Construct: sgRNA BRDN0001145790
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TGAATCCCATTCCAAAATGT
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- SCYL3 (57147)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 76794
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000001.11 |
1 |
169868972 |
- |
SCYL3 |
NNNATCCCATTCCAAAATGT |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000001.11 |
1 |
185982363 |
+ |
HMCN1 |
NNNATCCCATTCCAGAACGT |
NGG |
2 |
0.2786 |
Tier I |
3 |
NC_000010.11 |
10 |
74959994 |
+ |
KAT6B |
NNNATCCCATTCCAATATGT |
NGC |
2 |
0.0 |
Tier I |
4 |
NC_000005.10 |
5 |
76199312 |
+ |
SV2C |
NNNATAACATTCCAAAATGT |
NGG |
2 |
0.6964 |
Tier II |
5 |
NC_000018.10 |
18 |
34571820 |
+ |
DTNA |
NNNACCCCATTCCAAAAAGT |
NGG |
2 |
0.6667 |
Tier II |
6 |
NC_000003.12 |
3 |
129305306 |
- |
HMCES |
NNNATCACTTTCCAAAATGT |
NGG |
2 |
0.45 |
Tier II |
7 |
NC_000016.10 |
16 |
81381318 |
+ |
GAN |
NNNATCCCCTTCCAGAATGT |
NGG |
2 |
0.3714 |
Tier II |
8 |
NC_000003.12 |
3 |
133404753 |
- |
BFSP2 |
NNNATCCCAGTGCAAAATGT |
NGG |
2 |
0.2222 |
Tier II |
9 |
NC_000003.12 |
3 |
1298579 |
- |
CNTN6 |
NNNATCCCATGCAAAAATGT |
NGG |
2 |
0.1538 |
Tier II |
10 |
NC_000003.12 |
3 |
69392821 |
+ |
FRMD4B |
NNNATCCCATTCCAAAAAGG |
NGG |
2 |
0.1176 |
Tier II |
11 |
NC_000012.12 |
12 |
8515592 |
- |
CLEC4D |
NNNATCCCAGTCCAAAATGG |
NGG |
2 |
0.0882 |
Tier II |
12 |
NC_000002.12 |
2 |
132661479 |
+ |
LYPD1 |
NNNATCCCATTCCATAAGGT |
NGG |
2 |
0.0667 |
Tier II |
13 |
NC_000004.12 |
4 |
79982401 |
- |
ANTXR2 |
NNNATCTCATTCCAAAATGT |
NTG |
2 |
0.0317 |
Tier II |
14 |
NC_000004.12 |
4 |
155361073 |
- |
MAP9 |
NNNATCCCATTCCAAAATGT |
NGT |
1 |
0.0161 |
Tier II |
15 |
NC_000015.10 |
15 |
33933062 |
+ |
AVEN |
NNNATCCCATTCAAAAATGT |
NTG |
2 |
0.015 |
Tier II |
16 |
NC_000012.12 |
12 |
12242152 |
+ |
LRP6 |
NNNATCCCATTCCAAAATTT |
NGT |
2 |
0.0108 |
Tier II |
17 |
NC_000009.12 |
9 |
111004837 |
+ |
LPAR1 |
NNNATCCCATTCCAGAATGT |
NGT |
2 |
0.0105 |
Tier II |
18 |
NC_000003.12 |
3 |
185488059 |
+ |
MAP3K13 |
NNNATCCCATTCCAAAATGT |
NTC |
2 |
0.0 |
Tier II |
19 |
NC_000009.12 |
9 |
13466700 |
- |
LOC105375977 |
NNNATCCCAGTCCAAAATGT |
NAG |
2 |
0.1296 |
Tier III |
20 |
NC_000011.10 |
11 |
23019248 |
+ |
LINC02718 |
NNNATCCCATTCAAAAAGGT |
NGG |
2 |
0.1282 |
Tier III |
21 |
NC_000011.10 |
11 |
23019248 |
+ |
LOC124902646 |
NNNATCCCATTCAAAAAGGT |
NGG |
2 |
0.1282 |
Tier III |
22 |
NC_000005.10 |
5 |
7909613 |
- |
LOC124900936 |
NNNTTCCCATTCCAAAATGG |
NGG |
2 |
0.1123 |
Tier III |
23 |
NC_000011.10 |
11 |
