Annotation Summary for Cell Line: WM-115  

Cell line primary name: WM-115
Cell line aliases:
Gender: F
Site Primary: skin
Histology: malignant_melanoma
Hist Subtype1: NS
Notes: Metastatic pair: WM-115 and WM-266-4 are from the same patient
Source: ATCC
Expression arrays: BRAKE_p_NCLE_RNA2_HG-U133_Plus_2_B12_241088
SNP arrays: ARLES_p_NCLE_DNAAffy2_S_GenomeWideSNP_6_D05_256082
Oncomap: yes
Hybrid Capture Sequencing: yes


Mutations in WM-115

GeneProtein
Change
ChrStartEnd SampleNCBI
Build
Variant
Classification
Variant TypeReference
Allele
Tumor
Allele 1
dbSNP IDAnnotation
Transcript
Other
Transcripts
Method View
Reads
Mutation
Assessor
AAK1 p.541_542QQ>Q 2 69741754 69741756 WM115_SKIN 37 In_Frame_Del Del TGT - rs55712143 uc002sfp.2 AAK1_uc010fdk.2... Hybrid_Cap...
ADAM17 2 9630245 9630245 WM115_SKIN 37 3'UTR Del T - uc002qzu.2 IAH1_uc010yiz.1... Hybrid_Cap...
ADAM28 8 24211994 24211997 WM115_SKIN 37 3'UTR Del CTAT - rs10610134 uc003xdy.2 ADAM28_uc011laa... Hybrid_Cap...
ADCK1 14 78390632 78390637 WM115_SKIN 37 Intron Del AAACT... - rs78274857;rs74969652 uc001xui.2 ADCK1_uc010tvo.... Hybrid_Cap...
AKAP12 p.1531_1532insE 6 151674116 151674117 WM115_SKIN 37 In_Frame_Ins Ins - GAG rs34737819 uc011eep.1 AKAP12_uc003qoe... Hybrid_Cap...
AURKC 19 57742494 57742507 WM115_SKIN 37 5'UTR Del GGACG... - rs67926438;rs112039303;rs59094959 uc002qoe.2 AURKC_uc002qoc.... Hybrid_Cap...
BCL9 p.P467L 1 147091361 147091362 WM115_SKIN 37 Missense_Mutation DNP CC TT uc001epq.2 BCL9_uc010ozr.1... Hybrid_Cap...
BIRC6 p.I733T 2 32640557 32640557 WM115_SKIN 37 Missense_Mutation SNP T C uc010ezu.2 Hybrid_Cap... view
BMX p.N267I X 15543458 15543458 WM115_SKIN 37 Missense_Mutation SNP A T uc004cww.2 BMX_uc004cwx.3_... Hybrid_Cap... view
BRAF p.V600D 7 140453135 140453136 WM115_SKIN 37 Missense_Mutation DNP CA AT rs113488022 uc003vwc.3 Hybrid_Cap...
C17ORF37 17 37885640 37885641 WM115_SKIN 37 3'UTR Ins - G rs75811535 uc002hsq.2 Hybrid_Cap...
CDK11B 1 1654066 1654068 WM115_SKIN 37 Intron Del GCG - uc001agv.1 CDK11B_uc001aha... Hybrid_Cap...
CLTCL1 p.V1201_splice 22 19189003 19189004 WM115_SKIN 37 Splice_Site_Ins Ins - C rs11386977 uc002zpb.2 CLTCL1_uc011agv... Hybrid_Cap...
CREB3L2 p.T100del 7 137612914 137612916 WM115_SKIN 37 In_Frame_Del Del TGG - uc003vtw.2 CREB3L2_uc003vt... Hybrid_Cap...
CTBP2 p.K974fs 10 126678123 126678123 WM115_SKIN 37 Frame_Shift_Del Del T - uc001lie.3 CTBP2_uc009yak.... Hybrid_Cap...
