Construct: sgRNA BRDN0001145783
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GGGGTGTCATCAAGTCACCT
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- MAPKAPK5 (8550)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000012.12 | 12 | 111871135 | - | MAPKAPK5 | NNNGTGTCATCAAGTCACCT | NGG | 0 | 1.0 | Tier I |
2 | NC_000019.10 | 19 | 35720974 | + | KMT2B | NNNGTGTCATCAAGACACCC | NGG | 2 | 0.0526 | Tier I |
3 | NC_000010.11 | 10 | 60096614 | - | ANK3 | NNNGTGTCAAAAAGTCACCT | NGG | 2 | 0.6429 | Tier II |
4 | NC_000012.12 | 12 | 117629161 | - | KSR2 | NNNGGGTCATCAACTCACCT | NGG | 2 | 0.2743 | Tier II |
5 | NC_000016.10 | 16 | 81337273 | - | GAN | NNNATGTCATCATGTCACCT | NGG | 2 | 0.27 | Tier II |
6 | NC_000006.12 | 6 | 143866639 | + | ZC2HC1B | NNNATGTCATCAAGTCACCT | NAG | 2 | 0.2333 | Tier II |
7 | NC_000002.12 | 2 | 232182002 | + | DIS3L2 | NNNGTTTCATCATGTCACCT | NGG | 2 | 0.2 | Tier II |
8 | NC_000012.12 | 12 | 14490908 | - | ATF7IP | NNNGGGTCATCAAGTCACCT | NAG | 2 | 0.1659 | Tier II |
9 | NC_000003.12 | 3 | 175032819 | + | NAALADL2 | NNNGTGTCATCAAGTTACTT | NGG | 2 | 0.142 | Tier II |
10 | NC_000002.12 | 2 | 213811884 | - | SPAG16 | NNNGTGTCATCCAGCCACCT | NGG | 2 | 0.0718 | Tier II |
11 | NC_000023.11 | X | 6728878 | + | PUDP | NNNGAGTCATCAAGTCTCCT | NGG | 2 | 0.0667 | Tier II |
12 | NC_000016.10 | 16 | 90005613 | + | DBNDD1 | NNNGTGTCATCAAGTCTCTT | NGG | 2 | 0.0615 | Tier II |
13 | NC_000022.11 | 22 | 46247654 | - | CDPF1 | NNNGTGTCATCATGTCACCC | NGG | 2 | 0.0273 | Tier II |
14 | NC_000010.11 | 10 | 23298803 | - | C10orf67 | NNNGTGTCATCAAGCCACCC | NGG | 2 | 0.0248 | Tier II |
15 | NC_000010.11 | 10 | 43512465 | - | ZNF487 | NNNGGGTCATCAAGTCACCT | NGC | 2 | 0.0142 | Tier II |
16 | NC_000001.11 | 1 | 77185960 | + | PIGK | NNNGTGTCATCAAGTCACCA | NGC | 2 | 0.0125 | Tier II |
17 | NC_000011.10 | 11 | 101918813 | + | CEP126 | NNNGTGTCATCAAGTCATCT | NGT | 2 | 0.0104 | Tier II |
18 | NC_000018.10 | 18 | 3519332 | - | DLGAP1 | NNNGTGTCATCAAGTCACAT | NGC | 2 | 0.0095 | Tier II |
19 | NC_000002.12 | 2 | 40094667 | - | SLC8A1-AS1 | NNNGCTTCATCAAGTCACCT | NGG | 2 | 0.6667 | Tier III |
20 | NC_000009.12 | 9 | 7557392 | + | PPIAP33 | NNNATGTCACCAAGTCACCT | NGG | 2 | 0.48 | Tier III |
21 | NC_000013.11 | 13 | 22429373 | + | LOC107984599 | NNNCTGTCAACAAGTCACCT | NGG | 2 | 0.4538 | Tier III |
22 | NC_000005.10 | 5 | 41096415 | + | LOC105374739 | NNNGTGTCTTCAGGTCACCT | NGG | 2 | 0.3913 | Tier III |
