cmap
 

about cmap

The Connectivity Map: Using Gene-Expression Signatures to Connect
Small Molecules, Genes, and Disease

Justin Lamb, Emily D Crawford, David Peck, Joshua W Modell, Irene C Blat,
Matthew J Wrobel, Jim Lerner, Jean-Philippe Brunet, Aravind Subramanian,
Kenneth N Ross, Michael Reich, Haley Hieronymus, Guo Wei, Scott A
Armstrong, Stephen J Haggarty, Paul A Clemons, Ru Wei, Steven A Carr, Eric S
Lander and Todd R Golub

Science 313 1929-1935 (2006)
http://www.sciencemag.org/cgi/reprint/313/5795/1929.pdf

The Connectivity Map: A New Tool for Biomedical Research
Justin Lamb

Nature Reviews Cancer 7 54-60 (2007)
http://www.nature.com/nrc/journal/v7/n1/pdf/nrc2044.pdf

cmap applications

Gene expression signature-based chemical genomic prediction identifies
novel class of HSP90 pathway modulators

Haley Hieronymus, Justin Lamb, Kenneth N Ross, Xiao P Peng, Cristina
Clement, Anna Rodina, Maria Nieto, Jinyan Du, Kimberly Stegmaier, Srilakshmi
M Raj, Katherine N Maloney, Jon Clardy, William C Hahn, Gabriela Chiosis and
Todd R Golub

Cancer Cell 10 321-330 (2006)
http://download.cancercell.org/pdfs/1535-6108/PIIS1535610806002820.pdf

Gene expression-based chemical genomics identifies rapamycin as a
modulator of MCL-1 and glucocorticoid resistance

Guo Wei, David Twomey, Justin Lamb, Krysta Schlis, Jyoti Agarwal, Ronald W
Stam, Joseph T Opferman, Stephen E Sallan, Monique L den Boer, Rob Pieters,
Todd R Golub and Scott A Armstrong

Cancer Cell 10 331-342 (2006)
http://download.cancercell.org/pdfs/1535-6108/PIIS1535610806002832.pdf

Discovery of Agents that Eradicate Leukemia Stem Cells Using an In Silico
Screen of Public Gene Expression Data

Duane C Hassane, Monica L Guzman, Cheryl Corbett, Xiaojie Li, Ramzi Abboud,
Fay Young, Jane L Liesveld, Martin Carroll and Craig T Jordan

Blood 111 5654-5662 (2008)
http://bloodjournal.hematologylibrary.org/cgi/reprint/111/12/5654

A Gene Signature-Based Approach Identifies mTOR as a Regulator of p73
Jennifer M Rosenbluth, Deborah J Mays,Maria F Pino, Luo Jia Tang and Jennifer A Pietenpol

Molecular and Cellular Biology 28 5951-5964 (2008)
http://mcb.asm.org/cgi/reprint/28/19/5951

A genomic approach to identify molecular pathways associated with chemotherapy resistance
Richard F Riedel, Alessandro Porrello, Emily Pontzer, Emily J Chenette, David S Hsu,
Bala Balakumaran, Anil Potti, Joseph Nevins and Phillip G Febbo

Molecular Cancer Therapy 7 3141-3149 (2008)
http://mct.aacrjournals.org/cgi/reprint/7/10/3141

Small-Molecule Inhibitors of HIF-2a Translation Link Its
5'UTR Iron-Responsive Element to Oxygen Sensing

Michael Zimmer, Benjamin L Ebert, Christopher Neil, Keith Brenner, Ioannis Papaioannou,
Antonia Melas, Nicola Tolliday, Justin Lamb, Kostas Pantopoulos, Todd R Golub and Othon Iliopoulos

Molecular Cell 32 838-848 (2008)
http://download.cell.com/molecular-cell/pdf/PIIS1097276508008459.pdf

A genomic approach to colon cancer risk stratification yields biologic
insights into therapeutic opportunities

Katherine S Garman, Chaitanya R Acharya, Elena Edelman, Marian Grade, Jochen Gaedcke, Shivani Sud,
William Barry, Anna Mae Diehl, Dawn Provenzale, Geoffrey S Ginsburg, B Michael Ghadimi, Thomas Ried,
Joseph R Nevins, Sayan Mukherjee, David Hsu and Anil Potti

Proceedings of the National Academy of Sciences 105 19432-19437 (2008)
http://www.pnas.org/content/105/49/19432.full.pdf

Transforming Growth Factor β Engages TACE and ErbB3 To Activate Phosphatidylinositol-3 Kinase/Akt
in ErbB2-Overexpressing Breast Cancer and Desensitizes Cells to Trastuzumab

Shizhen Emily Wang, Bin Xiang, Marta Guix, Maria Graciela Olivares, Joel Parker, Christine H Chung,
Atanasio Pandiella and Carlos L Arteaga

Molecular and Cellular Biology 28 5605-5620 (2008)
http://mcb.asm.org/cgi/reprint/28/18/5605.pdf

Oncomine 3.0: genes, pathways, and networks in a collection of
18,000 cancer gene expression profiles

Daniel R Rhodes, Shanker Kalyana-Sundaram, Vasudeva Mahavisno, Radhika Varambally, Jianjun Yu,
Benjamin B Briggs, Terrence R Barrette, Matthew J Anstet, Colleen Kincead-Beal, Prakash Kulkarni,
Sooryanaryana Varambally, Debashis Ghoshy and Arul M Chinnaiyan

Neoplasia 9 166-180 (2007)
http://www.neoplasia.com/pdf/manuscript/v09i02/neo07112.pdf

Estrogen-Dependent Signaling in a Molecularly Distinct Subclass
of Aggressive Prostate Cancer

Sunita R Setlur, Kirsten D Mertz, Yujin Hoshida, Francesca Demichelis, Mathieu Lupien, Sven Perner,
Andrea Sboner, Yudi Pawitan, Ove Andren, Laura A Johnson, Jeff Tang, Hans-Olov Adami, Stefano Calza,
Arul M Chinnaiyan, Daniel Rhodes, Scott Tomlins, Katja Fall, Lorelei A Mucci, Philip W Kantoff, Meir J Stampfer,
Swen-Olof Andersson, Eberhard Varenhorst, Jan-Erik Johansson, Myles Brown, Todd R Golub and Mark A Rubin

Journal of the National Cancer Institute 100 815-825 (2008)
http://jnci.oxfordjournals.org/cgi/reprint/100/11/815.pdf