CXCL12 10 44873992 44873993 WM115_SKIN 37 Intron Ins - CT rs117617571 uc001jbh.2 CXCL12_uc001jbf... Hybrid_Cap...
DACH1 13 72014625 72014626 WM115_SKIN 37 3'UTR Ins - T rs117109529 uc010thn.1 DACH1_uc010tho.... Hybrid_Cap...
DDX6 p.N289_splice 11 118629613 118629614 WM115_SKIN 37 Splice_Site_Ins Ins - G uc001pub.2 DDX6_uc001pua.2... Hybrid_Cap...
DST p.I2784V 6 56420572 56420572 WM115_SKIN 37 Missense_Mutation SNP T C uc003pdf.2 DST_uc003pcz.3_... Hybrid_Cap... view
DYRK1A 21 38884966 38884967 WM115_SKIN 37 3'UTR Ins - T rs72430212 uc002ywk.2 DYRK1A_uc002ywi... Hybrid_Cap...
EDN1 6 12290729 12290729 WM115_SKIN 37 5'UTR Del A - uc003nae.3 EDN1_uc010jpb.2... Hybrid_Cap...
EIF4E 4 99808137 99808141 WM115_SKIN 37 Intron Del TTAAA - uc011ceb.1 EIF4E_uc011cea.... Hybrid_Cap...
EP300 22 41574970 41574972 WM115_SKIN 37 3'UTR Del GTA - rs76489032 uc003azl.3 Hybrid_Cap...
EPHA6 3 97367230 97367231 WM115_SKIN 37 Intron Ins - A rs115253553 uc010how.1 EPHA6_uc003drs.... Hybrid_Cap...
ETV1 p.A61A 7 14017104 14017104 WM115_SKIN 37 Silent SNP A T uc011jxq.1 ETV1_uc011jxn.1... Hybrid_Cap... view
ETV1 7 14028708 14028708 WM115_SKIN 37 5'UTR Del A - rs77190713 uc011jxq.1 ETV1_uc011jxn.1... Hybrid_Cap...
FBN1 p.H2392Y 15 48719794 48719795 WM115_SKIN 37 Missense_Mutation DNP GG AA uc001zwx.1 FBN1_uc010beo.1... Hybrid_Cap...
FGFR1OP 6 167453519 167453520 WM115_SKIN 37 3'UTR Ins - T rs115519488 uc003qvj.2 CCR6_uc003qvl.2... Hybrid_Cap...
FGFR3 p.P404L 4 1806186 1806186 WM115_SKIN 37 Missense_Mutation SNP C T uc003gdu.2 FGFR3_uc003gdr.... Hybrid_Cap... view
FLCN p.Q354_splice 17 17122331 17122331 WM115_SKIN 37 Splice_Site_SNP SNP A G uc002gra.3 PLD6_uc010cpn.2... Hybrid_Cap... view
FLI1 11 128638217 128638217 WM115_SKIN 37 Intron Del G - uc010sbu.1 FLI1_uc010sbt.1... Hybrid_Cap...
FMN2 p.PPLPGAGIPPP939del 1 240370914 240370946 WM115_SKIN 37 In_Frame_Del Del GCCCC... - rs4997328;rs4997329 uc010pye.1 FMN2_uc010pyd.1... Hybrid_Cap...
FN1 2 216244182 216244185 WM115_SKIN 37 Intron Del GTAC - uc002vfa.2 FN1_uc002vfb.2_... Hybrid_Cap...
GPR112 p.D2657del X 135474445 135474447 WM115_SKIN 37 In_Frame_Del Del GAT - rs3030295 uc004ezu.1 GPR112_uc010nsb... Hybrid_Cap...
GPR137 11 64037937 64037937 WM115_SKIN 37 5'UTR SNP G A uc009ypj.1 BAD_uc001nzd.2_... Hybrid_Cap... view
GRIA3 X 122318386 122318387 WM115_SKIN 37 Splice_Site_Ins Ins - G rs66632982 uc004etq.3 GRIA3_uc004etr.... Hybrid_Cap...
