GIANT consortium data files

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We are releasing the summary data from our 2010-2017 meta-analyses of Genome-wide Association (GWA) data, in order to enable other researchers to examine particular variants or loci for their evidence of association with anthropometric traits. The files include p-values and direction of effect at over 2 million directly genotyped or imputed single nucleotide polymorphisms (SNPs). To prevent the possibility of identification of individuals from these summary results, we are not releasing allele frequency data from our samples. =2018 WHR Exome for Public Release= File Name Structure: PublicRelease.WHRadjBMI.*.*.*.txt.gz '''Abbreviations in filenames:''' C-Combined Sexes M-Men W-Women All- All Ancestries Eur- European descent only Add- Additive genetic model Rec- Recessive genetic model '''File headers:''' 1. snpname - dbSNP rsID 2. chr - chromosome 3. pos - position 4. markername - chr:pos 5. ref - reference allele (hg19 + strand) 6. alt - alternate allele (hg19 + strand) 7. beta - beta 8. se - standard error 9. pvalue - P value 10. n - sample size 11. gmaf/eur_maf - alternate allele frequency in 1000 Genome Combined/European Ancestries 12. exac_maf/exac_nfe_maf -alternate allele frequency in ExAC Combined/Non-Finnish European Ancestries *WHR Data Files: **[[Media:PublicRelease.WHRadjBMI.C.All.Add.txt.gz | Download WHRadjBMI.C.All.Add GZIP ]] **[[Media:PublicRelease.WHRadjBMI.C.All.Rec.txt.gz | WHRadjBMI.C.All.Rec]] **[[Media:PublicRelease.WHRadjBMI.C.Eur.Add.txt.gz | WHRadjBMI.C.Eur.Add]] **[[Media:PublicRelease.WHRadjBMI.C.Eur.Rec.txt.gz | WHRadjBMI.C.Eur.Rec]] **[[Media:PublicRelease.WHRadjBMI.M.All.Add.txt.gz | WHRadjBMI.M.All.Add]] **[[Media:PublicRelease.WHRadjBMI.M.All.Rec.txt.gz | WHRadjBMI.M.All.Rec]] **[[Media:PublicRelease.WHRadjBMI.M.Eur.Add.txt.gz | WHRadjBMI.M.Eur.Add]] **[[Media:PublicRelease.WHRadjBMI.M.Eur.Rec.txt.gz|WHRadjBMI.M.Eur.Rec]] **[[Media:PublicRelease.WHRadjBMI.W.All.Add.txt.gz| WHRadjBMI.W.All.Add]] **[[Media:PublicRelease.WHRadjBMI.W.All.Rec.txt.gz | WHRadjBMI.W.All.Rec]] **[[Media:PublicRelease.WHRadjBMI.W.Eur.Add.txt.gz|WHRadjBMI.W.Eur.Add]] **[[Media:PublicRelease.WHRadjBMI.W.Eur.Rec.txt.gz|WHRadjBMI.W.Eur.Rec]] =2018 GIANT and UK BioBank Meta Analysis for Public Release= WHR UK BioBank Meta Analysis for Public Release: *[[Media: whr.giant-ukbb.meta-analysis.combined.23May2018.txt.gz]] *[[Media: whr.giant-ukbb.meta-analysis.females.23May2018.txt.gz]] *[[Media: bmi.giant-ukbb.meta-analysis.males.23May2018.HapMap2_only.txt.gz]] *[[Media: bmi.giant-ukbb.meta-analysis.females.23May2018.HapMap2_only.txt.gz]] *[[Media: bmi.giant-ukbb.meta-analysis.combined.23May2018.HapMap2_only.txt.gz]] *[[Media: whradjbmi.giant-ukbb.meta-analysis.combined.23May2018.HapMap2_only.txt.gz]] *[[Media: whradjbmi.giant-ukbb.meta-analysis.females.23May2018.HapMap2_only.txt.gz]] *[[Media: whradjbmi.giant-ukbb.meta-analysis.males.23May2018.HapMap2_only.txt.gz]] *[[Media: README_summary_statistics_Pulit_et_al_2018]] Access link for GWAS data for all ~27M sites: https://zenodo.org/record/1251813#.XCLJ7vZKhE4 The website has a DOI (10.5281/zenodo.1251813) ---- Please Note: We discovered that the BMI files for the meta-analysis of UK Biobank and GIANT originally uploaded did not reflect the full sample size and have now been corrected. If you downloaded these files prior to June 25, 2018, please download them again. Our apologies for any inconvenience. *[[Media: Meta-analysis_Locke_et_al+UKBiobank_2018_UPDATED.txt.gz | Download Updated Meta-analysis Locke et al + UKBiobank 2018 GZIP]] *[[Media: Meta-analysis_Wood_et_al+UKBiobank_2018.txt.gz | Download Meta-analysis Wood et al + UKBiobank 2018 GZIP]] *[[Media: Meta-analysis_Locke_et_al+UKBiobank_2018_top_941_from_COJO_analysis_UPDATED.txt.gz | Download Updated Meta-analysis Lock et al + UKBiobank 2018 