Construct: sgRNA BRDN0001145509
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GCATGGAGATGACCCGCAGG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- CKB (1152)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 76589
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000014.9 |
14 |
103520542 |
+ |
CKB |
NNNTGGAGATGACCCGCAGG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000017.11 |
17 |
75730276 |
- |
ITGB4 |
NNNTGGAGAAGACCAGCAGG |
NGG |
2 |
0.1905 |
Tier I |
3 |
NC_000020.11 |
20 |
35292123 |
+ |
FAM83C |
NNNCGGAGATGACCCGCAGG |
NAG |
2 |
0.1678 |
Tier I |
4 |
NC_000011.10 |
11 |
17442772 |
- |
ABCC8 |
NNNTGGAGACGACCCGCAGG |
NAG |
2 |
0.1383 |
Tier I |
5 |
NC_000010.11 |
10 |
87505446 |
- |
MINPP1 |
NNNTGGTGATGAGCCGCAGG |
NGG |
2 |
0.0597 |
Tier I |
6 |
NC_000019.10 |
19 |
45308482 |
+ |
CKM |
NNNTGGAGATGACCCGGAGG |
NGA |
2 |
0.0041 |
Tier I |
7 |
NC_000005.10 |
5 |
32091003 |
+ |
PDZD2 |
NNNTGGAGATCACCCCCAGG |
NGG |
2 |
0.0 |
Tier I |
8 |
NC_000021.9 |
21 |
26091666 |
+ |
APP |
NNNTGGAGATGACCAACAGG |
NGG |
2 |
0.2222 |
Tier II |
9 |
NC_000004.12 |
4 |
76690458 |
- |
SHROOM3 |
NNNTGGAGATGACCCGCATG |
NAG |
2 |
0.1728 |
Tier II |
10 |
NC_000016.10 |
16 |
3191303 |
- |
OR1F1 |
NNNTGGAGATGACCCGCCAG |
NGG |
2 |
0.1361 |
Tier II |
11 |
NC_000010.11 |
10 |
686318 |
- |
DIP2C |
NNNTGGAGAGGCCCCGCAGG |
NGG |
2 |
0.1316 |
Tier II |
12 |
NC_000007.14 |
7 |
130308227 |
- |
CPA4 |
NNNTGGAGATGACACGCAGG |
NAG |
2 |
0.0907 |
Tier II |
13 |
NC_000001.11 |
1 |
109187607 |
- |
ELAPOR1 |
NNNTGGAGATGACCCGCAGG |
NGA |
1 |
0.0694 |
Tier II |
14 |
NC_000012.12 |
12 |
119155381 |
+ |
SRRM4 |
NNNTGGAGATGACCTGGAGG |
NGG |
2 |
0.0039 |
Tier II |
15 |
NC_000007.14 |
7 |
152262329 |
- |
KMT2C |
NNNTGGAGATGACCCTCAGG |
NGC |
2 |
0.0 |
Tier II |
16 |
NC_000016.10 |
16 |
46843989 |
+ |
CKBP1 |
NNNCGGAGATGGCCCGCAGG |
NGG |
2 |
0.4673 |
Tier III |
17 |
NC_000013.11 |
13 |
27053722 |
- |
LOC105370124 |
NNNTGGAGATGCCCAGCAGG |
NGG |
2 |
0.0585 |
Tier III |
18 |
NC_000001.11 |
1 |
207194928 |
- |
C4BPAP3 |
NNNTGGAGATGACCAGCAGG |
NAG |
2 |
0.0576 |
Tier III |
19 |
NC_000001.11 |
1 |
207194928 |
- |
LOC107985251 |
NNNTGGAGATGACCAGCAGG |
NAG |
2 |
0.0576 |
Tier III |
20 |
NC_000021.9 |
21 |
10465654 |
+ |
BAGE2 |
NNNTGGAGATGACCCTCAGG |
NGC |
2 |
0.0 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000078.6 |
12 |
111670235 |
+ |
Ckb |
NNNTGGAGATGACTCGCAGG |
NGG |
1 |
0.7333 |
Tier I |
2 |
NC_000073.6 |
7 |
102484373 |
+ |
Olfr544 |
NNNTGAAGATGACCAGCAGG |
NGG |
2 |
0.2222 |
Tier I |
3 |
NC_000073.6 |
7 |
102494028 |
+ |
Olfr545 |
NNNTGAAGATGACCAGCAGG |
NGG |
2 |
0.2222 |
Tier I |
4 |
NC_000080.6 |
14 |
78502208 |
- |
Akap11 |
NNNTGGAGATGACGAGCAGG |
NGG |
2 |
0.0 |
Tier I |
5 |
NC_000073.6 |
7 |
46150779 |
- |
Abcc8 |
NNNTGGAGATGACGCGCAGG |
NAG |
2 |
0.0 |
Tier I |
6 |
NC_000082.6 |
16 |
38483974 |
- |
Cd80 |
NNNTGGAGATGACCCGCAGG |
NGG |
0 |
1.0 |
Tier II |
7 |
NC_000067.6 |
1 |
65289697 |
- |
Pth2r |
NNNTGGAGGTGACCCGCAGT |
NGG |
2 |
0.4667 |
Tier II |
8 |
NC_000084.6 |
18 |
21283866 |
- |
Garem1 |
NNNTGGAGCCGACCCGCAGG |
NGG |
2 |
0.3048 |
Tier II |
9 |
NC_000071.6 |
5 |
121818709 |
+ |
Sh2b3 |
NNNTGGTGGTGACCCGCAGG |
NGG |
2 |
0.2917 |
Tier II |
10 |
NC_000072.6 |
6 |
143914875 |
+ |
Sox5 |
NNNTTGAGATGAACCGCAGG |
NGG |
2 |
0.1154 |
Tier II |
11 |
NC_000070.6 |
4 |
87125001 |
+ |
Slc24a2 |
NNNTGGAGGTGAGCCGCAGG |
NGG |
2 |
0.0909 |
Tier II |
12 |
NC_000067.6 |
1 |
125738352 |
+ |
Gpr39 |
NNNTGGTGATGAGCCGCAGG |
NGG |
2 |
0.0597 |
Tier II |
13 |
NC_000081.6 |
15 |
100260115 |
+ |
Atf1 |
NNNTGGAGATGACCTGCAGG |
NAG |
2 |
0.0173 |
Tier II |
14 |
NC_000068.7 |
2 |
35571444 |
+ |
Dab2ip |
NNNTGGAGATCACCCGCAGG |
NGC |
2 |
0.0095 |
Tier II |
15 |
NC_000082.6 |
16 |
21640119 |
- |
Vps8 |
NNNTGGAGATGACCCTCAGG |
NGG |
1 |
0.0 |
Tier II |
16 |
NC_000082.6 |
16 |
38483974 |
- |
Ck-ps3 |
NNNTGGAGATGACCCGCAGG |
NGG |
0 |
1.0 |
Tier III |
17 |
NC_000070.6 |
4 |
122008897 |
- |
Gm12892 |
NNNTGGAGATGACTCGCAGG |
NGG |
1 |
0.7333 |
Tier III |
18 |
NC_000083.6 |
17 |
53746847 |
- |
Ckb-ps2 |
NNNTGGAGATGACCCGCAGG |
NGT |
1 |
0.0161 |
Tier III |
Other clones with same target sequence:
(none)