What is Oncotator?
Oncotator is a web application for annotating human genomic point mutations and indels with data relevant to cancer researchers. Annotations are aggregated from the following resources:
Genomic Annotations
- Gene, transcript, and functional consequence annotations using GENCODE for hg19.
- Reference sequence around a variant.
- GC content around a variant.
- Human DNA Repair Gene annotations from Wood et al.
Protein Annotations
Cancer Variant Annotations
- Observed cancer mutation frequency annotations from COSMIC.
- Cancer gene and mutation annotations from the Cancer GenCensus.
- Overlapping mutations from the Cancer Cell Line Encyclopedia.
- Cancer gene annotations from the Familial Cancer Database.
- Cancer variant annotations from ClinVar.
Non-Cancer Variant Annotations
- Common SNP annotations from dbSNP.
- Variant annotations from 1000 Genomes.
- Variant annotations from NHLBI GO Exome Sequencing Project (ESP).
Please see the help page for detailed information regarding all annotations.
Latest News
29 April 2015
Max input size increased to 5,000 variants
The issue preventing downloading of large input files has been resolved and the cap on input size has been increased back to 5,000 variants.
Get Started
Upload your input data below. Please note, only GRCh37/hg19 coordinates are supported and there is a maximum of 5,000 alterations per input file. If you need additional help, please visit our help page or feel free to contact us directly.
Upload Mutations
Paste Mutations
Web service API
Explore Oncotator's API.
