Construct: sgRNA BRDN0001146407
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- TGATATTAGATATTGATCAG
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- MAPK8 (5599)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000010.11 | 10 | 48425896 | + | MAPK8 | NNNTATTAGATATTGATCAG | NGG | 0 | 1.0 | Tier I |
2 | NC_000005.10 | 5 | 180242748 | - | MAPK9 | NNNCCTTAGATATTGATCAG | NGG | 2 | 0.3235 | Tier I |
3 | NC_000006.12 | 6 | 36095995 | + | MAPK14 | NNNCATTAGATATTGATCAG | NTG | 2 | 0.0252 | Tier I |
4 | NC_000018.10 | 18 | 63546006 | - | SERPINB12 | NNNTATAAGATATTGACCAG | NGG | 2 | 0.6176 | Tier II |
5 | NC_000010.11 | 10 | 67516742 | - | CTNNA3 | NNNTAGTAGATATTGATCAA | NGG | 2 | 0.5357 | Tier II |
6 | NC_000010.11 | 10 | 126378563 | + | ADAM12 | NNNTATCAGATATTGATTAG | NGG | 2 | 0.442 | Tier II |
7 | NC_000012.12 | 12 | 28358721 | + | CCDC91 | NNNTAGTGGATATTGATCAG | NGG | 2 | 0.419 | Tier II |
8 | NC_000004.12 | 4 | 15824617 | + | CD38 | NNNTATAAGATTTTGATCAG | NGG | 2 | 0.2917 | Tier II |
9 | NC_000011.10 | 11 | 100938977 | - | ARHGAP42 | NNNTATTTGATATTGATCAC | NGG | 2 | 0.1837 | Tier II |
10 | NC_000022.11 | 22 | 33083626 | + | LARGE1 | NNNTATCAGATAGTGATCAG | NGG | 2 | 0.1793 | Tier II |
11 | NC_000019.10 | 19 | 43918756 | + | ZNF45 | NNNGATTAGATATTCATCAG | NGG | 2 | 0.1705 | Tier II |
12 | NC_000009.12 | 9 | 92365192 | + | CENPP | NNNTATTAGATATCGATAAG | NGG | 2 | 0.1538 | Tier II |
13 | NC_000009.12 | 9 | 109489125 | + | PTPN3 | NNNTATTAGAAATTGGTCAG | NGG | 2 | 0.1442 | Tier II |
14 | NC_000011.10 | 11 | 21453345 | - | NELL1 | NNNTATTAGATAATTATCAG | NGG | 2 | 0.0989 | Tier II |
15 | NC_000004.12 | 4 | 75801399 | + | USO1 | NNNTATTAGATAATGATGAG | NGG | 2 | 0.0923 | Tier II |
16 | NC_000004.12 | 4 | 121935685 | + | TRPC3 | NNNTATTATATATTGATGAG | NGG | 2 | 0.0711 | Tier II |
17 | NC_000010.11 | 10 | 10639662 | - | CELF2 | NNNTATTAGATATTGATCAG | NGA | 1 | 0.0694 | Tier II |
18 | NC_000002.12 | 2 | 188444481 | - | GULP1 | NNNTATTAGATATTGATCAA | NGA | 2 | 0.0651 | Tier II |
19 | NC_000003.12 | 3 | 61638823 | + | PTPRG | NNNTATTAGATATTGGTCAG | NTG | 2 | 0.0075 | Tier II |
20 | NC_000005.10 | 5 | 94951356 | - | MCTP1 | NNNTATTAGATATTGGTCAG | NTG | 2 | 0.0075 | Tier II |
21 | NC_000014.9 | 14 | 54972848 | + | WDHD1 | NNNTATTAGATATTGGTCAG | NGT | 2 | 0.0031 | Tier II |
22 | NC_000023.11 | X | 29639844 | + | IL1RAPL1 | NNNTATTAGATATGCATCAG | NGG | 2 | 0.0 | Tier II |
23 | NC_000010.11 | 10 | 47967025 | + | ANXA8 | NNNTATTAGATATTGATCAG | NTC | 2 | 0.0 | Tier II |
