Construct: sgRNA BRDN0001145424
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CAAATATAAGTGCCACCACA
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- TRPM7 (54822)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 76113
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000015.10 |
15 |
50634535 |
+ |
TRPM7 |
NNNATATAAGTGCCACCACA |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000006.12 |
6 |
143573685 |
- |
PHACTR2 |
NNNAGATAAGTGCCAACACA |
NGG |
2 |
0.64 |
Tier II |
3 |
NC_000023.11 |
X |
75467247 |
- |
ZDHHC15 |
NNNATTAAAGTGCCACCACA |
NGG |
2 |
0.625 |
Tier II |
4 |
NC_000012.12 |
12 |
5969521 |
+ |
VWF |
NNNATGTAAGTCCCACCACA |
NGG |
2 |
0.3782 |
Tier II |
5 |
NC_000006.12 |
6 |
165793701 |
- |
PDE10A |
NNNATCTAAGTGCCACCACT |
NGG |
2 |
0.2727 |
Tier II |
6 |
NC_000015.10 |
15 |
78575695 |
- |
CHRNA5 |
NNNATATAAGTGCCAGCACA |
NGG |
1 |
0.1538 |
Tier II |
7 |
NC_000014.9 |
14 |
22577699 |
- |
DAD1 |
NNNATATAAGTGAAACCACA |
NGG |
2 |
0.1346 |
Tier II |
8 |
NC_000020.11 |
20 |
20539858 |
+ |
RALGAPA2 |
NNNATATAAGTGACACCACA |
NAG |
2 |
0.0997 |
Tier II |
9 |
NC_000007.14 |
7 |
108266224 |
- |
NRCAM |
NNNATAGAAGTGCCAGCACA |
NGG |
2 |
0.0905 |
Tier II |
10 |
NC_000019.10 |
19 |
46074201 |
+ |
IGFL4 |
NNNATATTAGTGCCTCCACA |
NGG |
2 |
0.0857 |
Tier II |
11 |
NC_000004.12 |
4 |
110480404 |
+ |
ENPEP |
NNNATATAAGGGCCACCAGA |
NGG |
2 |
0.05 |
Tier II |
12 |
NC_000016.10 |
16 |
70137436 |
- |
PDPR |
NNNATATAAGTGGAACCACA |
NGG |
2 |
0.0477 |
Tier II |
13 |
NC_000009.12 |
9 |
97664275 |
- |
NCBP1 |
NNNATATATGTGCCACCACA |
NTG |
2 |
0.0234 |
Tier II |
14 |
NC_000009.12 |
9 |
97664275 |
- |
XPA |
NNNATATATGTGCCACCACA |
NTG |
2 |
0.0234 |
Tier II |
15 |
NC_000008.11 |
8 |
81852585 |
- |
LINC02235 |
NNNATATAATTGCCACCACA |
NGG |
1 |
0.8125 |
Tier III |
16 |
NC_000013.11 |
13 |
38642563 |
- |
LINC00437 |
NNNATATATTTGCCACCACA |
NGG |
2 |
0.4875 |
Tier III |
17 |
NC_000002.12 |
2 |
207206254 |
+ |
MYOSLID-AS1 |
NNNATATTAGTGCCACCACA |
NGG |
1 |
0.4286 |
Tier III |
18 |
NC_000007.14 |
7 |
44999451 |
- |
LOC102723334 |
NNNATAGAAGTGCAACCACA |
NGG |
2 |
0.2059 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000072.6 |
6 |
100787286 |
+ |
Gxylt2 |
NNNATAAAAGTGCCATCACA |
NGG |
2 |
0.2692 |
Tier I |
2 |
NC_000069.6 |
3 |
129868532 |
- |
Cfi |
NNNATATAAATGCCACCACA |
NGT |
2 |
0.0151 |
Tier I |
3 |
NC_000068.7 |
2 |
25037601 |
+ |
Pnpla7 |
NNNAGACAAGTGCCACCACA |
NGG |
2 |
0.44 |
Tier II |
4 |
NC_000070.6 |
4 |
85225953 |
- |
Sh3gl2 |
NNNACATAAGTGCCACCAAA |
NGG |
2 |
0.4286 |
Tier II |
5 |
NC_000080.6 |
14 |
39177524 |
+ |
Nrg3 |
NNNATCTAAGTGCTACCACA |
NGG |
2 |
0.3333 |
Tier II |
6 |
NC_000080.6 |
14 |
31293569 |
+ |
Dnah1 |
NNNAAAGAAGTGCCACCACA |
NGG |
2 |
0.2941 |
Tier II |
7 |
NC_000082.6 |
16 |
45712834 |
- |
Tagln3 |
NNNAAAGAAGTGCCACCACA |
NGG |
2 |
0.2941 |
Tier II |
8 |
NC_000067.6 |
1 |
24521560 |
+ |
Col19a1 |
NNNATATGAGTGACACCACA |
NGG |
2 |
0.2821 |
Tier II |
9 |
NC_000073.6 |
7 |
141135724 |
- |
Ptdss2 |
NNNATGTAAGTGCCATCACA |
NGG |
2 |
0.2198 |
Tier II |
10 |
NC_000075.6 |
9 |
56475833 |
+ |
Hmg20a |
NNNATATTAGTGACACCACA |
NGG |
2 |
0.1648 |
Tier II |
11 |
NC_000072.6 |
6 |
38868950 |
+ |
Hipk2 |
NNNATATAAGTGACACCACA |
NGA |
2 |
0.0267 |
Tier II |
12 |
NC_000072.6 |
6 |
38868950 |
+ |
Tbxas1 |
NNNATATAAGTGACACCACA |
NGA |
2 |
0.0267 |
Tier II |
13 |
NC_000067.6 |
1 |
36382383 |
- |
Fer1l5 |
NNNATATATGTGCCACCACA |
NGC |
2 |
0.0133 |
Tier II |
14 |
NC_000077.6 |
11 |
42155150 |
- |
Gabra1 |
NNNATCTAAGTGCCACCACA |
NGT |
2 |
0.0073 |
Tier II |
15 |
NC_000080.6 |
14 |
31293569 |
+ |
Gm35823 |
NNNAAAGAAGTGCCACCACA |
NGG |
2 |
0.2941 |
Tier III |
16 |
NC_000070.6 |
4 |
87644382 |
+ |
Gm34180 |
NNNATCTAAGTGACACCACA |
NGG |
2 |
0.1748 |
Tier III |
17 |
NC_000067.6 |
1 |
64164746 |
+ |
Gm35880 |
NNNATATTAGGGCCACCACA |
NGG |
2 |
0.1714 |
Tier III |
18 |
NC_000076.6 |
10 |
67378946 |
- |
Gm46230 |
NNNATATAAGTCCCACCACC |
NGG |
2 |
0.1203 |
Tier III |
Other clones with same target sequence:
(none)