Construct: sgRNA BRDN0001145897
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GAAATAGCAGCAATTACACA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- TAOK1 (57551)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000017.11 | 17 | 29478294 | + | TAOK1 | NNNATAGCAGCAATTACACA | NGG | 0 | 1.0 | Tier I |
2 | NC_000013.11 | 13 | 46044960 | - | ZC3H13 | NNNATAGCAGCAATTATAGA | NGG | 2 | 0.0583 | Tier I |
3 | NC_000018.10 | 18 | 13680470 | + | FAM210A | NNNACAGCATCAATTACACA | NGG | 2 | 0.8125 | Tier II |
4 | NC_000017.11 | 17 | 68549831 | - | PRKAR1A | NNNATAACAGCAAATACACA | NGG | 2 | 0.619 | Tier II |
5 | NC_000017.11 | 17 | 68549831 | - | FAM20A | NNNATAACAGCAAATACACA | NGG | 2 | 0.619 | Tier II |
6 | NC_000007.14 | 7 | 102187427 | - | CUX1 | NNNATAACAGCAATTACTCA | NGG | 2 | 0.5 | Tier II |
7 | NC_000019.10 | 19 | 11610624 | - | ZNF627 | NNNTTAGCAGCAGTTACACA | NGG | 2 | 0.415 | Tier II |
8 | NC_000007.14 | 7 | 147877342 | - | CNTNAP2 | NNNATAGCAGCTATTACACA | NGG | 1 | 0.3333 | Tier II |
9 | NC_000016.10 | 16 | 22019043 | - | MOSMO | NNNATAACAGCACTTACACA | NGG | 2 | 0.2105 | Tier II |
10 | NC_000011.10 | 11 | 12215371 | - | MICAL2 | NNNATATCAGCATTTACACA | NGG | 2 | 0.1714 | Tier II |
11 | NC_000012.12 | 12 | 132742361 | + | ANKLE2 | NNNATAACAGCAATTACAGA | NGG | 2 | 0.125 | Tier II |
12 | NC_000017.11 | 17 | 17830121 | - | SREBF1 | NNNTTAGCAGCAATTACCCA | NGG | 2 | 0.1212 | Tier II |
13 | NC_000015.10 | 15 | 31815247 | + | OTUD7A | NNNATAGCAGCAATTACATA | NAG | 2 | 0.1197 | Tier II |
14 | NC_000016.10 | 16 | 23148070 | + | USP31 | NNNATAGCAGCAAATACACA | NGA | 2 | 0.043 | Tier II |
15 | NC_000008.11 | 8 | 135596563 | - | KHDRBS3 | NNNATATCAGCAATTACACA | NGA | 2 | 0.0397 | Tier II |
16 | NC_000008.11 | 8 | 91028066 | + | PIP4P2 | NNNATAGCAGCAATTAAACA | NTG | 2 | 0.0182 | Tier II |
17 | NC_000005.10 | 5 | 90913287 | + | ADGRV1 | NNNATAGCAGCAATTACACT | NGC | 2 | 0.0133 | Tier II |
18 | NC_000001.11 | 1 | 110618481 | - | KCNA2 | NNNAGAGCAGCAATTCCACA | NGG | 2 | 0.0 | Tier II |
19 | NC_000011.10 | 11 | 9589141 | - | WEE1 | NNNATAGCAGCAAATTCACA | NGG | 2 | 0.0 | Tier II |
20 | NC_000003.12 | 3 | 143528697 | + | SLC9A9 | NNNATAGCAGCAATTTCATA | NGG | 2 | 0.0 | Tier II |
21 | NC_000004.12 | 4 | 118949350 | - | SYNPO2 | NNNATAGCAGCAATTTCATA | NGG | 2 | 0.0 | Tier II |
22 | NC_000018.10 | 18 | 36513249 | - | FHOD3 | NNNATAGCAGCAATTTCATA | NGG | 2 | 0.0 | Tier II |
23 | NC_000009.12 | 9 | 107373099 | + | LOC107987111 | NNNATAACAACAATTACACA | NGG | 2 | 0.9333 | Tier III |
24 | NC_000001.11 | 1 | 212262501 | + | LINC02608 | NNNATAATAGCAATTACACA | NGG | 2 | 0.875 | Tier III |
25 | NC_000024.10 | Y | 18461180 | - | OFD1P4Y | NNNATAGCATAAATTACACA | NGG | 2 | 0.6094 | Tier III |
26 | NC_000024.10 | Y | 18859218 | + | OFD1P7Y | NNNATAGCATAAATTACACA | NGG | 2 | 0.6094 | Tier III |
