Construct: sgRNA BRDN0001146264
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- GAGTCAAGTGATCAGTGCTG
Original Target:
- Taxon:
-
Homo sapiens (human)
- Gene:
- GTF2H1 (2965)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Vector Information:
- Vector Backbone:
- pXPR_003
- Pol II Cassette 1:
- EF1A-PuroR
- Pol II Cassette 2:
- n/a
- Selection Marker:
- PuroR
- Visible Reporter:
- n/a
- Epitope Tag:
- n/a
Additional Information:
- Addgene ID:
- 76600
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000011.10 |
11 |
18338177 |
+ |
GTF2H1 |
NNNTCAAGTGATCAGTGCTG |
NGG |
0 |
1.0 |
Tier I |
2 |
NC_000003.12 |
3 |
38002586 |
- |
VILL |
NNNTCAAGTGGTCAGTGCTG |
NGG |
1 |
0.65 |
Tier I |
3 |
NC_000015.10 |
15 |
77686838 |
- |
LINGO1 |
NNNCCAAGTGATCAGAGCTG |
NGG |
2 |
0.5882 |
Tier II |
4 |
NC_000005.10 |
5 |
116019873 |
+ |
LVRN |
NNNTGAAGTGACCAGTGCTG |
NGG |
2 |
0.5684 |
Tier II |
5 |
NC_000002.12 |
2 |
20212191 |
- |
SDC1 |
NNNTCTGGTGATCAGTGCTG |
NGG |
2 |
0.5042 |
Tier II |
6 |
NC_000012.12 |
12 |
3671318 |
+ |
CRACR2A |
NNNCCAGGTGATCAGTGCTG |
NGG |
2 |
0.4567 |
Tier II |
7 |
NC_000021.9 |
21 |
44400580 |
- |
TRPM2 |
NNNTCATGAGATCAGTGCTG |
NGG |
2 |
0.4062 |
Tier II |
8 |
NC_000015.10 |
15 |
76613668 |
- |
SCAPER |
NNNTCTAGTGATCAGTGATG |
NGG |
2 |
0.3846 |
Tier II |
9 |
NC_000020.11 |
20 |
14183791 |
+ |
MACROD2 |
NNNTCTAGTGATCAGTGATG |
NGG |
2 |
0.3846 |
Tier II |
10 |
NC_000010.11 |
10 |
5966051 |
- |
IL15RA |
NNNTCAAGGGATCTGTGCTG |
NGG |
2 |
0.3302 |
Tier II |
11 |
NC_000007.14 |
7 |
121364306 |
+ |
FAM3C |
NNNTCAATTGTTCAGTGCTG |
NGG |
2 |
0.1923 |
Tier II |
12 |
NC_000008.11 |
8 |
101632036 |
- |
GRHL2 |
NNNTCAAGTGAGCACTGCTG |
NGG |
2 |
0.1364 |
Tier II |
13 |
NC_000012.12 |
12 |
52827272 |
- |
KRT79 |
NNNTCAAGTGATGAGAGCTG |
NGG |
2 |
0.124 |
Tier II |
14 |
NC_000012.12 |
12 |
101079737 |
+ |
ANO4 |
NNNTCAAGTGTTCCGTGCTG |
NGG |
2 |
0.0659 |
Tier II |
15 |
NC_000003.12 |
3 |
57603583 |
+ |
PDE12 |
NNNTCAAGTGATCTGTGCTG |
NGA |
2 |
0.037 |
Tier II |
16 |
NC_000014.9 |
14 |
61403674 |
+ |
PRKCH |
NNNACAAGTGATCAGTGCTG |
NGA |
2 |
0.0331 |
Tier II |
17 |
NC_000010.11 |
10 |
7374764 |
- |
SFMBT2 |
NNNTCAAGTCATCAGTGCTG |
NGC |
2 |
0.0089 |
Tier II |
18 |
NC_000002.12 |
2 |
20212191 |
- |
LOC124905978 |
NNNTCTGGTGATCAGTGCTG |
NGG |
2 |
0.5042 |
Tier III |
19 |
NC_000016.10 |
16 |
27165785 |
- |
LINC02129 |
NNNTCCAGTGATCAGAGCTG |
NGG |
2 |
0.4132 |
Tier III |
20 |
NC_000010.11 |
10 |
5966051 |
- |
LOC107984200 |
NNNTCAAGGGATCTGTGCTG |
NGG |
2 |
0.3302 |
Tier III |
21 |
NC_000003.12 |
3 |
8001404 |
- |
LOC101927394 |
NNNAAAAGTGATCAGTGCTG |
NGG |
2 |
0.2721 |
Tier III |
22 |
NC_000018.10 |
18 |
60196966 |
+ |
LOC342784 |
NNNCCAAGTGATGAGTGCTG |
