Construct: sgRNA BRDN0001146475
Construct Description:
- Construct Type:
- sgRNA
- Other Identifiers:
- n/a
- DNA Barcode:
- ATGGCATTATATTTCCCACA
Original Target:
- Taxon:
- Homo sapiens (human)
- Gene:
- CSNK1G1 (53944)
- Gene Description:
- n/a
- CRISPR Mechanism
- CRISPRko
Gene matches for this target sequence (CRISPRko, PAM=NGG, human):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000015.10 | 15 | 64216676 | + | CSNK1G1 | NNNGCATTATATTTCCCACA | NGG | 0 | 1.0 | Tier I |
2 | NC_000005.10 | 5 | 123573428 | - | CSNK1G3 | NNNGCATTGTATTTACCACA | NGG | 2 | 0.1481 | Tier I |
3 | NC_000007.14 | 7 | 11446251 | + | THSD7A | NNNGCATTATATTTGTCACA | NGG | 2 | 0.0154 | Tier I |
4 | NC_000023.11 | X | 136213538 | - | MAP7D3 | NNNGCATTATGTCTCCCACA | NGG | 2 | 0.5132 | Tier II |
5 | NC_000012.12 | 12 | 23909162 | + | SOX5 | NNNGCATTATATTTCAAACA | NGG | 2 | 0.4667 | Tier II |
6 | NC_000001.11 | 1 | 15713581 | - | PLEKHM2 | NNNGAATTATAATTCCCACA | NGG | 2 | 0.4571 | Tier II |
7 | NC_000007.14 | 7 | 147269400 | - | CNTNAP2 | NNNGCATTATATATCCAACA | NGG | 2 | 0.3231 | Tier II |
8 | NC_000013.11 | 13 | 41849412 | + | VWA8 | NNNTCAATATATTTCCCACA | NGG | 2 | 0.3182 | Tier II |
9 | NC_000005.10 | 5 | 42568255 | - | GHR | NNNTCATTAAATTTCCCACA | NGG | 2 | 0.3117 | Tier II |
10 | NC_000004.12 | 4 | 71269714 | - | SLC4A4 | NNNGCATTATATTTCTCACA | NGG | 1 | 0.3077 | Tier II |
11 | NC_000015.10 | 15 | 32098054 | - | CHRNA7 | NNNGAATTATAGTTCCCACA | NGG | 2 | 0.2857 | Tier II |
12 | NC_000008.11 | 8 | 3490228 | + | CSMD1 | NNNGCATTATGTTTCCCAAA | NGG | 2 | 0.2786 | Tier II |
13 | NC_000013.11 | 13 | 36294521 | + | CCDC169 | NNNGCATTTTATTTCCCATA | NGG | 2 | 0.2769 | Tier II |
14 | NC_000013.11 | 13 | 36294521 | + | CCDC169-SOHLH2 | NNNGCATTTTATTTCCCATA | NGG | 2 | 0.2769 | Tier II |
15 | NC_000003.12 | 3 | 53130084 | - | RFT1 | NNNGCATTCTATTTCCCATA | NGG | 2 | 0.2637 | Tier II |
16 | NC_000006.12 | 6 | 53098263 | + | FBXO9 | NNNGCATTTTATTTCCCGCA | NGG | 2 | 0.24 | Tier II |
17 | NC_000011.10 | 11 | 40455178 | - | LRRC4C | NNNGCATTATATTTCCCTTA | NGG | 2 | 0.2308 | Tier II |
18 | NC_000002.12 | 2 | 30574482 | - | LCLAT1 | NNNTCATTATATTTCCCATA | NGG | 2 | 0.1678 | Tier II |
19 | NC_000008.11 | 8 | 123257341 | - | ZHX1 | NNNGGATTATATGTCCCACA | NGG | 2 | 0.1565 | Tier II |
20 | NC_000008.11 | 8 | 123257341 | - | ZHX1-C8orf76 | NNNGGATTATATGTCCCACA | NGG | 2 | 0.1565 | Tier II |
21 | NC_000012.12 | 12 | 815019 | - | WNK1 | NNNGCATTAGATTTCTCACA | NGG | 2 | 0.1538 | Tier II |
22 | NC_000019.10 | 19 | 53521014 | + | ZNF331 | NNNGCATTACATTTCCCAGA | NGG | 2 | 0.0667 | Tier II |
23 | NC_000006.12 | 6 | 142309330 | - | ADGRG6 | NNNGCATTTTATTTGCCACA | NGG | 2 | 0.03 | Tier II |
24 | NC_000014.9 | 14 | 71459169 | + | SIPA1L1 | NNNGCATTATATTTCTCACA | NGA | 2 | 0.0214 | Tier II |
25 | NC_000004.12 | 4 | 23173037 | - | LOC105374524 | NNNGAATTATAATTCCCACA | NGG | 2 | 0.4571 | Tier III |
26 | NC_000006.12 | 6 | 104349426 | - | LOC102724443 | NNNGCATTATTTTTCTCACA | NGG | 2 | 0.0947 | Tier III |
27 | NC_000008.11 | 8 | 71931492 | - | MSC-AS1 | NNNGCATTATACTTCCCACA | NGA | 2 | 0.0658 | Tier III |
28 | NC_000011.10 | 11 | 109757341 | + | LINC02715 | NNNGCATAATATTTCCCACA | NTG | 2 | 0.0312 | Tier III |
29 | NC_000002.12 | 2 | 19031742 | - | LOC105373456 | NNNGGATTATATTTCCCACA | NGT | 2 | 0.0097 | Tier III |
