Construct: sgRNA BRDN0001145081
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- ATAGCATTGTATTTACCACA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- CSNK1G3 (1456)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000005.10 | 5 | 123573428 | - | CSNK1G3 | NNNGCATTGTATTTACCACA | NGG | 0 | 1.0 | Tier I |
2 | NC_000015.10 | 15 | 64216676 | + | CSNK1G1 | NNNGCATTATATTTCCCACA | NGG | 2 | 0.1753 | Tier I |
3 | NC_000015.10 | 15 | 24846377 | - | SNRPN | NNNGCAATGTATATACCACA | NGG | 2 | 0.6058 | Tier II |
4 | NC_000011.10 | 11 | 18361921 | + | GTF2H1 | NNNGCATTGTATTTAAAACA | NGG | 2 | 0.4667 | Tier II |
5 | NC_000006.12 | 6 | 122625414 | + | PKIB | NNNCCATTGTATCTACCACA | NGG | 2 | 0.418 | Tier II |
6 | NC_000002.12 | 2 | 172956338 | - | RAPGEF4 | NNNTCATTGTATTTACCACA | NGG | 1 | 0.3636 | Tier II |
7 | NC_000006.12 | 6 | 142309330 | - | ADGRG6 | NNNGCATTTTATTTGCCACA | NGG | 2 | 0.3467 | Tier II |
8 | NC_000005.10 | 5 | 113520598 | + | YTHDC2 | NNNGCCTGGTATTTACCACA | NGG | 2 | 0.3333 | Tier II |
9 | NC_000012.12 | 12 | 65853962 | + | HMGA2 | NNNGCACTGTATTTACAACA | NGG | 2 | 0.3208 | Tier II |
10 | NC_000003.12 | 3 | 27313675 | - | NEK10 | NNNGCATTGTATATACCATA | NGG | 2 | 0.3195 | Tier II |
11 | NC_000007.14 | 7 | 116542128 | + | CAV1 | NNNGCATTGTATATACCAAA | NGG | 2 | 0.2967 | Tier II |
12 | NC_000010.11 | 10 | 66951053 | + | CTNNA3 | NNNGCACTGTATTTATCACA | NGG | 2 | 0.2115 | Tier II |
13 | NC_000010.11 | 10 | 66951053 | + | LRRTM3 | NNNGCACTGTATTTATCACA | NGG | 2 | 0.2115 | Tier II |
14 | NC_000006.12 | 6 | 157537972 | + | ZDHHC14 | NNNGCCTTGTCTTTACCACA | NGG | 2 | 0.1818 | Tier II |
15 | NC_000005.10 | 5 | 84229210 | - | EDIL3 | NNNGCATGGTATTTTCCACA | NGG | 2 | 0.1467 | Tier II |
16 | NC_000002.12 | 2 | 45657002 | + | PRKCE | NNNGCATTGCATTTAGCACA | NGG | 2 | 0.0821 | Tier II |
17 | NC_000001.11 | 1 | 182878714 | + | DHX9 | NNNGCATTGTATTTACCAGT | NGG | 2 | 0.075 | Tier II |
18 | NC_000001.11 | 1 | 165216412 | - | LMX1A | NNNGCATTGTTTTTACCCCA | NGG | 2 | 0.0586 | Tier II |
19 | NC_000001.11 | 1 | 71643777 | - | NEGR1 | NNNGCATTCTATTTACCACA | NGA | 2 | 0.0374 | Tier II |
20 | NC_000020.11 | 20 | 14976861 | - | MACROD2 | NNNGCATTGTATTTGCCACA | NTG | 2 | 0.0253 | Tier II |
21 | NC_000005.10 | 5 | 150710838 | - | DCTN4 | NNNGCATTGTATTTACCACC | NGA | 2 | 0.0158 | Tier II |
22 | NC_000005.10 | 5 | 58674605 | - | RAB3C | NNNGTATTGTATTGACCACA | NGG | 2 | 0.0 | Tier II |
