Construct: sgRNA BRDN0001144720
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TCAGACAAGAAAGCCAAACG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- NEK11 (79858)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 75560
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000003.12 |
3 |
131029864 |
+ |
NEK11 |
NNNGACAAGAAAGCCAAACG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000018.10 |
18 |
52623959 |
+ |
DCC |
NNNGACAAGAAAGCCAAACA |
NGG |
1 |
0.9375 |
Tier II |
3 |
NC_000007.14 |
7 |
86750806 |
+ |
GRM3 |
NNNGAAAAGAAAGCCAAACT |
NGG |
2 |
0.65 |
Tier II |
4 |
NC_000019.10 |
19 |
38951954 |
- |
FBXO17 |
NNNGAAAAGAAAGCCAAACT |
NGG |
2 |
0.65 |
Tier II |
5 |
NC_000001.11 |
1 |
179644791 |
- |
TDRD5 |
NNNAACAAGAAAGCCAAACT |
NGG |
2 |
0.63 |
Tier II |
6 |
NC_000012.12 |
12 |
10603376 |
- |
MAGOHB |
NNNGACAAGAAAGACAAACA |
NGG |
2 |
0.3281 |
Tier II |
7 |
NC_000004.12 |
4 |
74984051 |
- |
PARM1 |
NNNGCCAAGAAAGCCAAATG |
NGG |
2 |
0.2308 |
Tier II |
8 |
NC_000011.10 |
11 |
86671612 |
+ |
ME3 |
NNNGACAAGAAAGCCAAACC |
NAG |
2 |
0.1111 |
Tier II |
9 |
NC_000011.10 |
11 |
115216807 |
- |
CADM1 |
NNNGACCAGAAAGCCAAAGG |
NGG |
2 |
0.0547 |
Tier II |
10 |
NC_000002.12 |
2 |
190596161 |
+ |
NEMP2 |
NNNGACAAGAAAACCAAACG |
NTG |
2 |
0.036 |
Tier II |
11 |
NC_000002.12 |
2 |
148105645 |
- |
MBD5 |
NNNGACAAGAAAGCTAAAAG |
NGG |
2 |
0.0286 |
Tier II |
12 |
NC_000023.11 |
X |
11252694 |
+ |
ARHGAP6 |
NNNGACAAGAAAGCCAAAGG |
NGC |
2 |
0.0028 |
Tier II |
13 |
NC_000011.10 |
11 |
112303552 |
+ |
LINC02762 |
NNNGACATGAATGCCAAACG |
NGG |
2 |
0.1429 |
Tier III |
14 |
NC_000017.11 |
17 |
16980448 |
+ |
LOC284191 |
NNNGACAAGAAGGCCAGACG |
NGG |
2 |
0.1275 |
Tier III |
15 |
NC_000002.12 |
2 |
190596161 |
+ |
NEMP2-DT |
NNNGACAAGAAAACCAAACG |
NTG |
2 |
0.036 |
Tier III |
16 |
NC_000007.14 |
7 |
142627826 |
- |
TRB |
NNNGACAAGAAAGCCAATCG |
NTG |
2 |
0.0195 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000075.6 |
9 |
105392864 |
- |
Nek11 |
NNNGACAAGAAAGCCAAACC |
NGG |
1 |
0.4286 |
Tier I |
2 |
NC_000081.6 |
15 |
92339561 |
- |
Cntn1 |
NNNGACAAGAAAGCCAAGGG |
NGG |
2 |
0.05 |
Tier I |
3 |
NC_000068.7 |
2 |
76318153 |
- |
Pde11a |
NNNGACAAGAAAACCAAAAG |
NGG |
2 |
0.3956 |
Tier II |
4 |
NC_000072.6 |
6 |
39055358 |
+ |
Tbxas1 |
NNNAACAAGAAAGCCAAAAG |
NGG |
2 |
0.3857 |
Tier II |
5 |
NC_000080.6 |
14 |
117450189 |
+ |
Gpc6 |
NNNGACAGGAAAGCCAAATG |
NGG |
2 |
0.3385 |
Tier II |
6 |
NC_000071.6 |
5 |
100364795 |
- |
Sec31a |
NNNGACAAGAAAGCCAAGCT |
NGG |
2 |
0.28 |
Tier II |
7 |
NC_000077.6 |
11 |
105969277 |
+ |
Ace |
NNNGAGTAGAAAGCCAAACG |
NGG |
2 |
0.2188 |
Tier II |
8 |
NC_000071.6 |
5 |