27 | NC_000001.11 | 1 | 205968408 | - | SLC26A9-AS1 | NNNATTCCAGCAATTACACA | NGG | 2 | 0.4911 | Tier III |
28 | NC_000006.12 | 6 | 170678959 | + | LOC101929692 | NNNATAGCTGAAATTACACA | NGG | 2 | 0.45 | Tier III |
29 | NC_000019.10 | 19 | 20135558 | + | LOC105372310 | NNNTTAGCAGCAATTACAAA | NGG | 2 | 0.2727 | Tier III |
30 | NC_000011.10 | 11 | 12215371 | - | LOC124902634 | NNNATATCAGCATTTACACA | NGG | 2 | 0.1714 | Tier III |
31 | NC_000002.12 | 2 | 103901123 | + | LINC01965 | NNNATAGCTGCAATTACACA | NGA | 2 | 0.0417 | Tier III |
32 | NC_000005.10 | 5 | 97534321 | - | LINC01340 | NNNATAGCAGCAATAACACA | NGA | 2 | 0.0402 | Tier III |
33 | NC_000022.11 | 22 | 22196278 | + | IGL | NNNATAGCAGCAATCACACA | NTG | 2 | 0.0106 | Tier III |
34 | NC_000022.11 | 22 | 22196278 | + | IGLV6-57 | NNNATAGCAGCAATCACACA | NTG | 2 | 0.0106 | Tier III |
35 | NC_000014.9 | 14 | 48869627 | - | LOC105378178 | NNNACAGCAGCAATTTCACA | NGG | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000077.6 | 11 | 77575627 | - | Taok1 | NNNATAGCAGCAATTACACA | NGG | 0 | 1.0 | Tier I |
2 | NC_000080.6 | 14 | 75292283 | + | Zc3h13 | NNNACAGCAGCAATTACAGA | NGG | 2 | 0.125 | Tier I |
3 | NC_000079.6 | 13 | 30864923 | + | Exoc2 | NNNATAGCAGCAATTACTCA | NGA | 2 | 0.0347 | Tier I |
4 | NC_000074.6 | 8 | 14598786 | - | Dlgap2 | NNNATAGCATCAAATACACA | NGG | 2 | 0.503 | Tier II |
5 | NC_000079.6 | 13 | 77194932 | - | 2210408I21Rik | NNNATAGCAGCAATTACTCA | NGG | 1 | 0.5 | Tier II |
6 | NC_000084.6 | 18 | 71947997 | + | Dcc | NNNATATCAGCGATTACACA | NGG | 2 | 0.4127 | Tier II |
7 | NC_000067.6 | 1 | 25514417 | + | Adgrb3 | NNNATAGCAGAAATTATACA | NGG | 2 | 0.35 | Tier II |
8 | NC_000075.6 | 9 | 100720283 | + | Stag1 | NNNAGAGCAGCAATTAAACA | NGG | 2 | 0.2987 | Tier II |
9 | NC_000078.6 | 12 | 37323407 | - | Agmo | NNNTTAGCAGCAATTATACA | NGG | 2 | 0.297 | Tier II |
10 | NC_000067.6 | 1 | 66204459 | - | Map2 | NNNATAACAGCAATCACACA | NGG | 2 | 0.2727 | Tier II |
11 | NC_000067.6 | 1 | 87346335 | - | Gigyf2 | NNNATAACAGCAATTACACA | NAG | 2 | 0.2593 | Tier II |
12 | NC_000068.7 | 2 | 15058685 | - | Arl5b | NNNATACCAGCAATTACACA | NAG | 2 | 0.1782 | Tier II |
13 | NC_000067.6 | 1 | 92155830 | + | Hdac4 | NNNATAGCAGCAAATACCCA | NGG | 2 | 0.1179 | Tier II |
14 | NC_000084.6 | 18 | 7898109 | - | Wac | NNNATAGCAGAAATTACACA | NGA | 2 | 0.0521 | Tier II |
15 | NC_000084.6 | 18 | 44547156 | + | Mcc | NNNATAGCCGCAATTACACA | NGT | 2 | 0.0092 | Tier II |
16 | NC_000068.7 | 2 | 140182781 | + | Ndufaf5 | NNNAAAGCAGCAATTTCACA | NGG | 2 | 0.0 | Tier II |
17 | NC_000073.6 | 7 | 110142663 | - | Wee1 | NNNATAGCAGCAAATTCACA | NGG | 2 | 0.0 | Tier II |
18 | NC_000085.6 | 19 | 38599002 | + | Plce1 | NNNGTAGCAGCAATTTCACA | NGG | 2 | 0.0 | Tier II |
19 | NC_000081.6 | 15 | 93722693 | + | Gm30339 | NNNATAACAGCAATTACAGA | NGG | 2 | 0.125 | Tier III |
20 | NC_000084.6 | 18 | 44547156 | + | Gm52347 | NNNATAGCCGCAATTACACA | NGT | 2 | 0.0092 | Tier III |