388_1389FF>F 18 56203253 56203255 SCC4_UPPER_AERO... 37 In_Frame_Del Del AAG - uc002lhj.3 ALPK2_uc002lhk.... Hybrid_Cap...
BIRC6 p.V181A 2 32605255 32605255 SCC4_UPPER_AERO... 37 Missense_Mutation SNP T C uc010ezu.2 Hybrid_Cap... view
BMP4 14 54416601 54416602 SCC4_UPPER_AERO... 37 3'UTR Ins - AT rs74495140;rs76335800 uc001xal.3 BMP4_uc010aoh.2... Hybrid_Cap...
CACNB2 10 18828721 18828722 SCC4_UPPER_AERO... 37 3'UTR Ins - AA rs3841459 uc001ipr.2 CACNB2_uc009xjz... Hybrid_Cap...
CASP4 11 104819546 104819547 SCC4_UPPER_AERO... 37 Intron Ins - AGACACAC rs33910737;rs113139978 uc001pid.1 CASP4_uc001pib.... Hybrid_Cap...
CDK11B 1 1654066 1654068 SCC4_UPPER_AERO... 37 Intron Del GCG - uc001agv.1 CDK11B_uc001aha... Hybrid_Cap...
CDK14 p.R370C 7 90708749 90708749 SCC4_UPPER_AERO... 37 Missense_Mutation SNP C T uc003uky.2 CDK14_uc003ukz.... Hybrid_Cap... view
CHD9 p.2164_2165SS>S 16 53338410 53338412 SCC4_UPPER_AERO... 37 In_Frame_Del Del TTC - uc002ehb.2 CHD9_uc002egy.2... Hybrid_Cap...
CLTCL1 p.V1201_splice 22 19189003 19189004 SCC4_UPPER_AERO... 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
CREB3L2 p.T100del 7 137612914 137612916 SCC4_UPPER_AERO... 37 In_Frame_Del Del TGG - uc003vtw.2 CREB3L2_uc003vt... Hybrid_Cap...
DACH1 13 72014625 72014626 SCC4_UPPER_AERO... 37 3'UTR Ins - T rs117109529 uc010thn.1 DACH1_uc010tho.... Hybrid_Cap...
DDR2 1 162750211 162750212 SCC4_UPPER_AERO... 37 3'UTR Del TT - uc001gcf.2 DDR2_uc001gcg.2... Hybrid_Cap...
DFNA5 7 24783982 24783982 SCC4_UPPER_AERO... 37 Intron Del C - uc010kus.1 DFNA5_uc003swz.... Hybrid_Cap...
EDN1 6 12290729 12290729 SCC4_UPPER_AERO... 37 5'UTR Del A - uc003nae.3 EDN1_uc010jpb.2... Hybrid_Cap...
EDN1 6 12296150 12296151 SCC4_UPPER_AERO... 37 Intron Ins - T rs66570617 uc003nae.3 EDN1_uc003nad.2... Hybrid_Cap...
EPHA2 p.R357H 1 16464590 16464590 SCC4_UPPER_AERO... 37 Missense_Mutation SNP C T uc001aya.1 EPHA2_uc010oca.... Hybrid_Cap... view
EPHA6 3 97367230 97367231 SCC4_UPPER_AERO... 37 Intron Ins - A rs115253553 uc010how.1 EPHA6_uc003drs.... Hybrid_Cap...
EPHB3 p.A474E 3 184295197 184295197 SCC4_UPPER_AERO... 37 Missense_Mutation SNP C A uc003foz.2 Hybrid_Cap... view
ESR2 14 64701527 64701527 SCC4_UPPER_AERO... 37 Intron SNP G A uc001xha.1 ESR2_uc001xgu.2... Hybrid_Cap... view
FASLG p.G246G 1 172635048 172635048 SCC4_UPPER_AERO... 37 Silent SNP G A uc001gis.2 FASLG_uc001git.... Hybrid_Cap... view
FGFR1OP 6 167453519 167453520 SCC4_UPPER_AERO... 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
FGFR3 4 1809128 1809129 SCC4_UPPER_AERO... 37 3'UTR Del GT - uc003gdu.2 FGFR3_uc003gdr.... Hybrid_Cap...
