Construct: sgRNA BRDN0001145295
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CATCCAGGGCTACAATGTTG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- CAMK1 (8536)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 77477
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000003.12 |
3 |
9763199 |
+ |
CAMK1 |
NNNCCAGGGCTACAATGTTG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000023.11 |
X |
129829060 |
- |
ZDHHC9 |
NNNCCATGGCTACACTGTTG |
NGG |
2 |
0.1558 |
Tier I |
3 |
NC_000021.9 |
21 |
46272595 |
- |
MCM3AP |
NNNCCAGGGCTACAATGTTC |
NGC |
2 |
0.0095 |
Tier I |
4 |
NC_000003.12 |
3 |
9763199 |
+ |
OGG1 |
NNNCCAGGGCTACAATGTTG |
NGG |
0 |
1.0 |
Tier II |
5 |
NC_000004.12 |
4 |
4432664 |
+ |
STX18 |
NNNCCAGGGCTGCAATGATG |
NGG |
2 |
0.4815 |
Tier II |
6 |
NC_000021.9 |
21 |
25976795 |
+ |
APP |
NNNCCAGTGCAACAATGTTG |
NGG |
2 |
0.4688 |
Tier II |
7 |
NC_000022.11 |
22 |
50054482 |
+ |
TTLL8 |
NNNCCAGGGCCATAATGTTG |
NGG |
2 |
0.4667 |
Tier II |
8 |
NC_000012.12 |
12 |
121422986 |
+ |
RNF34 |
NNNCCAGGGCTACAAAGCTG |
NGG |
2 |
0.3896 |
Tier II |
9 |
NC_000012.12 |
12 |
121422986 |
+ |
KDM2B |
NNNCCAGGGCTACAAAGCTG |
NGG |
2 |
0.3896 |
Tier II |
10 |
NC_000005.10 |
5 |
7435947 |
- |
ADCY2 |
NNNCCAAGGCTAAAATGTTG |
NGG |
2 |
0.3846 |
Tier II |
11 |
NC_000021.9 |
21 |
15781045 |
+ |
USP25 |
NNNCCTGGGCTACAAGGTTG |
NGG |
2 |
0.2473 |
Tier II |
12 |
NC_000004.12 |
4 |
141695059 |
- |
IL15 |
NNNCCAGGGCTACCATATTG |
NGG |
2 |
0.2 |
Tier II |
13 |
NC_000015.10 |
15 |
42190514 |
- |
VPS39 |
NNNGCAGGGCTACACTGTTG |
NGG |
2 |
0.1364 |
Tier II |
14 |
NC_000010.11 |
10 |
113030226 |
+ |
TCF7L2 |
NNNCAAGGGCTACCATGTTG |
NGG |
2 |
0.1224 |
Tier II |
15 |
NC_000005.10 |
5 |
139482342 |
- |
STING1 |
NNNCCAGGGCTAGAGTGTTG |
NGG |
2 |
0.0886 |
Tier II |
16 |
NC_000019.10 |
19 |
29667678 |
+ |
PLEKHF1 |
NNNCCAGGGCTACCATCTTG |
NGG |
2 |
0.0504 |
Tier II |
17 |
NC_000020.11 |
20 |
1513464 |
- |
LOC105372499 |
NNNCCTGGGCTCCAATGTTG |
NGG |
2 |
0.188 |
Tier III |
18 |
NT_187505.1 |
|
34129 |
+ |
LOC105379562 |
NNNCCAGGGCTACAATGCTG |
NCG |
2 |
0.0459 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000072.6 |
6 |
113339567 |
+ |
Camk1 |
NNNCCAGGGCTACAATGTTG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000070.6 |
4 |
152315966 |
+ |
Rnf207 |
NNNCCAGGGCTACAATGTCA |
NGG |
2 |
0.2586 |
Tier I |
