Construct: sgRNA BRDN0001145548
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- ACAGTGGTAGGTATCTCAGG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- BRD2 (6046)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 77986
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000006.12 |
6 |
32976333 |
- |
BRD2 |
NNNGTGGTAGGTATCTCAGG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000014.9 |
14 |
25020618 |
- |
STXBP6 |
NNNGTGGTAGGTGTCTCAGG |
NGG |
1 |
0.6522 |
Tier II |
3 |
NC_000002.12 |
2 |
154235058 |
- |
GALNT13 |
NNNGTCGTAGGAATCTCAGG |
NGG |
2 |
0.5455 |
Tier II |
4 |
NC_000005.10 |
5 |
141953052 |
- |
RNF14 |
NNNGTGGCAGGTATCTTAGG |
NGG |
2 |
0.4667 |
Tier II |
5 |
NC_000005.10 |
5 |
141953052 |
- |
PCDH12 |
NNNGTGGCAGGTATCTTAGG |
NGG |
2 |
0.4667 |
Tier II |
6 |
NC_000014.9 |
14 |
32488882 |
+ |
AKAP6 |
NNNGAGGTAGGTATCTCAGT |
NGG |
2 |
0.35 |
Tier II |
7 |
NC_000003.12 |
3 |
60161663 |
+ |
FHIT |
NNNGAGGTAGGTAACTCAGG |
NGG |
2 |
0.3095 |
Tier II |
8 |
NC_000015.10 |
15 |
50343508 |
- |
GABPB1 |
NNNGTGGTAGCTATCTTAGG |
NGG |
2 |
0.2 |
Tier II |
9 |
NC_000007.14 |
7 |
149858789 |
+ |
ZNF862 |
NNNGTGGTAGGTATTTCAGG |
NGG |
1 |
0.0667 |
Tier II |
10 |
NC_000008.11 |
8 |
31087955 |
- |
WRN |
NNNGTGGTAGGTATCACAGG |
NGA |
2 |
0.0631 |
Tier II |
11 |
NC_000023.11 |
X |
109394501 |
- |
GUCY2F |
NNNGTGGCAGGTATCTGAGG |
NGG |
2 |
0.0588 |
Tier II |
12 |
NC_000022.11 |
22 |
23088772 |
+ |
GNAZ |
NNNGTGGTAGGTATCTGGGG |
NGG |
2 |
0.0235 |
Tier II |
13 |
NC_000022.11 |
22 |
23088772 |
+ |
RSPH14 |
NNNGTGGTAGGTATCTGGGG |
NGG |
2 |
0.0235 |
Tier II |
14 |
NC_000015.10 |
15 |
70909513 |
+ |
LRRC49 |
NNNGTTGTAGGTATCTCAGG |
NGC |
2 |
0.0148 |
Tier II |
15 |
NC_000018.10 |
18 |
49368607 |
- |
DYM |
NNNGCGGTAGGTAGCTCAGG |
NGG |
2 |
0.0 |
Tier II |
16 |
NC_000023.11 |
X |
19587994 |
+ |
SH3KBP1 |
NNNGTGGTAGGTATCTCAGG |
NCT |
2 |
0.0 |
Tier II |
17 |
NC_000011.10 |
11 |
90700911 |
- |
DISC1FP1 |
NNNGTGGCAAGTATCTCAGG |
NGG |
2 |
0.9333 |
Tier III |
18 |
NC_000013.11 |
13 |
82823984 |
+ |
GYG1P2 |
NNNGTGGAAGATATCTCAGG |
NGG |
2 |
0.8 |
Tier III |
19 |
NC_000006.12 |
6 |
140833160 |
- |
LOC102723724 |
NNNGTGATAGGTATCTCAGG |
NTG |
2 |
0.039 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000083.6 |
17 |
34115494 |
+ |
Brd2 |
NNNGTGGTAGGTATTTCAGG |
NGG |
1 |
0.0667 |
Tier I |
2 |
NC_000069.6 |
3 |
19646018 |
+ |
Trim55 |
NNNGTGGCTGGTATCTCAGG |
NGG |
2 |
0.6 |
Tier II |
3 |
NC_000076.6 |
10 |
52277688 |
- |
Dcbld1 |
NNNGTGGCTGGTATCTCAGG |
NGG |
2 |
0.6 |
Tier II |
4 |
NC_000084.6 |
18 |
39224206 |
+ |
Arhgap26 |
NNNGTGGAAGTTATCTCAGG |
NGG |
2 |
0.3077 |
Tier II |
5 |
NC_000085.6 |
19 |
41226979 |
- |
Tm9sf3 |
NNNGTGGTAGATTTCTCAGG |
NGG |
2 |
0.3 |
Tier II |
6 |
NC_000077.6 |
11 |
51577172 |
+ |
Col23a1 |
NNNGTGGTAGGTGTCTCAGC |
NGG |
2 |
0.2795 |
Tier II |
7 |
NC_000077.6 |
11 |
87542037 |
- |
Tex14 |
NNNGTGGTGCGTATCTCAGG |
NGG |
2 |
0.2667 |
Tier II |
8 |
NC_000068.7 |
2 |
153841492 |
- |
Efcab8 |
NNNGTGGTTGGTACCTCAGG |
NGG |
2 |
0.1714 |
Tier II |
9 |
NC_000073.6 |
7 |
35438904 |
- |
Cep89 |
NNNGTGGTAGGTCACTCAGG |
NGG |
2 |
0.1303 |
Tier II |
10 |
NC_000070.6 |
4 |
150861956 |
+ |
Errfi1 |
NNNGTGGTAGGTACCTCAGG |
NAG |
2 |
0.0741 |
Tier II |
11 |
NC_000086.7 |
X |
73263069 |
+ |
Xlr3c |
NNNGTGGTAGGAATTTCAGG |
NGG |
2 |
0.0533 |
Tier II |
12 |
NC_000073.6 |
7 |
112249411 |
- |
Mical2 |
NNNGTGGGAGGTATCTCAGG |
NTG |
2 |
0.0286 |
Tier II |
13 |
NC_000078.6 |
12 |
102650733 |
+ |
Itpk1 |
NNNGAGGTAGGTATCTCAGG |
NGC |
2 |
0.0111 |
Tier II |
14 |
NC_000071.6 |
5 |
34313896 |
+ |
Cfap99 |
NNNGTGGTAGGGAGCTCAGG |
NGG |
2 |
0.0 |
Tier II |
15 |
NC_000070.6 |
4 |
125911420 |
+ |
2610028E06Rik |
NNNGTGGAAGGTCTCTCAGG |
NGG |
2 |
0.1684 |
Tier III |
16 |
NC_000073.6 |
7 |
35438904 |
- |
Gm42378 |
NNNGTGGTAGGTCACTCAGG |
NGG |
2 |
0.1303 |
Tier III |
17 |
NC_000067.6 |
1 |
170254950 |
- |
Gm6345 |
NNNGTGGTTGGTCTCTCAGG |
NGG |
2 |
0.1263 |
Tier III |
18 |
NC_000086.7 |
X |
81585805 |
+ |
LOC115489112 |
NNNGTGGTTGGTCTCTCAGG |
NGG |
2 |
0.1263 |
Tier III |
19 |
NC_000086.7 |
X |
74912767 |
- |
Xlr3e-ps |
NNNGTGGTAGGAATTTCAGG |
NGG |
2 |
0.0533 |
Tier III |
Other clones with same target sequence:
(none)