top 716 BMI SNPs from COJO analysis GZIP]] *[[Media: Meta-analysis_Wood_et_al+UKBiobank_2018_top_3290_from_COJO_analysis.txt.gz | Download Meta-analysis Wood et al + UKBiobank 2018 top 3290 Height SNPs from COJO analysis GZIP]] *[[Media: README_summary_statistics_Yengo_et_al_2018.txt | Download README Summary Statistics for Yengo et al 2018]] If you use this data please cite: Yengo L, Sidorenko J, Kemper KE, Zheng Z, Wood AR, Weedon MN, Frayling TM, Hirschhorn J, Yang J, Visscher PM, GIANT Consortium. (2018). Meta-analysis of genome-wide association studies for height and body mass index in ~700,000 individuals of European ancestry. Biorxiv. =2018 GIANT BMI Exome Array for Public Release= *'''BMI Data Files''' **[[Media:BMI_African_American.fmt.gzip|BMI_African_American gzip]] **[[Media:BMI_All_ancestry.fmt.gzip|BMI_All_Ancestry gzip]] **[[Media:BMI_Eastern_Asian.fmt.gzip| BMI_Eastern_Asian gzip]] **[[Media:BMI_European.fmt.gzip| BMI_European gzip]] **[[Media:BMI_Hispanic_American.fmt.gzip| BMI_Hispanic_American gzip]] **[[Media:BMI_South_Asian.fmt.gzip| BMI_South_Asian gzip]] If you use this data please cite: Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, et al. (2018). Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2018 Jan;50(1):26-41. doi: 10.1038/s41588-017-0011-x. Epub 2017 Dec 22. PMID: 29273807 =2017 GIANT GxSMK Project Files for Public Release= == '''Summary Statistics for Models Adjusting for Smoking Status''' == '''Column headers:''' 1. chromosome 2. rs_id: dbSNP ID 3. markername: chr:pos 4. allele_1: effect allele 5. allele_2: other allele 6. freq_Allele1_HapMapCEU: The allele frequency of Allele1 in the HapMap CEU population 7. effect: beta 8. stderr: standard error 9. p_value: p-value after correction for inflation of test statistics using genomic control both at the individual study level and again after meta-analysis 10. N: sample size *'''BMI Data Files''' **[[Media: BMI.SNPadjSMK.zip | Download BMI GZIP]] BMI.SNPadjSMK.CombinedSexes.EuropeanOnly.txt BMI.SNPadjSMK.CombinedSexes.AllAncestry.txt BMI.SNPadjSMK.Men.EuropeanOnly.txt BMI.SNPadjSMK.Men.AllAncestry.txt BMI.SNPadjSMK.Women.EuropeanOnly.txt BMI.SNPadjSMK.Women.AllAncestry.txt *'''WCadjBMI:''' **[[Media: WCadjBMI.SNPadjSMK.zip | Download WCadjBMI.SNPadjSMK.zip ]] WCadjBMI.SNPadjSMK.CombinedSexes.EuropeanOnly.txt WCadjBMI.SNPadjSMK.CombinedSexes.AllAncestry.txt WCadjBMI.SNPadjSMK.Men.EuropeanOnly.txt WCadjBMI.SNPadjSMK.Men.AllAncestry.txt WCadjBMI.SNPadjSMK.Women.EuropeanOnly.txt WCadjBMI.SNPadjSMK.Women.AllAncestry.txt *'''WHRadjBMI:''' **[[Media: WHRadjBMI.SNPadjSMK.zip | Download WHRadjBMI GZIP]] WHRadjBMI.SNPadjSMK.CombinedSexes.EuropeanOnly.txt WHRadjBMI.SNPadjSMK.CombinedSexes.AllAncestry.txt WHRadjBMI.SNPadjSMK.Men.EuropeanOnly.txt WHRadjBMI.SNPadjSMK.Men.AllAncestry.txt WHRadjBMI.SNPadjSMK.Women.EuropeanOnly.txt WHRadjBMI.SNPadjSMK.Women.AllAncestry.txt == '''Summary Statistics for Stratified Models''' == '''Column headers:''' 1. Chromosome 2. rs_id: dbSNP ID 3. markername: chr:pos 4. position_hg18: base pair position on build hg18 5. Effect_allele 6. Other_allele 7. EAF_HapMapCEU: The allele frequency of Allele1 in the HapMap CEU population 8. N_SMK: sample size for smokers 9. Effect_SMK: beta in smokers 10. StdErr_SMK: standard error in smokers 11. P_value_SMK: p- value for smokers after correction for inflation of test statistics using genomic control both at the individual study level and again after meta-analysis 12. N_NONSMK: sample size for nonsmokers 13. Effect_NonSMK: beta in nonsmokers 14. StdErr_NonSMK: standard error in nonsmokers 15. P_value_NonSMK: p- value for nonsmokers after correction for inflation of test statistics using genomic control both at the individual study level and again after meta-analysis *'''BMI:''' **[[Media: BMI.Stratified.zip | Download BMI GZIP]] BMI.StratifiedBySMK.CombinedSexes.EuropeanOnly.txt