The Genetic Perturbation Platform (GPP), formerly known as the RNA interference (RNAi) Platform, supports functional investigations of the mammalian genome that can reveal how genetic alterations lead to changes in phenotype.
Design Tools
- CRISPick (GPP sgRNA Designer)
- Design sgRNA sequences for CRISPRko/a/i targets
- Fragmid
- Fragmid Design Tool
- Beagle (GPP CRISPRbe Designer)
- Design base editor (CRISPRbe) tiling libraries
- Design Hairpins for a Target Transcript Sequence (RNAi)
- Generate matching shRNA designs for a transcript sequence
Screening Analysis
- Analysis Guides
- Pooled Screen Analysis Guide
- Pooled Screen Analysis Tools
- Hypergeometric and Negative Binomial Analysis
- Software Tool Downloads
- Software tools and related resources for screen analysis
Reagents
- Individual and Arrayed Constructs
- Search by gene
- Search by clone
- Pooled Libraries
- Browse available libraries
- Vectors
- Browse Fragmid modular vectors via dimgarF; view legacy vectors
Resources
- Protocols
- Protocols including clone, DNA, and virus production
- Library Resources
- Clone inventory downloads