Construct: sgRNA BRDN0001145650
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TTTGAGGAAGACTCAATGAT
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- RP2 (6102)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000023.11 | X | 46853782 | - | RP2 | NNNGAGGAAGACTCAATGAT | NGG | 0 | 1.0 | Tier I |
2 | NC_000006.12 | 6 | 21010512 | + | CDKAL1 | NNNGAGAAAGAGTCAATGAT | NGG | 2 | 0.4444 | Tier II |
3 | NC_000002.12 | 2 | 100284166 | + | LONRF2 | NNNGAGGAGGACTCAATGTT | NGG | 2 | 0.359 | Tier II |
4 | NC_000011.10 | 11 | 16961378 | + | PLEKHA7 | NNNGAGTAAGACTCAAAGAT | NGG | 2 | 0.3048 | Tier II |
5 | NC_000003.12 | 3 | 85978679 | - | CADM2 | NNNTAGGAAGACTTAATGAT | NGG | 2 | 0.2667 | Tier II |
6 | NC_000001.11 | 1 | 121342501 | + | SRGAP2C | NNNGAAGAAGACTCAATGAT | NAG | 2 | 0.2593 | Tier II |
7 | NC_000001.11 | 1 | 144937574 | - | SRGAP2B | NNNGAAGAAGACTCAATGAT | NAG | 2 | 0.2593 | Tier II |
8 | NC_000001.11 | 1 | 206361150 | + | SRGAP2 | NNNGAAGAAGACTCAATGAT | NAG | 2 | 0.2593 | Tier II |
9 | NC_000006.12 | 6 | 71308216 | + | OGFRL1 | NNNGAGAAAGACTCAGTGAT | NGG | 2 | 0.1923 | Tier II |
10 | NC_000016.10 | 16 | 55681275 | + | SLC6A2 | NNNGAGAAAGACTCAGTGAT | NGG | 2 | 0.1923 | Tier II |
11 | NC_000018.10 | 18 | 23622588 | - | ANKRD29 | NNNGAGCAAGACTCCATGAT | NGG | 2 | 0.1875 | Tier II |
12 | NC_000003.12 | 3 | 50688839 | - | DOCK3 | NNNGGGGAAGACTCAATGAT | NAG | 2 | 0.1867 | Tier II |
13 | NC_000010.11 | 10 | 125911766 | - | FANK1 | NNNGAGGAAGACTCAATAAT | NAG | 2 | 0.1795 | Tier II |
14 | NC_000002.12 | 2 | 207556851 | + | CREB1 | NNNGAGGAAGACACAATGCT | NGG | 2 | 0.1432 | Tier II |
15 | NC_000010.11 | 10 | 59268417 | + | FAM13C | NNNGATGAAGACTCTATGAT | NGG | 2 | 0.1333 | Tier II |
16 | NC_000016.10 | 16 | 23634008 | - | PALB2 | NNNGAGGAAGACTCTATGTT | NGG | 2 | 0.1077 | Tier II |
17 | NC_000011.10 | 11 | 12206876 | - | MICAL2 | NNNCAGGAAGACTCAGTGAT | NGG | 2 | 0.1018 | Tier II |
18 | NC_000012.12 | 12 | 24177835 | - | SOX5 | NNNGAGAAAGACTCAATGAC | NGG | 2 | 0.0909 | Tier II |
19 | NC_000013.11 | 13 | 41696830 | - | VWA8 | NNNGAGGAAGAATCAATGAT | NTG | 2 | 0.0278 | Tier II |
20 | NC_000016.10 | 16 | 17359633 | - | XYLT1 | NNNGAGGAAGACTCAATGCC | NGG | 2 | 0.0188 | Tier II |
21 | NC_000007.14 | 7 | 40490146 | + | SUGCT | NNNGAGGAAGACTCAATGAG | NGC | 2 | 0.0039 | Tier II |
22 | NC_000005.10 | 5 | 50739229 | - | PARP8 | NNNGAGGAAGACTGAATGAC | NGG | 2 | 0.0 | Tier II |
23 | NC_000005.10 | 5 | 89584322 | + | LINC02161 | NNNGAGGAAGAAACAATGAT | NGG | 2 | 0.4945 | Tier III |