BMI.StratifiedBySMK.CombinedSexes.AllAncestry.txt BMI.StratifiedBySMK.Men.EuropeanOnly.txt BMI.StratifiedBySMK.Men.AllAncestry.txt BMI.StratifiedBySMK.Women.EuropeanOnly.txt BMI.StratifiedBySMK.Women.AllAncestry.txt *'''WCadjBMI:''' **[[Media: WCadjBMI.Stratified.zip | Download WCadjBMI GZIP]] WCadjBMI.StratifiedBySMK.CombinedSexes.EuropeanOnly.txt WCadjBMI.StratifiedBySMK.CombinedSexes.AllAncestry.txt WCadjBMI.StratifiedBySMK.Men.EuropeanOnly.txt WCadjBMI.StratifiedBySMK.Men.AllAncestry.txt WCadjBMI.StratifiedBySMK.Women.EuropeanOnly.txt WCadjBMI.StratifiedBySMK.Women.AllAncestry.txt *'''WHRadjBMI:''' **[[Media: WHRadjBMI.Stratified.zip | Download WHRadjBMI GZIP]] WHRadjBMI.StratifiedBySMK.CombinedSexes.EuropeanOnly.txt WHRadjBMI.StratifiedBySMK.CombinedSexes.AllAncestry.txt WHRadjBMI.StratifiedBySMK.Men.EuropeanOnly.txt WHRadjBMI.StratifiedBySMK.Men.AllAncestry.txt WHRadjBMI.StratifiedBySMK.Women.EuropeanOnly.txt WHRadjBMI.StratifiedBySMK.Women.AllAncestry.txt = 2017 GIANT Gene-Physical Activity Interaction Meta-analysis Files Available Here for Download = *Column1: rsid *Column2: Chromosome *Column3: Position_hg19 *Column4: Effect_allele (positive strand) *Column5: Other_allele (positive strand) *Column6: EAF_HapMapCEU (frequency of effect allele based on the HapMap CEU reference population) *Column7: Sample_size *Column8: Effect effect estimate *Column9: Stderr standard error *Column10: Pvalue (p-value after meta-analysis in METAL based on regression coefficients: effect and standard error) *Column11: HetIsq '''File naming scheme:''' *Trait: BMI, WaistadjBMI (Waist circumference adjusted for BMI), WHRadjBMI (Waist-to-hip ratio adjusted for BMI) *Physical activity: ACTIVE (individuals defined as active), INACTIVE (individuals defined as inactive), SNPadjPA (all individuals, added covariate of physical activity level) *Gender: MEN, WOMEN, ALL (Men and Women) *Ancestry: European (only European cohorts included in meta-anlaysis), All Ancestry (all cohorts included) *'''BMI Data Files''' **BMI Active ***[[Media: BMI.ACTIVE.ALL.AllAncestry.txt.gz | Download All AllAncestry GZIP]] ***[[Media: BMI.ACTIVE.ALL.European.txt.gz | Download All European Ancestry GZIP]] ***[[Media: BMI.ACTIVE.MEN.AllAncestry.txt.gz | Download Men AllAncestry GZIP]] ***[[Media: BMI.ACTIVE.MEN.European.txt.gz | Download Men European Ancestry GZIP]] ***[[Media: BMI.ACTIVE.WOMEN.AllAncestry.txt.gz | Download Women AllAncestry GZIP]] ***[[Media: BMI.ACTIVE.WOMEN.European.txt.gz | Download Women European Ancestry GZIP]] **BMI Inactive ***[[Media: BMI.INACTIVE.ALL.AllAncestry.txt.gz | Download All AllAncestry GZIP]] ***[[Media: BMI.INACTIVE.ALL.European.txt.gz | Download All European Ancestry GZIP]] ***[[Media: BMI.INACTIVE.MEN.AllAncestry.txt.gz | Download Men AllAncestry GZIP]] ***[[Media: BMI.INACTIVE.MEN.European.txt.gz | Download Men European Ancestry GZIP]] ***[[Media: BMI.INACTIVE.WOMEN.AllAncestry.txt.gz | Download Women AllAncestry GZIP]] ***[[Media: BMI.INACTIVE.WOMEN.European.txt.gz | Download Women European Ancestry GZIP]] **BMI SNPadjPA ***[[Media: BMI.SNPadjPA.ALL.AllAncestry.txt.gz | Download All AllAncestry GZIP]] ***[[Media: BMI.SNPadjPA.ALL.European.txt.gz | Download All European Ancestry GZIP]] ***[[Media: BMI.SNPadjPA.MEN.AllAncestry.txt.gz | Download Men AllAncestry GZIP]] ***[[Media: BMI.SNPadjPA.MEN.European.txt.gz | Download Men European Ancestry GZIP]] ***[[Media: BMI.SNPadjPA.WOMEN.AllAncestry.txt.gz | Download Women AllAncestry GZIP]] ***[[Media: BMI.SNPadjPA.WOMEN.European.txt.gz | Download Women European Ancestry GZIP]] *'''WAISTadjBMI Data Files''' **WAISTadjBMI Active ***[[Media: WAISTadjBMI.ACTIVE.ALL.AllAncestry.txt.gz | Download All AllAncestry GZIP]] ***[[Media: WAISTadjBMI.ACTIVE.ALL.European.txt.gz | Download All European Ancestry GZIP]] ***[[Media: WAISTadjBMI.ACTIVE.MEN.AllAncestry.txt.gz | Download Men AllAncestry GZIP]] ***[[Media: