Construct: sgRNA BRDN0001145971
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TGTATGAGAAACCTGAACGA
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- DCK (1633)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 78059
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000004.12 |
4 |
71022430 |
+ |
DCK |
NNNATGAGAAACCTGAACGA |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000006.12 |
6 |
47965063 |
- |
PTCHD4 |
NNNATGAGAAACCTGAATAA |
NGG |
2 |
0.4592 |
Tier II |
3 |
NC_000010.11 |
10 |
45765269 |
- |
WASHC2C |
NNNATGAGAAACCAGAACAA |
NGG |
2 |
0.4422 |
Tier II |
4 |
NC_000010.11 |
10 |
50105924 |
- |
WASHC2A |
NNNATGAGAAACCAGAACAA |
NGG |
2 |
0.4422 |
Tier II |
5 |
NC_000006.12 |
6 |
110438022 |
- |
SLC22A16 |
NNNATCAGAAACCTGAATGA |
NGG |
2 |
0.4383 |
Tier II |
6 |
NC_000005.10 |
5 |
79058440 |
+ |
DMGDH |
NNNATGAGAAGCCTGAAAGA |
NGG |
2 |
0.35 |
Tier II |
7 |
NC_000011.10 |
11 |
115395284 |
- |
CADM1 |
NNNATGAGAAATCTGAAAGA |
NGG |
2 |
0.2899 |
Tier II |
8 |
NC_000004.12 |
4 |
181906543 |
+ |
TENM3 |
NNNATGAGAAACCAGAAGGA |
NGG |
2 |
0.0825 |
Tier II |
9 |
NC_000001.11 |
1 |
213827798 |
+ |
RPS6KC1 |
NNNATGAGACACCTGAAGGA |
NGG |
2 |
0.0444 |
Tier II |
10 |
NC_000015.10 |
15 |
32951771 |
+ |
FMN1 |
NNNATGAGAAAACTGTACGA |
NGG |
2 |
0.0 |
Tier II |
11 |
NC_000010.11 |
10 |
45706973 |
+ |
FAM21FP |
NNNATGAGAAACCAGAACAA |
NGG |
2 |
0.4422 |
Tier III |
12 |
NC_000010.11 |
10 |
50048744 |
+ |
FAM21EP |
NNNATGAGAAACCAGAACAA |
NGG |
2 |
0.4422 |
Tier III |
13 |
NC_000006.12 |
6 |
135234447 |
+ |
LOC105378011 |
NNNATGAGAAACCTGAAACA |
NGG |
2 |
0.2414 |
Tier III |
14 |
NC_000006.12 |
6 |
82069173 |
+ |
LINC02542 |
NNNATGAGAAAGATGAACGA |
NGG |
2 |
0.1709 |
Tier III |
15 |
NC_000006.12 |
6 |
82069173 |
+ |
LOC107986617 |
NNNATGAGAAAGATGAACGA |
NGG |
2 |
0.1709 |
Tier III |
16 |
NC_000001.11 |
1 |
90842716 |
- |
LINC02609 |
NNNATAAGAAACCTGATCGA |
NGG |
2 |
0.1333 |
Tier III |
17 |
NC_000001.11 |
1 |
90842716 |
- |
LINC02788 |
NNNATAAGAAACCTGATCGA |
NGG |
2 |
0.1333 |
Tier III |
18 |
NC_000006.12 |
6 |
164086686 |
- |
LOC105378106 |
NNNATGAGAAACCTGAACGG |
NGA |
2 |
0.0531 |
Tier III |
19 |
NC_000001.11 |
1 |
213827798 |
+ |
PROX1-AS1 |
NNNATGAGACACCTGAAGGA |
NGG |
2 |
0.0444 |
Tier III |
20 |