24 | NC_000018.10 | 18 | 39320394 | + | MIR924HG | NNNGAGGAAGACACAATGGT | NGG | 2 | 0.2596 | Tier III |
25 | NC_000018.10 | 18 | 39320394 | + | LOC101927879 | NNNGAGGAAGACACAATGGT | NGG | 2 | 0.2596 | Tier III |
26 | NC_000006.12 | 6 | 71308216 | + | LOC124901339 | NNNGAGAAAGACTCAGTGAT | NGG | 2 | 0.1923 | Tier III |
27 | NC_000007.14 | 7 | 6667364 | - | LOC124901583 | NNNGAGGAAGACACAATGAG | NGG | 2 | 0.1222 | Tier III |
28 | NC_000023.11 | X | 17979478 | + | LINC01456 | NNNTAGGAAGACTCAATGAT | NAG | 2 | 0.0943 | Tier III |
29 | NC_000008.11 | 8 | 33931903 | + | LOC105379364 | NNNGAGTAAGACTCAATGAT | NGT | 2 | 0.0092 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000078.6 | 12 | 105180038 | + | Tcl1b5 | NNNGAGGATGACTGAATGAT | NGG | 2 | 0.0 | Tier I |
2 | NC_000067.6 | 1 | 156192098 | - | Fam163a | NNNGAGAAAGAATCAATGAT | NGG | 2 | 0.7143 | Tier II |
3 | NC_000072.6 | 6 | 24098295 | + | Slc13a1 | NNNAAGGGAGACTCAATGAT | NGG | 2 | 0.66 | Tier II |
4 | NC_000072.6 | 6 | 80056334 | - | Lrrtm4 | NNNGAAGAAGACTCAAAGAT | NGG | 2 | 0.5333 | Tier II |
5 | NC_000076.6 | 10 | 19888976 | + | Pex7 | NNNGAGGAAAACTCAATGAT | NAG | 2 | 0.242 | Tier II |
6 | NC_000083.6 | 17 | 50083902 | - | Rftn1 | NNNGAGGATCACTCAATGAT | NGG | 2 | 0.24 | Tier II |
7 | NC_000073.6 | 7 | 112292544 | + | Mical2 | NNNGTGGAAGACTCAATGAA | NGG | 2 | 0.2045 | Tier II |
8 | NC_000078.6 | 12 | 28479052 | - | Dcdc2c | NNNGAGAAAGACTCTATGAT | NGG | 2 | 0.2 | Tier II |
9 | NC_000086.7 | X | 98572185 | - | Ophn1 | NNNAAGGAAGACTCTATGAT | NGG | 2 | 0.18 | Tier II |
10 | NC_000074.6 | 8 | 105780139 | - | Ranbp10 | NNNGAGGTAGACTAAATGAT | NGG | 2 | 0.15 | Tier II |
11 | NC_000071.6 | 5 | 65453095 | - | Smim14 | NNNGAGGAAGACTCAATTCT | NGG | 2 | 0.1379 | Tier II |
12 | NC_000082.6 | 16 | 91559334 | + | Ifngr2 | NNNGAGGAAAACTCAATGAT | NCG | 2 | 0.1 | Tier II |
13 | NC_000070.6 | 4 | 35878191 | + | Lingo2 | NNNGAGGAAGAATCAAGGAT | NGG | 2 | 0.084 | Tier II |
14 | NC_000067.6 | 1 | 178419509 | - | Efcab2 | NNNGAGTAAGACTCAATGAT | NTG | 2 | 0.0223 | Tier II |
15 | NC_000067.6 | 1 | 84589065 | - | Dner | NNNGAGGAAGAGTCACTGAT | NGG | 2 | 0.0 | Tier II |
16 | NC_000069.6 | 3 | 135306254 | + | Gm46826 | NNNGAGTAAGACTCAAAGAT | NGG | 2 | 0.3048 | Tier III |
17 | NC_000076.6 | 10 | 43624744 | + | F930017D23Rik | NNNGAGGAAGACTCCATGAT | NGG | 1 | 0.2727 | Tier III |
18 | NC_000074.6 | 8 | 50149881 | - | 1700019L22Rik | NNNGAGGAAGACTGAAGGAT | NGG | 2 | 0.0 | Tier III |