WAISTadjBMI.ACTIVE.MEN.European.txt.gz | Download Men European Ancestry GZIP]] ***[[Media: WAISTadjBMI.ACTIVE.WOMEN.AllAncestry.txt.gz | Download Women AllAncestry GZIP]] ***[[Media: WAISTadjBMI.ACTIVE.WOMEN.European.txt.gz | Download Women European Ancestry GZIP]] **WAISTadjBMI Inactive ***[[Media: WAISTadjBMI.INACTIVE.ALL.AllAncestry.txt.gz | Download All AllAncestry GZIP]] ***[[Media: WAISTadjBMI.INACTIVE.ALL.European.txt.gz | Download All European Ancestry GZIP]] ***[[Media: WAISTadjBMI.INACTIVE.MEN.AllAncestry.txt.gz | Download Men AllAncestry GZIP]] ***[[Media: WAISTadjBMI.INACTIVE.MEN.European.txt.gz | Download Men European Ancestry GZIP]] ***[[Media: WAISTadjBMI.INACTIVE.WOMEN.AllAncestry.txt.gz | Download Women AllAncestry GZIP]] ***[[Media: WAISTadjBMI.INACTIVE.WOMEN.European.txt.gz | Download Women European Ancestry GZIP]] **WAISTadjBMI SNPadjPA ***[[Media: WAISTadjBMI.SNPadjPA.ALL.AllAncestry.txt.gz | Download All AllAncestry GZIP]] ***[[Media: WAISTadjBMI.SNPadjPA.ALL.European.txt.gz | Download All European Ancestry GZIP]] ***[[Media: WAISTadjBMI.SNPadjPA.MEN.AllAncestry.txt.gz | Download Men AllAncestry GZIP]] ***[[Media: WAISTadjBMI.SNPadjPA.MEN.European.txt.gz | Download Men European Ancestry GZIP]] ***[[Media: WAISTadjBMI.SNPadjPA.WOMEN.AllAncestry.txt.gz | Download Women AllAncestry GZIP]] ***[[Media: WAISTadjBMI.SNPadjPA.WOMEN.European.txt.gz | Download Women European Ancestry GZIP]] *'''WHRadjBMI Data Files''' **WHRadjBMI Active ***[[Media: WHRadjBMI.ACTIVE.ALL.AllAncestry.txt.gz | Download All AllAncestry GZIP]] ***[[Media: WHRadjBMI.ACTIVE.ALL.European.txt.gz | Download All European Ancestry GZIP]] ***[[Media: WHRadjBMI.ACTIVE.MEN.AllAncestry.txt.gz | Download Men AllAncestry GZIP]] ***[[Media: WHRadjBMI.ACTIVE.MEN.European.txt.gz | Download Men European Ancestry GZIP]] ***[[Media: WHRadjBMI.ACTIVE.WOMEN.AllAncestry.txt.gz | Download Women AllAncestry GZIP]] ***[[Media: WHRadjBMI.ACTIVE.WOMEN.European.txt.gz | Download Women European Ancestry GZIP]] **WHRadjBMI Inactive ***[[Media: WHRadjBMI.INACTIVE.ALL.AllAncestry.txt.gz | Download All AllAncestry GZIP]] ***[[Media: WHRadjBMI.INACTIVE.ALL.European.txt.gz | Download All European Ancestry GZIP]] ***[[Media: WHRadjBMI.INACTIVE.MEN.AllAncestry.txt.gz | Download Men AllAncestry GZIP]] ***[[Media: WHRadjBMI.INACTIVE.MEN.European.txt.gz | Download Men European Ancestry GZIP]] ***[[Media: WHRadjBMI.INACTIVE.WOMEN.AllAncestry.txt.gz | Download Women AllAncestry GZIP]] ***[[Media: WHRadjBMI.INACTIVE.WOMEN.European.txt.gz | Download Women European Ancestry GZIP]] **WHRadjBMI SNPadjPA ***[[Media: WHRadjBMI.SNPadjPA.ALL.AllAncestry.txt.gz | Download All AllAncestry GZIP]] ***[[Media: WHRadjBMI.SNPadjPA.ALL.European.txt.gz | Download All European Ancestry GZIP]] ***[[Media: WHRadjBMI.SNPadjPA.MEN.AllAncestry.txt.gz | Download Men AllAncestry GZIP]] ***[[Media: WHRadjBMI.SNPadjPA.MEN.European.txt.gz | Download Men European Ancestry GZIP]] ***[[Media: WHRadjBMI.SNPadjPA.WOMEN.AllAncestry.txt.gz | Download Women AllAncestry GZIP]] ***[[Media: WHRadjBMI.SNPadjPA.WOMEN.European.txt.gz | Download Women European Ancestry GZIP]] = GIANT Consortium 2016 Exome Array Data is Available Here for Download = *[[Media:height_HA_add_SV.txt.gz| Download Height HA SV GZIP]] *[[Media:height_AA_add_SV.txt.gz| Download Height AA SV GZIP]] *[[Media:height_EA_add_SV.txt.gz| Download Height EA SV GZIP]] *[[Media:height_EAS_add_SV.txt.gz| Download Height EAS SV GZIP]] *[[Media:height_SA_add_SV.txt.gz| Download Height SA SV GZIP]] *[[Media:height_All_add_SV.txt.gz| Download Height All SV GZIP]] ===2016 Data File Description:=== Each file consists of the following information for each SNP and its association to the specified trait based on meta-analysis in the respective publication. Significant digits for the p values, betas and standard errors are limited to two digits to further limit