Construct: sgRNA BRDN0001145482
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GTGAACTGCAATCTTATTAT
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- NO_SITE control
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 80250
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000001.11 |
1 |
173507047 |
- |
SLC9C2 |
NNNAAATGCAATTTTATTAT |
NGG |
2 |
0.65 |
Tier I |
2 |
NC_000011.10 |
11 |
18396904 |
- |
LDHA |
NNNAACTGTAATCTTATTCT |
NGG |
2 |
0.181 |
Tier I |
3 |
NC_000011.10 |
11 |
93697665 |
- |
CEP295 |
NNNAACTGCAATATTATTCT |
NGG |
2 |
0.0796 |
Tier I |
4 |
NC_000018.10 |
18 |
56681085 |
+ |
WDR7 |
NNNAAATGCAGTCTTATTAT |
NGG |
2 |
0.6036 |
Tier II |
5 |
NC_000011.10 |
11 |
131710507 |
+ |
NTM |
NNNTACTGAAATCTTATTAT |
NGG |
2 |
0.5455 |
Tier II |
6 |
NC_000003.12 |
3 |
69809150 |
- |
MITF |
NNNAACTGTAATATTATTAT |
NGG |
2 |
0.3365 |
Tier II |
7 |
NC_000006.12 |
6 |
151382223 |
+ |
ZBTB2 |
NNNCACTGAAATCTTATTAT |
NGG |
2 |
0.3025 |
Tier II |
8 |
NC_000005.10 |
5 |
22459319 |
- |
CDH12 |
NNNAACTGCAATCTTAATTT |
NGG |
2 |
0.2872 |
Tier II |
9 |
NC_000004.12 |
4 |
98633420 |
- |
TSPAN5 |
NNNATCTGCAATTTTATTAT |
NGG |
2 |
0.2545 |
Tier II |
10 |
NC_000012.12 |
12 |
12180220 |
- |
LRP6 |
NNNAACTGTAATCTCATTAT |
NGG |
2 |
0.2386 |
Tier II |
11 |
NC_000010.11 |
10 |
79837249 |
+ |
NUTM2E |
NNNAACTGCAATCTTATTTT |
NAG |
2 |
0.1396 |
Tier II |
12 |
NC_000023.11 |
X |
85142543 |
+ |
SATL1 |
NNNAACTGCAATTTTATTAG |
NGG |
2 |
0.1235 |
Tier II |
13 |
NC_000007.14 |
7 |
137534294 |
- |
DGKI |
NNNAACTGCAATGTTATTAA |
NGG |
2 |
0.0767 |
Tier II |
14 |
NC_000007.14 |
7 |
28090367 |
+ |
JAZF1 |
NNNAACTGCAATCTTAATAC |
NGG |
2 |
0.0485 |
Tier II |
15 |
NC_000005.10 |
5 |
90701856 |
+ |
ADGRV1 |
NNNAACTGCAATTTTATTAT |
NGT |
2 |
0.0113 |
Tier II |
16 |
NC_000013.11 |
13 |
99538459 |
- |
TM9SF2 |
NNNAACTGCCATCTTATTAT |
NGC |
2 |
0.0074 |
Tier II |
17 |
NC_000001.11 |
1 |
76542841 |
- |
ST6GALNAC3 |
NNNAACTGCAATCTTCTAAT |
NGG |
2 |
0.0 |
Tier II |
18 |
NC_000011.10 |
11 |
61074328 |
- |
LOC105369325 |
NNNAACTATAATCTTATTAT |
NGG |
2 |
0.875 |
Tier III |
19 |
NC_000011.10 |
11 |
61074328 |
- |
LOC124902677 |
NNNAACTATAATCTTATTAT |
NGG |
2 |
0.875 |
Tier III |
20 |
NC_000022.11 |
22 |
22390593 |
+ |
IGL |
NNNAACTGCAACCTTACTAT |
NGG |
2 |
0.6687 |
Tier III |
21 |
NC_000005.10 |
5 |
152879480 |
+ |
LINC01470 |
NNNACCAGCAATCTTATTAT |
NGG |
2 |
0.4375 |
Tier III |