FLI1 11 128638217 128638217 SCC4_UPPER_AERO... 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FMN2 p.P960L 1 240370979 240370979 SCC4_UPPER_AERO... 37 Missense_Mutation SNP C T uc010pye.1 FMN2_uc010pyd.1... Hybrid_Cap... view
FN1 2 216244182 216244185 SCC4_UPPER_AERO... 37 Intron Del GTAC - uc002vfa.2 FN1_uc002vfb.2_... Hybrid_Cap...
FSCB p.ESPSEEPPAEILPPPAE357del 14 44975072 44975122 SCC4_UPPER_AERO... 37 In_Frame_Del Del TTCAG... - rs117907661;rs117473622;rs17857204 uc001wvn.2 Hybrid_Cap...
FZD1 p.93_94insP 7 90894459 90894460 SCC4_UPPER_AERO... 37 In_Frame_Ins Ins - CCG uc003ula.2 Hybrid_Cap...
GOPC 6 117923464 117923464 SCC4_UPPER_AERO... 37 5'UTR SNP G A uc003pxu.2 GOPC_uc003pxv.2... Hybrid_Cap... view
GPR112 p.D2657del X 135474445 135474447 SCC4_UPPER_AERO... 37 In_Frame_Del Del GAT - rs3030295 uc004ezu.1 GPR112_uc010nsb... Hybrid_Cap...
GRB7 p.P21L 17 37898616 37898616 SCC4_UPPER_AERO... 37 Missense_Mutation SNP C T uc002hsr.2 GRB7_uc002hss.2... Hybrid_Cap... view
GRIA3 X 122318386 122318387 SCC4_UPPER_AERO... 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GUCY2C 12 14827464 14827466 SCC4_UPPER_AERO... 37 Intron Del ATC - rs72525754;rs3083879 uc001rcd.2 GUCY2C_uc009zhz... Hybrid_Cap...
HIF1A 14 62213929 62213930 SCC4_UPPER_AERO... 37 3'UTR Ins - T rs67890419 uc001xfs.2 HIF1A_uc001xfq.... Hybrid_Cap...
HNF1A 12 121434630 121434631 SCC4_UPPER_AERO... 37 Intron Ins - TCATTCAT rs75100977 uc010szn.1 HNF1A_uc001tze.... Hybrid_Cap...
ILK 11 6630029 6630029 SCC4_UPPER_AERO... 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
ITGB1 p.T208I 10 33214962 33214962 SCC4_UPPER_AERO... 37 Missense_Mutation SNP G A uc001iwq.3 ITGB1_uc001iwp.... Hybrid_Cap... view
ITPR2 p.R470_splice 12 26834804 26834805 SCC4_UPPER_AERO... 37 Splice_Site_Ins Ins - ACTC rs66696203;rs59199365 uc001rhg.2 Hybrid_Cap...
KIAA1549 p.I1514L 7 138555914 138555914 SCC4_UPPER_AERO... 37 Missense_Mutation SNP T G uc011kql.1 KIAA1549_uc011k... Hybrid_Cap... view
KLK7 19 51480672 51480675 SCC4_UPPER_AERO... 37 3'UTR Del GGTT - uc002puo.2 KLK7_uc002pup.2... Hybrid_Cap...
LDLR p.H656Y 19 11230888 11230888 SCC4_UPPER_AERO... 37 Missense_Mutation SNP C T uc002mqk.3 LDLR_uc010xlk.1... Hybrid_Cap... view
LETM2 8 38265796 38265798 SCC4_UPPER_AERO... 37 3'UTR Del ACT - uc003xlm.1 LETM2_uc003xll.... Hybrid_Cap...
LMNA p.Q517Q 1 156106966 156106966 SCC4_UPPER_AERO... 37 Silent SNP G A rs41314035 uc001fni.2 LMNA_uc001fnf.1... Hybrid_Cap... view
LRP1B p.P3567A 2 141130646 141130646 SCC4_UPPER_AERO... 37 Missense_Mutation SNP G C uc002tvj.1 Hybrid_Cap... view
MAF 16 79628537 79628537 SCC4_UPPER_AERO... 37 Intron Del T - uc002ffm.2 MAF_uc002ffn.2_... Hybrid_Cap...
