Construct: sgRNA BRDN0001145050
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- ATAGCCAGCCTTAAACATGG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- RIOK2 (55781)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 76960
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000005.10 |
5 |
97179123 |
- |
RIOK2 |
NNNGCCAGCCTTAAACATGG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000002.12 |
2 |
71148045 |
+ |
MPHOSPH10 |
NNNGCCAGCCATAACCATGG |
NGG |
2 |
0.2045 |
Tier I |
3 |
NC_000007.14 |
7 |
158413848 |
+ |
PTPRN2 |
NNNGCCACCCTTAAACATGG |
NGG |
1 |
0.6154 |
Tier II |
4 |
NC_000001.11 |
1 |
156835296 |
+ |
NTRK1 |
NNNCCCAGCCTAAAACATGG |
NGG |
2 |
0.4235 |
Tier II |
5 |
NC_000005.10 |
5 |
144355151 |
- |
KCTD16 |
NNNGCAAGCCGTAAACATGG |
NGG |
2 |
0.3714 |
Tier II |
6 |
NC_000017.11 |
17 |
7493210 |
- |
POLR2A |
NNNGCCTGCCTGAAACATGG |
NGG |
2 |
0.2188 |
Tier II |
7 |
NC_000014.9 |
14 |
51947502 |
+ |
GNG2 |
NNNGCCAGCTTTAAAGATGG |
NGG |
2 |
0.1448 |
Tier II |
8 |
NC_000009.12 |
9 |
114469919 |
- |
WHRN |
NNNGCCAGCCTTGAAGATGG |
NGG |
2 |
0.1003 |
Tier II |
9 |
NC_000023.11 |
X |
7208930 |
- |
STS |
NNNGCCAGCCTTGAAGATGG |
NGG |
2 |
0.1003 |
Tier II |
10 |
NC_000001.11 |
1 |
26841178 |
- |
ZDHHC18 |
NNNACCAGCCTTAAACATGG |
NGA |
2 |
0.0625 |
Tier II |
11 |
NC_000023.11 |
X |
14728628 |
- |
FANCB |
NNNGCCAGCCCTAAACATGG |
NTG |
2 |
0.026 |
Tier II |
12 |
NC_000023.11 |
X |
14728628 |
- |
GLRA2 |
NNNGCCAGCCCTAAACATGG |
NTG |
2 |
0.026 |
Tier II |
13 |
NC_000004.12 |
4 |
16224704 |
+ |
TAPT1 |
NNNTCCAGCCTTAAACATGG |
NGA |
2 |
0.0253 |
Tier II |
14 |
NC_000009.12 |
9 |
68597208 |
+ |
TMEM252-DT |
NNNACCAGCCTAAAACATGG |
NGG |
2 |
0.72 |
Tier III |
15 |
NC_000004.12 |
4 |
130384165 |
- |
LINC02479 |
NNNGTCAGCCTTAAAAATGG |
NGG |
2 |
0.6364 |
Tier III |
16 |
NC_000006.12 |
6 |
32389510 |
+ |
TSBP1-AS1 |
NNNGCGAGCCCTAAACATGG |
NGG |
2 |
0.3333 |
Tier III |
17 |
NC_000002.12 |
2 |
237030290 |
+ |
COPS8-DT |
NNNGCCAGCCTTCAGCATGG |
NGG |
2 |
0.1368 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000083.6 |
17 |
17377790 |
+ |
Riok2 |
NNNGCCAGCCTGAAACATGG |
NGG |
1 |
0.5 |
Tier I |
2 |
NC_000073.6 |
7 |
64378800 |
- |
Mphosph10 |
NNNGCCAGCCATAACCATGG |
NGG |
2 |
0.2045 |
Tier I |
3 |
NC_000070.6 |
4 |
152300615 |
- |
Icmt |
NNNGCCAGCCGTAAACATGG |
NAG |
2 |
0.1037 |
Tier I |
4 |