22 |
NC_000014.9 |
14 |
59000937 |
+ |
LINC01500 |
NNNAACTGGAATTTTATTAT |
NGG |
2 |
0.4333 |
Tier III |
23 |
NC_000009.12 |
9 |
14922274 |
+ |
LDHAP4 |
NNNAACTGTAATCTTATTCT |
NGG |
2 |
0.181 |
Tier III |
24 |
NC_000016.10 |
16 |
53518579 |
- |
LOC105371268 |
NNNAACTGCATTCTTATTAT |
NAG |
2 |
0.0798 |
Tier III |
25 |
NC_000016.10 |
16 |
79802860 |
- |
LINC01228 |
NNNAACTGCAATCTTCTTCT |
NGG |
2 |
0.0 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000075.6 |
9 |
110184417 |
+ |
Smarcc1 |
NNNAATTGCAAGCTTATTAT |
NGG |
2 |
0.4643 |
Tier II |
2 |
NC_000074.6 |
8 |
61529082 |
+ |
Palld |
NNNAACTGCAGTCTTACTAT |
NGG |
2 |
0.4588 |
Tier II |
3 |
NC_000067.6 |
1 |
125987858 |
+ |
Nckap5 |
NNNAACAGCCATCTTATTAT |
NGG |
2 |
0.2917 |
Tier II |
4 |
NC_000068.7 |
2 |
41187124 |
+ |
Lrp1b |
NNNAACTGAATTCTTATTAT |
NGG |
2 |
0.2637 |
Tier II |
5 |
NC_000084.6 |
18 |
82941057 |
+ |
Zfp516 |
NNNAACTGCAAGCTTATCAT |
NGG |
2 |
0.2143 |
Tier II |
6 |
NC_000068.7 |
2 |
140538517 |
- |
Macrod2 |
NNNAACTGCAATCCAATTAT |
NGG |
2 |
0.1654 |
Tier II |
7 |
NC_000069.6 |
3 |
59875328 |
- |
Aadacl2fm3 |
NNNAAGTGCAATCTTATTCT |
NGG |
2 |
0.1034 |
Tier II |
8 |
NC_000079.6 |
13 |
40231786 |
+ |
Ofcc1 |
NNNAACTGCATTCTTATTAG |
NGG |
2 |
0.0543 |
Tier II |
9 |
NC_000073.6 |
7 |
125801487 |
+ |
D430042O09Rik |
NNNACCTGCAATCTTATTAT |
NTG |
2 |
0.0195 |
Tier II |
10 |
NC_000083.6 |
17 |
11799066 |
+ |
Prkn |
NNNAACTGCCATCTTCTTAT |
NGG |
2 |
0.0 |
Tier II |
11 |
NC_000075.6 |
9 |
66493787 |
- |
Herc1 |
NNNAACTGCCATCTTTTTAT |
NGG |
2 |
0.0 |
Tier II |
12 |
NC_000075.6 |
9 |
63344847 |
+ |
Map2k5 |
NNNAACTGGAATCTTTTTAT |
NGG |
2 |
0.0 |
Tier II |
13 |
NC_000084.6 |
18 |
6291015 |
- |
Gm41664 |
NNNAACTGCTATCATATTAT |
NGG |
2 |
0.5462 |
Tier III |
14 |
NC_000084.6 |
18 |
35002328 |
+ |
Gm36037 |
NNNAGCTTCAATCTTATTAT |
NGG |
2 |
0.45 |
Tier III |
15 |
NC_000078.6 |
12 |
63073081 |
+ |
Gm5185 |
NNNAACTGTAATCTTATTCT |
NGG |
2 |
0.181 |
Tier III |
16 |
NC_000073.6 |
7 |
59622731 |
+ |
Ipw |
NNNAACTGCACTATTATTAT |
NGG |
2 |
0.1538 |
Tier III |
17 |
NC_000073.6 |
7 |
59622731 |
+ |
Snhg14 |
NNNAACTGCACTATTATTAT |
NGG |
2 |
0.1538 |
Tier III |
18 |
NC_000067.6 |
1 |
77827134 |
+ |
Gm33030 |
NNNAACTGCAATCTTAGTAG |
NGG |
2 |
0.0208 |
Tier III |
19 |
NC_000067.6 |
1 |
77827134 |
+ |
Gm33083 |
NNNAACTGCAATCTTAGTAG |
NGG |
2 |
0.0208 |
Tier III |
Other clones with same target sequence:
(none)