23 | NC_000001.11 | 1 | 38148201 | + | LOC105378654 | NNNGGGTCATCAAGTCACCA | NGG | 2 | 0.36 | Tier III |
24 | NC_000005.10 | 5 | 106915677 | - | LINC01950 | NNNGGGTCATCAAGTCACCA | NGG | 2 | 0.36 | Tier III |
25 | NC_000011.10 | 11 | 107234437 | - | LOC105369477 | NNNGGGTCATCAAGTCACCA | NGG | 2 | 0.36 | Tier III |
26 | NC_000005.10 | 5 | 61910837 | - | LOC105378998 | NNNGAGTCATCAAGTCACCA | NGG | 2 | 0.2813 | Tier III |
27 | NC_000001.11 | 1 | 60246813 | + | LINC02778 | NNNGGGTCATCAAGTCACCT | NTG | 2 | 0.0249 | Tier III |
28 | NC_000001.11 | 1 | 60246813 | + | LOC105378761 | NNNGGGTCATCAAGTCACCT | NTG | 2 | 0.0249 | Tier III |
29 | NC_000006.12 | 6 | 22574709 | - | LOC105374971 | NNNGTGTCATCAAGTCACCT | NAT | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000071.6 | 5 | 121534381 | + | Mapkapk5 | NNNGTGTCATCAAATCACCT | NGG | 1 | 0.75 | Tier I |
2 | NC_000082.6 | 16 | 20608741 | + | Alg3 | NNNGTGGCATCAACTCACCT | NGG | 2 | 0.2521 | Tier I |
3 | NC_000077.6 | 11 | 4923417 | - | Thoc5 | NNNCTGTCATCAGGTCACCT | NGG | 2 | 0.3453 | Tier II |
4 | NC_000076.6 | 10 | 80301693 | - | Apc2 | NNNGTGTCAACCAGTCACCT | NGG | 2 | 0.2256 | Tier II |
5 | NC_000070.6 | 4 | 3731341 | - | Lyn | NNNGTGTCATCTAGACACCT | NGG | 2 | 0.193 | Tier II |
6 | NC_000067.6 | 1 | 84258232 | - | Pid1 | NNNGTGTCATCATGTCATCT | NGG | 2 | 0.1929 | Tier II |
7 | NC_000082.6 | 16 | 40850455 | - | Lsamp | NNNGTGGCATGAAGTCACCT | NGG | 2 | 0.1471 | Tier II |
8 | NC_000067.6 | 1 | 155806608 | + | Qsox1 | NNNGTGTCATCATGTCACTT | NGG | 2 | 0.1385 | Tier II |
9 | NC_000073.6 | 7 | 144027190 | + | Shank2 | NNNGTGTCATCAGGTGACCT | NGG | 2 | 0.1003 | Tier II |
10 | NC_000077.6 | 11 | 119738968 | - | Rptor | NNNGTGGCATCAAGTCTCCT | NGG | 2 | 0.0784 | Tier II |
11 | NC_000084.6 | 18 | 12226808 | + | Npc1 | NNNGTGTCACCAAGTCTCCT | NGG | 2 | 0.0711 | Tier II |
12 | NC_000078.6 | 12 | 28752195 | - | Eipr1 | NNNGTGTAATCAAGTCACCT | NCG | 2 | 0.0696 | Tier II |
13 | NC_000081.6 | 15 | 59572774 | + | Nsmce2 | NNNGTGTCATCAAGTAACCT | NGC | 2 | 0.0222 | Tier II |
14 | NC_000083.6 | 17 | 64029482 | + | Fer | NNNGTGTCATCAAGTCTCCT | NGA | 2 | 0.0093 | Tier II |
15 | NC_000067.6 | 1 | 152538510 | - | Rgl1 | NNNGAGTCATCAAGTCACCT | NGT | 2 | 0.0081 | Tier II |
16 | NC_000068.7 | 2 | 93954249 | + | Gm33160 | NNNGTGTCATCCAGACACCT | NGG | 2 | 0.1524 | Tier III |
17 | NC_000073.6 | 7 | 71155951 | - | Gm36071 | NNNGTGTCATCAAGTCCCCT | NGA | 2 | 0.0123 | Tier III |