108196446 |
- |
Ccdc18 |
NNNGAGAAGAAAGCCAAACC |
NGG |
2 |
0.2143 |
Tier II |
9 |
NC_000078.6 |
12 |
17936997 |
- |
Gm9222 |
NNNGAGAAGAAAGCCAAACC |
NGG |
2 |
0.2143 |
Tier II |
10 |
NC_000078.6 |
12 |
18981626 |
- |
Gm40847 |
NNNGAGAAGAAAGCCAAACC |
NGG |
2 |
0.2143 |
Tier II |
11 |
NC_000078.6 |
12 |
20668085 |
- |
LOC108167368 |
NNNGAGAAGAAAGCCAAACC |
NGG |
2 |
0.2143 |
Tier II |
12 |
NC_000078.6 |
12 |
23494809 |
+ |
Gm40862 |
NNNGAGAAGAAAGCCAAACC |
NGG |
2 |
0.2143 |
Tier II |
13 |
NC_000078.6 |
12 |
24304678 |
+ |
Gm4120 |
NNNGAGAAGAAAGCCAAACC |
NGG |
2 |
0.2143 |
Tier II |
14 |
NC_000072.6 |
6 |
54486177 |
- |
Scrn1 |
NNNGACAAGAAAGCCAAGAG |
NGG |
2 |
0.1714 |
Tier II |
15 |
NC_000072.6 |
6 |
54486177 |
- |
Wipf3 |
NNNGACAAGAAAGCCAAGAG |
NGG |
2 |
0.1714 |
Tier II |
16 |
NC_000078.6 |
12 |
103218182 |
+ |
Prima1 |
NNNGACAAGAAAGCCAGACT |
NGG |
2 |
0.1235 |
Tier II |
17 |
NC_000080.6 |
14 |
21316489 |
- |
Adk |
NNNGGCAAGAAAGCCAAACG |
NGA |
2 |
0.05 |
Tier II |
18 |
NC_000076.6 |
10 |
69630816 |
- |
Ank3 |
NNNGACAAGAAAGCCAAAAG |
NGA |
2 |
0.0298 |
Tier II |
19 |
NC_000069.6 |
3 |
87445229 |
+ |
Fcrl5 |
NNNGACAAGAAAGCCAAAAG |
NTG |
2 |
0.0167 |
Tier II |
20 |
NC_000076.6 |
10 |
76434183 |
+ |
Pcnt |
NNNGACAAGACAGCCAAACG |
NTG |
2 |
0.0156 |
Tier II |
21 |
NC_000069.6 |
3 |
80689064 |
+ |
Gria2 |
NNNGACAAGAAAGCTAAACG |
NGC |
2 |
0.0015 |
Tier II |
22 |
NC_000070.6 |
4 |
3741777 |
+ |
Lyn |
NNNGACAAGAAAGCCTAACT |
NGG |
2 |
0.0 |
Tier II |
23 |
NC_000072.6 |
6 |
34365344 |
- |
Akr1b8 |
NNNGAGAAGAAAGCCTAACG |
NGG |
2 |
0.0 |
Tier II |
24 |
NC_000077.6 |
11 |
105969277 |
+ |
Gm11651 |
NNNGAGTAGAAAGCCAAACG |
NGG |
2 |
0.2188 |
Tier III |
25 |
NC_000078.6 |
12 |
21626872 |
+ |
Gm4036 |
NNNGAGAAGAAAGCCAAACC |
NGG |
2 |
0.2143 |
Tier III |
26 |
NC_000078.6 |
12 |
22205031 |
+ |
Gm9289 |
NNNGAGAAGAAAGCCAAACC |
NGG |
2 |
0.2143 |
Tier III |
27 |
NC_000078.6 |
12 |
22956636 |
+ |
2410018L13Rik |
NNNGAGAAGAAAGCCAAACC |
NGG |
2 |
0.2143 |
Tier III |
28 |
NC_000078.6 |
12 |
23363791 |
+ |
Gm9285 |
NNNGAGAAGAAAGCCAAACC |
NGG |
2 |
0.2143 |
Tier III |
29 |
NC_000067.6 |
1 |
184542675 |
+ |
1700112H15Rik |
NNNGATAAGAAAGCCAAACG |
NTG |
2 |
0.0362 |
Tier III |
30 |
NC_000086.7 |
X |
153049901 |
- |
9530051G07Rik |
NNNGACAAGAAAGCAAAAGG |
NGG |
2 |
0.0278 |
Tier III |
31 |
NC_000070.6 |
4 |
3513453 |
- |
LOC108168924 |
NNNGACAAGAAAGCCTAACT |
NGG |
2 |
0.0 |
Tier III |
32 |
NC_000076.6 |
10 |
111598519 |
+ |
Gm30262 |
NNNGACAAGAAAGGCAACCG |
NGG |
2 |
0.0 |
Tier III |
33 |
NC_000072.6 |
6 |
34365344 |
- |
Gm13858 |
NNNGAGAAGAAAGCCTAACG |
NGG |
2 |
0.0 |
Tier III |
Other clones with same target sequence:
(none)