GPP sgRNA Designer Changelog

Below is a summary of changes to the GPP sgRNA Designer, including bugfixes and improvements.

Date Summary of Changes
1 2021-01-13 Updated Ensembl annotation for GRCh38 and GRCm38 to v.102
2 2021-01-13 Updated NCBI annotation for GRCh38 to v.109.20201120
3 2020-11-09 Updated NCBI annotation for GRCh37 to v.105.20201022
4 2020-10-13 Updated NCBI annotation for GRCh38 to v.109.20200815
5 2020-09-18 Changed default on-target rank weight to 2.0 for *Cas12a picking
6 2020-07-23 Updated NCBI annotation for GRCm38 to v.108.20200622
7 2020-06-12 Updated NCBI annotation for GRCh38 to v.109.20200522
8 2020-06-02 Updated Ensembl annotation for GRCh38 and GRCm38 to v.100
9 2020-03-20 Updated Ensembl annotation for GRCh38 and GRCm38 to v.99
10 2020-02-26 Upgraded to enPAM+GB on-target scorer for enAsCas12a
11 2019-10-28 Added "Other Target Matches" output column
12 2019-10-03 Updated RefSeq annotation for GRCh38 to v.109 and GRCm38 to v.108
13 2019-10-03 Updated Ensembl annotation for GRCh38 and GRCm38 to v.98
14 2019-10-03 Added support for AsCas12a and enAsCas12a in GRCh38 and GRCm38
15 2019-06-14 Added support for human GRCh37 (SpyoCas9 only)
16 2019-06-03 Updated user interface
17 2019-05-02 Updated reference data and added Ensembl support for Human/Mouse
18 2019-01-24 Updated reference data and added Rat Rnor_6.0
19 2017-11-17 Fixed minor threat matrix bug
20 2017-10-17 Fixed S. aureus on-target scoring bug
21 2017-05-09 S. aureus design support enabled
22 2016-11-03 Rule Set 2 support upgraded to Azimuth 2.0
23 2016-10-05 CRISPRa/i design support enabled
24 2016-01-18 Rule Set 2 support enabled
25 2015-10-19 First public version of sgRNA Design Tool enabled

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