Construct: sgRNA BRDN0001146109
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GACAGTGAAATTAGCTCCCA
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- NO_SITE control
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 80242
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000003.12 |
3 |
65393179 |
+ |
MAGI1 |
NNNAGTGAATTCAGCTCCCA |
NGG |
2 |
0.8359 |
Tier II |
2 |
NC_000002.12 |
2 |
233794099 |
- |
MROH2A |
NNNTGTGAAAATAGCTCCCA |
NGG |
2 |
0.4773 |
Tier II |
3 |
NC_000005.10 |
5 |
68283937 |
+ |
PIK3R1 |
NNNTGTGAAATTAGCCCCCA |
NGG |
2 |
0.4242 |
Tier II |
4 |
NC_000007.14 |
7 |
47285847 |
+ |
TNS3 |
NNNGGTGAAATTAGCTCCCT |
NGG |
2 |
0.375 |
Tier II |
5 |
NC_000012.12 |
12 |
40013700 |
- |
SLC2A13 |
NNNAGTGAAATAAGCTCCAA |
NGG |
2 |
0.3429 |
Tier II |
6 |
NC_000023.11 |
X |
139922605 |
- |
ATP11C |
NNNAGTGAAATGAGCTCCCT |
NGG |
2 |
0.3 |
Tier II |
7 |
NC_000012.12 |
12 |
70352588 |
- |
CNOT2 |
NNNAGTGACATTAGCTACCA |
NGG |
2 |
0.2667 |
Tier II |
8 |
NC_000003.12 |
3 |
59993696 |
- |
FHIT |
NNNAGTGAAATCAGCTCCCA |
NAG |
2 |
0.2456 |
Tier II |
9 |
NC_000008.11 |
8 |
143475189 |
+ |
ZC3H3 |
NNNAGTGAAATTAACTCCCA |
NGA |
2 |
0.0521 |
Tier II |
10 |
NC_000007.14 |
7 |
2694037 |
- |
AMZ1 |
NNNAGTGACATTAGCTGCCA |
NGG |
2 |
0.0336 |
Tier II |
11 |
NC_000001.11 |
1 |
67398298 |
- |
IL12RB2 |
NNNAGTGAAGTTAGCTCCCA |
NTG |
2 |
0.0216 |
Tier II |
12 |
NC_000023.11 |
X |
19690933 |
- |
SH3KBP1 |
NNNAGTGAAATTAACTCCCA |
NGC |
2 |
0.0167 |
Tier II |
13 |
NC_000017.11 |
17 |
43148008 |
- |
BRCA1 |
NNNAGTGAAATTAGCTCCCC |
NGC |
2 |
0.0051 |
Tier II |
14 |
NC_000017.11 |
17 |
46335909 |
+ |
LRRC37A |
NNNAGTGAAATTAGCTCCCC |
NGC |
2 |
0.0051 |
Tier II |
15 |
NC_000017.11 |
17 |
46335909 |
+ |
ARL17B |
NNNAGTGAAATTAGCTCCCC |
NGC |
2 |
0.0051 |
Tier II |
16 |
NC_000017.11 |
17 |
46553764 |
+ |
ARL17A |
NNNAGTGAAATTAGCTCCCC |
NGC |
2 |
0.0051 |
Tier II |
17 |
NC_000017.11 |
17 |
46553764 |
+ |
LRRC37A2 |
NNNAGTGAAATTAGCTCCCC |
NGC |
2 |
0.0051 |
Tier II |
18 |
NC_000017.11 |
17 |
64855520 |
- |
LRRC37A3 |
NNNAGTGAAATTAGCTCCCC |
NGC |
2 |
0.0051 |
Tier II |
19 |
NC_000004.12 |
4 |
75997360 |
- |
SDAD1-AS1 |