GUCY2C 12 14827464 14827466 WM115_SKIN 37 Intron Del ATC - rs72525754;rs3083879 uc001rcd.2 GUCY2C_uc009zhz... Hybrid_Cap...
HGF p.R197C 7 81381472 81381472 WM115_SKIN 37 Missense_Mutation SNP G A uc003uhl.2 HGF_uc003uhm.2_... Hybrid_Cap... view
HIF1A 14 62213929 62213930 WM115_SKIN 37 3'UTR Ins - T rs67890419 uc001xfs.2 HIF1A_uc001xfq.... Hybrid_Cap...
HNF1A 12 121434630 121434631 WM115_SKIN 37 Intron Ins - TCATTCAT rs75100977 uc010szn.1 HNF1A_uc001tze.... Hybrid_Cap...
ILK 11 6630029 6630029 WM115_SKIN 37 Intron Del C - uc001mee.2 ILK_uc001mef.2_... Hybrid_Cap...
ITGA7 p.G439C 12 56091585 56091585 WM115_SKIN 37 Missense_Mutation SNP C A uc001shh.2 ITGA7_uc001shg.... Hybrid_Cap... view
KIAA2022 p.P339S X 73963377 73963377 WM115_SKIN 37 Missense_Mutation SNP G A uc004eby.2 Hybrid_Cap... view
KLK7 19 51480672 51480675 WM115_SKIN 37 3'UTR Del GGTT - uc002puo.2 KLK7_uc002pup.2... Hybrid_Cap...
LRP1B p.S2719F 2 141272335 141272335 WM115_SKIN 37 Missense_Mutation SNP G A uc002tvj.1 Hybrid_Cap... view
MAF 16 79628537 79628537 WM115_SKIN 37 Intron Del T - uc002ffm.2 MAF_uc002ffn.2_... Hybrid_Cap...
MAML3 p.Q767_splice 4 140651585 140651587 WM115_SKIN 37 Splice_Site_Del Del CTG - uc003ihz.1 MGST2_uc010ioi.... Hybrid_Cap...
MAP3K14 p.R218_splice 17 43364293 43364294 WM115_SKIN 37 Splice_Site_Ins Ins - G rs66766023 uc002iiw.1 MAP3K14_uc010da... Hybrid_Cap...
MAPKAPK3 3 50685575 50685575 WM115_SKIN 37 3'UTR Del A - rs76026164 uc003day.1 MAPKAPK3_uc003d... Hybrid_Cap...
MAX 14 65543066 65543066 WM115_SKIN 37 3'UTR Del A - uc001xif.1 MAX_uc001xic.1_... Hybrid_Cap...
MCF2 X 138724842 138724842 WM115_SKIN 37 Intron Del A - uc011mwo.1 MCF2_uc004fau.2... Hybrid_Cap...
MSH3 p.PPA66del 5 79950742 79950750 WM115_SKIN 37 In_Frame_Del Del CCCCC... - rs60484572;rs1047489 uc003kgz.2 DHFR_uc011ctl.1... Hybrid_Cap...
MYH10 p.P552L 17 8439200 8439200 WM115_SKIN 37 Missense_Mutation SNP G A uc002glm.2 MYH10_uc002gll.... Hybrid_Cap... view
NACA p.P1053S 12 57112157 57112157 WM115_SKIN 37 Missense_Mutation SNP G A uc009zoy.1 NACA_uc001slz.2... Hybrid_Cap... view
NCAM1 11 112832307 112832308 WM115_SKIN 37 5'UTR Ins - A rs117108942 uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NCAM1 11 112832340 112832340 WM115_SKIN 37 5'UTR Del C - uc009yyq.1 NCAM1_uc001pno.... Hybrid_Cap...
NEK3 p.K313_splice 13 52718050 52718051 WM115_SKIN 37 Splice_Site_Ins Ins - T rs72514762 uc001vgh.2 NEK3_uc001vgg.2... Hybrid_Cap...