MAGEB16 X 35820248 35820248 SCC4_UPPER_AERO... 37 5'UTR SNP G C uc010ngt.1 Hybrid_Cap... view
MAML3 p.Q767_splice 4 140651585 140651587 SCC4_UPPER_AERO... 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP3K1 p.T949del 5 56177849 56177851 SCC4_UPPER_AERO... 37 In_Frame_Del Del CAA - uc003jqw.3 Hybrid_Cap...
MAP3K14 p.R218_splice 17 43364293 43364294 SCC4_UPPER_AERO... 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
MAP3K4 p.A1199del 6 161519351 161519353 SCC4_UPPER_AERO... 37 In_Frame_Del Del CTG - uc003qtn.2 MAP3K4_uc010kkc... Hybrid_Cap...
MAPKBP1 15 42111753 42111754 SCC4_UPPER_AERO... 37 Intron Ins - C rs3034891 uc001zok.3 MAPKBP1_uc001zo... Hybrid_Cap...
MCM3APAS 21 47671275 47671276 SCC4_UPPER_AERO... 37 3'UTR Ins - AAT rs67797185 uc002zin.2 MCM3APAS_uc002z... Hybrid_Cap...
MIF 22 24236621 24236621 SCC4_UPPER_AERO... 37 5'UTR SNP C T uc002zyr.1 MIF_uc011aje.1_... Hybrid_Cap... view
MLL3 p.Y816fs 7 151945071 151945072 SCC4_UPPER_AERO... 37 Frame_Shift_Ins Ins - T uc003wla.2 Hybrid_Cap...
MLLT6 17 36881873 36881873 SCC4_UPPER_AERO... 37 3'UTR Del C - uc002hqi.3 MLLT6_uc002hqk.... Hybrid_Cap...
MYLK p.A1300A 3 123383037 123383037 SCC4_UPPER_AERO... 37 Silent SNP C G uc003ego.2 MYLK_uc010hrr.2... Hybrid_Cap... view
NCAM1 11 112832307 112832308 SCC4_UPPER_AERO... 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 SCC4_UPPER_AERO... 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCOA3 20 46282339 46282340 SCC4_UPPER_AERO... 37 3'UTR Ins - AT uc002xtk.2 NCOA3_uc002xtl.... Hybrid_Cap...
NEK3 p.K313_splice 13 52718050 52718051 SCC4_UPPER_AERO... 37 Splice_Site_Ins Ins - T rs72514762 uc001vgh.2 NEK3_uc001vgg.2... Hybrid_Cap...
NF1 p.L499P 17 29541572 29541572 SCC4_UPPER_AERO... 37 Missense_Mutation SNP T C uc002hgg.2 NF1_uc002hge.1_... Hybrid_Cap... view
NR1H2 p.176_177insQ 19 50881820 50881821 SCC4_UPPER_AERO... 37 In_Frame_Ins Ins - AAC rs66783852;rs112359270 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
NSD1 p.S752fs 5 176637654 176637654 SCC4_UPPER_AERO... 37 Frame_Shift_Del Del T - uc003mfr.3 NSD1_uc003mft.3... Hybrid_Cap...
PAX3 2 223158653 223158653 SCC4_UPPER_AERO... 37 Intron Del T - rs112753212 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PGGT1B 5 114548071 114548072 SCC4_UPPER_AERO... 37 3'UTR Ins - C uc003kqw.3 PGGT1B_uc003kqx... Hybrid_Cap...
PLD1 p.L389V 3 171417597 171417597 SCC4_UPPER_AERO... 37 Missense_Mutation SNP G C uc003fhs.2 PLD1_uc003fht.2... Hybrid_Cap... view
PRKAA1 p.L234F 5 40767732 40767732 SCC4_UPPER_AERO... 37 Missense_Mutation SNP T A uc003jmb.2 PRKAA1_uc003jmc... Hybrid_Cap... view
PRKDC p.L1244fs 8 48805816 48805817 SCC4_UPPER_AERO... 37 Frame_Shift_Ins Ins - G rs67588121 uc003xqi.2 PRKDC_uc003xqj.... Hybrid_Cap...
