Construct: sgRNA BRDN0001145648
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- CTGGAACTTTGGGCCACCCA
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- FXN (2395)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 77814
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000009.12 |
9 |
69046478 |
+ |
FXN |
NNNGAACTTTGGGCCACCCA |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000003.12 |
3 |
11256171 |
+ |
HRH1 |
NNNGGACTTTGGGTCACCCA |
NGG |
2 |
0.528 |
Tier II |
3 |
NC_000001.11 |
1 |
2158726 |
- |
PRKCZ |
NNNGAGCTTTGGGCCACTCA |
NGG |
2 |
0.4592 |
Tier II |
4 |
NC_000008.11 |
8 |
123020645 |
- |
DERL1 |
NNNGAACTTTTGGCCAACCA |
NGG |
2 |
0.1795 |
Tier II |
5 |
NC_000002.12 |
2 |
46599063 |
+ |
PIGF |
NNNGTACTTTGGGCCAACCA |
NGG |
2 |
0.1697 |
Tier II |
6 |
NC_000010.11 |
10 |
48428597 |
+ |
MAPK8 |
NNNGAACTTTGGGAAACCCA |
NGG |
2 |
0.0778 |
Tier II |
7 |
NC_000003.12 |
3 |
140354264 |
+ |
CLSTN2 |
NNNGAACTTTGGGCTACTCA |
NGG |
2 |
0.0429 |
Tier II |
8 |
NC_000009.12 |
9 |
124968669 |
- |
SCAI |
NNNGAACTTTGGGCCACCCA |
NGC |
1 |
0.0222 |
Tier II |
9 |
NC_000022.11 |
22 |
44735918 |
+ |
PRR5 |
NNNGAACTTTGAGCCACCCA |
NGC |
2 |
0.0207 |
Tier II |
10 |
NC_000022.11 |
22 |
44735918 |
+ |
PRR5-ARHGAP8 |
NNNGAACTTTGAGCCACCCA |
NGC |
2 |
0.0207 |
Tier II |
11 |
NC_000002.12 |
2 |
200337392 |
+ |
SPATS2L |
NNNGAACTTTGGGCCAGCCA |
NAG |
2 |
0.0153 |
Tier II |
12 |
NC_000004.12 |
4 |
186211606 |
- |
KLKB1 |
NNNGAACTTTGGGCCAGGCA |
NGG |
2 |
0.0078 |
Tier II |
13 |
NC_000004.12 |
4 |
186211606 |
- |
CYP4V2 |
NNNGAACTTTGGGCCAGGCA |
NGG |
2 |
0.0078 |
Tier II |
14 |
NC_000014.9 |
14 |
33744512 |
+ |
NPAS3 |
NNNGAACTTTGGGCCAGGCA |
NGG |
2 |
0.0078 |
Tier II |
15 |
NC_000002.12 |
2 |
208012474 |
+ |
PLEKHM3 |
NNNGTACTTTGGGCCACCCA |
NGT |
2 |
0.0059 |
Tier II |
16 |
NC_000022.11 |
22 |
30608161 |
+ |
TCN2 |
NNNGAACTTTGGGCCGCCCA |
NGC |
2 |
0.0043 |
Tier II |
17 |
NC_000002.12 |
2 |
183124625 |
- |
NUP35 |
NNNGAACTTGGGGGCACCCA |
NGG |
2 |
0.0 |
Tier II |
18 |
NC_000020.11 |
20 |
48634496 |
- |
PREX1 |
NNNGAACTTTGGGGCACACA |
NGG |
2 |
0.0 |
Tier II |
19 |
NC_000016.10 |
16 |
71594403 |
+ |
LOC105371334 |
NNNGAACTAGGGGCCACCCA |
NGG |
2 |
0.4643 |
Tier III |
20 |
NC_000011.10 |
11 |
112732887 |
+ |
LOC105369496 |
NNNGAACTTTGGCCCACCCA |
NGG |
1 |
0.4211 |
Tier III |
21 |
NC_000008.11 |
8 |
123020645 |
- |
LOC124902013 |
NNNGAACTTTTGGCCAACCA |
NGG |
2 |
0.1795 |
Tier III |
22 |
NC_000002.12 |
2 |
46599063 |
+ |
LOC124906003 |
NNNGTACTTTGGGCCAACCA |
NGG |
2 |
0.1697 |
Tier III |
23 |
NC_000012.12 |
12 |
48015126 |
+ |
LOC105369750 |
NNNGAACTATGGGCCAGCCA |
NGG |
2 |
0.0546 |
Tier III |
24 |
NC_000009.12 |
9 |
124968669 |
- |
FXNP2 |
NNNGAACTTTGGGCCACCCA |
NGC |
1 |
0.0222 |
Tier III |
25 |
NC_000002.12 |
2 |
183124625 |
- |
LOC124907917 |
NNNGAACTTGGGGGCACCCA |
NGG |
2 |
0.0 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000071.6 |
5 |
107547931 |
- |
1700028K03Rik |
NNNGAATTTTAGGCCACCCA |
NGG |
2 |
0.8125 |
Tier II |
2 |
NC_000079.6 |
13 |
11949133 |
- |
Ryr2 |
NNNGAACTTAGTGCCACCCA |
NGG |
2 |
0.3297 |
Tier II |
3 |
NC_000080.6 |
14 |
31180114 |
+ |
Nisch |
NNNGACCTTTGTGCCACCCA |
NGG |
2 |
0.1748 |
Tier II |
4 |
NC_000083.6 |
17 |
32156448 |
- |
Notch3 |
NNNGAACTTTGGGCCACCCC |
NAG |
2 |
0.0589 |
Tier II |
5 |
NC_000071.6 |
5 |
115497741 |
- |
Pxn |
NNNGAACTCTGGGCCAGCCA |
NGG |
2 |
0.0543 |
Tier II |
6 |
NC_000073.6 |
7 |
125711770 |
- |
D430042O09Rik |
NNNGAACTTAGGGCCAGCCA |
NGG |
2 |
0.0504 |
Tier II |
7 |
NC_000083.6 |
17 |
35225415 |
- |
Nfkbil1 |
NNNGAAATTTGGGCTACCCA |
NGG |
2 |
0.05 |
Tier II |
8 |
NC_000078.6 |
12 |
86951087 |
- |
Cipc |
NNNGAGCTTTGGGCCAGCCA |
NGG |
2 |
0.042 |
Tier II |
9 |
NC_000081.6 |
15 |
20842792 |
+ |
Cdh12 |
NNNGAACTTTGAGCCACCCA |
NTG |
2 |
0.0364 |
Tier II |
10 |
NC_000078.6 |
12 |
83224409 |
- |
Dpf3 |
NNNGAACTTTGGGCCAGCCT |
NGG |
2 |
0.0353 |
Tier II |
11 |
NC_000081.6 |
15 |
78289662 |
- |
Csf2rb2 |
NNNGAGCTTTGGGCCACCCA |
NGC |
2 |
0.0159 |
Tier II |
12 |
NC_000073.6 |
7 |
140198842 |
+ |
Cd163l1 |
NNNGAACTTTGGGCCAGCCA |
NGT |
2 |
0.0009 |
Tier II |
13 |
NC_000073.6 |
7 |
36176861 |
+ |
Gm46016 |
NNNGAACTGTGGGCCACTCA |
NGG |
2 |
0.398 |
Tier III |
14 |
NC_000084.6 |
18 |
13974230 |
- |
6330525I24Rik |
NNNGAACTTTGGACCACCCA |
NGC |
2 |
0.0205 |
Tier III |
Other clones with same target sequence:
(none)