41764696 |
+ |
LINC01499 |
NNNTTCCCATTCCAAAATGG |
NGG |
2 |
0.1123 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000082.6 |
16 |
56917396 |
- |
Lnp1 |
NNNAGCCCATTCCAAAATGC |
NGG |
2 |
0.0582 |
Tier I |
2 |
NC_000080.6 |
14 |
21609778 |
+ |
Kat6b |
NNNATCCCATTCCAATATGT |
NGC |
2 |
0.0 |
Tier I |
3 |
NC_000073.6 |
7 |
63625754 |
+ |
Otud7a |
NNNATTCCATTCCAAAATGT |
NGG |
1 |
0.9286 |
Tier II |
4 |
NC_000069.6 |
3 |
142073051 |
+ |
Bmpr1b |
NNNATACTATTCCAAAATGT |
NGG |
2 |
0.8125 |
Tier II |
5 |
NC_000086.7 |
X |
151425596 |
- |
Fam120c |
NNNTTACCATTCCAAAATGT |
NGG |
2 |
0.5909 |
Tier II |
6 |
NC_000086.7 |
X |
105891454 |
+ |
Atrx |
NNNATCCCATTATAAAATGT |
NGG |
2 |
0.5 |
Tier II |
7 |
NC_000074.6 |
8 |
114876662 |
+ |
Wwox |
NNNAACCCATTCCAAAAAGT |
NGG |
2 |
0.3333 |
Tier II |
8 |
NC_000083.6 |
17 |
57921765 |
+ |
Cntnap5c |
NNNATGCCATTCCTAAATGT |
NGG |
2 |
0.2667 |
Tier II |
9 |
NC_000073.6 |
7 |
57632906 |
- |
Gabrb3 |
NNNTTCCCATTCCAAAATGT |
NAG |
2 |
0.165 |
Tier II |
10 |
NC_000079.6 |
13 |
52614690 |
- |
Syk |
NNNATCCCATCCCAAAATGG |
NGG |
2 |
0.1176 |
Tier II |
11 |
NC_000073.6 |
7 |
135555438 |
+ |
Ptpre |
NNNAGCCCATTCCAAAGTGT |
NGG |
2 |
0.1129 |
Tier II |
12 |
NC_000076.6 |
10 |
28849445 |
- |
Themis |
NNNTTCCCATTCCAAAATGG |
NGG |
2 |
0.1123 |
Tier II |
13 |
NC_000078.6 |
12 |
79369143 |
- |
Rad51b |
NNNTTCCCATTCCAAAATGG |
NGG |
2 |
0.1123 |
Tier II |
14 |
NC_000082.6 |
16 |
22033365 |
- |
Senp2 |
NNNATCCCATTCTAAAATGT |
NGA |
2 |
0.0486 |
Tier II |
15 |
NC_000072.6 |
6 |
21472735 |
+ |
Kcnd2 |
NNNATCCCATTCCAAAACGT |
NGA |
2 |
0.0298 |
Tier II |
16 |
NC_000072.6 |
6 |
116111033 |
- |
Tmcc1 |
NNNATCCCATTCCTAAATGT |
NTG |
2 |
0.0208 |
Tier II |
17 |
NC_000077.6 |
11 |
105752010 |
+ |
Tanc2 |
NNNATCCCATTCCAAAATGG |
NGT |
2 |
0.0028 |
Tier II |
18 |
NC_000068.7 |
2 |
53058273 |
+ |
Fmnl2 |
NNNATCCCATTCCAACATGT |
NGT |
2 |
0.0 |
Tier II |
19 |
NC_000072.6 |
6 |
28325886 |
- |
Zfp800 |
NNNATCCCATTCCACCATGT |
NGG |
2 |
0.0 |
Tier II |
20 |
NC_000068.7 |
2 |
52649907 |
- |
Cacnb4 |
NNNATCCCTTTCCAACATGT |
NGG |
2 |
0.0 |
Tier II |
21 |
NC_000081.6 |
15 |
11849785 |
- |
Npr3 |
NNNATCTCATTCCAACATGT |
NGG |
2 |
0.0 |
Tier II |
22 |
NC_000067.6 |
1 |
194890394 |
- |
Gm39748 |
NNNTTCCCATTCCAAAATGT |
NGG |
1 |
0.6364 |
Tier III |
23 |
NC_000077.6 |
11 |
17958239 |
+ |
Etaa1os |
NNNTTACCATTCCAAAATGT |
NGG |
2 |
0.5909 |
Tier III |
24 |
NC_000078.6 |
12 |
68656592 |
- |
Gm31307 |
NNNATGCCATTCAAAAATGT |
NGG |
2 |
0.1923 |
Tier III |
Other clones with same target sequence:
(none)