RABEP1 p.E166G 17 5238608 5238608 SCC4_UPPER_AERO... 37 Missense_Mutation SNP A G uc002gbm.3 RABEP1_uc010clc... Hybrid_Cap... view
RALGDS p.K731N 9 135977892 135977892 SCC4_UPPER_AERO... 37 Missense_Mutation SNP C G uc011mcw.1 RALGDS_uc004cct... Hybrid_Cap... view
RAPGEF2 4 160189224 160189224 SCC4_UPPER_AERO... 37 5'UTR SNP A T uc003iqg.3 Hybrid_Cap... view
RECQL4 p.R766fs 8 145738768 145738768 SCC4_UPPER_AERO... 37 Frame_Shift_Del Del G - uc003zdj.2 Hybrid_Cap...
RFC4 p.V61A 3 186518934 186518934 SCC4_UPPER_AERO... 37 Missense_Mutation SNP A G uc003fqz.2 RFC4_uc011bsc.1... Hybrid_Cap... view
RIMS2 8 104831718 104831719 SCC4_UPPER_AERO... 37 5'UTR Ins - A uc003ylw.2 RIMS2_uc003ylp.... Hybrid_Cap...
SIRT1 p.I270K 10 69651179 69651179 SCC4_UPPER_AERO... 37 Missense_Mutation SNP T A uc001jnd.2 SIRT1_uc010qis.... Hybrid_Cap... view
SMG1 16 18820800 18820800 SCC4_UPPER_AERO... 37 3'UTR SNP C T uc002dfm.2 SMG1_uc010bwb.2... Hybrid_Cap... view
SSU72 1 1477435 1477435 SCC4_UPPER_AERO... 37 3'UTR SNP G A uc001agd.2 C1orf70_uc009vk... Hybrid_Cap... view
STAT5A 17 40462797 40462800 SCC4_UPPER_AERO... 37 3'UTR Del TGTG - uc002hzj.1 STAT5A_uc010cya... Hybrid_Cap...
STK25 2 242435659 242435662 SCC4_UPPER_AERO... 37 Intron Del AAGG - rs3215138;rs75497042 uc002wbm.2 STK25_uc002wbk.... Hybrid_Cap...
STK31 7 23872024 23872025 SCC4_UPPER_AERO... 37 3'UTR Ins - TTTG rs66787534 uc003sws.3 STK31_uc003swt.... Hybrid_Cap...
TLK1 2 171850178 171850179 SCC4_UPPER_AERO... 37 3'UTR Ins - AA rs71008739 uc002ugo.2 TLK1_uc002ugn.2... Hybrid_Cap...
TLR3 p.K147_splice 4 186998216 186998216 SCC4_UPPER_AERO... 37 Splice_Site_SNP SNP T C uc003iyq.2 Hybrid_Cap... view
TMEM123 11 102269398 102269398 SCC4_UPPER_AERO... 37 3'UTR Del G - uc001pha.2 TMEM123_uc009yx... Hybrid_Cap...
TNKS2 10 93622889 93622889 SCC4_UPPER_AERO... 37 3'UTR SNP G A uc001khp.2 Hybrid_Cap... view
TNNI3K p.S915C 1 75009599 75009599 SCC4_UPPER_AERO... 37 Missense_Mutation SNP C G uc001dge.1 TNNI3K_uc001dgf... Hybrid_Cap... view
TP53 p.P151S 17 7578479 7578479 SCC4_UPPER_AERO... 37 Missense_Mutation SNP G A rs28934874 uc002gim.2 TP53_uc002gig.1... Hybrid_Cap... view
TRIP11 p.D1392Y 14 92470146 92470146 SCC4_UPPER_AERO... 37 Missense_Mutation SNP C A uc001xzy.2 TRIP11_uc010auf... Hybrid_Cap... view
TRPS1 8 116635872 116635873 SCC4_UPPER_AERO... 37 5'UTR Ins - A rs76893349 uc003yny.2 TRPS1_uc011lhy.... Hybrid_Cap...
VEGFC p.S419_splice 4 177605082 177605084 SCC4_UPPER_AERO... 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
ZMYND10 3 50380014 50380014 SCC4_UPPER_AERO... 37 Intron SNP C G uc003dag.1 RASSF1_uc003dad... Hybrid_Cap... view