Construct: sgRNA BRDN0001145526
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CAGCACCCGCTTCTCAACCA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- PRKCD (5580)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000003.12 | 3 | 53186267 | - | PRKCD | NNNCACCCGCTTCTCAACCA | NGG | 0 | 1.0 | Tier I |
2 | NC_000016.10 | 16 | 24154784 | - | PRKCB | NNNCACCCGCTTCTCCACCA | NAG | 2 | 0.0 | Tier I |
3 | NC_000006.12 | 6 | 43043085 | + | CUL7 | NNNCACCTGCTTCTCCACCA | NGG | 2 | 0.0 | Tier I |
4 | NC_000008.11 | 8 | 1757294 | + | CLN8 | NNNAACCTGCTTCTCAACCA | NGG | 2 | 0.7368 | Tier II |
5 | NC_000016.10 | 16 | 17215945 | - | XYLT1 | NNNCACCCACTCCTCAACCA | NGG | 2 | 0.609 | Tier II |
6 | NC_000012.12 | 12 | 132255112 | + | GALNT9 | NNNGAGCCGCTTCTCAACCA | NGG | 2 | 0.25 | Tier II |
7 | NC_000003.12 | 3 | 141342598 | - | ZBTB38 | NNNCACCCGCTTCTCAACCG | NAG | 2 | 0.1983 | Tier II |
8 | NC_000002.12 | 2 | 88172538 | + | THNSL2 | NNNCACCCTCTTCTCAACCC | NGG | 2 | 0.1212 | Tier II |
9 | NC_000017.11 | 17 | 12982502 | + | ARHGAP44 | NNNCACCTGCTTCTCATCCA | NGG | 2 | 0.1167 | Tier II |
10 | NC_000017.11 | 17 | 66750208 | + | PRKCA | NNNCAGCCGCTTCTGAACCA | NGG | 2 | 0.025 | Tier II |
11 | NC_000006.12 | 6 | 44290018 | - | TCTE1 | NNNCACCCGCCTCTCAACCA | NGC | 2 | 0.0148 | Tier II |
12 | NC_000006.12 | 6 | 41741957 | + | PGC | NNNCACCCGCTTCTCCACCA | NGA | 2 | 0.0 | Tier II |
13 | NC_000016.10 | 16 | 8678516 | + | ABAT | NNNCACCCGCTTCTCCACCA | NGC | 2 | 0.0 | Tier II |
14 | NC_000011.10 | 11 | 112283557 | - | LINC02762 | NNNCACCTGCTTCTCAATCA | NGG | 2 | 0.5625 | Tier III |
15 | NC_000011.10 | 11 | 9764586 | + | SBF2-AS1 | NNNCACCCTCCTCTCAACCA | NGG | 2 | 0.3556 | Tier III |
16 | NC_000008.11 | 8 | 126620224 | - | LOC105375751 | NNNCAGCCCCTTCTCAACCA | NGG | 2 | 0.2692 | Tier III |
17 | NC_000008.11 | 8 | 65538603 | + | LINC01299 | NNNGACCCGCTTCTCAACCC | NGG | 2 | 0.1136 | Tier III |
18 | NC_000017.11 | 17 | 77274369 | - | SEPTIN9-DT | NNNCACCCGCTTCTCCACCA | NGT | 2 | 0.0 | Tier III |
19 | NC_000006.12 | 6 | 43043085 | + | LOC124901318 | NNNCACCTGCTTCTCCACCA | NGG | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000073.6 | 7 | 122568234 | - | Prkcb | NNNCACCCGCTTCTCCACCA | NGG | 1 | 0.0 | Tier I |
2 | NC_000080.6 | 14 | 30602107 | + | Prkcd | NNNCACCCGCTTCTCCACCA | NGG | 1 | 0.0 | Tier I |
3 | NC_000077.6 | 11 | 107983959 | + | Prkca | NNNCACGCGCTTCTCCACCA | NGG | 2 | 0.0 | Tier I |
4 | NC_000084.6 | 18 | 25727699 | - | Celf4 | NNNCACCCCCATCTCAACCA | NGG | 2 | 0.4038 | Tier II |
5 | NC_000076.6 | 10 | 53650046 | - | Fam184a | NNNCACCCCCTTCTCAACCT | NGG | 2 | 0.3231 | Tier II |
6 | NC_000068.7 | 2 | 175086117 | - | Gm14393 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier II |
7 | NC_000068.7 | 2 | 175086117 | - | LOC115489542 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier II |
8 | NC_000068.7 | 2 | 175282907 | - | Gm14440 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier II |
9 | NC_000068.7 | 2 | 175380063 | - | Zfp968 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier II |
10 | NC_000068.7 | 2 | 175477615 | - | Gm4724 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier II |
11 | NC_000068.7 | 2 | 175477615 | - | Zfp965 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier II |