NC_000079.6 |
13 |
92333008 |
+ |
Msh3 |
NNNGCCAGTCATAAACATGG |
NGG |
2 |
0.6563 |
Tier II |
5 |
NC_000075.6 |
9 |
77347456 |
+ |
Mlip |
NNNGCCAGCTTTGAACATGG |
NGG |
2 |
0.6138 |
Tier II |
6 |
NC_000072.6 |
6 |
121035897 |
- |
Mical3 |
NNNGCAAGCCTTGAACATGG |
NGG |
2 |
0.6056 |
Tier II |
7 |
NC_000073.6 |
7 |
49073625 |
+ |
Nav2 |
NNNGCCAGCCTAAAACATAG |
NGG |
2 |
0.5714 |
Tier II |
8 |
NC_000072.6 |
6 |
35237624 |
- |
Nup205 |
NNNGACAGCCTTAAACATGA |
NGG |
2 |
0.5357 |
Tier II |
9 |
NC_000072.6 |
6 |
144056889 |
+ |
Sox5 |
NNNGCCAGCCTCAGACATGG |
NGG |
2 |
0.4421 |
Tier II |
10 |
NC_000068.7 |
2 |
59824366 |
+ |
Tanc1 |
NNNGGCAGCCTGAAACATGG |
NGG |
2 |
0.3 |
Tier II |
11 |
NC_000084.6 |
18 |
67969045 |
+ |
Ldlrad4 |
NNNGCCAGACTTAAACATGG |
NAG |
2 |
0.2222 |
Tier II |
12 |
NC_000071.6 |
5 |
105706586 |
+ |
Lrrc8d |
NNNGCCAGCCTAAAACATGG |
NAG |
2 |
0.2074 |
Tier II |
13 |
NC_000068.7 |
2 |
122774852 |
- |
Sqor |
NNNGCCAGCTTTAAAGATGG |
NGG |
2 |
0.1448 |
Tier II |
14 |
NC_000076.6 |
10 |
21156038 |
+ |
Myb |
NNNTCCAGCCTTAAAGATGG |
NGG |
2 |
0.0559 |
Tier II |
15 |
NC_000076.6 |
10 |
61944200 |
- |
Col13a1 |
NNNGCCAGCCTGAAACATGG |
NCG |
2 |
0.0536 |
Tier II |
16 |
NC_000069.6 |
3 |
101578497 |
- |
Atp1a1 |
NNNCCCAGCCTTAAACATGG |
NGA |
2 |
0.0368 |
Tier II |
17 |
NC_000074.6 |
8 |
16981285 |
+ |
Csmd1 |
NNNGCCATCCTTAAACATGG |
NTG |
2 |
0.0244 |
Tier II |
18 |
NC_000073.6 |
7 |
46687094 |
+ |
Saal1 |
NNNGCCAGCCTTAAAGATGG |
NCG |
2 |
0.0165 |
Tier II |
19 |
NC_000079.6 |
13 |
58384804 |
- |
2210016F16Rik |
NNNGCCAGCCTTAAACCTGG |
NTG |
2 |
0.0069 |
Tier II |
20 |
NC_000071.6 |
5 |
115015071 |
- |
Sppl3 |
NNNGCCAGCCTTAAACTTGG |
NGC |
2 |
0.003 |
Tier II |
21 |
NC_000073.6 |
7 |
49073625 |
+ |
Gm32849 |
NNNGCCAGCCTAAAACATAG |
NGG |
2 |
0.5714 |
Tier III |
22 |
NC_000072.6 |
6 |
147652478 |
- |
Gm36244 |
NNNGCCAGCCTTAAACATCG |
NGG |
1 |
0.4483 |
Tier III |
23 |
NC_000080.6 |
14 |
79910905 |
- |
Gm6999 |
NNNTCCTGCCTTAAACATGG |
NGG |
2 |
0.1591 |
Tier III |
24 |
NC_000070.6 |
4 |
16257238 |
- |
A530072M11Rik |
NNNGACAGCCTTCAACATGG |
NGG |
2 |
0.1203 |
Tier III |
25 |
NC_000069.6 |
3 |
130685416 |
+ |
Gm36373 |
NNNGCCAGCCTTAAACGGGG |
NGG |
2 |
0.0588 |
Tier III |
26 |
NC_000081.6 |
15 |
51236813 |
+ |
Gm19303 |
NNNGCCAGCCTTAAACATGT |
NGA |
2 |
0.0486 |
Tier III |
Other clones with same target sequence:
(none)