NF2 p.F591F 22 30090776 30090776 WM115_SKIN 37 Silent SNP C T uc003age.3 NF2_uc003agf.3_... Hybrid_Cap... view
NLRP1 p.D570N 17 5462308 5462308 WM115_SKIN 37 Missense_Mutation SNP C T uc002gci.2 NLRP1_uc002gcg.... Hybrid_Cap... view
NPR1 1 153665919 153665920 WM115_SKIN 37 3'UTR Ins - C rs66682713 uc001fcs.3 NPR1_uc010pdz.1... Hybrid_Cap...
NR1H2 p.176_177insQ 19 50881822 50881823 WM115_SKIN 37 In_Frame_Ins Ins - CAG rs61751954;rs1052533 uc010enw.2 NR1H2_uc002prv.... Hybrid_Cap...
OBSCN p.R1269W 1 228434276 228434276 WM115_SKIN 37 Missense_Mutation SNP C T uc009xez.1 OBSCN_uc001hsn.... Hybrid_Cap... view
OBSCN p.R2526P 1 228467702 228467702 WM115_SKIN 37 Missense_Mutation SNP G C uc009xez.1 OBSCN_uc001hsn.... Hybrid_Cap... view
PAX3 2 223158653 223158653 WM115_SKIN 37 Intron Del T - rs112753212 uc002vmt.1 PAX3_uc002vmy.1... Hybrid_Cap...
PCDH15 p.K1866fs 10 55581909 55581910 WM115_SKIN 37 Frame_Shift_Ins Ins - TTAA uc010qhy.1 PCDH15_uc010qhq... Hybrid_Cap...
PIK3C2A 11 17111198 17111199 WM115_SKIN 37 3'UTR Del GT - uc001mmq.3 PIK3C2A_uc009yg... Hybrid_Cap...
PIK3C2G p.P129del 12 18435399 18435401 WM115_SKIN 37 In_Frame_Del Del CCC - uc010sib.1 PIK3C2G_uc001rd... Hybrid_Cap...
PIK3R1 p.R642* 5 67592108 67592108 WM115_SKIN 37 Nonsense_Mutation SNP C T uc003jva.2 PIK3R1_uc003jvb... Hybrid_Cap... view
PKN1 p.E396K 19 14568845 14568845 WM115_SKIN 37 Missense_Mutation SNP G A uc002myq.2 PKN1_uc002myp.2... Hybrid_Cap... view
PLCB2 p.R39C 15 40596249 40596249 WM115_SKIN 37 Missense_Mutation SNP G A uc001zld.2 PLCB2_uc010bbo.... Hybrid_Cap... view
PPARG 3 12393036 12393036 WM115_SKIN 37 5'UTR SNP C G rs35206526 uc003bwx.2 PPARG_uc003bwr.... Hybrid_Cap... view
PPP1R3A 7 113517758 113517758 WM115_SKIN 37 3'UTR SNP A G uc010ljy.1 Hybrid_Cap... view
PRKCI p.T410I 3 170009667 170009667 WM115_SKIN 37 Missense_Mutation SNP C T uc003fgs.2 PRKCI_uc003fgt.... Hybrid_Cap... view
PTPRT p.S1177F 20 40733276 40733276 WM115_SKIN 37 Missense_Mutation SNP G A uc010ggj.2 PTPRT_uc002xkg.... Hybrid_Cap... view
RAPGEF2 4 160189200 160189201 WM115_SKIN 37 5'UTR Ins - T rs72011511 uc003iqg.3 Hybrid_Cap...
RBPJ p.R238* 4 26426291 26426291 WM115_SKIN 37 Nonsense_Mutation SNP C T rs5007634 uc003grx.1 RBPJ_uc003gry.1... Hybrid_Cap... view
RECQL4 p.R766fs 8 145738768 145738768 WM115_SKIN 37 Frame_Shift_Del Del G - uc003zdj.2 Hybrid_Cap...