the possibility of identifiability. *Column 1. CHR: chromosome *Column 2. POS: position of the variant (hg19) *Column 3. REF: reference allele (hg19 + strand) *Column 4. ALT: alternate allele (hg19 + strand) *Column 5. SNPNAME: dbSNP name of the genetic marker *Column 6. (one among these) **GMAF: Non-reference allele and frequency of existing variant in 1000 Genomes **AFR_MAF: Non-reference allele and frequency of existing variant in 1000 Genomes combined African population **AMR_MAF: Non-reference allele and frequency of existing variant in 1000 Genomes combined American population **EUR_MAF: Non-reference allele and frequency of existing variant in 1000 Genomes combined European population **EAS_MAF: Non-reference allele and frequency of existing variant in 1000 Genomes combined East Asian population **SAS_MAF: Non-reference allele and frequency of existing variant in 1000 Genomes combined South Asian population *Column 7. (one among these) **ExAC_MAF: Frequency of existing variant in ExAC combined population **ExAC_AFR_MAF: Frequency of existing variant in ExAC African/American population **ExAC_AMR_MAF: Frequency of existing variant in ExAC American population **ExAC_EAS_MAF: Frequency of existing variant in ExAC East Asian population **ExAC_NFE_MAF: Frequency of existing variant in ExAC Non-Finnish European population **ExAC_SAS_MAF: Frequency of existing variant in ExAC South Asian population *Column 8. beta: beta *Column 9. se: standard error *Column 10. Pvalue: p-value after meta-analysis using regression coefficients (beta and standard error) = GIANT consortium 2012-2015 GWAS Metadata is Available Here for Download = ===2012-2015 Data File Description:=== Each file consists of the following information for each SNP and its association to the specified trait based on meta-analysis in the respective publication. Significant digits for the p values, betas and standard errors are limited to two digits to further limit the possibility of identifiability. *'''MarkerName''': The [http://www.ncbi.nlm.nih.gov/SNP/ dbSNP] name of the genetic marker *'''Allele1''': The first allele (hg19 + strand). Where the regression coefficients (betas) are provided, the first allele is the effect allele. Where betas are not provided (typically the 2010 data), the first allele is the trait-increasing allele. *'''Allele2''': The second allele (hg19 + strand) *'''Freq.Allele1.HapMapCEU''': The allele frequency of Allele1 in the [http://www.hapmap.org HapMap] CEU population *'''b''': beta *'''SE''': standard error *'''p''': p-value after meta-analysis using regression coefficients (beta and standard error), and after correction for inflation of test statistics using genomic control both at the individual study level and again after meta-analysis *'''N''': Number of observations For the Height DEPICT Gene Set Enrichment Analysis file, the columns are as follows: *'''A''': the ID of the predefined gene set (before reconstitution by DEPICT); *'''B''': the name of the gene set; *'''C''': the DEPICT P-value for enrichment; *'''D''': the false discovery rate for enrichment; *'''E''': the genes in the gene set that overlap height-associated loci ==GWAMA Age-/Sex-Stratified 2015 BMI and WHR== *[[Media:BMI.MEN.GT50.publicrelease.txt.gz | Download BMI Men >=50y GZIP]] *[[Media:BMI.MEN.LE50.publicrelease.txt.gz | Download BMI Men <=50y GZIP]] *[[Media:BMI.WOMEN.GT50.publicrelease.txt.gz | Download BMI Women >=50y GZIP]] *[[Media:BMI.WOMEN.LE50.publicrelease.txt.gz | Download BMI Women <=50y GZIP]] *[[Media:WHRADJ.MEN.GT50.publicrelease.txt.gz | Download WHRadjBMI Men >=50y GZIP]] *[[Media:WHRADJ.MEN.LE50.publicrelease.txt.gz | Download WHRadjBMI Men <=50y GZIP]] *[[Media:WHRADJ.WOMEN.GT50.publicrelease.txt.gz | Download WHRadjBMI Women >=50y GZIP]] *[[Media: WHRADJ.WOMEN.LE50.publicrelease.txt.gz | Download WHRadjBMI Women <=50y GZIP]] If you use these