12 | NC_000068.7 | 2 | 175696098 | + | Gm4724 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier II |
13 | NC_000068.7 | 2 | 175793256 | + | Gm14288 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier II |
14 | NC_000068.7 | 2 | 175923500 | + | Zfp966 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier II |
15 | NC_000068.7 | 2 | 176234915 | - | 2210418O10Rik | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier II |
16 | NC_000068.7 | 2 | 176528605 | - | Zfp967 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier II |
17 | NC_000068.7 | 2 | 176678152 | - | Zfp973 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier II |
18 | NC_000068.7 | 2 | 176919464 | + | Gm14296 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier II |
19 | NC_000068.7 | 2 | 177472902 | - | Zfp970 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier II |
20 | NC_000068.7 | 2 | 177767640 | - | Gm14322 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier II |
21 | NC_000068.7 | 2 | 177835025 | + | Gm14325 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier II |
22 | NC_000068.7 | 2 | 177903901 | - | Zfp972 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier II |
23 | NC_000068.7 | 2 | 178070358 | + | Zfp931 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier II |
24 | NC_000076.6 | 10 | 20988497 | - | Ahi1 | NNNCACACGCTTCTCATCCA | NGG | 2 | 0.1 | Tier II |
25 | NC_000067.6 | 1 | 59599842 | + | Gm973 | NNNCACCTGCTTCTCAACCA | NGA | 2 | 0.0608 | Tier II |
26 | NC_000073.6 | 7 | 113817461 | + | Spon1 | NNNCACCCGCTTCTCAGCCA | NAG | 2 | 0.0458 | Tier II |
27 | NC_000069.6 | 3 | 129965266 | + | Mcub | NNNCACCAGCTTCTCTACCA | NGG | 2 | 0.0 | Tier II |
28 | NC_000078.6 | 12 | 29999307 | - | Pxdn | NNNCACCCGCTTCTCCATCA | NGG | 2 | 0.0 | Tier II |
29 | NC_000068.7 | 2 | 176431438 | - | Zfp968-ps | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier III |
30 | NC_000068.7 | 2 | 176855933 | + | Gm14405 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier III |
31 | NC_000068.7 | 2 | 176855933 | + | Gm14408 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier III |
32 | NC_000068.7 | 2 | 176919464 | + | Gm14408 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier III |
33 | NC_000068.7 | 2 | 177138276 | - | LOC115489545 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier III |
34 | NC_000068.7 | 2 | 177389958 | + | Gm14418 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier III |
35 | NC_000068.7 | 2 | 177389958 | + | Gm14412 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier III |
36 | NC_000068.7 | 2 | 177903901 | - | Gm14327 | NNNCACCCCCTTCTCAACCA | NAG | 2 | 0.1396 | Tier III |
37 | NC_000068.7 | 2 | 177267540 | + | Gm14412 | NNNCACCCTCTTCTCAACCA | NAG | 2 | 0.1383 | Tier III |
38 | NC_000068.7 | 2 | 177267540 | + | LOC115489547 | NNNCACCCTCTTCTCAACCA | NAG | 2 | 0.1383 | Tier III |
39 | NC_000068.7 | 2 | 177572224 | + | Gm14406 | NNNCACCCTCTTCTCAACCA | NAG | 2 | 0.1383 | Tier III |
40 | NC_000082.6 | 16 | 20253541 | + | Gm49566 | NNNCACCCTCTTCTCATCCA | NGG | 2 | 0.0711 | Tier III |
41 | NC_000071.6 | 5 | 113472309 | - | Gm30812 | NNNCACCCACTTCTCAACCA | NGT | 2 | 0.0104 | Tier III |