cmap
 

about cmap

The Connectivity Map: Using Gene-Expression Signatures to Connect
Small Molecules, Genes, and Disease

Justin Lamb, Emily D Crawford, David Peck, Joshua W Modell, Irene C Blat,
Matthew J Wrobel, Jim Lerner, Jean-Philippe Brunet, Aravind Subramanian,
Kenneth N Ross, Michael Reich, Haley Hieronymus, Guo Wei, Scott A
Armstrong, Stephen J Haggarty, Paul A Clemons, Ru Wei, Steven A Carr, Eric S
Lander and Todd R Golub

Science 313 1929-1935 (2006)
http://www.sciencemag.org/cgi/reprint/313/5795/1929.pdf

The Connectivity Map: A New Tool for Biomedical Research
Justin Lamb

Nature Reviews Cancer 7 54-60 (2007)
http://www.nature.com/nrc/journal/v7/n1/pdf/nrc2044.pdf

cmap applications

Gene expression signature-based chemical genomic prediction identifies
novel class of HSP90 pathway modulators

Haley Hieronymus, Justin Lamb, Kenneth N Ross, Xiao P Peng, Cristina
Clement, Anna Rodina, Maria Nieto, Jinyan Du, Kimberly Stegmaier, Srilakshmi
M Raj, Katherine N Maloney, Jon Clardy, William C Hahn, Gabriela Chiosis and
Todd R Golub

Cancer Cell 10 321-330 (2006)
http://download.cancercell.org/pdfs/1535-6108/PIIS1535610806002820.pdf

Gene expression-based chemical genomics identifies rapamycin as a
modulator of MCL-1 and glucocorticoid resistance

Guo Wei, David Twomey, Justin Lamb, Krysta Schlis, Jyoti Agarwal, Ronald W
Stam, Joseph T Opferman, Stephen E Sallan, Monique L den Boer, Rob Pieters,
Todd R Golub and Scott A Armstrong

Cancer Cell 10 331-342 (2006)
http://download.cancercell.org/pdfs/1535-6108/PIIS1535610806002832.pdf

Discovery of Agents that Eradicate Leukemia Stem Cells Using an In Silico
Screen of Public Gene Expression Data

Duane C Hassane, Monica L Guzman, Cheryl Corbett, Xiaojie Li, Ramzi Abboud,
Fay Young, Jane L Liesveld, Martin Carroll and Craig T Jordan

Blood 111 5654-5662 (2008)
http://bloodjournal.hematologylibrary.org/cgi/reprint/111/12/5654