NGG |
2 |
0.0882 |
Tier III |
23 |
NC_000001.11 |
1 |
63164202 |
+ |
LINC00466 |
NNNTCAGGTGATCAGTGCTG |
NGA |
2 |
0.049 |
Tier III |
24 |
NC_000010.11 |
10 |
38674744 |
+ |
SLC9B1P3 |
NNNTCAAGTGAACAGTGCTG |
NGT |
2 |
0.0129 |
Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
| Reference Sequence |
Chromosome |
Cut Position |
Match Strand |
Match Gene |
Match Sequence |
PAM Seq. |
Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. |
CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. |
Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. |
1 |
NC_000073.6 |
7 |
46805029 |
+ |
Gtf2h1 |
NNNCCAAGTGATCAGTGCTG |
NGG |
1 |
0.6471 |
Tier I |
2 |
NC_000070.6 |
4 |
64008833 |
+ |
Tnc |
NNNCCAGGTGATCAGTGCTG |
NGG |
2 |
0.4567 |
Tier I |
3 |
NC_000078.6 |
12 |
24581622 |
- |
Grhl1 |
NNNTGAACTGATCAGTGCTG |
NGG |
2 |
0.3692 |
Tier I |
4 |
NC_000081.6 |
15 |
92117422 |
+ |
Cntn1 |
NNNTCAAATGATCAATGCTG |
NGG |
2 |
0.9412 |
Tier II |
5 |
NC_000086.7 |
X |
49237212 |
- |
Enox2 |
NNNTCAAATGATCAGTGATG |
NGG |
2 |
0.5385 |
Tier II |
6 |
NC_000079.6 |
13 |
108374683 |
- |
Depdc1b |
NNNGTAAGTGATCAGTGCTG |
NGG |
2 |
0.3977 |
Tier II |
7 |
NC_000077.6 |
11 |
35901745 |
+ |
Wwc1 |
NNNTCAAGTGATCAGAGCTC |
NGG |
2 |
0.3896 |
Tier II |
8 |
NC_000072.6 |
6 |
54448103 |
+ |
Wipf3 |
NNNTCCAGGGATCAGTGCTG |
NGG |
2 |
0.2814 |
Tier II |
9 |
NC_000071.6 |
5 |
98764323 |
- |
Cfap299 |
NNNTCAAGTGCTCAGTGTTG |
NGG |
2 |
0.2571 |
Tier II |
10 |
NC_000080.6 |
14 |
117882892 |
- |
Gpc6 |
NNNTCAAGTGATCAGAGCTG |
NAG |
2 |
0.2357 |
Tier II |
11 |
NC_000075.6 |
9 |
28183945 |
+ |
Opcml |
NNNTCATGTGATCAGTGATG |
NGG |
2 |
0.2356 |
Tier II |
12 |
NC_000080.6 |
14 |
47160894 |
- |
Gch1 |
NNNTGAAGTGATCAGTGCGG |
NGG |
2 |
0.15 |
Tier II |
13 |
NC_000071.6 |
5 |
103725511 |
- |
Aff1 |
NNNTCAAGAGATCAGTGCTG |
NGC |
2 |
0.0206 |
Tier II |
14 |
NC_000067.6 |
1 |
38315818 |
- |
Aff3 |
NNNTCAAGGGATCAGTGCTG |
NGC |
2 |
0.0138 |
Tier II |
15 |
NC_000073.6 |
7 |
120588039 |
+ |
Gm4105 |
NNNTCAGGTGATCAGTGCTG |
NGG |
1 |
0.7059 |
Tier III |
16 |
NC_000073.6 |
7 |
120588039 |
+ |
Gm46020 |
NNNTCAGGTGATCAGTGCTG |
NGG |
1 |
0.7059 |
Tier III |
17 |
NC_000070.6 |
4 |
64008833 |
+ |
8030451A03Rik |
NNNCCAGGTGATCAGTGCTG |
NGG |
2 |
0.4567 |
Tier III |
18 |
NC_000068.7 |
2 |
14538943 |
- |
Gm13266 |
NNNTTAACTGATCAGTGCTG |
NGG |
2 |
0.3916 |
Tier III |
19 |
NC_000072.6 |
6 |
32641366 |
- |
Gm32007 |
NNNTTAAGTGATAAGTGCTG |
NGG |
2 |
0.2448 |
Tier III |
20 |
NC_000079.6 |
13 |
100274819 |
+ |
Naip3-ps1 |
NNNTCAAGTGGTCAGTGCCG |
NGG |
2 |
0.1793 |
Tier III |
21 |
NC_000079.6 |
13 |
100353996 |
+ |
Naip3 |
NNNTCAAGTGGTCAGTGCCG |
NGG |
2 |
0.1793 |
Tier III |
Other clones with same target sequence:
(none)