data, please cite: Winkler TW*, Justice AE*, Graff M*, Barata L*, Feitosa MF, Chu S, Czajkowski J, Esko T, Fall T, Kilpeläinen TO, Lu Y, Mägi R et al. (2015). The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study. PLoS Genetics. In press. ==GWAS Anthropometric 2015 BMI== *[[Media:Men_SNP_gwas_mc_merge_nogc.tbl.uniq.gz|Download BMI Men Only GZIP]] *[[Media:Women_SNP_gwas_mc_merge_nogc.tbl.uniq.gz|Download BMI Women Only GZIP]] *[[Media:SNP_gwas_mc_merge_nogc.tbl.uniq.gz|Download BMI EUR Ancestry GZIP]] *[[Media:All_ancestries_SNP_gwas_mc_merge_nogc.tbl.uniq.gz|Download BMI All Ancestries GZIP]] If you use these '''BMI''' data, please cite: Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T et al. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature 518, 197-206. ==GWAS Anthropometric 2015 Waist== '''HIP:''' *[[Media:GIANT_2015_HIP_MALES_EUR.txt.gz| Download HIP Males EUR GZIP]] *[[Media:GIANT_2015_HIP_MALES_AllAncestries.txt.gz| Download HIP Males All Ancestries GZIP ]] *[[Media:GIANT_2015_HIP_FEMALES_EUR.txt.gz| Download HIP Females EUR GZIP ]] *[[Media:GIANT_2015_HIP_FEMALES_AllAncestries.txt.gz| Download HIP Females All Ancestries GZIP ]] *[[Media:GIANT_2015_HIP_COMBINED_EUR.txt.gz| Download HIP Combined EUR GZIP ]] *[[Media:GIANT_2015_HIP_COMBINED_AllAncestries.txt.gz| Download HIP Combined All Ancestries GZIP]] '''HIPadjBMI:''' *[[Media:GIANT_2015_HIPadjBMI_MALES_EUR.txt.gz| Download HIPadjBMI Males EUR GZIP]] *[[Media:GIANT_2015_HIPadjBMI_MALES_AllAncestries.txt.gz| Download HIPadjBMI Males All Ancestries GZIP]] *[[Media:GIANT_2015_HIPadjBMI_FEMALES_EUR.txt.gz| Download HIPadjBMI Females EUR GZIP]] *[[Media:GIANT_2015_HIPadjBMI_FEMALES_AllAncestries.txt.gz| Download HIPadjBMI Females All Ancestries GZIP]] *[[Media:GIANT_2015_HIPadjBMI_COMBINED_EUR.txt.gz| Download HIPadjBMI Combined EUR GZIP]] *[[Media:GIANT_2015_HIPadjBMI_COMBINED_AllAncestries.txt.gz| Download HIPadjBMI Combined All Ancestries GZIP]] '''WC:''' *[[Media:GIANT_2015_WC_MALES_EUR.txt.gz| Download WC Males EUR GZIP]] *[[Media:GIANT_2015_WC_MALES_AllAncestries.txt.gz| Download WC Males All Ancestries GZIP]] *[[Media:GIANT_2015_WC_FEMALES_EUR.txt.gz| Download WC Females EUR GZIP]] *[[Media:GIANT_2015_WC_FEMALES_AllAncestries.txt.gz| Download WC Females All Ancestries GZIP]] *[[Media:GIANT_2015_WC_COMBINED_EUR.txt.gz| Download WC Combined EUR GZIP]] *[[Media:GIANT_2015_WC_COMBINED_AllAncestries.txt.gz| Download WC Combined All Ancestries GZIP]] '''WCadjBMI:''' *[[Media:GIANT_2015_WCadjBMI_MALES_EUR.txt.gz| Download WCadjBMI Males EUR GZIP]] *[[Media:GIANT_2015_WCadjBMI_MALES_AllAncestries.txt.gz| Download WCadjBMI Males All Ancestries GZIP]] *[[Media:GIANT_2015_WCadjBMI_FEMALES_EUR.txt.gz| Download WCadjBMI Females EUR GZIP]] *[[Media:GIANT_2015_WCadjBMI_FEMALES_AllAncestries.txt.gz| Download WCadjBMI Females All Ancestries GZIP]] *[[Media:GIANT_2015_WCadjBMI_COMBINED_EUR.txt.gz| Download WCadjBMI Combined EUR GZIP]] *[[Media:GIANT_2015_WCadjBMI_COMBINED_AllAncestries.txt.gz| Download WCadjBMI Combined All Ancestries GZIP]] '''WHR:''' *[[Media:GIANT_2015_WHR_MALES_EUR.txt.gz| Download WHR Males EUR GZIP]] *[[Media:GIANT_2015_WHR_MALES_AllAncestries.txt.gz| Download WHR Males All Ancestries GZIP]] *[[Media:GIANT_2015_WHR_FEMALES_EUR.txt.gz| Download WHR Females EUR GZIP]] *[[Media:GIANT_2015_WHR_FEMALES_AllAncestries.txt.gz| Download WHR Females All Ancestries GZIP]] *[[Media:GIANT_2015_WHR_COMBINED_EUR.txt.gz| Download WHR Combined EUR GZIP]] *[[Media:GIANT_2015_WHR_COMBINED_AllAncestries.txt.gz| Download WHR Combined All Ancestries GZIP]] '''WHRadjBMI:''' *[[Media:GIANT_2015_WHRadjBMI_MALES_EUR.txt.gz| Download WHRadjBMI Males EUR GZIP]] *[[Media:GIANT_2015_WHRadjBMI_MALES_AllAncestries.txt.gz| Download WHRadjBMI Males All Ancestries GZIP]] *[[Media:GIANT_2015_WHRadjBMI_FEMALES_EUR.txt.gz| Download WHRadjBMI Females EUR