NNNAGTGGAATTAGCTCCCA |
NGT |
2 |
0.0118 |
Tier III |
20 |
NC_000017.11 |
17 |
43148008 |
- |
NBR2 |
NNNAGTGAAATTAGCTCCCC |
NGC |
2 |
0.0051 |
Tier III |
21 |
NC_000017.11 |
17 |
45509922 |
- |
LRRC37A4P |
NNNAGTGAAATTAGCTCCCC |
NGC |
2 |
0.0051 |
Tier III |
22 |
NC_000017.11 |
17 |
45509922 |
- |
LOC105369225 |
NNNAGTGAAATTAGCTCCCC |
NGC |
2 |
0.0051 |
Tier III |
23 |
NC_000017.11 |
17 |
64855520 |
- |
LOC105376844 |
NNNAGTGAAATTAGCTCCCC |
NGC |
2 |
0.0051 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000086.7 |
X |
20130942 |
- |
Slc9a7 |
NNNAGAGAAAATAGCTCCCA |
NGG |
2 |
0.65 |
Tier II |
2 |
NC_000079.6 |
13 |
95860211 |
+ |
Iqgap2 |
NNNACTGAAAATAGCTCCCA |
NGG |
2 |
0.5893 |
Tier II |
3 |
NC_000068.7 |
2 |
121567740 |
+ |
Frmd5 |
NNNAGTGAAATCACCTCCCA |
NGG |
2 |
0.406 |
Tier II |
4 |
NC_000074.6 |
8 |
84371239 |
- |
Cacna1a |
NNNAGTGAAAGTAGCTCCCA |
NGG |
1 |
0.4 |
Tier II |
5 |
NC_000072.6 |
6 |
38983389 |
+ |
Tbxas1 |
NNNAGGGAAATTAGCCCCCA |
NGG |
2 |
0.381 |
Tier II |
6 |
NC_000067.6 |
1 |
188176194 |
- |
Esrrg |
NNNAGAGAAAGTAGCTCCCA |
NGG |
2 |
0.3467 |
Tier II |
7 |
NC_000067.6 |
1 |
123573811 |
- |
Dpp10 |
NNNAGTTAAATGAGCTCCCA |
NGG |
2 |
0.2857 |
Tier II |
8 |
NC_000080.6 |
14 |
28121448 |
+ |
Erc2 |
NNNAGTGAAATCTGCTCCCA |
NGG |
2 |
0.2842 |
Tier II |
9 |
NC_000084.6 |
18 |
45679763 |
- |
Kcnn2 |
NNNAGTGAAAATTGCTCCCA |
NGG |
2 |
0.225 |
Tier II |
10 |
NC_000073.6 |
7 |
89326610 |
+ |
Tmem135 |
NNNAGTGAACTTAGCTCCCC |
NGG |
2 |
0.0758 |
Tier II |
11 |
NC_000077.6 |
11 |
20562376 |
- |
Sertad2 |
NNNAGTGAAATTAGCTCCCA |
NGA |
1 |
0.0694 |
Tier II |
12 |
NC_000072.6 |
6 |
3727885 |
- |
Calcr |
NNNATTGAAATTAGCTCCCC |
NGG |
2 |
0.0682 |
Tier II |
13 |
NC_000075.6 |
9 |
114789477 |
- |
Cmtm8 |
NNNAGTTAAATTAGCTCCCA |
NTG |
2 |
0.0223 |
Tier II |
14 |
NC_000082.6 |
16 |
94247787 |
- |
Hlcs |
NNNAGTGACATTAGCTCCCA |
NGT |
2 |
0.0092 |
Tier II |
15 |
NC_000080.6 |
14 |
52584168 |
+ |
Tcra |
NNNAGTGAAAATAGCACCCA |
NGG |
2 |
0.6818 |
Tier III |
16 |
NC_000080.6 |
14 |
44891103 |
- |
Gm16976 |
NNNAGTGAAATTATTTCCCA |
NGG |
2 |
0.0178 |
Tier III |
Other clones with same target sequence:
(none)