3 |
NC_000082.6 |
16 |
45560296 |
- |
Slc9c1 |
NNNCCATGGCTTCAATGTTG |
NGG |
2 |
0.1905 |
Tier I |
4 |
NC_000083.6 |
17 |
36845128 |
+ |
Trim26 |
NNNCTAGGGCTACAATATTG |
NGG |
2 |
0.5939 |
Tier II |
5 |
NC_000076.6 |
10 |
30742537 |
+ |
Ncoa7 |
NNNTAAGGGCTACAATGTTG |
NGG |
2 |
0.4571 |
Tier II |
6 |
NC_000074.6 |
8 |
27116583 |
- |
Adgra2 |
NNNCCAGGGCTATAGTGTTG |
NGG |
2 |
0.455 |
Tier II |
7 |
NC_000082.6 |
16 |
17872763 |
- |
Dgcr2 |
NNNCCAGGGCTACGATGATG |
NGG |
2 |
0.3111 |
Tier II |
8 |
NC_000071.6 |
5 |
27423776 |
+ |
Dpp6 |
NNNCCAGGGCTACAGTGTTC |
NGG |
2 |
0.2786 |
Tier II |
9 |
NC_000077.6 |
11 |
16791787 |
- |
Egfr |
NNNCCAGTGCGACAATGTTG |
NGG |
2 |
0.25 |
Tier II |
10 |
NC_000082.6 |
16 |
13662122 |
+ |
Parn |
NNNCCAGGGCTACAAAGTTG |
NAG |
2 |
0.2357 |
Tier II |
11 |
NC_000071.6 |
5 |
31322335 |
- |
Gckr |
NNNCCAGGGCTACAAACTTG |
NGG |
2 |
0.2139 |
Tier II |
12 |
NC_000077.6 |
11 |
29932188 |
- |
Eml6 |
NNNCCTGGGCTACACTGTTG |
NGG |
2 |
0.1948 |
Tier II |
13 |
NC_000068.7 |
2 |
33568504 |
- |
Lmx1b |
NNNCCAGGGCTCCAATGTTT |
NGG |
2 |
0.1842 |
Tier II |
14 |
NC_000081.6 |
15 |
84953852 |
- |
5031439G07Rik |
NNNCCAGGGCTACACTGATG |
NGG |
2 |
0.1818 |
Tier II |
15 |
NC_000070.6 |
4 |
106966200 |
- |
Ssbp3 |
NNNCCAGGGCTACATAGTTG |
NGG |
2 |
0.1818 |
Tier II |
16 |
NC_000071.6 |
5 |
65887528 |
+ |
Rhoh |
NNNCCAGGGCTACAAGTTTG |
NGG |
2 |
0.0865 |
Tier II |
17 |
NC_000081.6 |
15 |
35614600 |
- |
Vps13b |
NNNCCAGGGCTACAATCGTG |
NGG |
2 |
0.0784 |
Tier II |
18 |
NC_000080.6 |
14 |
22584598 |
+ |
Lrmda |
NNNCCAGGGCTAGAATGCTG |
NGG |
2 |
0.0584 |
Tier II |
19 |
NC_000070.6 |
4 |
87967003 |
+ |
Mllt3 |
NNNCCAGGACTACAATGTTG |
NGA |
2 |
0.0446 |
Tier II |
20 |
NC_000067.6 |
1 |
182503212 |
+ |
Capn2 |
NNNCCATGGCTACAATGTTG |
NTG |
2 |
0.0223 |
Tier II |
21 |
NC_000072.6 |
6 |
122627205 |
- |
Dppa3 |
NNNCCAGGGCTACAAGGTTG |
NGT |
2 |
0.0056 |
Tier II |
22 |
NC_000083.6 |
17 |
67915993 |
- |
Arhgap28 |
NNNCCAGGGCTACAAGGTTG |
NGT |
2 |
0.0056 |
Tier II |
23 |
NC_000072.6 |
6 |
48253914 |
- |
Gm16630 |
NNNCCAAGGCTACAATGTTC |
NGG |
2 |
0.4286 |
Tier III |
24 |
NC_000077.6 |
11 |
16791787 |
- |
Gm39584 |
NNNCCAGTGCGACAATGTTG |
NGG |
2 |
0.25 |
Tier III |
25 |
NC_000067.6 |
1 |
76071519 |
- |
Gm32622 |
NNNCCAGGGCTCCAATGTTC |
NGG |
2 |
0.1128 |
Tier III |
Other clones with same target sequence:
(none)