NC_000013.11 |
13 |
60342511 |
- |
LOC105370228 |
NNNATGAGAAACGTGAAGGA |
NGG |
2 |
0.0182 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000071.6 |
5 |
88772693 |
+ |
Dck |
NNNATGAGAAACCTGAACGG |
NGG |
1 |
0.7647 |
Tier I |
2 |
NC_000070.6 |
4 |
148947104 |
+ |
Casz1 |
NNNATGAGAAGGCTGAACGA |
NGG |
2 |
0.2889 |
Tier I |
3 |
NC_000079.6 |
13 |
41157451 |
+ |
Sycp2l |
NNNTTGAGAAACCTGAACGA |
NGA |
2 |
0.0442 |
Tier I |
4 |
NC_000082.6 |
16 |
14138451 |
- |
Marf1 |
NNNATGAGAAACCTGCACGA |
NGC |
2 |
0.0 |
Tier I |
5 |
NC_000072.6 |
6 |
140593804 |
- |
Plekha5 |
NNNATGAGAAACCTGAACTA |
NGG |
1 |
0.6667 |
Tier II |
6 |
NC_000068.7 |
2 |
10170608 |
- |
Itih5 |
NNNATGAGAAATCTGAACGA |
NGG |
1 |
0.5385 |
Tier II |
7 |
NC_000077.6 |
11 |
110431493 |
+ |
Map2k6 |
NNNATGAGAAACCTGAACTT |
NGG |
2 |
0.4 |
Tier II |
8 |
NC_000073.6 |
7 |
43723528 |
- |
Klk13 |
NNNATGAGAAACCTGAAAGT |
NGG |
2 |
0.3231 |
Tier II |
9 |
NC_000074.6 |
8 |
122979077 |
+ |
Ankrd11 |
NNNATGAGAAAACTGAACCA |
NGG |
2 |
0.3202 |
Tier II |
10 |
NC_000084.6 |
18 |
35598962 |
- |
Paip2 |
NNNATGAGAAAAATGAACGA |
NGG |
2 |
0.2747 |
Tier II |
11 |
NC_000070.6 |
4 |
149002747 |
- |
Pex14 |
NNNATGAGAAACCTGAACAA |
NAG |
2 |
0.1852 |
Tier II |
12 |
NC_000073.6 |
7 |
134125179 |
- |
Adam12 |
NNNATGAGAATCCTGAAAGA |
NGG |
2 |
0.1657 |
Tier II |
13 |
NC_000076.6 |
10 |
75762066 |
+ |
Cabin1 |
NNNATGAGGAACCTGAAGGA |
NGG |
2 |
0.0889 |
Tier II |
14 |
NC_000079.6 |
13 |
100606199 |
- |
Marveld2 |
NNNATGAGAAACCTGATGGA |
NGG |
2 |
0.0178 |
Tier II |
15 |
NC_000073.6 |
7 |
105579100 |
- |
Apbb1 |
NNNATGAGAAACATGAACGA |
NTG |
2 |
0.015 |
Tier II |
16 |
NC_000078.6 |
12 |
52565795 |
+ |
Arhgap5 |
NNNATGAGAAACCGGATCGA |
NGG |
2 |
0.0 |
Tier II |
17 |
NC_000073.6 |
7 |
143560941 |
+ |
Cars |
NNNATGAGAAACCTGCACCA |
NGG |
2 |
0.0 |
Tier II |
18 |
NC_000076.6 |
10 |
24672232 |
- |
Enpp1 |
NNNATGAGAAACCTTCACGA |
NGG |
2 |
0.0 |
Tier II |
19 |
NC_000078.6 |
12 |
39494426 |
- |
Gm34923 |
NNNATGAGAAACATGAATGA |
NGG |
2 |
0.2473 |
Tier III |
20 |
NC_000079.6 |
13 |
90486077 |
- |
Gm35111 |
NNNATGAGACACCTGAATGA |
NGG |
2 |
0.2143 |
Tier III |
21 |
NC_000070.6 |
4 |
149002747 |
- |
Gm42351 |
NNNATGAGAAACCTGAACAA |
NAG |
2 |
0.1852 |
Tier III |
Other clones with same target sequence:
(none)