23 | NC_000011.10 | 11 | 25869445 | - | LINC02699 | NNNGCATTGTGTTTACCACA | NGG | 1 | 0.65 | Tier III |
24 | NC_000015.10 | 15 | 24846377 | - | SNHG14 | NNNGCAATGTATATACCACA | NGG | 2 | 0.6058 | Tier III |
25 | NC_000013.11 | 13 | 59574221 | - | LOC107984625 | NNNGCATTGTGGTTACCACA | NGG | 2 | 0.325 | Tier III |
26 | NC_000012.12 | 12 | 65853962 | + | HMGA2-AS1 | NNNGCACTGTATTTACAACA | NGG | 2 | 0.3208 | Tier III |
27 | NC_000010.11 | 10 | 66951053 | + | LOC101928961 | NNNGCACTGTATTTATCACA | NGG | 2 | 0.2115 | Tier III |
28 | NC_000013.11 | 13 | 89415528 | - | LOC107984621 | NNNGCATTGTATTTAGCACA | NGG | 1 | 0.1538 | Tier III |
29 | NC_000001.11 | 1 | 165216412 | - | LMX1A-AS1 | NNNGCATTGTTTTTACCCCA | NGG | 2 | 0.0586 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000084.6 | 18 | 53917010 | - | Csnk1g3 | NNNGCGTTGTATTTACCACA | NGG | 1 | 0.7143 | Tier I |
2 | NC_000073.6 | 7 | 44192323 | - | Klk1b24 | NNNGCATTGGGTTTACCACA | NGG | 2 | 0.325 | Tier I |
3 | NC_000072.6 | 6 | 23072996 | - | Aass | NNNGCATTGTATTTAACACA | NAG | 2 | 0.2593 | Tier I |
4 | NC_000075.6 | 9 | 65999433 | - | Csnk1g1 | NNNGCATTGTACTTCCCACA | NGG | 2 | 0.2584 | Tier I |
5 | NC_000070.6 | 4 | 145003647 | + | Vps13d | NNNACATTGTATTTACCACA | NGG | 1 | 0.9 | Tier II |
6 | NC_000076.6 | 10 | 127476491 | + | R3hdm2 | NNNGCATTGTATTTACAACT | NGG | 2 | 0.28 | Tier II |
7 | NC_000072.6 | 6 | 64220354 | - | Grid2 | NNNGCATTGTATCTACCACC | NGG | 2 | 0.1794 | Tier II |
8 | NC_000070.6 | 4 | 114500832 | - | Trabd2b | NNNTCATTGTATTTACCATA | NGG | 2 | 0.1678 | Tier II |
9 | NC_000083.6 | 17 | 27938689 | - | Anks1 | NNNGCATTCTATTTAGCACA | NGG | 2 | 0.0828 | Tier II |
10 | NC_000068.7 | 2 | 158455131 | + | Ralgapb | NNNGCATTGTATTTTTCACA | NGG | 2 | 0.0615 | Tier II |
11 | NC_000078.6 | 12 | 71863004 | - | Daam1 | NNNGCATAGTATTTACCACA | NGA | 2 | 0.0556 | Tier II |
12 | NC_000069.6 | 3 | 10418943 | - | Snx16 | NNNGCATTGTATTTACTACA | NTG | 2 | 0.0182 | Tier II |
13 | NC_000079.6 | 13 | 74267425 | + | Ahrr | NNNGCATTGAATTTACCACA | NGT | 2 | 0.0138 | Tier II |
14 | NC_000079.6 | 13 | 20538997 | + | Elmo1 | NNNGCATTGTATTTACCAAA | NGT | 2 | 0.0069 | Tier II |
15 | NC_000075.6 | 9 | 24590896 | + | Dpy19l2 | NNNGCATTGTATTGAGCACA | NGG | 2 | 0.0 | Tier II |
16 | NC_000067.6 | 1 | 28864225 | + | Gm45942 | NNNGCATTGTATTTACCATA | NGT | 2 | 0.0074 | Tier III |