30 | NC_000002.12 | 2 | 208631069 | + | LOC101927960 | NNNTCATTATATTTCCCACA | NGT | 2 | 0.0059 | Tier III |
Gene matches for this target sequence (CRISPRko, PAM=NGG, mouse):
Reference Sequence | Chromosome | Cut Position | Match Strand | Match Gene | Match Sequence | PAM Seq. | Mismatches[?]Genomic matches are found by querying with a reduced sequence corresponding to the final 17mer of the 20mer guide target sequence, combined with the `GG` of the PAM sequence. Mismatches are assessed within this set of bases only, for a total of 19 possible matching bases. | CFD Score[?]Off target matches are assesed via a Cutting Frequency Determination, or CFD score. This value provides an estimate of how specific mismatches affect the likelihood that an sgRNA will cut a given target sequence. For more information, see Doench, Fusi et al., Nature Biotechnology 2016. | Match Tier[?]For a description of CRISPR match tiers, see How the sgRNA Designer Works. | |
---|---|---|---|---|---|---|---|---|---|---|
1 | NC_000075.6 | 9 | 65999433 | - | Csnk1g1 | NNNGCATTGTACTTCCCACA | NGG | 2 | 0.6316 | Tier I |
2 | NC_000075.6 | 9 | 20314157 | + | Olfr18 | NNNGCTTTATATTTCCCACC | NGG | 2 | 0.1623 | Tier I |
3 | NC_000075.6 | 9 | 30958940 | - | Adamts8 | NNNGCATTATATTTCTCACA | NTG | 2 | 0.012 | Tier I |
4 | NC_000073.6 | 7 | 122529571 | - | Prkcb | NNNGCACCATATTTCCCACA | NGG | 2 | 0.6875 | Tier II |
5 | NC_000068.7 | 2 | 33168624 | - | Ralgps1 | NNNGCATTCCATTTCCCACA | NGG | 2 | 0.3048 | Tier II |
6 | NC_000084.6 | 18 | 43266742 | + | Stk32a | NNNTCATTATAATTCCCACA | NGG | 2 | 0.2909 | Tier II |
7 | NC_000081.6 | 15 | 3454137 | + | Ghr | NNNCCATTACATTTCCCACA | NGG | 2 | 0.2824 | Tier II |
8 | NC_000072.6 | 6 | 9048104 | + | Nxph1 | NNNGCAGTATTTTTCCCACA | NGG | 2 | 0.181 | Tier II |
9 | NC_000072.6 | 6 | 92875420 | - | Adamts9 | NNNGCATTTTATTTCCCACA | NAG | 2 | 0.1556 | Tier II |
10 | NC_000075.6 | 9 | 80364377 | - | Impg1 | NNNGCATTATATTTCCCCCT | NGG | 2 | 0.1143 | Tier II |
11 | NC_000069.6 | 3 | 55635668 | + | Nbea | NNNGCAATATATTTTCCACA | NGG | 2 | 0.0583 | Tier II |
12 | NC_000077.6 | 11 | 21831227 | - | Wdpcp | NNNCCATTATATTTCCCACA | NGA | 2 | 0.0368 | Tier II |
13 | NC_000069.6 | 3 | 68924074 | + | Ift80 | NNNGCATTATATTTCCCAAA | NGA | 2 | 0.0298 | Tier II |
14 | NC_000076.6 | 10 | 83167924 | - | Chst11 | NNNGCATTATGTTTCCCACA | NTG | 2 | 0.0253 | Tier II |
15 | NC_000070.6 | 4 | 48155858 | - | Stx17 | NNNGCAGTATATTTCCCACA | NTG | 2 | 0.0229 | Tier II |
16 | NC_000067.6 | 1 | 188480223 | + | Ush2a | NNNGCATTATATTTCACACA | NGC | 2 | 0.0222 | Tier II |
17 | NC_000070.6 | 4 | 83295482 | - | Ttc39b | NNNGCATTATATTTCTCACA | NTG | 2 | 0.012 | Tier II |
18 | NC_000073.6 | 7 | 61220645 | + | A230006K03Rik | NNNGCATTATATTACACACA | NGG | 2 | 0.619 | Tier III |
19 | NC_000081.6 | 15 | 32166187 | + | Gm32499 | NNNGAATTATATTTCACACA | NGG | 2 | 0.5714 | Tier III |
20 | NC_000068.7 | 2 | 3405973 | - | Gm39750 | NNNGCAATCTATTTCCCACA | NGG | 2 | 0.5 | Tier III |
21 | NC_000068.7 | 2 | 144887229 | - | Gm39952 | NNNGCATTAAATTTCCCATA | NGG | 2 | 0.3956 | Tier III |
22 | NC_000072.6 | 6 | 92875420 | - | Gm15737 | NNNGCATTTTATTTCCCACA | NAG | 2 | 0.1556 | Tier III |
23 | NC_000070.6 | 4 | 23819842 | - | Gm31145 | NNNGCATTATATTTTCCACA | NAG | 2 | 0.0173 | Tier III |
24 | NC_000075.6 | 9 | 113106238 | - | Gm36251 | NNNGCATTATATTTTCCCCA | NGG | 2 | 0.0127 | Tier III |