GZIP]] *[[Media:GIANT_2015_WHRadjBMI_FEMALES_AllAncestries.txt.gz| Download WHRadjBMI Females All Ancestries GZIP]] *[[Media:GIANT_2015_WHRadjBMI_COMBINED_EUR.txt.gz| Download WHRadjBMI Combined EUR GZIP]] *[[Media:GIANT_2015_WHRadjBMI_COMBINED_AllAncestries.txt.gz| Download WHRadjBMI Combined All Ancestries GZIP]] If you use these '''Waist''' data please cite: Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Magi R, Strawbridge R, Pers TH, Fischer K, Justice AE, Workalemahu T, Wu JM, et al. (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature <strong>518</strong>: 187-196. ==GWAS Anthropometric 2014 Height== *[[Media:GIANT_HEIGHT_Wood_et_al_2014_publicrelease_HapMapCeuFreq.txt.gz|Download Height GZIP]] *[[Media:GIANT_HEIGHT_Wood_et_al_2014_depict_gene_set_enrichment.txt.gz|Download full set of DEPICT gene set enrichment results GZIP]] If you use these '''Height''' data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=25282103 Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S et al.] (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics <strong>11</strong>:1173-86. ==Variability in BMI and Height== *[[Media:GIANT_Yang2012Nature_publicrelease_HapMapCeuFreq_BMI.txt.gz|Download BMI GZIP]] *[[Media:GIANT_Yang2012Nature_publicrelease_HapMapCeuFreq_Height.txt.gz|Download Height GZIP]] If you use these '''Body Mass Index''' or '''Height''' data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=22982992 Yang J, Loos RJ, Powell JE, Medland SE, Speliotes EK, Chasman DI, Rose LM, Thorleifsson G, Steinthorsdottir V, Mägi R, et al.] (2012). FTO genotype is associated with phenotypic variability of body mass index. Nature <strong>490</strong>:267-272. ==Sex Stratified Anthropometrics== *[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_BMI_MEN_N.txt|Download BMI Men]] *[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_BMI_WOMEN_N.txt|Download BMI Women]] *[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HEIGHT_MEN_N.txt|Download HEIGHT Men]] *[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HEIGHT_WOMEN_N.txt| Download HEIGHT Women]] *[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HIP_MEN_N.txt|Download HIP Men]] *[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HIP_WOMEN_N.txt|Download HIP Women]] *[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HIPadjBMI_MEN_N.txt|Download HIPadjBMI Men]] *[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_HIPadjBMI_WOMEN_N.txt|Download HIPadjBMI Women]] *[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WC_MEN_N.txt|Download WC Men]] *[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WC_WOMEN_N.txt|Download WC Women]] *[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WCadjBMI_MEN_N.txt| Download WCadjBMI Men]] *[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WCadjBMI_WOMEN_N.txt|Download WCadjBMI Women]] *[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WEIGHT_MEN_N.txt|Download WEIGHT Men]] *[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WEIGHT_WOMEN_N.txt|Download WEIGHT Women]] *[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WHR_MEN_N.txt|Download WHR Men]] *[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WHR_WOMEN_N.txt|Download WHR Women]] *[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WHRadjBMI_MEN_N.txt|Download WHRadjBMI Men]] *[[Media:GIANT_Randall2013PlosGenet_stage1_publicrelease_HapMapCeuFreq_WHRadjBMI_WOMEN_N.txt|Download WHRadjBMI Women]] If you use these data, please cite: [http://www.ncbi.nlm.nih.gov/pubmed/23754948?dopt=Citation Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, et al.] (2013). Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet <strong>9</strong>: e1003500. ==Extremes of Anthropometric Traits== *[[Media:GIANT_EXTREME_BMI_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz|Download Extreme BMI Stage 1 GZIP]] *[[Media:GIANT_EXTREME_HEIGHT_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz| Download Extreme Height Stage 1 GZIP]] *[[Media: GIANT_EXTREME_WHR_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz | Download Extreme WHR Stage 1 GZIP]] *[[Media:GIANT_OBESITY_CLASS1_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz | Download Obesity Class 1 Stage 1 GZIP]] *[[Media:GIANT_OBESITY_CLASS2_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz | Download Obesity Class 2 Stage1 GZIP]] *[[Media:GIANT_OBESITY_CLASS3_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz | Download Obesity Class 3 Stage1 GZIP]] *[[Media:GIANT_OVERWEIGHT_Stage1_Berndt2013_publicrelease_HapMapCeuFreq.txt.gz | Download Overweight Stage 1 GZIP]] If you use these data, please cite: [http://www.ncbi.nlm.nih.gov/pubmed/23563607?dopt=Citation Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, et al.] (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics <strong>45</strong>:501-512. = GIANT Consortium 2010 GWAS Metadata is Available Here for Download = ===2010 Data File Description:=== Each file consists of the following information for each SNP and its association to the specified trait based on meta-analysis in the respective publication. SNPs where N < 50% of the maximum have been excluded. *'''MarkerName''': The [http://www.ncbi.nlm.nih.gov/SNP/ dbSNP] name of the genetic marker *'''Allele1''': The first allele, by definition the trait-increasing allele (hg18 + strand) *'''Allele2''': The second allele (hg18 + strand) *'''Freq.Allele1.HapMapCEU''': The allele frequency of Allele1 in the [http://www.hapmap.org HapMap] CEU population *'''P''': P value after meta-analysis using regression coefficients (beta and standard error), and after correction for inflation of test statistics using genomic control both at the individual study level and again after meta-analysis *'''N''': Number of observations == BMI ([[Media:GIANT_BMI_Speliotes2010_publicrelease_HapMapCeuFreq.txt.gz|download GZIP]]) == <tt>MD5 ([[media:GIANT_BMI_Speliotes2010_publicrelease_HapMapCeuFreq.txt|GIANT_BMI_Speliotes2010_publicrelease_HapMapCeuFreq.txt]] -- 79 MB; 2,471,517 lines) = 38c836542807a3830101bcf48bb34472</tt> If you use these '''Body Mass Index''' data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=20935630 Speliotes, E.K., Willer, C.J., Berndt, S.I., Monda, K.L., Thorleifsson, G., Jackson, A.U., Allen, H.L., Lindgren, C.M., Luan, J., Magi, R., et al.] (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet <strong>42</strong>, 937-948. == Height ([[Media:GIANT_HEIGHT_LangoAllen2010_publicrelease_HapMapCeuFreq.txt.gz ‎|download GZIP]]) == <tt>MD5 ([[media:GIANT_HEIGHT_LangoAllen2010_publicrelease_HapMapCeuFreq.txt|GIANT_HEIGHT_LangoAllen2010_publicrelease_HapMapCeuFreq.txt]] -- 82 MB; 2,469,636 lines) = b51b4c4ff1f03bd33c4b2dfd6b10cb82</tt> If you use these '''height''' data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=20881960 Lango Allen, H., Estrada, K., Lettre, G., Berndt, S.I., Weedon, M.N., Rivadeneira, F., Willer, C.J., Jackson, A.U., Vedantam, S., Raychaudhuri, S., et al.] (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature <strong>467</strong>, 832-838. == WHRadjBMI ([[Media:GIANT WHRadjBMI Heid2010 publicrelease HapMapCeuFreq.txt.gz |download GZIP]]) == <tt>MD5 ([[media:GIANT_WHRadjBMI_Heid2010_publicrelease_HapMapCeuFreq.txt|GIANT_WHRadjBMI_Heid2010_publicrelease_HapMapCeuFreq.txt]] -- 75 MB; 2,483,326 lines) = 8f7e2ca61c33a120db9e7bfe51e3c053</tt> If you use these '''waist-hip ratio adjusted for BMI''' data, please cite: [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;dopt=Citation&amp;list_uids=20935629 Heid, I.M., Jackson, A.U., Randall, J.C., Winkler, T.W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M.C., Speliotes, E.K., Magi, R., et al.] (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet <strong>42</strong>, 949-960.

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