Construct: sgRNA BRDN0001145869
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TCATGCTTGCTTGGGCAAAA
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- NO_SITE control
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 80256
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000016.10 |
16 |
53776015 |
+ |
FTO |
NNNTACTTGCTTGGGAAAAA |
NGG |
2 |
0.8667 |
Tier II |
2 |
NC_000014.9 |
14 |
78949878 |
+ |
NRXN3 |
NNNTGCATGCTAGGGCAAAA |
NGG |
2 |
0.7 |
Tier II |
3 |
NC_000009.12 |
9 |
113289501 |
- |
PRPF4 |
NNNTGCTAGATTGGGCAAAA |
NGG |
2 |
0.6933 |
Tier II |
4 |
NC_000006.12 |
6 |
90574841 |
- |
MAP3K7 |
NNNTGCTTTCTTGAGCAAAA |
NGG |
2 |
0.4 |
Tier II |
5 |
NC_000014.9 |
14 |
77225837 |
- |
TMEM63C |
NNNTGTTTGCTTGGGCAGAA |
NGG |
2 |
0.3714 |
Tier II |
6 |
NC_000007.14 |
7 |
43242403 |
+ |
HECW1 |
NNNTGCTTGGTTGGACAAAA |
NGG |
2 |
0.366 |
Tier II |
7 |
NC_000016.10 |
16 |
81346950 |
- |
GAN |
NNNTGCTTGCTTTGGAAAAA |
NGG |
2 |
0.3 |
Tier II |
8 |
NC_000005.10 |
5 |
59324163 |
- |
PDE4D |
NNNTGCTTGCTTGAGCAAGA |
NGG |
2 |
0.2813 |
Tier II |
9 |
NC_000019.10 |
19 |
15237778 |
- |
BRD4 |
NNNTGTTTGCTTGTGCAAAA |
NGG |
2 |
0.2476 |
Tier II |
10 |
NC_000009.12 |
9 |
121765075 |
+ |
DAB2IP |
NNNTGCTTGCCTGGGCCAAA |
NGG |
2 |
0.1176 |
Tier II |
11 |
NC_000015.10 |
15 |
100512231 |
+ |
CERS3 |
NNNTGCCTGCTTGGGGAAAA |
NGG |
2 |
0.1058 |
Tier II |
12 |
NC_000002.12 |
2 |
24829922 |
- |
ADCY3 |
NNNTGCTTTCTTGGGGAAAA |
NGG |
2 |
0.0821 |
Tier II |
13 |
NC_000019.10 |
19 |
6757672 |
+ |
SH2D3A |
NNNTGCTTGCTTGGGTACAA |
NGG |
2 |
0.0586 |
Tier II |
14 |
NC_000003.12 |
3 |
122011981 |
- |
ILDR1 |
NNNTGCTTGCTTGGGAAAAA |
NTG |
2 |
0.039 |
Tier II |
15 |
NC_000007.14 |
7 |
90698717 |
+ |
CDK14 |
NNNTGCTTGCTTTGGCAAAA |
NTG |
2 |
0.0117 |
Tier II |
16 |
NC_000020.11 |
20 |
41126246 |
- |
PLCG1-AS1 |
NNNTGCTTGTTTGGGAAAAA |
NGG |
2 |
0.9412 |
Tier III |
17 |
NC_000017.11 |
17 |
72535230 |
- |
LINC00673 |
NNNTGCTTGCGTGGGCAAAA |
NGG |
1 |
0.4 |
Tier III |
18 |
NC_000023.11 |
X |
145057250 |
+ |
RN7SKP189 |
NNNTGCTTGCTTGGTCAAAG |
NGG |
2 |
0.1092 |
Tier III |
19 |
NC_000013.11 |
13 |
97573184 |
+ |
LOC105370324 |
NNNTGCTTGCTTGGCTAAAA |
NGG |
2 |
0.0839 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000068.7 |
2 |
22986496 |
+ |
Abi1 |
NNNTGCTTGCTTAGGCAAAT |
NGG |
2 |
0.5538 |
Tier II |
2 |
NC_000071.6 |
5 |
141522732 |
+ |
Sdk1 |
NNNGACTTGCTTGGGCAAAA |
NGG |
2 |
0.5417 |
Tier II |
3 |
NC_000073.6 |
7 |
78535809 |
- |
Ntrk3 |
NNNTGCTAGCTTGGGCAGAA |
NGG |
2 |
0.32 |
Tier II |
4 |
NC_000078.6 |
12 |
111864256 |
- |
Ppp1r13b |
NNNTGCTAGCTTGGGCAGAA |
NGG |
2 |
0.32 |
Tier II |
5 |
NC_000072.6 |
6 |
73058076 |
- |
Dnah6 |
NNNTGCTTGCTAGGGCAGAA |
NGG |
2 |
0.32 |
Tier II |
6 |
NC_000067.6 |
1 |
175330206 |
+ |
Rgs7 |
NNNTGCTTGCTTGGGAACAA |
NGG |
2 |
0.1905 |
Tier II |
7 |
NC_000079.6 |
13 |
68589067 |
- |
Fastkd3 |
NNNTGCTTCCTTGTGCAAAA |
NGG |
2 |
0.1436 |
Tier II |
8 |
NC_000085.6 |
19 |
46047952 |
- |
Ldb1 |
NNNTGCTTGCTTGTGCAACA |
NGG |
2 |
0.0552 |
Tier II |
9 |
NC_000071.6 |
5 |
141779067 |
+ |
Sdk1 |
NNNTGCTTGCTTGGGCAAAT |
NGT |
2 |
0.0097 |
Tier II |
10 |
NC_000068.7 |
2 |
102087754 |
- |
Ldlrad3 |
NNNTGCTTGCTTTGGCAAAA |
NGT |
2 |
0.0048 |
Tier II |
11 |
NC_000080.6 |
14 |
76042305 |
+ |
Gm36477 |
NNNTGTTTGCTTGGGCAGAA |
NGG |
2 |
0.3714 |
Tier III |
12 |
NC_000084.6 |
18 |
77793660 |
+ |
F830208F22Rik |
NNNTGCTTGCTTTGGCATAA |
NGG |
2 |
0.15 |
Tier III |
13 |
NC_000069.6 |
3 |
144894621 |
+ |
Clca4c-ps |
NNNTGCCTGCTTGGGCAAAA |
NTG |
2 |
0.0268 |
Tier III |
14 |
NC_000070.6 |
4 |
82071795 |
+ |
Gm5860 |
NNNTGCTTGCTTGGCCAAAA |
NGA |
2 |
0.0189 |
Tier III |
Other clones with same target sequence:
(none)