RPS6KA5 14 91360733 91360734 WM115_SKIN 37 Intron Ins - T rs77438853 uc001xys.2 RPS6KA5_uc010tw... Hybrid_Cap...
RPS6KL1 14 75373626 75373627 WM115_SKIN 37 3'UTR Ins - TGAT uc001xqx.1 RPS6KL1_uc001xq... Hybrid_Cap...
RPTOR p.R788C 17 78867626 78867626 WM115_SKIN 37 Missense_Mutation SNP C T uc002jyt.1 RPTOR_uc010wug.... Hybrid_Cap... view
RXRA p.S66L 9 137293646 137293646 WM115_SKIN 37 Missense_Mutation SNP C T uc004cfb.2 RXRA_uc004cfa.1... Hybrid_Cap... view
SGK223 p.S835F 8 8185788 8185788 WM115_SKIN 37 Missense_Mutation SNP G A uc003wsh.3 Hybrid_Cap... view
SHH 7 155604884 155604884 WM115_SKIN 37 5'UTR SNP G C rs111495739 uc003wmk.1 Hybrid_Cap... view
SMAD4 p.P313A 18 48586268 48586268 WM115_SKIN 37 Missense_Mutation SNP C G uc010xdp.1 SMAD4_uc002lfb.... Hybrid_Cap... view
STK31 7 23872024 23872025 WM115_SKIN 37 3'UTR Ins - TTTG rs66787534 uc003sws.3 STK31_uc003swt.... Hybrid_Cap...
TCERG1L 10 132891334 132891334 WM115_SKIN 37 3'UTR SNP C T uc001lkp.2 Hybrid_Cap... view
TEC 4 48139307 48139310 WM115_SKIN 37 3'UTR Del TTAT - rs79098351 uc003gxz.2 Hybrid_Cap...
TMEM123 11 102269398 102269398 WM115_SKIN 37 3'UTR Del G - uc001pha.2 TMEM123_uc009yx... Hybrid_Cap...
TOPBP1 p.R681C 3 133358995 133358995 WM115_SKIN 37 Missense_Mutation SNP G A uc003eps.2 Hybrid_Cap... view
TRIM33 1 114940215 114940216 WM115_SKIN 37 3'UTR Ins - G rs68133208 uc001eew.2 TRIM33_uc010owr... Hybrid_Cap...
TRPS1 8 116635872 116635873 WM115_SKIN 37 5'UTR Ins - A rs76893349 uc003yny.2 TRPS1_uc011lhy.... Hybrid_Cap...
TSSK1B p.P348L 5 112769494 112769494 WM115_SKIN 37 Missense_Mutation SNP G A uc003kqm.2 MCC_uc003kql.3_... Hybrid_Cap... view
TTN p.S22370G 2 179436047 179436047 WM115_SKIN 37 Missense_Mutation SNP T C uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.G22369E 2 179436049 179436049 WM115_SKIN 37 Missense_Mutation SNP C T uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
TTN p.E18569K 2 179452725 179452725 WM115_SKIN 37 Missense_Mutation SNP C T uc010zfg.1 TTN_uc010zfh.1_... Hybrid_Cap... view
UNC13C p.V1852G 15 54825123 54825123 WM115_SKIN 37 Missense_Mutation SNP T G uc002ack.2 Hybrid_Cap... view
VEGFC p.S419_splice 4 177605082 177605084 WM115_SKIN 37 Splice_Site_Del Del TCA - uc003ius.1 Hybrid_Cap...
WNK4 17 40948854 40948854 WM115_SKIN 37 3'UTR SNP C T uc002ibj.2 WNK4_uc010wgx.1... Hybrid_Cap... view
ZNF423 p.P107S 16 49672744 49672744 WM115_SKIN 37 Missense_Mutation SNP G A uc002efs.2 ZNF423_uc010vgn... Hybrid_Cap... view