24 | NC_000001.11 | 1 | 7337037 | - | CAMTA1 | NNNTATTAGTTATTGCTCAG | NGG | 2 | 0.0 | Tier II |
25 | NC_000012.12 | 12 | 45461448 | + | LOC105369743 | NNNCATTAGATATTGATCAG | NGG | 1 | 0.6471 | Tier III |
26 | NC_000012.12 | 12 | 87047133 | + | LOC105369878 | NNNTAATAGATATTGATCAT | NGG | 2 | 0.6067 | Tier III |
27 | NC_000001.11 | 1 | 98174671 | + | LOC124900404 | NNNTACTAGATATTGAACAG | NGG | 2 | 0.4848 | Tier III |
28 | NC_000008.11 | 8 | 69426449 | - | LINC01603 | NNNTCTTAGATAATGATCAG | NGG | 2 | 0.3462 | Tier III |
29 | NC_000019.10 | 19 | 43918756 | + | ZNF45-AS1 | NNNGATTAGATATTCATCAG | NGG | 2 | 0.1705 | Tier III |
30 | NC_000011.10 | 11 | 80141154 | - | LOC105369406 | NNNTATTAGATATTGATAAG | NGA | 2 | 0.0374 | Tier III |
31 | NC_000023.11 | X | 119256814 | + | AKAP17BP | NNNTATTAGTTATTGATCAG | NGC | 2 | 0.0196 | Tier III |
32 | NC_000010.11 | 10 | 46417637 | - | LINC00842 | NNNTATTAGATATTGATCAG | NTC | 2 | 0.0 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000080.6 | 14 | 33388975 | - | Mapk8 | NNNTAATAGATATTGATCAG | NGG | 1 | 0.8667 | Tier I |
2 | NC_000067.6 | 1 | 9552951 | + | Adhfe1 | NNNTATTAGATATGGAGCAG | NGG | 2 | 0.0 | Tier I |
3 | NC_000084.6 | 18 | 72000825 | + | Dcc | NNNTATTAGTCATTGATCAG | NGG | 2 | 0.5882 | Tier II |
4 | NC_000081.6 | 15 | 39238621 | - | Rims2 | NNNTATTACATATTGATTAG | NGG | 2 | 0.3462 | Tier II |
5 | NC_000072.6 | 6 | 47297661 | - | Cntnap2 | NNNTTTTAGATATTGATCAT | NGG | 2 | 0.2545 | Tier II |
6 | NC_000084.6 | 18 | 71990570 | - | Dcc | NNNTATAAGATAGTGATCAG | NGG | 2 | 0.2283 | Tier II |
7 | NC_000067.6 | 1 | 182017069 | - | Enah | NNNTATTAGATCTTGATTAG | NGG | 2 | 0.1692 | Tier II |
8 | NC_000067.6 | 1 | 184820693 | + | Mtarc2 | NNNTATTAGAAATTGATGAG | NGG | 2 | 0.1 | Tier II |
9 | NC_000073.6 | 7 | 43800958 | + | Klk8 | NNNTATTAGATATTGAGCTG | NGG | 2 | 0.0633 | Tier II |
10 | NC_000071.6 | 5 | 14593060 | + | Pclo | NNNTATTAGATATTGATCAA | NGT | 2 | 0.0151 | Tier II |
11 | NC_000077.6 | 11 | 47767430 | - | Sgcd | NNNTATTAGGTATTGATCAG | NGT | 2 | 0.009 | Tier II |
12 | NC_000086.7 | X | 51145171 | - | Mbnl3 | NNNGATTAGATATGGATCAG | NGG | 2 | 0.0 | Tier II |
13 | NC_000083.6 | 17 | 43156825 | + | E130008D07Rik | NNNTATTAGATATTGACCAA | NGG | 2 | 0.6618 | Tier III |
14 | NC_000076.6 | 10 | 70624623 | + | D630013N20Rik | NNNTATGAGTTATTGATCAG | NGG | 2 | 0.519 | Tier III |
15 | NC_000072.6 | 6 | 48872964 | + | Gm44764 | NNNTACTAGATATGGATCAG | NGG | 2 | 0.0 | Tier III |